| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu Gao, Long-Fei Gao, Xiang-Qing Kong, Ya-Nan Zhang, Shu Jia, Chun-Yang Men. Mesenchymal stem cell-derived extracellular vesicles carrying miR-99b-3p restrain microglial activation and neuropathic pain by stimulating autophagy. International immunopharmacology. vol 115. 2023-01-13. PMID:36638658. |
during in vivo studies, intrathecal injection of msc-evs significantly up-regulated the expression of mir-99b-3p, and alleviated mechanical allodynia caused by activated microglia in the spinal cord dorsal horn of cci rats. |
2023-01-13 |
2023-08-14 |
human |
| Jing Zhang, Jialin Si, Rongrong Liang, Yuxin Lu, Hongwei Shang, Xinwei Li, Shukai Sun, Li-An W. Ligand-gated ion channel P2X7 regulates hypoxia-induced factor-1α mediated pain induced by dental pulpitis in the medullary dorsal horn. Frontiers in molecular neuroscience. vol 15. 2022-11-17. PMID:36385758. |
accumulating evidence indicates that activated microglia in the medullary dorsal horn (mdh) contribute to dental pulpitis induced pain. |
2022-11-17 |
2023-08-14 |
rat |
| Rana Muhammad Shoaib, Muhammad Zaeem Ahsan, Usman Akhtar, Khalil Ali Ahmad, Usman Ali, Men-Yan Deng, Xin-Yan Li, Yong-Xiang Wan. Ginsenoside Rb1, a principal effective ingredient of Panax notoginseng, produces pain antihypersensitivity by spinal microglial dynorphin A expression. Neuroscience research. 2022-11-11. PMID:36368461. |
additionally, intrathecal ginsenoside rb1 specifically stimulated dynorphin a expression which was colocalized with microglia but not neurons or astrocytes in the spinal dorsal horn and primary cultured cells. |
2022-11-11 |
2023-08-14 |
Not clear |
| Nan Gu, Min-Hee Yi, Madhuvika Murugan, Manling Xie, Sebastian Parusel, Jiyun Peng, Ukpong B Eyo, Christine L Hunt, Hailong Dong, Long-Jun W. Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity. Molecular brain. vol 15. issue 1. 2022-10-27. PMID:36289499. |
using an ablation strategy to specifically deplete resident microglia in the cns, we demonstrate that microglia participate in formalin-induced acute sustained pain behaviors by amplifying neuronal activity in the spinal dorsal horn. |
2022-10-27 |
2023-08-14 |
mouse |
| Masatake Fujimur. Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats. Toxicology letters. 2022-10-16. PMID:36244566. |
our recent study using minamata disease model rats demonstrated that mehg-mediated neurodegeneration in the sensory nervous system may induce inflammatory microglia production in the dorsal horn of the spinal cord and subsequent somatosensory cortical rewiring, leading to neuropathic pain. |
2022-10-16 |
2023-08-14 |
rat |
| Masatake Fujimur. Fasudil, a ROCK inhibitor, prevents neuropathic pain in Minamata disease model rats. Toxicology letters. 2022-10-16. PMID:36244566. |
in this model, fasudil significantly suppressed nerve injury-induced inflammatory microglia production in the dorsal horn of the spinal cord and prevented subsequent somatosensory cortical rewiring. |
2022-10-16 |
2023-08-14 |
rat |
| Xuan Lu, Lunhao Chen, Chao Jiang, Kelei Cao, Zhihua Gao, Yue Wan. Microglia and macrophages contribute to the development and maintenance of sciatica in lumbar disc herniation. Pain. 2022-09-28. PMID:36170151. |
we found that nerve root compression using degenerated np tissues can initiate remarkable and persistent sciatica, with increased and prolonged macrophage infiltration in dorsal root ganglia (drg) and significant activation of microglia in the spinal dorsal horn. |
2022-09-28 |
2023-08-14 |
mouse |
| Jiang Bian, Bangjian Zhang, Ying Zhang, Yunyun Tian, LiYin, WanyunZo. FGF 10 Inhibited Spinal Microglial Activation in Neuropathic Pain via PPAR-γ/NF-κB Signaling. Neuroscience. 2022-08-07. PMID:35934252. |
immunofluorescence staining and western blot detection revealed that fgf 10 expression was upregulated in the ipsilateral spinal dorsal horn of spared nerve injury (sni) rat models and was mainly detected in neurons and microglia. |
2022-08-07 |
2023-08-14 |
rat |
| Jian Zhang, Xuan Zhang, Liren Li, Liying Bai, Yan Gao, Yin Yang, Li Wang, Yiming Qiao, Xueli Wang, Ji-Tian X. Activation of Double-Stranded RNA-Activated Protein Kinase in the Dorsal Root Ganglia and Spinal Dorsal Horn Regulates Neuropathic Pain Following Peripheral Nerve Injury in Rats. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-06-02. PMID:35655111. |
in the dorsal horn, p-pkr was located in neuronal cells, astrocytes, and microglia. |
2022-06-02 |
2023-08-14 |
rat |
| Dylan Maixner, David Christy, Lingwei Kong, Viacheslav Viatchenko-Karpinski, Ashley Horner, Shelley Hooks, Han-Rong Wen. Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord. Molecular pain. 2022-06-01. PMID:35647699. |
lancl2 is expressed only in microglia in the spinal dorsal horn. |
2022-06-01 |
2023-08-13 |
rat |
| Dylan Maixner, David Christy, Lingwei Kong, Viacheslav Viatchenko-Karpinski, Ashley Horner, Shelley Hooks, Han-Rong Wen. Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord. Molecular pain. 2022-06-01. PMID:35647699. |
pre-emptive treatment with aba attenuates activation of microglia and astrocytes, erk activity, and tnf□ protein abundance in the dorsal horn in rats with psnl. |
