| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Young S Gwak, Jonghoon Kang, Geda C Unabia, Claire E Hulsebosc. Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats. Experimental neurology. vol 234. issue 2. 2012-05-04. PMID:22036747. |
in addition, thoracic spinal cord injury produces activation of astrocytes and microglia that contributes to dorsal horn neuronal hyperexcitability and central neuropathic pain in above-level, at-level and below-level segments remote from the lesion in the spinal cord. |
2012-05-04 |
2023-08-12 |
rat |
| Eric D Crow. The role of mitogen activated protein kinase signaling in microglia and neurons in the initiation and maintenance of chronic pain. Experimental neurology. vol 234. issue 2. 2012-05-04. PMID:22062045. |
the review will also highlight the important interplay between neurons and non-neuronal cells (i.e., microglia and astrocytes) within the dorsal horn of the spinal cord in the generation and maintenance of chronic inflammatory and neuropathic pain. |
2012-05-04 |
2023-08-12 |
Not clear |
| Xu-Hong Wei, Tao Yang, Qiang Wu, Wen-Jun Xin, Jin-Lang Wu, Ya Qiong Wang, Ying Zang, Jun Wang, Yong-Yong Li, Xian-Guo Li. Peri-sciatic administration of recombinant rat IL-1β induces mechanical allodynia by activation of src-family kinases in spinal microglia in rats. Experimental neurology. vol 234. issue 2. 2012-05-04. PMID:22265659. |
the immunoreactivity (ir) of iba1 (a marker for microglia) and phosphorylated src-family kinases (p-sfks) increased significantly in the ipsilateral and contralateral lumbar spinal dorsal horn on day 1 and day 3 after rril-1β administration, respectively. |
2012-05-04 |
2023-08-12 |
rat |
| Ken-Ichiro Hayashida, Christopher M Peters, Silvia Gutierrez, James C Eisenac. Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. The journal of pain. vol 13. issue 1. 2012-04-24. PMID:22155404. |
in the spinal dorsal horn of spinal nerve ligation rats, dβh-saporin treatment increased choline acetyltransferase immunoreactivity as well as immunoreactivity in microglia of ionized calcium binding adaptor molecule 1[iba1] and in astrocytes of glial fibrillary acidic protein, and brain-derived nerve growth factor content. |
2012-04-24 |
2023-08-12 |
rat |
| Jessica Ruiz-Medina, Catherine Ledent, Olga Valverd. GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21352831. |
in addition, no differences in microglia and astrocytes activation were found when compared the ipsilateral dorsal horn of gpr3-/- and gpr3+/+ mice exposed to nerve ligature. |
2012-04-17 |
2023-08-12 |
mouse |
| Kimiko Kobayashi, Emiko Takahashi, Yasuko Miyagawa, Hiroki Yamanaka, Koichi Noguch. Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model. Neuroscience letters. vol 504. issue 1. 2012-02-14. PMID:21924325. |
double labeling studies revealed that cells expressing increased p2x7 mrna and protein after nerve injury were predominantly microglia in dorsal horn. |
2012-02-14 |
2023-08-12 |
Not clear |
| K Itoh, C-Y Chiang, Z Li, J-C Lee, J O Dostrovsky, B J Sessl. Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors. Neuroscience. vol 192. 2012-01-18. PMID:21763757. |
superfusion of the microglial blocker minocycline abolished the mo-induced mdh central sensitization, consistent with reports that dorsal horn p2x7 receptors are mostly expressed on microglia. |
2012-01-18 |
2023-08-12 |
rat |
| Peter M Grace, Paul E Rolan, Mark R Hutchinso. Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain, behavior, and immunity. vol 25. issue 7. 2012-01-16. PMID:21496480. |
in this way, t cells may contribute to the maintenance of neuropathic pain through pro-inflammatory interactions with microglia and by facilitating the activation of astrocytes in the spinal dorsal horn. |
2012-01-16 |
2023-08-12 |
Not clear |
| Ming Gu, Kan Miyoshi, Ronald Dubner, Wei Guo, Shiping Zou, Ke Ren, Koichi Noguchi, Feng We. Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900561. |
we found that there was neuron-to-microglia signaling via chemokine fractalkine, microglia to astrocyte signaling via the cytokine il-18, astrocyte to neuronal signaling by il-1β, and enhanced activation of glun (nmda) receptors in the spinal dorsal horn. |
2011-10-31 |
2023-08-12 |
rat |
| Loïs S Miraucourt, Cédric Peirs, Radhouane Dallel, Daniel L Voisi. Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine. Pain. vol 152. issue 6. 2011-09-23. PMID:21392888. |
here, we show that after blockade of glycine inhibition, orofacial tactile stimuli activated medullary dorsal horn (mdh) astrocytes, but not microglia. |
2011-09-23 |
2023-08-12 |
Not clear |
| K Hidaka, K Ono, N Harano, T Sago, M Nunomaki, S Shiiba, O Nakanishi, H Fukushima, K Inenag. Central glial activation mediates cancer-induced pain in a rat facial cancer model. Neuroscience. vol 180. 2011-08-04. PMID:21315808. |
