All Relations between microglial cell and mesencephalon

Publication Sentence Publish Date Extraction Date Species
Bingqing Cao, Tao Wang, Qiumin Qu, Tao Kang, Qian Yan. Long Noncoding RNA SNHG1 Promotes Neuroinflammation in Parkinson's Disease via Regulating miR-7/NLRP3 Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30031125. downregulation of snhg1 elevated mir-7 expression, suppressed the activation of microglia and nlrp3 inflammasome as well as dopaminergic neuron loss in the midbrain substantia nigra pars compacta in mptp-treated mice. 2019-03-29 2023-08-13 mouse
Xiaolai Zhou, Björn Spitta. Lipopolysaccharide-Induced Microglia Activation Promotes the Survival of Midbrain Dopaminergic Neurons In Vitro. Neurotoxicity research. vol 33. issue 4. 2019-03-20. PMID:29188488. lipopolysaccharide-induced microglia activation promotes the survival of midbrain dopaminergic neurons in vitro. 2019-03-20 2023-08-13 Not clear
Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. we also observed that the trem2 level was higher in the midbrain of pd mice, which was accompanied by an elevated level of arginase-1 and increased proinflammatory cytokines, suggesting that trem2 is an important factor in switching the microglia phenotypes. 2018-10-09 2023-08-13 mouse
Richard Gordon, Neeraj Singh, Vivek Lawana, Anamitra Ghosh, Dilshan S Harischandra, Huajun Jin, Colleen Hogan, Souvarish Sarkar, Dharmin Rokad, Nikhil Panicker, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasam. Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of disease. vol 93. 2018-02-27. PMID:27151770. importantly, we also observed a marked upregulation of pkcδ in the microglia of the ventral midbrain region of pd patients when compared to age-matched controls, suggesting a role for microglial pkcδ in neurodegenerative processes. 2018-02-27 2023-08-13 mouse
Jennifer N Jernberg, Caitlyn E Bowman, Michael J Wolfgang, Susanna Scafid. Developmental regulation and localization of carnitine palmitoyltransferases (CPTs) in rat brain. Journal of neurochemistry. vol 142. issue 3. 2017-09-21. PMID:28512781. the cpt system is highly enriched in vivo in hippocampus and cerebellum, relative to cortex and midbrain, and is exclusively present in astrocytes and neural progenitor cells, while absent in neurons, microglia, and oligodendrocytes. 2017-09-21 2023-08-13 rat
Nabil El Massri, Cécile Moro, Napoleon Torres, Fannie Darlot, Diane Agay, Claude Chabrol, Daniel M Johnstone, Jonathan Stone, Alim-Louis Benabid, John Mitrofani. Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys. Experimental brain research. vol 234. issue 11. 2017-08-30. PMID:27377070. sections of midbrain (containing the substantia nigra pars compacta; snc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; gfap) and ionised calcium-binding adaptor molecule 1 (to label microglia; iba1) immunohistochemistry. 2017-08-30 2023-08-13 monkey
Jin Xu, Tienan Wang, Yi Wu, Wan Jin, Zilong We. Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine. Developmental cell. vol 38. issue 2. 2017-06-19. PMID:27424497. microglia colonization of developing zebrafish midbrain is promoted by apoptotic neuron and lysophosphatidylcholine. 2017-06-19 2023-08-13 zebrafish
Jin Xu, Tienan Wang, Yi Wu, Wan Jin, Zilong We. Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine. Developmental cell. vol 38. issue 2. 2017-06-19. PMID:27424497. using in vivo imaging and genetic manipulation of zebrafish, we showed that microglial precursors enter the optic tectum of the midbrain, where the majority of microglia reside during early development, via the lateral periphery between the eyes and brain and the ventral periphery of the brain in a circulation-independent manner. 2017-06-19 2023-08-13 zebrafish
Jin Xu, Tienan Wang, Yi Wu, Wan Jin, Zilong We. Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine. Developmental cell. vol 38. issue 2. 2017-06-19. PMID:27424497. our study reveals that microglia colonization of developing zebrafish midbrain is triggered by apoptotic neuronal death, possibly via releasing lysophosphatidylcholine. 2017-06-19 2023-08-13 zebrafish
Heather L Martin, Matteo Santoro, Sarah Mustafa, Gernot Riedel, John V Forrester, Peter Teisman. Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson's disease. Glia. vol 64. issue 3. 2016-10-06. PMID:26511587. in wild-type mice mhc ii levels in the ventral midbrain were upregulated 1-2 days after mptp treatment and mhc ii was localized in both astrocytes and microglia. 2016-10-06 2023-08-13 mouse
