| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gumaro Galindo-Paredes, Gonzalo Flores, Julio César Morales-Medin. Olfactory bulbectomy induces nociceptive alterations associated with gliosis in male rats. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388490. |
the amount of iba1-positive microglia in the pfc also increased as a result of obx. |
2023-06-30 |
2023-08-14 |
rat |
| Chenhui Ji, Yalin Tang, Yanyan Zhang, Xiaoyan Huang, Congcong Li, Yuhong Yang, Qihui Wu, Xiaohuan Xia, Qingyuan Cai, Xin-Rui Qi, Jialin C Zhen. Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors. Cell reports. vol 42. issue 7. 2023-06-29. PMID:37384529. |
mice lacking gls1 in camkiiα-positive neurons display a series of asd-like behaviors, synaptic excitatory and inhibitory (e/i) imbalance, higher spine density, and glutamate receptor expression in the prefrontal cortex, as well as a compromised expression pattern of genes involved in synapse pruning and less engulfed synaptic puncta in microglia. |
2023-06-29 |
2023-08-14 |
mouse |
| Gideon Opeyemi Ayilara, Bamidele Victor Owoyel. Neuroinflammation and microglial expression in brains of social-isolation rearing model of schizophrenia. IBRO neuroscience reports. vol 15. 2023-06-27. PMID:37359498. |
furthermore, isolation rearing significantly increased microglia count (p < 0.05) in the hippocampus, nucleus accumbens, and prefrontal cortex, only in the male group. |
2023-06-27 |
2023-08-14 |
mouse |
| Osamu Nakagawasai, Kohei Takahashi, Taisei Koyama, Ryota Yamagata, Wataru Nemoto, Koichi Tan-N. Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice. Molecular brain. vol 16. issue 1. 2023-06-13. PMID:37312182. |
next, we measured the levels of ace2 activation in the cerebral cortex, prefrontal cortex, hippocampus, and amygdala after dize injection, and examined which cell types, including neurons, microglia, and astrocytes, express ace2 in the hippocampus using immunofluorescence. |
2023-06-13 |
2023-08-14 |
mouse |
| Hailong Li, Kristen A McLaurin, Charles F Mactutus, Rosemarie M Booz. Microglia proliferation underlies synaptic dysfunction in the prefrontal cortex: implications for the pathogenesis of HIV-1-associated neurocognitive and affective alterations. Journal of neurovirology. 2023-05-24. PMID:37222970. |
microglia proliferation underlies synaptic dysfunction in the prefrontal cortex: implications for the pathogenesis of hiv-1-associated neurocognitive and affective alterations. |
2023-05-24 |
2023-08-14 |
rat |
| Cristina Izquierdo-Luengo, Marc Ten-Blanco, María Ponce-Renilla, Ramiro Perezzan, Inmaculada Pereda-Pérez, Fernando Berrender. Adolescent exposure to the Spice/K2 cannabinoid JWH-018 impairs sensorimotor gating and alters cortical perineuronal nets in a sex-dependent manner. Translational psychiatry. vol 13. issue 1. 2023-05-24. PMID:37225721. |
furthermore, adolescent exposure to jwh-018 induced an activation of microglia and astrocytes in the prefrontal cortex of male mice at both time intervals. |
2023-05-24 |
2023-08-14 |
mouse |
| Natalie R Ricciardi, Farzaneh Modarresi, Ines Lohse, Nadja S Andrade, Ian R Newman, Jonathan M Brown, Caroline Borja, Brian Marples, Claes R Wahlestedt, Claude-Henry Volma. Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer's Disease Models. Molecular neurobiology. 2023-05-12. PMID:37171575. |
were assessed in the hippocampus (hip) and prefrontal cortex (pfc).ldct induced a tolerant, anti-inflammatory innate immune response in microglia and increased non-amyloidogenic app processing in vitro. |
2023-05-12 |
2023-08-14 |
mouse |
| Rong-Jun Ni, Yi-Yan Wang, Tian-Hao Gao, Qi-Run Wang, Jin-Xue Wei, Lian-Sheng Zhao, Yang-Rui Ma, Xiao-Hong Ma, Tao L. Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain. Zoological research. vol 44. issue 3. 2023-05-06. PMID:37147908. |
here, we found rapid elimination of microglia in the prefrontal cortex (pfc) and hippocampus (hpc) of mice following administration of the dual colony-stimulating factor 1 receptor (csf1r)/c-kit kinase inhibitor plx3397 (pexidartinib) in drinking water. |
2023-05-06 |
2023-08-14 |
mouse |
| Anhui Fu, Fei Qiao, Hao Feng, Qing Lu. Inhibition of TREM-1 Ameliorates Lipopolysaccharide-induced Depressive-like Behaviors by Alleviating Neuroinflammation in the PFC via PI3K/Akt Signaling Pathway. Behavioural brain research. 2023-05-04. PMID:37142164. |
next, we revealed that trem-1 was expressed on microglia, neurons, and astrocytes in the prefrontal cortex (pfc) after lps administration. |
2023-05-04 |
2023-08-14 |
mouse |
| Anina S von Arx, Kara Dawson, Han-Yu Lin, Daniele Mattei, Tina Notter, Urs Meyer, Sina M Schalbette. Prefrontal microglia deficiency during adolescence disrupts adult cognitive functions and synaptic structures: A follow-up study in female mice. Brain, behavior, and immunity. 2023-04-26. PMID:37100210. |
