| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuya Kawarai, Sumihisa Orita, Junichi Nakamura, Shuichi Miyamoto, Miyako Suzuki, Kazuhide Inage, Shigeo Hagiwara, Takane Suzuki, Takayuki Nakajima, Tsutomu Akazawa, Seiji Ohtor. Analgesic Effect of Duloxetine on an Animal Model of Monosodium Iodoacetate-Induced Hip Osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 38. issue 2. 2020-02-10. PMID:31538672. |
these results suggest that a single injection of duloxetine suppressed mechanical hyperalgesia and may influence the expression of iba1 in the microglia of the ipsilateral dorsal horn in the mia-induced hip oa. |
2020-02-10 |
2023-08-13 |
rat |
| Yuhua Yin, Jinpyo Hong, Thuỳ Linh Phạm, Juhee Shin, Do Hyeong Gwon, Hyeok Hee Kwon, Nara Shin, Hyo Jung Shin, Sun Yeul Lee, Won-Hyung Lee, Dong Woon Ki. Evans Blue Reduces Neuropathic Pain Behavior by Inhibiting Spinal ATP Release. International journal of molecular sciences. vol 20. issue 18. 2020-01-30. PMID:31505901. |
taken together, these data demonstrate that eb prevents atp release in the spinal dorsal horn and reduces the atp/purinergic receptor-induced activation of spinal microglia followed by a decline in algogenic substances, thereby relieving neuropathic pain in rats with snl. |
2020-01-30 |
2023-08-13 |
rat |
| Coralie Brifault, HyoJun Kwon, Wendy M Campana, Steven L Gonia. LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. Glia. vol 67. issue 6. 2019-12-30. PMID:30746765. |
lrp1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. |
2019-12-30 |
2023-08-13 |
mouse |
| Coralie Brifault, HyoJun Kwon, Wendy M Campana, Steven L Gonia. LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. Glia. vol 67. issue 6. 2019-12-30. PMID:30746765. |
following injury to the peripheral nervous system (pns), microglia in the spinal dorsal horn (sdh) become activated and contribute to the development of local neuro-inflammation, which may regulate neuropathic pain processing. |
2019-12-30 |
2023-08-13 |
mouse |
| Hou-Sheng Deng, Long-Sheng Xu, Hua-Dong Ni, Ting-Ting Wang, Ming-Juan Liu, Mao-Xian Yang, Hui Shen, Huan Pan, Ming Ya. Proteomic profiling reveals Arl6ip-1 as a candidate target in cancer-induced bone pain rat model after oxycodone treatment. Neuroscience letters. vol 699. 2019-12-17. PMID:30708128. |
fluorescent staining revealed that arl6ip-1 co-localized with spinal dorsal horn neurons, but not with astrocytes or microglia. |
2019-12-17 |
2023-08-13 |
rat |
| Ryota Yamagata, Wataru Nemoto, Osamu Nakagawasai, Wan-Yi Hung, Kazuhiro Shima, Yasuo Endo, Koichi Tan-N. Etidronate attenuates tactile allodynia by spinal ATP release inhibition in mice with partial sciatic nerve ligation. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 3. 2019-12-06. PMID:30515539. |
in mice subjected to psnl, slc17a9 was present in neurons and microglia, but not in astrocytes of the lumbar superficial dorsal horn. |
2019-12-06 |
2023-08-13 |
mouse |
| Jaung-Geng Lin, Yu-Chen Lee, Chien-Hsin Tseng, Dai-Yin Chen, Chieh-Yun Shih, Iona MacDonald, Shih-Ya Hung, Yi-Hung Che. Electroacupuncture inhibits pruritogen-induced spinal microglial activation in mice. Brain research. vol 1649. issue Pt A. 2019-11-20. PMID:27396909. |
ea application (2hz) to li4 and li11 attenuated gnti-induced scratching behavior and repressed gnti-induced iba1 expression and iba1 (+) microglia in the dorsal horn. |
2019-11-20 |
2023-08-13 |
mouse |
| Yangyang Chen, Yiqian Shi, Guoxiang Wang, Yimei Li, Longzhen Cheng, Yun Wan. Memantine selectively prevented the induction of dynamic allodynia by blocking Kir2.1 channel and inhibiting the activation of microglia in spinal dorsal horn of mice in spared nerve injury model. Molecular pain. vol 15. 2019-08-12. PMID:30845882. |
memantine selectively prevented the induction of dynamic allodynia by blocking kir2.1 channel and inhibiting the activation of microglia in spinal dorsal horn of mice in spared nerve injury model. |
2019-08-12 |
2023-08-13 |
mouse |
| Akira Sayo, Hiroyuki Konishi, Masaaki Kobayashi, Kuniyuki Kano, Hiroki Kobayashi, Hideharu Hibi, Junken Aoki, Hiroshi Kiyam. GPR34 in spinal microglia exacerbates neuropathic pain in mice. Journal of neuroinflammation. vol 16. issue 1. 2019-08-12. PMID:30975169. |
microglia are activated in the spinal dorsal horn after sensory nerve injury and contribute to neuropathic pain. |
2019-08-12 |
2023-08-13 |
mouse |
| Kuang-Yi Tseng, Hung-Chen Wang, Lin-Li Chang, Kuang-I Chen. Advances in Experimental Medicine and Biology: Intrafascicular Local Anesthetic Injection Damages Peripheral Nerve-Induced Neuropathic Pain. Advances in experimental medicine and biology. vol 1099. 2019-07-26. PMID:30306515. |
in spinal dorsal horn (sdh), the microglia and astrocytes located in sdh were activated and proliferated after intrafascicular la injection and returned to baseline gradually at the end of the month. |
2019-07-26 |
2023-08-13 |
Not clear |
