All Relations between microglial cell and prefrontal cortex

Publication Sentence Publish Date Extraction Date Species
Gangjing Li, Li Hu, Xiangcheng Gu, Weijun Zhu, Xuechu Zhen, Xiaohui Su. Targeting Large-Conductance Calcium-Activated Potassium Channels to Ameliorate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice. Neurochemical research. 2024-02-22. PMID:38383879. ), a specific bk channel blocker, or bk shrna-aav effectively inhibited the activation of microglia, reduced the production of il-1β in the hippocampus and suppressed the expression and activity of ido in the hippocampus and prefrontal cortex, resulting in the amelioration of depressive-like behavior in mice. 2024-02-22 2024-02-24 mouse
Ki-Joong Kim, Jinyeon Hwang, Kang-Woo Lee, Jieun Kim, Yunha Han, Uk Namgun. Neuron-Microglia Interaction is Involved in Anti-inflammatory Response by Vagus Nerve Stimulation in the Prefrontal Cortex of Rats Injected with Polyinosinic:Polycytidylic Acid. Molecular neurobiology. 2024-02-22. PMID:38383920. the microglia in the prefrontal cortex (pfc) displayed the activated form of morphology in poly(i:c)-injected rats and changed to a normal shape after acute vns (avns). 2024-02-22 2024-02-24 rat
Ming-Lei Guo, Yan Cheng, Damian Martinez Pineda, Rachael E Dempsey, Lifang Yan. Lipid Droplets Accumulation in the Brain of HIV Transgenic Rat: Implication in the Accelerated Aging of HIV Infected Individuals. Aging and disease. 2024-02-20. PMID:38377024. increased lds are mainly presented in microglia in the hp but largely co-localized with astrocytes in the pfc. 2024-02-20 2024-02-23 human
Aaron Y Lai, Dustin Loren V Almanza, Jessica A Ribeiro, Mary E Hill, Matthew Mandrozos, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Obesity Facilitates Sex-Specific Improvement In Cognition And Neuronal Function In A Rat Model Of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328066. pathological analyses of prefrontal cortex and hippocampus showed that obesity in tgf344-ad rats produced varied effects, with increased density of myelin and oligodendrocytes, lowered density and activation of microglia that we propose contributes to the cognitive improvement. 2024-02-08 2024-02-10 human
Mohit Kumar, Babita Bhatt, Chitralekha Gusain, Nayan Mahajan, Mahendra Bishno. Sex-Specific Effects of Ketogenic Diet on Anxiety-like Behavior and Neuroimmune Response in C57Bl/6J Mice. The Journal of nutritional biochemistry. 2024-02-04. PMID:38311044. kd suppressed the mrna expression of the putative microglial markers (cd68, p2ry12, nox2) and induced morphological changes in the male pfc microglia. 2024-02-04 2024-02-07 mouse
Jingwei Zhao, Mingming Zhang, Huamin Zhang, Ying Wang, Bingyu Chen, Jing Sha. Diosmin ameliorates LPS-induced depression-like behaviors in mice: inhibition of inflammation and oxidative stress in the prefrontal cortex. Brain research bulletin. 2023-12-13. PMID:38092305. specifically, diosmin treatment significantly suppressed the secretion of pro-inflammatory cytokines (tnf-α, il-6 and il-1β), reduced the activation of microglia, and inhibited the expression of nlrp3 inflammasome and its downstream effector caspase-1 in both pfc of mice and bv2 microglial cells exposed to lps. 2023-12-13 2023-12-17 mouse
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Sing. S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology. vol 126. 2023-11-27. PMID:38011768. it further enhanced anti-inflammatory microglia in the hippocampus and prefrontal cortex (pfc), as evidenced by increased arg-1, cd206, and ym-1 levels and decreased inos, cd16, and mhcii levels. 2023-11-27 2023-11-29 mouse
Marcia Spoelder, Yami Bright, Martine C Morrison, Veerle van Kempen, Lilian de Groodt, Malvina Begalli, Nikita Schuijt, Eva Kruiger, Ronald Bulthuis, Gabriele Gross, Robert Kleemann, Janna A van Diepen, Judith R Homber. Cognitive Performance during the Development of Diabetes in the Zucker Diabetic Fatty Rat. Cells. vol 12. issue 20. 2023-10-27. PMID:37887307. histological analyses in early adulthood showed no group differences in the number of prefrontal cortex neurons and microglia, nor psd95 and sirt1 mrna expression levels. 2023-10-27 2023-11-08 rat
Jacqueline Barker, Lauren Buck, Qiaowei Xie, Michelle Willis, Christine Side, Laura Giacometti, Peter Gaskill, Kyewon Park, Farida Shaheen, Lili Guo, Santhi Gorantl. Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation. Research square. 2023-10-16. PMID:37841842. behavioral alterations were accompanied by immune changes in hiv infected mice, including increased prefrontal cortex astrocyte immunoreactivity and brain-region specific effects on microglia number and reactivity. 2023-10-16 2023-11-08 mouse
Giulia Galimberti, Giada Amodeo, Giulia Magni, Benedetta Riboldi, Gianfranco Balboni, Valentina Onnis, Stefania Ceruti, Paola Sacerdote, Silvia Franch. Prokineticin System Is a Pharmacological Target to Counteract Pain and Its Comorbid Mood Alterations in an Osteoarthritis Murine Model. Cells. vol 12. issue 18. 2023-09-28. PMID:37759478. in addition, pk upregulation and reactive astrogliosis in the hippocampus and microglia reactivity in the prefrontal cortex were detected. 2023-09-28 2023-10-07 mouse
