| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jee Youn Lee, Chan Sol Park, Kyung Jin Seo, In Yi Kim, Sungmin Han, Inchan Youn, Tae Young Yun. IL-6/JAK2/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Experimental neurology. 2023-10-20. PMID:37863306. |
in particular, ag490 treatment inhibited both microglial and astrocyte activation in the lumbar (l) 4-5 dorsal horn and significantly decreased levels of p-p38mapk, p-erk and p-jnk, which are known to be activated in microglia (p-p38mapk and p-erk) and astrocyte (p-jnk). |
2023-10-20 |
2023-11-08 |
rat |
| Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. |
however, aging causes microglia in the ventral but not dorsal horn to lose their spatial organization. |
2023-09-22 |
2023-10-07 |
mouse |
| Longqing Zhang, Xi Tan, Fanhe Song, Danyang Li, Jiayi Wu, Shaojie Gao, Jia Sun, Daiqiang Liu, Yaqun Zhou, Wei Me. Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model. Neural regeneration research. vol 19. issue 3. 2023-09-18. PMID:37721302. |
in this study, we established a sprague-dawley rat model of spared nerve injury-induced neuropathic pain and found that gpr39 expression was significantly decreased in neurons and microglia in the spinal dorsal horn compared with sham-operated rats. |
2023-09-18 |
2023-10-07 |
rat |
| Andrea Angeli, Laura Micheli, Rita Turnaturi, Lorella Pasquinucci, Carmela Parenti, Vincenzo Alterio, Anna Di Fiore, Giuseppina De Simone, Simona Maria Monti, Fabrizio Carta, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Claudiu T Supura. Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia. European journal of medicinal chemistry. vol 260. 2023-09-07. PMID:37678143. |
by means of repeated treatment of 3 daily administrations for 17 days, fentanyl (0.1 mg/kg, subcutaneously) led to tolerance development, pain threshold alterations and withdrawal symptoms in cd-1 mice, as well as astrocyte and microglia activation in the dorsal horn of the lumbar spinal cord. |
2023-09-07 |
2023-10-07 |
mouse |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
moreover, sni-induced microglia activation and upregulation of p2x7r in spinal dorsal horn could be markedly inhibited by prf + drg. |
2023-08-14 |
2023-08-16 |
Not clear |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
the results suggest that the analgesic effect of prf + drg increased with time whereas the other two not and microglia and p2x7r in the ipsilateral spinal dorsal horn may be involved in the process. |
2023-08-14 |
2023-08-16 |
Not clear |
| Yaswanth Kuthati, Vaikar Navakanth Rao, Wei-Hsiu Huang, Prabhakar Busa, Chih-Shung Won. Teneligliptin Co-Infusion Alleviates Morphine Tolerance by Inhibition of Spinal Microglial Cell Activation in Streptozotocin-Induced Diabetic Rats. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37508016. |
microglial cell activation and mononucleate cell infiltration in the spinal cord dorsal horn were assessed by immunofluorescence assay (ifa) and western blotting (wb). |
2023-07-29 |
2023-08-14 |
rat |
| Yaswanth Kuthati, Vaikar Navakanth Rao, Wei-Hsiu Huang, Prabhakar Busa, Chih-Shung Won. Teneligliptin Co-Infusion Alleviates Morphine Tolerance by Inhibition of Spinal Microglial Cell Activation in Streptozotocin-Induced Diabetic Rats. Antioxidants (Basel, Switzerland). vol 12. issue 7. 2023-07-29. PMID:37508016. |
the results showed that co-infusion of ten with mor significantly attenuated mat in dnp rats through the restoration of neuroprotective proteins nrf2 and ho-1 and suppression of microglial cell activation in the dorsal horn. |
2023-07-29 |
2023-08-14 |
rat |
| Jia-Xuan Yang, Jiang Zhu, Kun Ni, Hai-Kou Yang, Hai-Long Zhang, Zheng-Liang M. Electroacupuncture relieves chronic pain by promoting microglia M2 polarization in lumbar disc herniation rats. Neuroreport. vol 34. issue 12. 2023-07-20. PMID:37470743. |
we show that pwt and pwl decreased in the ldh group while iba-1, inos, and tnf-α expression increased significantly in lumbar spinal dorsal horn (sdh) after ldh surgery, and revealing that microglia were activated and polarized towards proinflammatory m1 phenotype. |
2023-07-20 |
2023-08-14 |
rat |
| Xuan Zhao, Tingting Zhang, Yun Wang, Zihan Hu, Xinren Yu, Pei Chen, Keyu Jin, Jing Zhou, Guoxiang Wang, Jiangning Yu, Tong Wu, Yulong Wang, Fuqing Li. BDNF-TrkB signaling pathway-mediated microglial activation induces neuronal KCC2 downregulation contributing to dynamic allodynia following spared nerve injury. Molecular pain. 2023-06-15. PMID:37321969. |
