All Relations between microglial cell and spinal cord posterior horn

Publication Sentence Publish Date Extraction Date Species
Lorenzo Di Cesare Mannelli, Francesca Corti, Laura Micheli, Matteo Zanardelli, Carla Ghelardin. Delay of morphine tolerance by palmitoylethanolamide. BioMed research international. vol 2015. 2015-12-28. PMID:25874232. pea prevented both microglia and astrocyte cell number increase induced by morphine in the dorsal horn; on the contrary, the morphine-dependent increase of spinal tnf-α levels was not modified by pea. 2015-12-28 2023-08-13 rat
Qian-Jun Li, Zhen Wang, Yong-Xing Yao, Shen-Hui Jin, Mei-Zi Qian, Na-Na Li, Ya-Nan Wang, Ya-Wen Zhang, Bin-Yu Chen, Dan-Yun Jia, Ying Shen, Jun-Lu Wan. Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw. Neurochemical research. vol 40. issue 3. 2015-12-04. PMID:25547463. furthermore, the number of activated microglia in spinal dorsal horn increased in line with pain hypersensitivity. 2015-12-04 2023-08-13 mouse
Lorenzo Di Cesare Mannelli, Lorenzo Cinci, Laura Micheli, Matteo Zanardelli, Alessandra Pacini, J Michael McIntosh, Carla Ghelardin. α-conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement. Pain. vol 155. issue 10. 2015-11-24. PMID:25008370. in the dorsal horn of the spinal cord, rgia prevented cci-induced activation of microglia and astrocytes. 2015-11-24 2023-08-13 rat
Iriana Galan-Arriero, Gerardo Avila-Martin, Agueda Ferrer-Donato, Julio Gomez-Soriano, Elisabeth Bravo-Esteban, Julian Taylo. Oral administration of the p38α MAPK inhibitor, UR13870, inhibits affective pain behavior after spinal cord injury. Pain. vol 155. issue 10. 2015-11-24. PMID:25180015. the effect of ur13870, a p38α mapk inhibitor, on microglia expression in the anterior cingulate cortex (acc) and spinal dorsal horn was addressed after t9 contusion spinal cord injury (sci) in the rat, in addition to behavioral testing of pain-related aversion and anxiety. 2015-11-24 2023-08-13 rat
Cayo Almeida, Aline DeMaman, Ricardo Kusuda, Flaviane Cadetti, Maria Ida Ravanelli, André L Queiroz, Thais A Sousa, Sonia Zanon, Leonardo R Silveira, Guilherme Luca. Exercise therapy normalizes BDNF upregulation and glial hyperactivity in a mouse model of neuropathic pain. Pain. vol 156. issue 3. 2015-11-02. PMID:25687543. finally, prolonged swim exercise reversed astrocyte and microglia hyperactivity in the dorsal horn after nerve lesion, which remained normalized after training cessation. 2015-11-02 2023-08-13 mouse
Hideaki Matsuo, Kenzo Uchida, Hideaki Nakajima, Alexander Rodriguez Guerrero, Shuji Watanabe, Naoto Takeura, Daisuke Sugita, Seiichiro Shimada, Terumasa Nakatsuka, Hisatoshi Bab. Early transcutaneous electrical nerve stimulation reduces hyperalgesia and decreases activation of spinal glial cells in mice with neuropathic pain. Pain. vol 155. issue 9. 2015-10-26. PMID:25010326. early tens decreased p-p38 within microglia (p<0.05), the expression levels of protein kinase c (pkc-γ), and phosphorylated anti-phospho-cyclic amp response element-binding protein (p-creb) in the superficial spinal dorsal horn neurons (p<0.05), mitogen-activated protein (map) kinases, and proinflammatory cytokines, and increased the expression levels of opioid receptors (p<0.05). 2015-10-26 2023-08-13 mouse