| Hiroai Okutani, Hiroki Yamanaka, Kimiko Kobayashi, Masamichi Okubo, Koichi Noguch. Recombinant interleukin-4 alleviates mechanical allodynia via injury-induced interleukin-4 receptor alpha in spinal microglia in a rat model of neuropathic pain. Glia. vol 66. issue 8. 2019-07-18. PMID:29693281. |
in particular, activated microglia in the spinal cord facilitate the hyper-excitability of dorsal horn neurons after peripheral nerve injury via pro-inflammatory molecules. |
2019-07-18 |
2023-08-13 |
rat |
| Bo-Jun Xiong, Ying Xu, Gui-Lin Jin, Ming Liu, Jian Yang, Chang-Xi Y. Analgesic effects and pharmacologic mechanisms of the Gelsemium alkaloid koumine on a rat model of postoperative pain. Scientific reports. vol 7. issue 1. 2019-07-16. PMID:29079733. |
our results showed that microglia and astroglia were activated in the spinal dorsal horn post-incision, along with an increase of proinflammatory cytokines (interleukin 1β, interleukin 6, and tumor necrosis factor α). |
2019-07-16 |
2023-08-13 |
rat |
| Xisheng Yan, Fen Li, Dylan W Maixner, Ruchi Yadav, Mei Gao, Mourad Wagdy Ali, Shelley B Hooks, Han-Rong Wen. Interleukin-1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel-associated acute pain syndrome. Glia. vol 67. issue 3. 2019-06-13. PMID:30578561. |
interleukin-1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel-associated acute pain syndrome. |
2019-06-13 |
2023-08-13 |
mouse |
| Yuya Kawarai, Sumihisa Orita, Junichi Nakamura, Shuichi Miyamoto, Miyako Suzuki, Kazuhide Inage, Shigeo Hagiwara, Takane Suzuki, Takayuki Nakajima, Tsutomu Akazawa, Seiji Ohtor. Changes in proinflammatory cytokines, neuropeptides, and microglia in an animal model of monosodium iodoacetate-induced hip osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 36. issue 11. 2019-05-09. PMID:29888808. |
mia rats also presented significantly more fg-labeled gap-43-ir drg neurons than the sham group on post-induction days 28, 42, and 56 (p < 0.05), and a significantly higher number of iba-1-ir microglia in the ipsilateral dorsal horn than the other groups, on post-induction days 28, 42, and 56. |
2019-05-09 |
2023-08-13 |
rat |
| Andrea J Mothe, Nardos G Tassew, Alirezha P Shabanzadeh, Romeo Penheiro, Robin J Vigouroux, Lili Huang, Christine Grinnell, Yi-Fang Cui, Emma Fung, Philippe P Monnier, Bernhard K Mueller, Charles H Tato. RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury. Scientific reports. vol 7. issue 1. 2019-05-01. PMID:28874746. |
rgma antibody also attenuated neuropathic pain responses, which was associated with fewer activated microglia and reduced cgrp expression in the dorsal horn caudal to the lesion. |
2019-05-01 |
2023-08-13 |
human |
| Kelsi N Dodds, Elizabeth A H Beckett, Susan F Evans, Mark R Hutchinso. Spinal Glial Adaptations Occur in a Minimally Invasive Mouse Model of Endometriosis: Potential Implications for Lesion Etiology and Persistent Pelvic Pain. Reproductive sciences (Thousand Oaks, Calif.). vol 26. issue 3. 2019-04-17. PMID:29730970. |
spinal cords (t13-s1) from female c57bl/6 mice with endometriosis-like lesions (endo) were imaged via fluorescent immunohistochemistry for the expression of glial fibrillary acidic protein (gfap; astrocytes) and cd11b (microglia) in the dorsal horn (n = 5). |
2019-04-17 |
2023-08-13 |
mouse |
| Louise S C Nicol, Peter Thornton, Jon P Hatcher, Colin P Glover, Carl I Webster, Matthew Burrell, Kessia Hammett, Clare A Jones, Matthew A Sleeman, Andrew Billinton, Iain Chessel. Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain. Pain. vol 159. issue 3. 2019-04-01. PMID:29351125. |
despite observing gm-csf receptor expression in microglia and astrocytes, the gliosis response in the dorsal horn was not altered in nerve injured knockout mice compared with wild-type littermate controls as evaluated by ionized calcium binding adapter molecule 1 (iba1) and glial fibrillary acidic protein, respectively. |
2019-04-01 |
2023-08-13 |
mouse |
| Yuying Tang, Lian Liu, Dan Xu, Wensheng Zhang, Yi Zhang, Jieshu Zhou, Wei Huan. Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29080683. |
accumulation of microglia occurs in the dorsal horn in the rodent model of chronic post ischemic pain (cpip), while the mechanism how microglia affects the development of persistent pain largely remains unknown. |
2019-03-12 |
2023-08-13 |
rat |
| Yuying Tang, Lian Liu, Dan Xu, Wensheng Zhang, Yi Zhang, Jieshu Zhou, Wei Huan. Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29080683. |
the accumulated microglia released bdnf, increased neuronal excitability in dorsal horn, and produced pain behaviors in the modeled rodents. |
2019-03-12 |
2023-08-13 |
rat |
| Kelly Bruno, Sarah A Woller, Yury I Miller, Tony L Yaksh, Mark Wallace, Graham Beaton, Krishnan Chakravarth. Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states. Pain. vol 159. issue 10. 2019-02-19. PMID:29889119. |
the receptor is located not only on inflammatory cells (meningeal and peripheral macrophages) but on neuraxial glia (microglia and astrocytes), schwann cells, fibroblasts, dorsal root ganglia, and dorsal horn neurons. |
2019-02-19 |
2023-08-13 |
Not clear |