| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojuan Sun, Hongxing Zhan. miR-451 elevation relieves inflammatory pain by suppressing microglial activation-evoked inflammatory response via targeting TLR4. Cell and tissue research. vol 374. issue 3. 2019-01-14. PMID:30069596. |
in this study, the expression of mir-451 was decreased in spinal dorsal horn and spinal microglia of complete freund's adjuvant (cfa)-induced inflammatory pain mice model. |
2019-01-14 |
2023-08-13 |
mouse |
| Chao Li, Wei Mao, Yun-Ke Huang, Zhi-Qi Zhao, Ning Ly. [Roles of CX3CR1 in mediation of post-incision induced mechanical pain hypersensitivity: Effects of acupuncture-combined anesthesia]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 3. 2019-01-04. PMID:29926064. |
cx3cr1 was mainly expressed in microglia in the spinal cord dorsal horn, and its protein level was significantly increased at 3 d after incision compared with that of naïve c57bl/6j mice. |
2019-01-04 |
2023-08-13 |
mouse |
| Yi-Mei Ma, Chuan-da Li, Ya-Bing Zhu, Xia Xu, Jun Li, Hong Ca. [The mechanism of RvD1 alleviates type 2 diabetic neuropathic pain by influencing microglia polarization in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 33. issue 3. 2018-11-06. PMID:29931947. |
to study the relationship between microglia polarization in the spinal dorsal horn and type 2 diabetic neuropathic pain (dnp). |
2018-11-06 |
2023-08-13 |
rat |
| Tao Yang, Sujuan Du, Xianguo Liu, Xijiu Ye, Xuhong We. Withdrawal from spinal application of remifentanil induces long-term potentiation of c-fiber-evoked field potentials by activation of Src family kinases in spinal microglia. Neurochemical research. vol 43. issue 8. 2018-10-26. PMID:29959648. |
remifentanil withdrawal could activate src family kinases (sfks) in microglia, and upregulate the expression of tumor necrosis factor alpha (tnfα) in spinal dorsal horn. |
2018-10-26 |
2023-08-13 |
rat |
| Keita Kohno, Junko Kitano, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsud. Temporal Kinetics of Microgliosis in the Spinal Dorsal Horn after Peripheral Nerve Injury in Rodents. Biological & pharmaceutical bulletin. vol 41. issue 7. 2018-10-24. PMID:29962405. |
previous studies have implicated activated microglia in the spinal dorsal horn (sdh) as key cellular intermediaries in neuropathic pain. |
2018-10-24 |
2023-08-13 |
Not clear |
| Satoru Koyanagi, Naoki Kusunose, Marie Taniguchi, Takahiro Akamine, Yuki Kanado, Yui Ozono, Takahiro Masuda, Yuta Kohro, Naoya Matsunaga, Makoto Tsuda, Michael W Salter, Kazuhide Inoue, Shigehiro Ohd. Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia. Nature communications. vol 7. 2018-09-05. PMID:27739425. |
diurnal enhancement of pain hypersensitivity is mediated by glucocorticoid-induced enhancement of the extracellular release of atp in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. |
2018-09-05 |
2023-08-13 |
mouse |
| Takahiro Masuda, Yui Ozono, Satsuki Mikuriya, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Ken Iwatsuki, Hisayuki Uneyama, Reiko Ichikawa, Michael W Salter, Makoto Tsuda, Kazuhide Inou. Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain. Nature communications. vol 7. 2018-09-04. PMID:27515581. |
these phenotypes were recapitulated in mice with specific deletion of vnut in spinal dorsal horn (sdh) neurons, but not in mice lacking vnut in primary sensory neurons, microglia or astrocytes. |
2018-09-04 |
2023-08-13 |
mouse |
| Laura Micheli, Elena Lucarini, Francesca Corti, Roberto Ciccocioppo, Girolamo Calò, Anna Rizzi, Carla Ghelardini, Lorenzo Di Cesare Mannell. Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad? European journal of pharmacology. vol 823. 2018-08-29. PMID:29378191. |
immunohistochemical analysis of the dorsal horn of the spinal cord of morphine tolerant nop(+/+) rats showed an increased number of iba1- and gfap-positive cells (microglia and astrocytes, respectively). |
2018-08-29 |
2023-08-13 |
rat |
| Jee Youn Lee, Hae Young Choi, Bong-Gun Ju, Tae Young Yun. Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 7. 2018-08-06. PMID:29653184. |
both microglia and astrocyte activation in the lamina i and ii of l4-5 dorsal horn was also inhibited by 17β-estradiol. |
2018-08-06 |
2023-08-13 |
rat |
| Xiao-Wen Meng, Jian-Ling Gao, Jian-Ling Zuo, Li-Na Wang, Si-Lan Liu, Xiao-Hong Jin, Ming Yao, Michael Namak. Toll-like receptor-4/p38 MAPK signaling in the dorsal horn contributes to P2X4 receptor activation and BDNF over-secretion in cancer induced bone pain. Neuroscience research. vol 125. 2018-08-03. PMID:28668500. |
