| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
nerve injury-activated microglia engulf myelinated axons in a p2y12 signaling-dependent manner in the dorsal horn. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
however, several studies have implied a role for reactive microglia located in the dorsal horn in neuropathic pain. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
to clarify the roles of activated microglia in neuropathic pain, we investigated the interactions among microglia and other neural components in the dorsal horn using electron microscopy. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
microglia were more abundantly localized in layers ii-iii of the dorsal horn than in other areas, and some of them adhered to and engulfed both injured and uninjured myelinated axons. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
this microglial engulfment was rarely observed in the normal dorsal horn, and the number of microglia attached to myelinated axons was markedly increased on postoperative day 7 on the operated side. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mitsuyo Maeda, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Hiroshi Kiyam. Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. Glia. vol 58. issue 15. 2011-01-26. PMID:20665560. |
these results indicate that engulfment of myelinated axons by activated microglia via p2y12 signaling in the dorsal horn may be a critical event in the pathogenesis of neuropathic pain. |
2011-01-26 |
2023-08-12 |
Not clear |
| Yinyin Xia, Haiou Liu, Aiguo Shen, Yonghua Liu, Linlin Sun, Tao Tao, Qing Ke, Chun Chen. A critical role of SRC-suppressed C kinase substrate in rat astrocytes after chronic constriction injury. Neuromolecular medicine. vol 12. issue 3. 2011-01-13. PMID:19937403. |
double immunofluorescence staining showed ssecks immunoreactivity was mostly co-localized with neurons, partly with activated astrocytes and rarely with microglia in the superficial laminar of spinal dorsal horn. |
2011-01-13 |
2023-08-12 |
rat |
| S Matsumura, K Takagi, E Okuda-Ashitaka, J Lu, H Naritsuka, M Yamaguchi, S It. Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury. Neuroscience. vol 170. issue 3. 2011-01-11. PMID:20673789. |
on the other hand, the activation and increase in number of microglia and astrocytes are restricted to the superficial layer of the dorsal horn, the central terminal of injured primary afferent fibers. |
2011-01-11 |
2023-08-12 |
mouse |
| Simon Beggs, Michael W Salte. Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0. Current opinion in neurobiology. vol 20. issue 4. 2011-01-06. PMID:20817512. |
the core signalling pathway is through p2x4 purinergic receptors on the microglia which, via the release of brain-derived neurotrophic factor, cause disinhibition of nociceptive dorsal horn neurons by raising intracellular chloride levels. |
2011-01-06 |
2023-08-12 |
Not clear |
| Lingli Liang, Zhiyong Wang, Ning Lü, Jiale Yang, Yuqiu Zhang, Zhiqi Zha. Involvement of nerve injury and activation of peripheral glial cells in tetanic sciatic stimulation-induced persistent pain in rats. Journal of neuroscience research. vol 88. issue 13. 2010-12-06. PMID:20544834. |
furthermore, reactive microglia and astrocytes were found in the spinal dorsal horn after tss. |
2010-12-06 |
2023-08-12 |
rat |
| Yi Zhong, Li-Jun Zhou, Wen-Jie Ren, Wen-Jun Xin, Yong-Yong Li, Tong Zhang, Xian-Guo Li. The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-alpha. Brain, behavior, and immunity. vol 24. issue 6. 2010-10-08. PMID:20116424. |
the direction of synaptic plasticity mediated by c-fibers in spinal dorsal horn is decided by src-family kinases in microglia: the role of tumor necrosis factor-alpha. |
2010-10-08 |
2023-08-12 |
mouse |
| Yi Zhong, Li-Jun Zhou, Wen-Jie Ren, Wen-Jun Xin, Yong-Yong Li, Tong Zhang, Xian-Guo Li. The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-alpha. Brain, behavior, and immunity. vol 24. issue 6. 2010-10-08. PMID:20116424. |
the results suggested that in spinal dorsal horn activation of sfks in microglia might control the direction of plastic changes at c-fiber synapses and tnf-alpha might be involved in the process. |
2010-10-08 |
2023-08-12 |
mouse |
| Donghoon Kim, Byunghyun You, Eun-Kyeong Jo, Sang-Kyou Han, Melvin I Simon, Sung Joong Le. NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 33. 2010-09-27. PMID:20679217. |
nox2 expression was induced in dorsal horn microglia immediately after l5 spinal nerve transection (snt). |
2010-09-27 |
2023-08-12 |
mouse |
| James E Biggs, Van B Lu, Martin J Stebbing, Sridhar Balasubramanyan, Peter A Smit. Is BDNF sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization? Molecular pain. vol 6. 2010-09-23. PMID:20653959. |
is bdnf sufficient for information transfer between microglia and dorsal horn neurons during the onset of central sensitization? |
2010-09-23 |
2023-08-12 |
Not clear |
| Kazuhide Inou. [The mechanism and control of neuropathic pain]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 11. 2010-09-02. PMID:20030208. |
emerging evidence indicate that the enhanced activity of dorsal horn neurons requires a communication with microglia. |
2010-09-02 |
2023-08-12 |
mouse |
| Kazuhide Inou. [The mechanism and control of neuropathic pain]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 11. 2010-09-02. PMID:20030208. |
results of our laboratory have shown that activating p2x4r upregulated in spinal microglia after nerve injury contributes to neuropathic pain through a release of bdnf from microglia, which is a crucial factor to signal to dorsal horn neurons to cause neuronal hyperexcitability. |
2010-09-02 |
2023-08-12 |
mouse |
| Tao Chen, Kohei Koga, Xiang-Yao Li, Min Zhu. Spinal microglial motility is independent of neuronal activity and plasticity in adult mice. Molecular pain. vol 6. 2010-08-25. PMID:20380706. |
in the spinal cord dorsal horn, microglia stay in resting condition during physiological sensory processing, and are activated under pathological conditions such as peripheral nerve injury. |
2010-08-25 |
2023-08-12 |
mouse |
| Tao Chen, Kohei Koga, Xiang-Yao Li, Min Zhu. Spinal microglial motility is independent of neuronal activity and plasticity in adult mice. Molecular pain. vol 6. 2010-08-25. PMID:20380706. |
our results provide the first evidence that the activation of microglia in the spinal cord after nerve injury is unlikely due solely to neuronal activity, non-neuronal factors are likely responsible for the activation of nerve injury-related microglial cells in the spinal dorsal horn. |
2010-08-25 |
2023-08-12 |
mouse |
| Ji-Tain Xu, Xiuli Zhao, Myron Yaster, Yuan-Xiang Ta. Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn. Brain research. vol 1336. 2010-08-20. PMID:20399760. |
in the dorsal horn, mtor, p70s6k, and 4e-bp1 were detected in neurons, but not in astrocytes or microglia. |
2010-08-20 |
2023-08-12 |
rat |
| Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Pain and purinergic signaling. Brain research reviews. vol 63. issue 1-2. 2010-08-02. PMID:19931560. |
within the spinal dorsal horn, peripheral nerve injury leads to a progressive series of changes in microglia including morphological hypertrophy of the cell body and proliferation, which are considered indicative of activation. |
2010-08-02 |
2023-08-12 |
Not clear |