All Relations between microglial cell and substantia nigra compacta

Reference Sentence Publish Date Extraction Date Species
Zhaofei Yang, Ying Wang, Min Wei, Song Li, Congcong Jia, Cheng Cheng, Murad Al-Nusaif, Jun Zhang, Cong Liu, Weidong L. Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates \\xce\\xb1-synucleinopathy in rat brain. Cell death & disease vol 14 issue 1 2023 36604420 moreover, significant activation of microglia and the development of astrogliosis were observed in the substantia nigra pars compacta of the injected rats. 2023-01-05 2023-01-08 Not clear
Eric N Moca, Daniela Lecca, Keenan T Hope, Fanny Etienne, Ari W Schaler, Katherine Espinoza, Megan S Chappell, Daniel T Gray, David Tweedie, Shanaya Sidhu, Lindsay Masukawa, Hannah Sitoy, Rose Mathew, Daniel R Saban, Nigel H Greig, Lindsay M De Bias. Microglia drive pockets of neuroinflammation in middle age. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2022 35396327 in male and female mice, we demonstrate that ventral tegmental area (vta) and substantia nigra pars compacta (snc) microglia exhibit unique and premature responses to aging, compared to cortex and nucleus accumbens (nac) microglia. 2022-04-09 2022-04-14 Not clear
Rui Huang, Yuyuan Gao, Jianing Chen, Qingrui Duan, Peikun He, Jiahui Zhang, Heling Huang, Qingxi Zhang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wan. TGR5 agonist INT-777 alleviates inflammatory neurodegeneration in parkinson's disease mouse model by modulating mitochondrial dynamics in microglia. Neuroscience vol issue 2022 35257795 int-777 prevented mptp-induced neurodegeneration and microglia activation in the substantia nigra pars compacta, hippocampus, and cortical layer v. based on bioinformatics and wet lab data, int-777 inhibited microglia activation by suppressing the release of tumor necrosis factor alpha (tnf-\xce\xb1) in the hippocampus, along with secondary chemokines (c-c motif ligand 3 (ccl3) and ccl6) in these three brain regions. 2022-03-14 2022-03-09 Not clear
Rui Huang, Yuyuan Gao, Jianing Chen, Qingrui Duan, Peikun He, Jiahui Zhang, Heling Huang, Qingxi Zhang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wan. TGR5 agonist INT-777 alleviates inflammatory neurodegeneration in parkinson's disease mouse model by modulating mitochondrial dynamics in microglia. Neuroscience vol issue 2022 35257795 int-777 prevented mptp-induced neurodegeneration and microglia activation in the substantia nigra pars compacta, hippocampus, and cortical layer v. based on bioinformatics and wet lab data, int-777 inhibited microglia activation by suppressing the release of tumor necrosis factor alpha (tnf-\xce\xb1) in the hippocampus, along with secondary chemokines (c-c motif ligand 3 (ccl3) and ccl6) in these three brain regions. 2022-03-08 2022-03-09 Not clear
Anahita Shahraz, Jannis Wi\\xc3\\x9ffeld, Aur\\xc3\\xa9lien Ginolhac, Mona Mathews, Lasse Sinkkonen, Harald Neuman. Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides. Glia vol 69 issue 1 2021 32721081 repeated systemic challenge with lipopolysaccharides (lps) can induce microglia activation and inflammatory neurodegeneration in the substantia nigra pars compacta region of mice. 2022-02-02 2022-01-13 Not clear
Fatemeh Shaerzadeh, Leah Phan, Douglas Miller, Maxwell Dacquel, William Hachmeister, Carissa Hansen, Alexandra Bechtle, Duan Tu, Maia Martcheva, Thomas C Foster, Ashok Kumar, Wolfgang J Streit, Habibeh Khoshboue. Microglia senescence occurs in both substantia nigra and ventral tegmental area. Glia vol 68 issue 11 2021 32275335 since aging is the greatest risk factor for parkinson's disease, we hypothesized that aging-related changes in microglia and neurons occur in the vulnerable substantia nigra pars compacta (snc) but not the ventral tegmental area (vta). 2021-11-30 2022-01-13 Not clear