the over activation of microglia in the spinal dorsal horn after sni was at least one of the triggers in sni-induced mkcc2 reduction and dynamic allodynia, as these effects were blocked by the inhibition of microglial activation. |
2023-06-15 |
2023-08-14 |
mouse |
| Xin Jia, Ziyang Li, Xiafeng Shen, Yu Zhang, Li Zhang, Ling Zhan. High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic post-ischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282487. |
finally, shrna-mediated silencing of chemerin receptor 23 in the spinal cord reversed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammatory polarization of microglia in the dorsal horn of the spinal cord. |
2023-06-07 |
2023-08-14 |
mouse |
| Xue Wang, Cong Lin, Sha Jin, Yibo Wang, Yinghua Peng, Xiaohui Wan. Cannabidiol alleviates neuroinflammation and attenuates neuropathic pain via targeting FKBP5. Brain, behavior, and immunity. 2023-05-17. PMID:37196785. |
furthermore, systemic administration of cbd inhibited chronic constriction injury (cci)-induced microglia activation and fkbp5 overexpression in lumbar spinal cord dorsal horn. |
2023-05-17 |
2023-08-14 |
Not clear |
| Erliang Kong, Yongchang Li, Peng Ma, Yixuan Zhang, Ruifeng Ding, Tong Hua, Mei Yang, Hongbin Yua. Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn. Journal of cellular and molecular medicine. 2023-05-03. PMID:37132040. |
lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating irf5 nuclear translocation in spinal dorsal horn. |
2023-05-03 |
2023-08-14 |
mouse |
| Erliang Kong, Yongchang Li, Peng Ma, Yixuan Zhang, Ruifeng Ding, Tong Hua, Mei Yang, Hongbin Yua. Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn. Journal of cellular and molecular medicine. 2023-05-03. PMID:37132040. |
cci led to the upregulation of lyn expression and glycolysis enhancement in microglia of spinal dorsal horn. |
2023-05-03 |
2023-08-14 |
mouse |
| Erliang Kong, Yongchang Li, Peng Ma, Yixuan Zhang, Ruifeng Ding, Tong Hua, Mei Yang, Hongbin Yua. Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn. Journal of cellular and molecular medicine. 2023-05-03. PMID:37132040. |
lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating irf5 nuclear translocation in spinal dorsal horn. |
2023-05-03 |
2023-08-14 |
mouse |
| Yajing Xu, Dale Moulding, Wenanlan Jin, Simon Begg. Microglial phagocytosis mediates long-term restructuring of spinal GABAergic circuits following early life injury. Brain, behavior, and immunity. 2023-04-10. PMID:37037363. |
we hypothesised that neonatal injury (1) alters microglial phagocytosis of synapses in the dorsal horn leading to long-term structural changes in neurons, and/or (2) trains microglia, leading to a stronger microglial response after re-injury in adulthood. |
2023-04-10 |
2023-08-14 |
Not clear |
| Yajing Xu, Dale Moulding, Wenanlan Jin, Simon Begg. Microglial phagocytosis mediates long-term restructuring of spinal GABAergic circuits following early life injury. Brain, behavior, and immunity. 2023-04-10. PMID:37037363. |
dorsal horn microglia increased engulfment of synapses following injury, with a preference for those expressing the vesicular gaba transporter vgat and primary afferent a-fibre terminals in neonates. |
2023-04-10 |
2023-08-14 |
Not clear |
| Yifan Zhou, Yaowei Xu, Jingjie Yang, Zhixiang Yu, Wenting Wang, Meng Yuan, Yiming Wang, Qian Bai, Zhisong L. Spinal cannabinoid receptor 2 activation alleviates neuropathic pain by regulating microglia and suppressing P2X7 receptor. Frontiers in molecular neuroscience. vol 16. 2023-03-27. PMID:36969555. |
in this study, we report increased and more reactive microglia (with larger cell body, shorter processes, and fewer endpoints) observed in the spinal dorsal horn of spared nerve injury (sni) rats. |
2023-03-27 |
2023-08-14 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
this rat in vivo study determined whether ep injury results in spinal dorsal horn sensitization (substance p, subp), microglia (iba1) and astrocytes (gfap), and evaluated their relationship with pain-related behaviors, ivd degeneration, and spinal macrophages (cd68). |
2023-02-25 |
2023-08-14 |
rat |
| Xiaona Zhao, Xinxin Li, Huiling Guo, Panmei Liu, Minyu Ma, Yanping Wan. Resolvin D1 Attenuates Mechanical Allodynia after Burn Injury: Involvement of Spinal Glia, p38 MAPK, and BDNF/TrkB signaling. Molecular pain. 2023-02-11. PMID:36765459. |
pain behavior and the expression levels of spinal dorsal horn iba-1 (microglia marker), gfap (astrocyte marker), p-p38 mitogen-activated protein kinase (mapk), brain-derived neurotrophic factor (bdnf), and tropomyosin-related kinase b (trkb) were detected by behavioral and immunocytochemical assays. |
2023-02-11 |
2023-08-14 |
rat |