| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang Fang Zhang, Norimitsu Morioka, Hiromi Abe, Shiori Fujii, Kazuki Miyauchi, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakat. Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase. Neurochemistry international. vol 101. 2018-01-12. PMID:27840124. |
fourteen days after psnl, increased phosphorylation of both p38 mitogen-activated protein kinase (mapk) in microglia and c-jun n-terminal kinase (jnk) in astrocytes of ipsilateral spinal dorsal horn were observed. |
2018-01-12 |
2023-08-13 |
mouse |
| Nan Gu, Ukpong B Eyo, Madhuvika Murugan, Jiyun Peng, Sanjana Matta, Hailong Dong, Long-Jun W. Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26576724. |
next, we characterised both the electrophysiological and morphological properties of microglia in the superficial spinal cord dorsal horn following snt injury. |
2017-12-29 |
2023-08-13 |
mouse |
| Jian Li, Xiangnan Li, Xin Jiang, Mei Yang, Rui Yang, Geoffrey Burnstock, Zhenghua Xiang, Hongbin Yua. Microvesicles shed from microglia activated by the P2X7-p38 pathway are involved in neuropathic pain induced by spinal nerve ligation in rats. Purinergic signalling. vol 13. issue 1. 2017-11-17. PMID:27683228. |
first, we found that mvs shed from microglia were increased in the cerebrospinal fluid and dorsal horn of the spinal cord after snl. |
2017-11-17 |
2023-08-13 |
rat |
| Katherine A Mifflin, Bradley J Ker. Pain in autoimmune disorders. Journal of neuroscience research. vol 95. issue 6. 2017-11-16. PMID:27448322. |
pathological pain has been linked to t-cell activation and the release of cytokines from activated microglia in the dorsal horn of the spinal cord. |
2017-11-16 |
2023-08-13 |
Not clear |
| Wenlong Huang, Margarita Calvo, Tim Pheby, David L H Bennett, Andrew S C Ric. A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. Pain. vol 158. issue 1. 2017-11-02. PMID:27682209. |
furthermore, we found a small but significant increase in microglia with the effector morphology in the lumbar spinal dorsal horn in indinavir-treated animals, coupled with significantly increased expression of phospho-p38 in microglia. |
2017-11-02 |
2023-08-13 |
rat |
| Ting Zhang, Kai Sun, Wen Shen, Le Qi, Wei Yin, Li-Wei Wan. SOCS1 regulates neuropathic pain by inhibiting neuronal sensitization and glial activation in mouse spinal cord. Brain research bulletin. vol 124. 2017-10-26. PMID:27233783. |
accumulating evidence indicates that astrocytes and microglia are activated in the spinal cord dorsal horn (scdh) after cci. |
2017-10-26 |
2023-08-13 |
mouse |
| C Richard Chapman, Charles J Vierc. The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms. The journal of pain. vol 18. issue 4. 2017-09-20. PMID:27908839. |
these propose that chronic pain results from: 1) persistent noxious signaling in the periphery; 2) enduring maladaptive neuroplastic changes at the spinal dorsal horn and/or higher central nervous system structures reflecting a multiplicity of factors, including peripherally released neurotrophic factors and interactions between neurons and microglia; 3) compromised inhibitory modulation of noxious signaling in medullary-spinal pathways; 4) descending facilitatory modulation; and 5) maladaptive brain remodeling in function, structure, and connectivity. |
2017-09-20 |
2023-08-13 |
Not clear |
| Katsuya Kami, Satoru Taguchi, Fumihiro Tajima, Emiko Senb. Histone Acetylation in Microglia Contributes to Exercise-Induced Hypoalgesia in Neuropathic Pain Model Mice. The journal of pain. vol 17. issue 5. 2017-09-19. PMID:26844418. |
we intended to clarify whether histone acetylation in microglia in the spinal dorsal horn contributes to eih in npp model mice. |
2017-09-19 |
2023-08-13 |
mouse |
| Katsuya Kami, Satoru Taguchi, Fumihiro Tajima, Emiko Senb. Histone Acetylation in Microglia Contributes to Exercise-Induced Hypoalgesia in Neuropathic Pain Model Mice. The journal of pain. vol 17. issue 5. 2017-09-19. PMID:26844418. |
in immunofluorescence analysis, psl surgery markedly increased the number of histone deacetylase 1-positive/cd11b-positive microglia in the ipsilateral superficial dorsal horn, and they were significantly decreased by treadmill-running. |
2017-09-19 |
2023-08-13 |
mouse |
| Katsuya Kami, Satoru Taguchi, Fumihiro Tajima, Emiko Senb. Histone Acetylation in Microglia Contributes to Exercise-Induced Hypoalgesia in Neuropathic Pain Model Mice. The journal of pain. vol 17. issue 5. 2017-09-19. PMID:26844418. |
moreover, the number of microglia with nuclear expression of acetylated h3k9 in the ipsilateral superficial dorsal horn was maintained at low levels in psl-sedentary mice, but running exercise significantly increased them. |
2017-09-19 |
2023-08-13 |
mouse |
