| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Harysh Winster Suresh Babu, Sindduja Muthu Kumar, Harsimrat Kaur, Mahalaxmi Iyer, Balachandar Vellingir. Midbrain organoids for Parkinson's disease (PD) - A powerful tool to understand the disease pathogenesis. Life sciences. 2024-04-05. PMID:38580194. |
in the context of parkinson's disease (pd), recent advancements have been made in the development of midbrain organoids (mbos) models that consider key pathophysiological mechanisms such as alpha-synuclein (α-syn), lewy bodies, dopamine loss, and microglia activation. |
2024-04-05 |
2024-04-10 |
human |
| Pusheng Quan, Xueying Li, Yao Si, Linlin Sun, Fei Fan Ding, Yuwei Fan, Han Liu, Chengqun Wei, Ruihua Li, Xue Zhao, Fan Yang, Lifen Ya. Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson's disease. Cell communication and signaling : CCS. vol 22. issue 1. 2024-04-02. PMID:38566100. |
furthermore, single-cell trajectory detection demonstrated that microglia in the midbrain of pd patients were in a pro-inflammatory activation state, which was validated in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd mouse model as well. |
2024-04-02 |
2024-04-05 |
mouse |
| Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui L. LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease. Journal of cellular physiology. 2024-03-13. PMID:38477420. |
neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (da) neurons in the midbrain are its primary pathological manifestations. |
2024-03-13 |
2024-03-15 |
mouse |
| Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui L. LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease. Journal of cellular physiology. 2024-03-13. PMID:38477420. |
additionally, we observed abundant expression of lrrk2 and p-p65 in the midbrain, which was elevated in the mptp-induced pd model, along with microglia activation. |
2024-03-13 |
2024-03-15 |
mouse |
| Mingjie Zhang, Congyan Duan, Weifang Lin, Honghua Wu, Lu Chen, Hong Guo, Minyu Yu, Qi Liu, Yaling Nie, Hong Wang, Shaoxia Wan. Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson's Disease. Molecules (Basel, Switzerland). vol 29. issue 4. 2024-02-24. PMID:38398662. |
in vivo experiments further corroborated these findings, demonstrating that la mitigated the death of th-positive dopaminergic neurons and reduced microglia activation in the ventral snpc brain region of the midbrain and the striatum. |
2024-02-24 |
2024-02-26 |
Not clear |
| Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen, Anastasia Shakirzyanova, Mireia Gómez-Budia, Nelli-Noora Välimäki, Jonna Niskanen, Nea Korvenlaita, Ilkka Fagerlund, Jari Koistinaho, Mahmood Amiry-Moghaddam, Ekaterina Savchenko, Laurent Roybon, Šárka Lehtonen, Paula Korhonen, Tarja Mal. Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function. Scientific reports. vol 13. issue 1. 2023-12-13. PMID:38092815. |
here we demonstrate that lrrk2-g2019s carrying imgl recapitulate aspects of the transcriptional signature of human idiopathic pd midbrain microglia. |
2023-12-13 |
2023-12-17 |
human |
| Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen, Anastasia Shakirzyanova, Mireia Gómez-Budia, Nelli-Noora Välimäki, Jonna Niskanen, Nea Korvenlaita, Ilkka Fagerlund, Jari Koistinaho, Mahmood Amiry-Moghaddam, Ekaterina Savchenko, Laurent Roybon, Šárka Lehtonen, Paula Korhonen, Tarja Mal. Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function. Scientific reports. vol 13. issue 1. 2023-12-13. PMID:38092815. |
investigation of microglial transcriptional state in the midbrains of pd patients revealed a subset of microglia with a transcriptional overlap between the in vitro pd-imgl and human midbrain pd microglia. |
2023-12-13 |
2023-12-17 |
human |
| Jie Yu, Lan Tang, Lilin Yang, Mucong Zheng, Huawen Yu, Ya Luo, Jinqing Liu, Jie X. Role and mechanism of MiR-542-3p in regulating TLR4 in nonylphenol-induced neuronal cell pyroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 123. 2023-11-17. PMID:37976699. |
this study aimed to investigate the spatial learning/memory and motor abilities of rats and the alteration of mir-542-3p and pyroptosis in the midbrain nigrostriatal area in vivo after nonylphenol (np) gavage and to explore the mechanism of mir-542-3p regulation of toll-like receptor 4 (tlr4) in np-induced pyroptosis in bv2 microglia in vitro. |
2023-11-17 |
2023-11-20 |
rat |
| Flavio Pisani, Valerio Pisani, Francesca Arcangeli, Alice Harding, Simarjit Kaur Singhra. International journal of environmental research and public health. vol 20. issue 11. 2023-06-11. PMID:37297653. |
their direct and indirect effect via the interaction of their virulence factors and the microglia potentially leads to the host peripheral nerve, the midbrain (especially the locus coeruleus), and cortical damage. |
2023-06-11 |
2023-08-14 |
Not clear |
| Guy C Brown, Marta Camacho, Caroline H Williams-Gra. The Endotoxin Hypothesis of Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2023-05-09. PMID:37157885. |