Xiao-Hui Zhao, Ting Zhang, Yun-Qing L. The up-regulation of spinal Toll-like receptor 4 in rats with inflammatory pain induced by complete Freund's adjuvant. Brain research bulletin. vol 111. 2015-10-22. PMID:25592618. the results show that cfa induces significant pain hypersensitivity and paw edema as well as spinal dorsal horn (sdh) microglia activation with the increased expressions of ox-42 and tlr4 during the inflammatory pain, respectively. 2015-10-22 2023-08-13 rat
Nan-Fu Chen, Shi-Ying Huang, Ching-Hsiang Lu, Chun-Lin Chen, Chien-Wei Feng, Chun-Hong Chen, Han-Chun Hung, Yen-You Lin, Ping-Jyun Sung, Chun-Sung Sung, San-Nan Yang, Hui-Min David Wang, Yu-Chia Chang, Jyh-Horng Sheu, Wu-Fu Chen, Zhi-Hong We. Flexibilide obtained from cultured soft coral has anti-neuroinflammatory and analgesic effects through the upregulation of spinal transforming growth factor-β1 in neuropathic rats. Marine drugs. vol 12. issue 7. 2015-10-12. PMID:24979268. flexibilide significantly inhibited cci-induced activation of microglia and astrocytes, as well as the upregulated proinflammatory enzyme, inducible nitric oxide synthase, in the ipsilateral spinal dorsal horn. 2015-10-12 2023-08-13 rat
F Guida, R Lattanzi, S Boccella, D Maftei, R Romano, V Marconi, G Balboni, S Salvadori, M A Scafuro, V de Novellis, L Negri, S Maione, L Luong. PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. Pharmacological research. vol 91. 2015-10-09. PMID:25434589. emerging evidence indicates that the enhanced activity of dorsal horn neurons requires communication with glia and microglia, cells that are physiologically involved in neuronal wellbeing. 2015-10-09 2023-08-13 mouse
Xuehai Guan, Qiaochu Fu, Bingrui Xiong, Zhenpeng Song, Bin Shu, Huilian Bu, Bing Xu, Anne Manyande, Fei Cao, Yuke Tia. Activation of PI3Kγ/Akt pathway mediates bone cancer pain in rats. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25919859. our results showed that pi3kγ and its downstream target pakt were up-regulated in a time-dependent manner and distributed predominately in the superficial layers of the spinal dorsal horn neurons, astrocytes and a minority of microglia, and were colocalized with non-peptidergic, calcitonin gene-related peptide-peptidergic, and a-type neurons in dorsal root ganglion ipsilateral to tumor cell inoculation in rats. 2015-10-09 2023-08-13 rat
Tian-tian Zhou, Jing-ru Wu, Zi-yang Chen, Zhen-xiu Liu, Bei Mia. Effects of dexmedetomidine on P2X4Rs, p38-MAPK and BDNF in spinal microglia in rats with spared nerve injury. Brain research. vol 1568. 2015-08-21. PMID:24792496. thus, dex could attenuate the neuropathic pain in sni rats, of which the mechanism might be related to the down-expressed p2x4rs, p-p38 and bdnf in microglia of spinal dorsal horn. 2015-08-21 2023-08-13 rat
Jastrow Canlas, Phillip Holt, Alexander Carroll, Shane Rix, Paul Ryan, Lorena Davies, Dusan Matusica, Stuart M Pitson, Claire F Jessup, Ian L Gibbins, Rainer V Haberberge. Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in molecular neuroscience. vol 8. 2015-08-18. PMID:26283908. similarly, sphk2(-/-) mice showed in contrast to wild-type no cpi-dependent increase in areas of the dorsal horn immunoreactive for the microglia marker iba-1 and the astrocyte marker glial fibrillary acidic protein (gfap). 2015-08-18 2023-08-13 mouse
Nemat Khan, Richard Gordon, Trent M Woodruff, Maree T Smit. Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signaling in the dorsal horn of the spinal cord. Pharmacology research & perspectives. vol 3. issue 3. 2015-07-14. PMID:26171221. fully developed mechanical allodynia in the bilateral hindpaws of vehicle-treated rr-eae mice was accompanied by marked cd3(+) t-cell infiltration, microglia activation, and increased brain-derived neurotrophic factor (bdnf)-tyrosine kinase b (trkb) signaling in the dorsal horn of the lumbar spinal cord. 2015-07-14 2023-08-13 mouse