| Ying Shi, Wanxiang Qin, Fachuan Nie, Huizhong Wen, Kaizhi Lu, Jian Cu. Ulinastatin attenuates neuropathic pain via the ATP/P2Y2 receptor pathway in rat models. Gene. vol 627. 2017-09-18. PMID:28652182. |
we found that increased expression of p2y2 receptor in microglia was likely involved in the activation of microglia after nerve injury, and ulinastatin inhibited the abnormal microglia activation in the dorsal horn after nerve injury. |
2017-09-18 |
2023-08-13 |
rat |
| Martha E Zeeman, Sonia Kartha, Beth A Winkelstei. Whole-body vibration induces pain and lumbar spinal inflammation responses in the rat that vary with the vibration profile. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 34. issue 8. 2017-08-31. PMID:27571442. |
similarly, increased activation of microglia, macrophages, and astrocytes in the superficial dorsal horn of the lumbar spinal cord is only evident after the painful 8 hz wbv. |
2017-08-31 |
2023-08-13 |
rat |
| Christian König, Eric Morch, Annett Eitner, Christian Möller, Brian Turnquist, Hans-Georg Schaible, Andrea Ebersberge. Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 38. 2017-08-17. PMID:27656018. |
together, these data show that the induction of hyperexcitability of nociceptive deep dorsal horn neurons by tnf-α largely depends on the formation of il-6/sil-6r complexes that are downstream of tnf-α and requires the interactions of neurons and microglia orchestrated by tnf-α. |
2017-08-17 |
2023-08-13 |
rat |
| Preet G S Makker, Samuel S Duffy, Justin G Lees, Chamini J Perera, Ryan S Tonkin, Oleg Butovsky, Susanna B Park, David Goldstein, Gila Moalem-Taylo. Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy. PloS one. vol 12. issue 1. 2017-08-10. PMID:28125674. |
in the central nervous system, ptx induced significant astrocyte activation in the spinal cord dorsal horn, and both ptx and oxa caused reduction of p2ry12+ homeostatic microglia, with no measurable changes in iba-1+ microglia/macrophages in the dorsal and ventral horns. |
2017-08-10 |
2023-08-13 |
mouse |
| Makoto Tsuda, Kohei Koga, Tao Chen, Min Zhu. Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex. Journal of neurochemistry. vol 141. issue 4. 2017-08-07. PMID:28251660. |
nerve injury-induced pain hypersensitivity involves aberrant excitability in spinal dorsal horn (sdh) neurons as a consequence of dysfunction of inhibitory interneurons and of hyperactivity of glial cells, especially microglia, the immune cells of the central nervous system. |
2017-08-07 |
2023-08-13 |
Not clear |
| Yong Liu, Li-Jun Zhou, Jun Wang, Dai Li, Wen-Jie Ren, Jiyun Peng, Xiao Wei, Ting Xu, Wen-Jun Xin, Rui-Ping Pang, Yong-Yong Li, Zhi-Hai Qin, Madhuvika Murugan, Mark P Mattson, Long-Jun Wu, Xian-Guo Li. TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 4. 2017-08-01. PMID:28123022. |
furthermore, sni activated microglia in both spinal dorsal horn and hippocampus; pharmacological inhibition or genetic ablation of microglia prevented the region-dependent synaptic changes, neuropathic pain, and memory deficits induced by sni. |
2017-08-01 |
2023-08-13 |
mouse |
| Masaaki Kobayashi, Hiroyuki Konishi, Akira Sayo, Toshiyuki Takai, Hiroshi Kiyam. TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 43. 2017-07-14. PMID:27798193. |
the present study showed that the dnax-activating protein of 12 kda (dap12) and its associated "triggering receptor expressed on myeloid cells 2" (trem2) were predominantly expressed by microglia in the dorsal horn after spinal nerve injury, revealing a role for trem2/dap12 signaling in neuropathic pain. |
2017-07-14 |
2023-08-13 |
mouse |
| Mohammed Shaqura, Xiongjuan Li, Mahmoud Al-Khrasani, Mehdi Shakibaei, Sascha Tafelski, Susanna Fürst, Antje Beyer, Mitsuhiro Kawata, Michael Schäfer, Shaaban A Mous. Membrane-bound glucocorticoid receptors on distinct nociceptive neurons as potential targets for pain control through rapid non-genomic effects. Neuropharmacology. vol 111. 2017-07-11. PMID:27558347. |
within the spinal cord, gr predominantly localized in incoming presynaptic nociceptive neurons, in pre- and postsynaptic structures of the dorsal horn, as well as in microglia. |
2017-07-11 |
2023-08-13 |
Not clear |
| Sheu-Ran Choi, Dae-Hyun Roh, Seo-Yeon Yoon, Soon-Gu Kwon, Hoon-Seong Choi, Ho-Jae Han, Alvin J Beitz, Jang-Hern Le. Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice. Neuropharmacology. vol 111. 2017-07-11. PMID:27567941. |
sig-1rs were also increased in lumbar dorsal horn astrocytes, but not neurons or microglia. |
2017-07-11 |
2023-08-13 |
mouse |
| Li-Na Yu, Li-Hong Sun, Min Wang, Min Ya. Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5 (ERK5) pathway in pathological pain. Journal of Zhejiang University. Science. B. vol 17. issue 10. 2017-06-09. PMID:27704743. |
erk5 activation in the spinal dorsal horn occurs mainly in microglia. |
2017-06-09 |
2023-08-13 |
Not clear |