in immunostainings for iba1 and glial fibrillary acidic protein (gfap), although there were no morphological changes of gfap-immunopositive satellite glial cells in the trigeminal ganglion, iba1-immunopositive microglia and gfap-immunopositive astrocytes in the medullary dorsal horn showed large somata with cell proliferation. |
2011-08-04 |
2023-08-12 |
rat |
| Eun Hyun Kim, Da Hye Ryu, Sejin Hwan. The expression of corticotropin-releasing factor and its receptors in the spinal cord and dorsal root ganglion in a rat model of neuropathic pain. Anatomy & cell biology. vol 44. issue 1. 2011-07-14. PMID:21519550. |
after sni, crfr1 was expressed in the activated microglia in the ipsilateral dorsal horn, and immunoreaction for crfr2 was increased in the contralateral drg following sni. |
2011-07-14 |
2023-08-12 |
rat |
| Eun Hyun Kim, Da Hye Ryu, Sejin Hwan. The expression of corticotropin-releasing factor and its receptors in the spinal cord and dorsal root ganglion in a rat model of neuropathic pain. Anatomy & cell biology. vol 44. issue 1. 2011-07-14. PMID:21519550. |
consequently, it has been suggested that the increased expression of crf and crfr2 in drg neurons and primary afferent fibers in dorsal horn, and crfr1 in the activated microglia, may be involved in the mediation of stress responses as well as in microglial activation in the neuropathic pain state following sni. |
2011-07-14 |
2023-08-12 |
rat |
| Knut Biber, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Keiko Tsukamoto, Emika Toyomitsu, Takahiro Masuda, Hendrikus Boddeke, Kazuhide Inou. Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development. The EMBO journal. vol 30. issue 9. 2011-07-06. PMID:21441897. |
how nerve injury in the periphery leads to this microglia reaction in the dorsal horn of the spinal cord is not yet understood. |
2011-07-06 |
2023-08-12 |
mouse |
| Laurence Daulhac, Violette Maffre, Christophe Mallet, Monique Etienne, Anne-Marie Privat, Aline Kowalski-Chauvel, Catherine Seva, Joseph Fialip, Alain Eschalie. Phosphorylation of spinal N-methyl-d-aspartate receptor NR1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetes-induced painful neuropathy. European journal of pain (London, England). vol 15. issue 2. 2011-05-06. PMID:20594879. |
phosphorylation of spinal n-methyl-d-aspartate receptor nr1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetes-induced painful neuropathy. |
2011-05-06 |
2023-08-12 |
rat |
| Li-Jun Zhou, Tao Yang, Xiao Wei, Yong Liu, Wen-Jun Xin, Yuan Chen, Rui-Ping Pang, Ying Zang, Yong-Yong Li, Xian-Guo Li. Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat. Brain, behavior, and immunity. vol 25. issue 2. 2011-05-04. PMID:20933591. |
following sni bdnf and trkb receptor were up-regulated mainly in dorsal horn neurons and in activated microglia, and p-sfks and p-p38 mapk were increased exclusively in microglia. |
2011-05-04 |
2023-08-12 |
rat |
| Li-Jun Zhou, Tao Yang, Xiao Wei, Yong Liu, Wen-Jun Xin, Yuan Chen, Rui-Ping Pang, Ying Zang, Yong-Yong Li, Xian-Guo Li. Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat. Brain, behavior, and immunity. vol 25. issue 2. 2011-05-04. PMID:20933591. |
thus, the increased bdnf/trkb signaling in spinal dorsal horn may contribute to neuropathic pain by activation of microglia following peripheral nerve injury and inhibition of sfks or p38 mapk may selectively inhibit microglia in spinal dorsal horn. |
2011-05-04 |
2023-08-12 |
rat |
| Shunji Kunori, Shinji Matsumura, Emiko Okuda-Ashitaka, Tayo Katano, Laurent P Audoly, Yoshihiro Urade, Seiji It. A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord. Glia. vol 59. issue 2. 2011-04-14. PMID:21125641. |
mice deficient in microsomal prostaglandin e synthase-1 impaired the activation of microglia and the nmda-nitric oxide (no) cascade in spinal neurons in the dorsal horn and did not exhibit mechanical allodynia after peripheral nerve injury. |
2011-04-14 |
2023-08-12 |
mouse |
| Takayuki Nakagawa, Shuji Kanek. Spinal astrocytes as therapeutic targets for pathological pain. Journal of pharmacological sciences. vol 114. issue 4. 2011-03-22. PMID:21081837. |
although astrocyte-to-neuron signals implicated in pathological pain is poorly understood, activated astrocytes, as well as microglia, produce proinflammatory cytokines and chemokines, which lead to adaptation of the dorsal horn neurons. |
2011-03-22 |
2023-08-12 |
Not clear |
| Christina A Christianson, Maripat Corr, Gary S Firestein, Anahita Mobargha, Tony L Yaksh, Camilla I Svensso. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. vol 151. issue 2. 2011-02-14. PMID:20739123. |
the superficial dorsal horn of arthritic mice displayed increased staining of microglia at early and late time points, but astrocyte staining increased only during the inflammatory phase. |
2011-02-14 |
2023-08-12 |
mouse |