Hsiao-Yun Lin, Flurin Cathomas, Long Li, Romain Durand-de Cuttoli, Christopher Guevara, Cigdem Sevim Bayrak, Qian Wang, Swati Gupta, Kenny L Chan, Yusuke Shimo, Lyonna F Parise, Chongzhen Yuan, Antonio V Aubry, Fiona Chen, Jean Wong, Carole Morel, George W Huntley, Bin Zhang, Scott J Russo, Jun Wan. Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662400. in the brain, stress-susceptible mice displayed increased expression of c-c chemokine receptor 5 (ccr5), a receptor for ccl5, in microglia in the prefrontal cortex (pfc). 2023-09-04 2023-09-07 mouse
Lauren A Buck, Qiaowei Xie, Michelle Willis, Christine M Side, Laura L Giacometti, Peter J Gaskill, Kyewon Park, Farida Shaheen, Lili Guo, Santhi Gorantla, Jacqueline M Barke. Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645889. these behavioral alterations were accompanied by immune changes in hiv infected mice, including increased prefrontal cortex astrocyte immunoreactivity and brain-region specific effects on microglia number and reactivity. 2023-08-30 2023-09-07 mouse
Qing-Ren Liu, Cui-Na Shi, Fei Wang, Jian-Hua Ton. Neuroinflammation-induced parvalbumin interneuron and oscillation deficits might contribute to neurobehavioral abnormities in a two-hit model of depression. Heliyon. vol 9. issue 8. 2023-08-09. PMID:37554823. these behavioral alternations were related to enhanced neuroinflammation, as reflected by significantly increased il-1β and il-6 levels and microglia activation in the prefrontal cortex (pfc). 2023-08-09 2023-08-16 mouse
Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuk. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023-08-04. PMID:37540445. the expression of cd68, an m1 phenotypic marker of microglia, was significantly elevated in the prefrontal cortex and hippocampus of mrl/lpr mice, which was significantly suppressed by 2ccpa treatment. 2023-08-04 2023-08-14 mouse
Miquel Martin, Matteo M Pusceddu, Joan Teichenné, Teresa Negra, Alan Connolly, Xavier Escoté, Helena Torrell Galceran, Adrià Cereto Massagué, Iris Samarra Mestre, Antoni Del Pino Rius, Jordi Romero-Gimenez, Cristina Egea, Juan Maria Alcaide-Hidalgo, Josep Maria Del Ba. Preventive Treatment with Astaxanthin Microencapsulated with Spirulina Powder, Administered in a Dose Range Equivalent to Human Consumption, Prevents LPS-Induced Cognitive Impairment in Rats. Nutrients. vol 15. issue 13. 2023-07-14. PMID:37447181. our results demonstrate that lps modified long-term memory in the mwm and increased microglia activation in the hippocampus and prefrontal cortex. 2023-07-14 2023-08-14 human
Shuhan Li, Zhanpeng Zhu, Tian Lan, Yuhan Wu, Ye Li, Changmin Wang, Wencheng Jian, Shu Yan Y. Levomilnacipran ameliorates lipopolysaccharide-induced depression-like behaviors and suppressed the TLR4/Ras signaling pathway. International immunopharmacology. vol 122. 2023-07-06. PMID:37413934. furthermore, we found that levomilnacipran could decrease the number of microglia and suppress its activation in prefrontal cortex of rats. 2023-07-06 2023-08-14 rat
Gumaro Galindo-Paredes, Gonzalo Flores, Julio César Morales-Medin. Olfactory bulbectomy induces nociceptive alterations associated with gliosis in male rats. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388490. iba1-positive microglia in the pfc underwent selective hypotrophy due to obx and obx enhanced both gfap-positive astrocytes and iba1-positive microglia in the bla. 2023-06-30 2023-08-14 rat
Gumaro Galindo-Paredes, Gonzalo Flores, Julio César Morales-Medin. Olfactory bulbectomy induces nociceptive alterations associated with gliosis in male rats. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388490. the amount of iba1-positive microglia in the pfc also increased as a result of obx. 2023-06-30 2023-08-14 rat
Chenhui Ji, Yalin Tang, Yanyan Zhang, Xiaoyan Huang, Congcong Li, Yuhong Yang, Qihui Wu, Xiaohuan Xia, Qingyuan Cai, Xin-Rui Qi, Jialin C Zhen. Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors. Cell reports. vol 42. issue 7. 2023-06-29. PMID:37384529. mice lacking gls1 in camkiiα-positive neurons display a series of asd-like behaviors, synaptic excitatory and inhibitory (e/i) imbalance, higher spine density, and glutamate receptor expression in the prefrontal cortex, as well as a compromised expression pattern of genes involved in synapse pruning and less engulfed synaptic puncta in microglia. 2023-06-29 2023-08-14 mouse
Gideon Opeyemi Ayilara, Bamidele Victor Owoyel. Neuroinflammation and microglial expression in brains of social-isolation rearing model of schizophrenia. IBRO neuroscience reports. vol 15. 2023-06-27. PMID:37359498. furthermore, isolation rearing significantly increased microglia count (p < 0.05) in the hippocampus, nucleus accumbens, and prefrontal cortex, only in the male group. 2023-06-27 2023-08-14 mouse