Ning Yao, Yanhong Wu, Yan Zhou, Lili Ju, Yujun Liu, Rongkai Ju, Deyi Duan, Qunyuan X. Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson׳s disease. Brain research. vol 1625. 2016-08-15. PMID:26342895. our results indicate that the lesion in the lc is an important factor in promoting dopaminergic neuron degeneration by impacting the function of microglia in the midbrain. 2016-08-15 2023-08-13 mouse
Nikenza Viceconte, Miguel A Burguillos, Antonio J Herrera, Rocío M De Pablos, Bertrand Joseph, José L Vener. Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism. Journal of neuroinflammation. vol 12. 2016-08-10. PMID:25586882. importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was found in reactive microglia in the ventral mesencephalon from subjects with parkinson's disease, thus supporting the existence of endogenous factors activating microglia through a caspase-dependent mechanism. 2016-08-10 2023-08-13 human
E Lv, J Deng, Y Yu, Y Wang, X Gong, J Jia, X Wan. Nrf2-ARE signals mediated the anti-oxidative action of electroacupuncture in an MPTP mouse model of Parkinson's disease. Free radical research. vol 49. issue 11. 2016-06-28. PMID:26118717. in addition, ea reduced microglia activation and astrogliosis in the striatum and midbrain, increased tyrosine hydroxylase levels in the striatum, and improved vertical movement in mptp mice. 2016-06-28 2023-08-13 mouse
Kana Kiyofuji, Yuki Kurauchi, Akinori Hisatsune, Takahiro Seki, Satoshi Mishima, Hiroshi Katsuk. A natural compound macelignan protects midbrain dopaminergic neurons from inflammatory degeneration via microglial arginase-1 expression. European journal of pharmacology. vol 760. 2016-03-08. PMID:25917324. compounds regulating activation profiles of microglia may provide therapeutic benefits for parkinson disease characterized by degeneration of midbrain dopaminergic neurons. 2016-03-08 2023-08-13 Not clear
S Sarkar, B Gough, J Raymick, M A Beaudoin, S F Ali, A Virmani, Z K Biniend. Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. Neuroscience letters. vol 606. 2016-03-01. PMID:26321151. it was found that 100 mg/kg alc prevented loss of th and a decline of dat level in the midbrain and also prevented the activation of both microglia and astroglia after rotenone treatment. 2016-03-01 2023-08-13 rat
José Christian Machado Ximenes, Kelly Rose Tavares Neves, Luzia Kalyne A M Leal, Marta Regina Santos do Carmo, Gerly Anne de Castro Brito, Maria da Graça Naffah-Mazzacoratti, Ésper Abrão Cavalheiro, Glauce Socorro de Barros Vian. Valproic Acid Neuroprotection in the 6-OHDA Model of Parkinson's Disease Is Possibly Related to Its Anti-Inflammatory and HDAC Inhibitory Properties. Journal of neurodegenerative diseases. vol 2015. 2015-08-28. PMID:26317011. this neurotoxin increased the ox-42 and gfap immunoreactivities in the mesencephalon, indicating increased microglia and astrocyte reactivities, respectively, which were reversed by va. 2015-08-28 2023-08-13 rat
Y Tang, T Li, J Li, J Yang, H Liu, X J Zhang, W L. Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease. Cell death and differentiation. vol 21. issue 3. 2015-01-15. PMID:24212761. moreover, we showed that the jmjd3 level was lower in the midbrain of aged mice, which was accompanied by an elevated level of h3k27me3 and an increased ratio of m1 to m2 markers, suggesting that aging is an important factor in switching the microglia phenotypes. 2015-01-15 2023-08-12 mouse
Isabelle Bardou, Roxanne M Kaercher, Holly M Brothers, Sarah C Hopp, Sarah Royer, Gary L Wen. Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem. Neurobiology of aging. vol 35. issue 5. 2014-10-06. PMID:24315728. lps infusion also increased the density of activated microglia cells throughout the midbrain and brainstem. 2014-10-06 2023-08-12 rat
Seokheon Hong, Joohyun Hwang, Joo Yeon Kim, Ki Soon Shin, Shin Jung Kan. Heptachlor induced nigral dopaminergic neuronal loss and Parkinsonism-like movement deficits in mice. Experimental & molecular medicine. vol 46. 2014-09-25. PMID:24577234. in addition, the heptachlor injection induced gliosis of microglia and astrocytes selectively in the ventral midbrain area. 2014-09-25 2023-08-12 mouse
Francesca L'Episcopo, Cataldo Tirolo, Salvo Caniglia, Nuccio Testa, Maria Concetta Morale, Maria Francesca Serapide, Stefano Pluchino, Bianca Marchett. Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease. Journal of molecular cell biology. vol 6. issue 1. 2014-08-21. PMID:24431301. accumulating evidence points to a dysregulation of wnt signaling in major neurodegenerative pathologies including parkinson's disease (pd), a common neurodegenerative disorder characterized by the progressive loss of midbrain dopaminergic (mda) neurons and deregulated activation of astrocytes and microglia. 2014-08-21 2023-08-12 Not clear