Young Chan Jeong, Kihyun Pyun, Young Bae Kwo. Inhibition of mitogen-activated protein kinases phosphorylation plays an important role in the anti-nociceptive effect of pregabalin in zymosan-induced inflammatory pain model. Biological & pharmaceutical bulletin. vol 37. issue 10. 2015-06-22. PMID:25099229. pregabalin dramatically inhibited zymosan-induced fos expression (a marker for neuronal activation) and microglia activation (using markers cd11b and ed1) in the spinal dorsal horn. 2015-06-22 2023-08-13 Not clear
Young Chan Jeong, Kihyun Pyun, Young Bae Kwo. Inhibition of mitogen-activated protein kinases phosphorylation plays an important role in the anti-nociceptive effect of pregabalin in zymosan-induced inflammatory pain model. Biological & pharmaceutical bulletin. vol 37. issue 10. 2015-06-22. PMID:25099229. moreover, zymosan significantly increased phosphorylation of extracellular signal-regulated protein kinase (erk) 1/2 (double labeling with neuron), erk5 (double labelling with neuron and microglia) and p38 mapk (double labeling with microglia) in the spinal dorsal horn, which overall elevations were reversed by pregabalin. 2015-06-22 2023-08-13 Not clear
Xiao-Hong Jin, Li-Na Wang, Jian-Ling Zuo, Jian-Ping Yang, Si-Lan Li. P2X4 receptor in the dorsal horn partially contributes to brain-derived neurotrophic factor oversecretion and toll-like receptor-4 receptor activation associated with bone cancer pain. Journal of neuroscience research. vol 92. issue 12. 2015-06-19. PMID:24984884. although p2x4r is also localized within spinal microglia in the dorsal horn, little is known about its role in cancer-induced bone pain (cibp), which is in some ways unique. 2015-06-19 2023-08-13 rat
Anna K Clark, Doris Gruber-Schoffnegger, Ruth Drdla-Schutting, Katharina J Gerhold, Marzia Malcangio, Jürgen Sandkühle. Selective activation of microglia facilitates synaptic strength. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 11. 2015-06-15. PMID:25788673. the present data thus suggest that, under chronic pain states, cx3cr1-mediated activation of microglia drives the facilitation of excitatory synaptic transmission in the dorsal horn, which contributes to pain hypersensitivity in chronic pain states. 2015-06-15 2023-08-13 rat
Shigeru Ebisawa, Tsugunobu Andoh, Yutaka Shimada, Yasushi Kuraish. Yokukansan Improves Mechanical Allodynia through the Regulation of Interleukin-6 Expression in the Spinal Cord in Mice with Neuropathic Pain. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-04-13. PMID:25866544. il-6 immunoreactivity was detected in microglia and astrocytes in the spinal dorsal horn. 2015-04-13 2023-08-13 mouse
Masaya Yasui, Takashi Yoshimura, So Takeuchi, Kyohei Tokizane, Makoto Tsuda, Kazuhide Inoue, Hiroshi Kiyam. A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation. Glia. vol 62. issue 9. 2015-03-13. PMID:24852223. quantification analysis revealed a higher accumulation of microglia in the medial part of layers i-iv of the dorsal horn. 2015-03-13 2023-08-13 rat
Ming Liu, Kaijun Liao, Changxi Yu, Xuejun Li, Suhuan Liu, Shuyu Yan. Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord. Mediators of inflammation. vol 2014. 2015-02-12. PMID:25089076. meanwhile, in both models puerarin inhibited the activation of microglia and astroglia in the spinal dorsal horn. 2015-02-12 2023-08-13 Not clear