our previous research suggested that the p2x4 receptor (p2x4r) expression in microglia was involved in the activation of toll-like receptor-4 (tlr4) in the dorsal horn in the rat model of cancer induced bone pain (cibp). |
2018-08-03 |
2023-08-13 |
rat |
| Yangliang Huang, Yongyong Li, Xiongxiong Zhong, Yuming Hu, Pan Liu, Yuanshu Zhao, Zhen Deng, Xianguo Liu, Shaoyu Liu, Yi Zhon. Src-family kinases activation in spinal microglia contributes to central sensitization and chronic pain after lumbar disc herniation. Molecular pain. vol 13. 2018-07-23. PMID:28952414. |
furthermore, we found that the expression of ionized calcium-binding adapter molecule 1 (marker of microglia), tumor necrosis factor-α, interleukin 1 -β in spinal dorsal horn was increased in rats with nucleus pulposus. |
2018-07-23 |
2023-08-13 |
rat |
| Jian Qi, Chen Chen, Qing-Xi Meng, Yan Wu, Haitao Wu, Ting-Bao Zha. Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia. Scientific reports. vol 6. 2018-06-21. PMID:27995982. |
crosstalk between activated microglia and neurons in the spinal dorsal horn contributes to stress-induced hyperalgesia. |
2018-06-21 |
2023-08-13 |
Not clear |
| Jian Qi, Chen Chen, Qing-Xi Meng, Yan Wu, Haitao Wu, Ting-Bao Zha. Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia. Scientific reports. vol 6. 2018-06-21. PMID:27995982. |
interestingly, inhibition of microglia activation by minocycline significantly suppressed the activation of both neurons and microglia in spinal dorsal horn. |
2018-06-21 |
2023-08-13 |
Not clear |
| Jian Qi, Chen Chen, Qing-Xi Meng, Yan Wu, Haitao Wu, Ting-Bao Zha. Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia. Scientific reports. vol 6. 2018-06-21. PMID:27995982. |
together, our data suggest that the presence of a "crosstalk" between activated microglia and neurons in the spinal dorsal horn, which might contribute to the stress-induced hyperactivated state, leading to an increased pain sensitivity. |
2018-06-21 |
2023-08-13 |
Not clear |
| Wataru Nemoto, Ryota Yamagata, Yoshiki Ogata, Osamu Nakagawasai, Takeshi Tadano, Koichi Tan-N. Inhibitory effect of angiotensin (1-7) on angiotensin III-induced nociceptive behaviour in mice. Neuropeptides. vol 65. 2018-06-14. PMID:28559062. |
furthermore, we showed that in the lumbar superficial dorsal horn, mas receptors are expressed in neurons and microglia but absent from astrocytes. |
2018-06-14 |
2023-08-13 |
mouse |
| Suzanne Doolen, Jennifer Cook, Maureen Riedl, Kelley Kitto, Shinichi Kohsaka, Christopher N Honda, Carolyn A Fairbanks, Bradley K Taylor, Lucy Vulchanov. Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling. Glia. vol 65. issue 12. 2018-06-05. PMID:28850719. |
complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling. |
2018-06-05 |
2023-08-13 |
Not clear |
| Yuangui Lin, Lian Liu, Haixia Jiang, Jieshu Zhou, Yuying Tan. Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis. European journal of pharmacology. vol 811. 2018-05-30. PMID:28663035. |
blockade of il-6 function by tocilizumab markedly suppressed the activation of astrocytes and microglia in the ipsilateral dorsal horn, reduced c-fos immunoreactivity in dorsal horn neurons, and attenuated the upregulation of glutamate receptor subunits glur1 and nr2b in dorsal horn in the rats with mia-induced oa. |
2018-05-30 |
2023-08-13 |
rat |
| Juan Niu, Dujuan Huang, Rui Zhou, MingXia Yue, Tao Xu, Junna Yang, Li He, Hong Tian, XiaoHong Liu, Junwei Zen. Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y Journal of neuroinflammation. vol 14. issue 1. 2018-05-29. PMID:28899427. |
activation of dorsal horn cannabinoid cb2 receptor suppresses the expression of p2y more evidence suggests that dorsal spinal cord microglia is an important site contributing to cb2 receptor-mediated analgesia. |
2018-05-29 |
2023-08-13 |
Not clear |
| Fang Fang Zhang, Norimitsu Morioka, Hiromi Abe, Shiori Fujii, Kazuki Miyauchi, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakat. Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase. Neurochemistry international. vol 101. 2018-01-12. PMID:27840124. |
fourteen days after psnl, increased phosphorylation of both p38 mitogen-activated protein kinase (mapk) in microglia and c-jun n-terminal kinase (jnk) in astrocytes of ipsilateral spinal dorsal horn were observed. |
2018-01-12 |
2023-08-13 |
mouse |
| Nan Gu, Ukpong B Eyo, Madhuvika Murugan, Jiyun Peng, Sanjana Matta, Hailong Dong, Long-Jun W. Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26576724. |
next, we characterised both the electrophysiological and morphological properties of microglia in the superficial spinal cord dorsal horn following snt injury. |
2017-12-29 |
2023-08-13 |
mouse |