Miguel Lemos, Serena Venezia, Violetta Refolo, Antonio Heras-Garvin, Sabine Schmidhuber, Armin Giese, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Gergana Galabova, Guenther Staffler, Gregor Karl Wenning, Nadia Stefanov. Targeting \\xce\\xb1-synuclein by PD03 AFFITOPE\\xc2\\xae and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance. Translational neurodegeneration vol 9 issue 1 2021 32972456 misfolded oligomeric \xce\xb1-synuclein plays a pivotal role in the pathogenesis of \xce\xb1-synucleinopathies including parkinson's disease and multiple system atrophy, and its detection parallels activation of microglia and a loss of neurons in the substantia nigra pars compacta. 2021-09-30 2022-01-13 Not clear
Dmitrii E Korzhevskii, Olga V Kirik, Valeriia V Guselnikova, Darya L Tsyba, Elena A Fedorova, Igor P Grigore. Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging. European journal of histochemistry : EJH vol 65 issue s1 2021 34468106 we did not detect the appearance of amoeboid microglia in human sn pars compacta with aging, but we found an age-related increase in microglial phagocytic activity. 2021-09-23 2022-01-14 Not clear
Qingchun Lei, Tingting Wu, Jin Wu, Xiaogang Hu, Yingxia Guan, Ying Wang, Jinyuan Yan, Guolin Sh. Roles of \\xce\\xb1\\xe2\\x80\\x91synuclein in gastrointestinal microbiome dysbiosis\\xe2\\x80\\x91related Parkinson's disease progression (Review). Molecular medicine reports vol 24 issue 4 2021 34414447 the abnormal levels of \xce\xb1\xe2\x80\x91syn aggregate in the substantia nigra pars compacta, not only leading to the formation of eosinophilic lewis bodies in the cytoplasm and mitochondrial dysfunction in dopaminergic (da) neurons, but also leading to the stimulation of an inflammatory response in the microglia. 2021-09-03 2022-01-13 Not clear
Anahita Shahraz, Jannis Wi\\xc3\\x9ffeld, Aur\\xc3\\xa9lien Ginolhac, Mona Mathews, Lasse Sinkkonen, Harald Neuman. Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides. Glia vol 69 issue 1 2021 32721081 repeated systemic challenge with lipopolysaccharides (lps) can induce microglia activation and inflammatory neurodegeneration in the substantia nigra pars compacta region of mice. 2021-07-28 2022-01-13 Not clear
Qiankun Lv, Zhen Zhong, Binbin Hu, Si Yan, Yufang Yan, Junjun Zhang, Ting Shi, Lijuan Jiang, Wen Li, Wei Huan. MicroRNA-3473b regulates the expression of TREM2/ULK1 and inhibits autophagy in inflammatory pathogenesis of Parkinson disease. Journal of neurochemistry vol 157 issue 3 2021 33448372 in vivo, mir-3473b antagomir can inhibit the activation of substantia nigra pars compacta (snpc) microglia of c57bl/6 mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) and promote autophagy. 2021-06-21 2022-01-14 Not clear
Mohammed E Choudhury, Yuka Kigami, Junya Tanak. Dual Roles of Microglia in the Basal Ganglia in Parkinson's Disease. International journal of molecular sciences vol 22 issue 8 2021 33918947 in pd, dopaminergic (daergic) neuronal degeneration in the substantia nigra pars compacta (snc) activates the microglia, which then promote daergic neuronal degeneration by releasing potentially neurotoxic factors, including nitric oxide, cytokines, and reactive oxygen species. 2021-05-25 2022-01-13 Not clear
Collin M Bantle, C Tenley French, Jason E Cummings, Shankar Sadasivan, Kevin Tran, Richard A Slayden, Richard J Smeyne, Ronald B Tjalken. Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus. PloS one vol 16 issue 1 2021 33493177 analyses of dopaminergic neurons, microglia and astrocytes in basal ganglia indicated that although there was no significant loss of dopaminergic neurons within the substantia nigra pars compacta, there was more pronounced activation of microglia and astrocytes in animals sequentially exposed to mn and h1n1, as well as altered patterns of histone acetylation. 2021-05-10 2022-01-13 Not clear
Guobin Song, Guoping Xi, Yanhua Li, Yijin Zhao, Caixia Qi, Lijuan Song, Baoguo Xiao, Cungen M. Double triggers, nasal induction of a Parkinson's disease mouse model. Neuroscience letters vol 724 issue 2021 32114119 after administration once every three days for 7 consecutive weeks, these mice displayed enhanced motor dysfunction, loss of dopaminergic neurons, \xce\xb1-synuclein accumulation, as well as activation of microglia and astrocytes in the substantia nigra pars compacta compared with mice that were administered mptp or lps alone. 2021-04-19 2022-01-13 Not clear