the evidence supporting this hypothesis includes: (1) gut dysfunction, permeability, and bacterial changes occur early in pd, (2) serum levels of lps are increased in a proportion of pd patients, (3) lps induces α-synuclein expression, aggregation, and neurotoxicity, (4) lps causes activation of peripheral monocytes leading to inflammatory cytokine production, and (5) blood lps causes brain inflammation and specific loss of midbrain dopaminergic neurons, mediated by microglia. |
2023-05-09 |
2023-08-14 |
Not clear |
| Benjamin D Hobson, Adrien T Stanley, Mark B De Los Santos, Bruce Culbertson, Eugene V Mosharov, Peter A Sims, David Sulze. Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain. Brain, behavior, and immunity. 2023-04-26. PMID:37100211. |
we find that ifn-γ induces transcription of mhc class i antigen processing and presentation machinery in all major parenchymal cell types in the ventral midbrain in vivo; however, neuronal responses are low amplitude and limited to a small set of genes, mhc class ii expression and cellular proliferation are restricted to microglia, and dopamine neuronal responses require cell autonomous expression of ifngr1. |
2023-04-26 |
2023-08-14 |
mouse |
| Benjamin D Hobson, Adrien T Stanley, Mark B De Los Santos, Bruce Culbertson, Eugene V Mosharov, Peter A Sims, David Sulze. Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain. Brain, behavior, and immunity. 2023-04-26. PMID:37100211. |
we found that ifn-γ upregulated mhc-i and associated mrnas in ventral midbrain microglia, astrocytes, oligodendrocytes, and gabaergic, glutamatergic, and dopaminergic neurons. |
2023-04-26 |
2023-08-14 |
mouse |
| Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yu. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428560. |
in the situation of kidney ischemia reperfusion (ir)-induced aki, activation of microglia and astrocytes were observed in the striatum, ventral midbrain, hippocampus, and cortex. |
2022-11-26 |
2023-08-14 |
Not clear |
| Zhiqian Yu, Kazuko Ueno, Ryo Funayama, Mai Sakai, Naoki Nariai, Kaname Kojima, Yoshie Kikuchi, Xue Li, Chiaki Ono, Junpei Kanatani, Jiro Ono, Kazuya Iwamoto, Kenji Hashimoto, Kengo Kinoshita, Keiko Nakayama, Masao Nagasaki, Hiroaki Tomit. Sex-Specific Differences in the Transcriptome of the Human Dorsolateral Prefrontal Cortex in Schizophrenia. Molecular neurobiology. 2022-11-22. PMID:36414910. |
an ingenuity pathway analysis revealed that the differentially expressed genes related to schizophrenia in the female group were involved in midbrain dopaminergic and γ-aminobutyric acid (gaba)-ergic neurons and microglia. |
2022-11-22 |
2023-08-14 |
human |
| Minghao Yan, Haibo Jin, Chun Pan, Xiaodong Ha. Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia. Molecular neurobiology. 2022-11-17. PMID:36385231. |
in the mouse models of chronic mc-lr exposure, a large number of inflammatory factors (il-6, il-1β, and tnf-α) were deposited in brain tissue, and activation of nlrp3 in microglia was also observed in the midbrain. |
2022-11-17 |
2023-08-14 |
mouse |
| Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C Tseng, Ryan W Logan, Marianne L Sene. Brain region- and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry. vol 13. 2022-09-12. PMID:36090351. |
most notable was the distinct transcriptional profile of midbrain microglia, with enrichment for pathways related to immune function; these midbrain microglia exhibited a profile similar to disease-associated or immune-surveillant microglia. |
2022-09-12 |
2023-08-14 |
mouse |
| Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C Tseng, Ryan W Logan, Marianne L Sene. Brain region- and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry. vol 13. 2022-09-12. PMID:36090351. |
we also found evidence for a gradient of expression of microglia-specific transcripts across the rostral-to-caudal axes of the brain, with microglia extracted from the striatum exhibiting a transcriptional profile intermediate between that of the pfc and midbrain. |
2022-09-12 |
2023-08-14 |
mouse |
| Linxiu Wu, Rongtao Xue, Jiahao Chen, Jin X. dock8 deficiency attenuates microglia colonization in early zebrafish larvae. Cell death discovery. vol 8. issue 1. 2022-08-17. PMID:35977943. |
here, we generated zebrafish dock8 mutants by crispr/cas9 genome editing and showed that dock8 mutations attenuate microglia colonization in the zebrafish midbrain at early larvae stages. |
2022-08-17 |
2023-08-14 |
zebrafish |
| Sonia Sabate-Soler, Sarah Louise Nickels, Cláudia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia. 2022-03-09. PMID:35262217. |
microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. |
2022-03-09 |
2023-08-13 |
human |
| Sonia Sabate-Soler, Sarah Louise Nickels, Cláudia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia. 2022-03-09. PMID:35262217. |
however, the absence of microglia, with their ability to remodel neuronal networks and phagocytose apoptotic cells and debris, represents a major disadvantage for the current midbrain organoid systems. |
2022-03-09 |
2023-08-13 |
human |