using a mouse model of cell-specific, transient and local depletion of microglia, which was based on intracerebral injection of clodronate disodium salt (cds) into the pfc of adolescent male mice, we recently demonstrated that microglia contribute to the functional and structural maturation of the pfc in males. |
2023-04-26 |
2023-08-14 |
mouse |
| Anina S von Arx, Kara Dawson, Han-Yu Lin, Daniele Mattei, Tina Notter, Urs Meyer, Sina M Schalbette. Prefrontal microglia deficiency during adolescence disrupts adult cognitive functions and synaptic structures: A follow-up study in female mice. Brain, behavior, and immunity. 2023-04-26. PMID:37100210. |
inducing transient prefrontal microglia depletion in adult female mice did not cause these deficits, demonstrating that the adult pfc, unlike the adolescent pfc, is resilient to transient microglia deficiency in terms of lasting cognitive and synaptic mal-adaptations. |
2023-04-26 |
2023-08-14 |
mouse |
| Anina S von Arx, Kara Dawson, Han-Yu Lin, Daniele Mattei, Tina Notter, Urs Meyer, Sina M Schalbette. Prefrontal microglia deficiency during adolescence disrupts adult cognitive functions and synaptic structures: A follow-up study in female mice. Brain, behavior, and immunity. 2023-04-26. PMID:37100210. |
together with our previous findings in males, the present findings suggest that microglia contribute to the maturation of the female pfc in a similar way as to the prefrontal maturation occurring in males. |
2023-04-26 |
2023-08-14 |
mouse |
| Hongxiang Hong, Jianbin Su, Yi Zhang, Guanhua Xu, Chao Huang, Guofeng Bao, Zhiming Cu. A novel role of lactate: Promotion of Akt-dependent elongation of microglial process. International immunopharmacology. vol 119. 2023-04-19. PMID:37075668. |
pretreatment with lactate also prevented lipopolysaccharide (lps)-induced shortening of microglial processes under cultured and in vivo conditions, pro-inflammatory responses in primary cultured microglia and prefrontal cortex, and depression-like behaviors in mice. |
2023-04-19 |
2023-08-14 |
mouse |
| Hongxiang Hong, Jianbin Su, Yi Zhang, Guanhua Xu, Chao Huang, Guofeng Bao, Zhiming Cu. A novel role of lactate: Promotion of Akt-dependent elongation of microglial process. International immunopharmacology. vol 119. 2023-04-19. PMID:37075668. |
inhibition of akt also abolished the preventive effect of lactate on lps-induced inflammatory responses in primary cultured microglia and prefrontal cortex and on lps-induced depression-like behaviors in mice. |
2023-04-19 |
2023-08-14 |
mouse |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Dharmendra Kumar Khatri, Shashi Bala Sing. Sphingosine 1 phosphate lyase inhibition rescues cognition in diabetic mice by promoting anti-inflammatory microglia. Behavioural brain research. 2023-03-30. PMID:36997095. |
we further evaluated the effect of fingolimod on the activation of microglia in the pre-frontal cortex (pfc) and hippocampus of diabetic mice. |
2023-03-30 |
2023-08-14 |
mouse |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Dharmendra Kumar Khatri, Shashi Bala Sing. Sphingosine 1 phosphate lyase inhibition rescues cognition in diabetic mice by promoting anti-inflammatory microglia. Behavioural brain research. 2023-03-30. PMID:36997095. |
our study revealed that fingolimod inhibited s1pl and promoted anti-inflammatory microglia in both pfc and hippocampus of diabetic mice as it increased ym-1 and arginase-1. |
2023-03-30 |
2023-08-14 |
mouse |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of alzheimer's disease (amyloid-β, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy), microglial activation (proportion of activated microglia), and cognitive performance. |
2023-03-25 |
2023-08-14 |
Not clear |
| Alex P Vu, David Lam, Cayla Denney, Kelly V Lee, Jason R Plemel, Jesse Jackso. Social isolation produces a sex and brain-region specific alteration of microglia state. The European journal of neuroscience. 2023-03-15. PMID:36918398. |
the prefrontal cortex, central amygdala, nucleus accumbens shell, and visual cortex did not exhibit changes in microglia structure in either male or female mice. |
2023-03-15 |
2023-08-14 |
mouse |
| Jiande Li, Hongxuan Wang, Dandan Liu, Xiangpen Li, Lei He, Jingrui Pan, Qingyu Shen, Ying Pen. CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in the microglia of the prefrontal cortex in mice. Brain, behavior, and immunity. 2023-02-08. PMID:36754245. |
cb2r activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing nlrp3 inflammasome activation in the microglia of the prefrontal cortex in mice. |
2023-02-08 |
2023-08-14 |
mouse |
| Hailong Li, Kristen A McLaurin, Charles F Mactutus, Rosemarie M Booz. Microglia Proliferation Underlies Synaptic Dysfunction in the Prefrontal Cortex: Implications for the Pathogenesis of HIV-1-Associated Neurocognitive and Affective Alterations. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711456. |
microglia proliferation underlies synaptic dysfunction in the prefrontal cortex: implications for the pathogenesis of hiv-1-associated neurocognitive and affective alterations. |
2023-01-30 |
2023-08-14 |
rat |