Wen-Wen Liu, Shi-Zhuang Wei, Guo-Dong Huang, Lu-Bing Liu, Chao Gu, Yun Shen, Xian-Hui Wang, Shu-Ting Xia, An-Mu Xie, Li-Fang Hu, Fen Wang, Chun-Feng Li. BMAL1 regulation of microglia-mediated neuroinflammation in MPTP-induced Parkinson's disease mouse model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 34 issue 5 2021 32246801 we here showed that inactivation of brain and muscle arnt-like 1 (bmal1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (mptp)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (dans) in the substantia nigra pars compacta (snpc), decrease of dopamine (da) transmitter, and increased activation of microglia and astrocytes in the striatum. 2021-01-22 2022-01-13 Not clear
Daisuke Taguchi, Ayuka Ehara, Taro Kadowaki, Shin-Ichi Sakakibara, Kazuhiko Nakadate, Koichi Hirata, Shuichi Ued. Minocycline Alleviates Cluster Formation of Activated Microglia and Age-dependent Dopaminergic Cell Death in the Substantia Nigra of Zitter Mutant Rat. Acta histochemica et cytochemica vol 53 issue 6 2021 33437100 here, we examine whether activated microglia participate in age-related dopaminergic (da) cell death in the substantia nigra pars compacta (snc) of the zitter ( 2021-01-14 2022-01-13 Not clear
Francesca Siani, Rosaria Greco, Giovanna Levandis, Cristina Ghezzi, Francesca Daviddi, Chiara Demartini, Elisabetta Vegeto, Marie-Th\\xc3\\xa9r\\xc3\\xa8se Fuzzati-Armentero, Fabio Blandin. Influence of Estrogen Modulation on Glia Activation in a Murine Model of Parkinson's Disease. Frontiers in neuroscience vol 11 issue 2020 28620274 animals were sacrificed at different time points following 6-ohda injection and brain sections containing striatum and substantia nigra pars compacta (snc) underwent immunohistochemistry for tyrosine hydroxylase (th) (dopaminergic marker), immunofluorescence for iba1 and gfap (markers of microglia and astrocyte activation, respectively) and triple immunoflorescent to identify polarization of microglia toward the cytotoxic m1 (dapi/iba1/tnf\xce\xb1) or cytoprotective m2 (dapi/iba1/cd206) phenotype. 2020-10-01 2022-01-13 Not clear
Jong Hee Choi, Minhee Jang, Joon-Il Lee, Won-Seok Chung, Ik-Hyun Ch. Neuroprotective Effects of a Traditional Multi-Herbal Medicine Kyung-Ok-Ko in an Animal Model of Parkinson's Disease: Inhibition of MAPKs and NF-\\xce\\xbaB Pathways and Activation of Keap1-Nrf2 Pathway. Frontiers in pharmacology vol 9 issue 2020 30618742 these positive effects of kok were related to inhibition of loss of tyrosine hydroxylase-positive neurons, reduction of mitosox activity, increased apoptotic cells, microglia activation, and upregulation of inflammatory factors [interleukin (il)-1\xce\xb2, il-6, cyclooxygenase-2, and inducible nitric oxide], and reduced blood-brain barrier (bbb) disruption in the substantia nigra pars compacta (snpc) and/or striatum after mptp intoxication. 2020-10-01 2022-01-13 Not clear
Collin M Bantle, Aaron T Phillips, Richard J Smeyne, Savannah M Rocha, Ken E Olson, Ronald B Tjalken. Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation. NPJ Parkinson's disease vol 5 issue 2020 31531390 infection caused activation of microglia and astrocytes, selective loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) and neurobehavioral abnormalities. 2020-09-30 2022-01-13 Not clear
Yuan Guan, Xiaofang Zhao, Fengwei Liu, Shuxin Yan, Yalong Wang, Cuilian Du, Xiuyu Cui, Rena Li, Claire Xi Zhan. Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of \\xce\\xb1-Synuclein. Frontiers in cellular neuroscience vol 14 issue 2020 32595456 we investigated the effects of eight known pathogenic mutations in human \xce\xb1-syn (a18t, a29s, a30p, e46k, h50q, g51d, a53e, and a53t) on its pathological transmission in terms of secretion, aggregation, intracellular level, cytotoxicity, seeding, and induction of neuroinflammation in sh-sy5y neuroblastoma cells, cultured rat neurons, and microglia, and the rat substantia nigra pars compacta. 2020-09-28 2022-01-13 Not clear
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