2022-06-01 |
2023-08-13 |
rat |
| Juan Li, Yiyong Wei, Junli Zhou, Helin Zou, Lulin Ma, Chengxi Liu, Zhi Xiao, Xingfeng Liu, Xinran Tan, Tian Yu, Song Ca. Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn. Journal of neuroinflammation. vol 19. issue 1. 2022-05-27. PMID:35624514. |
activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn. |
2022-05-27 |
2023-08-13 |
mouse |
| Shannon Tansley, Ning Gu, Alba Ureña Guzmán, Weihua Cai, Calvin Wong, Kevin Lister, Einer Muñoz-Pino, Noosha Yousefpour, R Brian Roome, Jordyn Heal, Neil Wu, Annie Castonguay, Graham Lean, Elizabeth M Muir, Artur Kania, Masha Prager-Khoutorsky, Ji Zhang, Christos G Gkogkas, James W Fawcett, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Yves De Koninck, Jeffrey S Mogil, Arkady Khoutorsk. Microglia-mediated degradation of perineuronal nets promotes pain. Science (New York, N.Y.). 2022-05-26. PMID:35617374. |
activation of microglia in the spinal cord dorsal horn following peripheral nerve injury contributes to the development of pain hypersensitivity. |
2022-05-26 |
2023-08-13 |
Not clear |
| Shannon Tansley, Ning Gu, Alba Ureña Guzmán, Weihua Cai, Calvin Wong, Kevin Lister, Einer Muñoz-Pino, Noosha Yousefpour, R Brian Roome, Jordyn Heal, Neil Wu, Annie Castonguay, Graham Lean, Elizabeth M Muir, Artur Kania, Masha Prager-Khoutorsky, Ji Zhang, Christos G Gkogkas, James W Fawcett, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Yves De Koninck, Jeffrey S Mogil, Arkady Khoutorsk. Microglia-mediated degradation of perineuronal nets promotes pain. Science (New York, N.Y.). 2022-05-26. PMID:35617374. |
we discovered that following peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets (pnns), in lamina i of the spinal cord dorsal horn. |
2022-05-26 |
2023-08-13 |
Not clear |
| Qin Qingguang, Chen Zujiang, Fan Weimin, L I Junhua, Liao Liqing, L I Yika. Hyperpolarization-activated cyclic nucleotide-gated 2 contributes to electroacupuncture analgesia on lumbar disc herniation-induced radicular pain through activation of microglia in spinal dorsal horn. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 42. issue 3. 2022-05-24. PMID:35610006. |
hyperpolarization-activated cyclic nucleotide-gated 2 contributes to electroacupuncture analgesia on lumbar disc herniation-induced radicular pain through activation of microglia in spinal dorsal horn. |
2022-05-24 |
2023-08-13 |
Not clear |
| YuShan Tu, Milind M Muley, Simon Beggs, Michael W Salte. Microglia-independent peripheral neuropathic pain in male and female mice. Pain. 2022-04-06. PMID:35384869. |
the dominant view in the field of pain is that peripheral neuropathic pain is driven by microglia in the somatosensory processing region of the spinal dorsal horn. |
2022-04-06 |
2023-08-13 |
mouse |
| Donghwi Park, Min Cheol Chan. The mechanism of action of pulsed radiofrequency in reducing pain: a narrative review. Journal of Yeungnam medical science. 2022-04-06. PMID:35385898. |
in addition, deactivation of microglia at the level of the spinal dorsal horn, reduction of proinflammatory cytokines, increased endogenous opioid precursor messenger ribonucleic acid, enhancement of noradrenergic and serotonergic descending pain inhibitory pathways, suppression of excitation of c-afferent fibers, and microscopic damage of nociceptive c- and a-delta fibers have been found to contribute to pain reduction after prf application. |
2022-04-06 |
2023-08-13 |
Not clear |
| Danny Mortensen, Maria Soendergaard Thoefner, Joergen Steen Agerholm, Lasse Slumstrup, Troels Staehelin Jensen, Ole Jannik Bjerrum, Mette Berendt, Jens Randel Nyengaar. Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching. Pain. 2022-03-30. PMID:35353770. |
significant changes in cell number density were not found for astrocytes or microglia, suggesting that the dogs represented cases of end-stage syringomyelia and thus could not reveal astrogliosis and microgliosis, which may be involved in the early phases of syrinx development and phantom scratch.the present relationship between clinical findings and dorsal horn and pain pathway pathology in ckcs suggests that these dogs may be of interest as a supplement to experimental model pain research. |
2022-03-30 |
2023-08-13 |
Not clear |
| Rita Silva, Marzia Malcangi. Fractalkine/CX Frontiers in pain research (Lausanne, Switzerland). vol 2. 2022-03-17. PMID:35295489. |
specifically, following peripheral nerve injury, microglia, which are cns resident immune cells, respond to the activity of the first pain synapse in the dorsal horn of spinal cord and also to neuronal activity in higher centres in the brain. |
2022-03-17 |
2023-08-13 |
Not clear |
| Baorui Xing, Nana Feng, Juan Zhang, Yunmei Li, Xiuxiu Hou, Hao Wu, Wendong Liu, Guangpu Ha. Pinocembrin relieves hip fracture-induced pain by repressing spinal substance P signaling in aged rats. Journal of neurophysiology. 2022-01-05. PMID:34986062. |
the microglia and astrocytes activation and proliferation markers in the spinal dorsal horn were detected with real-time pcr and immunofluorescence staining. |
2022-01-05 |
2023-08-13 |
rat |