| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Guan, Xiaofang Zhao, Fengwei Liu, Shuxin Yan, Yalong Wang, Cuilian Du, Xiuyu Cui, Rena Li, Claire Xi Zhan. Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32595456. |
we investigated the effects of eight known pathogenic mutations in human α-syn (a18t, a29s, a30p, e46k, h50q, g51d, a53e, and a53t) on its pathological transmission in terms of secretion, aggregation, intracellular level, cytotoxicity, seeding, and induction of neuroinflammation in sh-sy5y neuroblastoma cells, cultured rat neurons, and microglia, and the rat substantia nigra pars compacta. |
2020-09-28 |
2023-08-13 |
human |
| Amanda L Blaker, Eric A Rodriguez, Bryan K Yamamot. Neurotoxicity to dopamine neurons after the serial exposure to alcohol and methamphetamine: Protection by COX-2 antagonism. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31228610. |
etoh drinking followed by meth increased microglial cell counts and produced morphological changes in microglia of the substantia nigra pars compacta 2 h after meth administration that were distinct from those produced by either etoh or meth alone. |
2020-08-14 |
2023-08-13 |
rat |
| Francesca L'Episcopo, Cataldo Tirolo, Luca Peruzzotti-Jametti, Maria F Serapide, Nunzio Testa, Salvatore Caniglia, Beatrice Balzarotti, Stefano Pluchino, Bianca Marchett. Neural Stem Cell Grafts Promote Astroglia-Driven Neurorestoration in the Aged Parkinsonian Brain via Wnt/β-Catenin Signaling. Stem cells (Dayton, Ohio). vol 36. issue 8. 2019-08-13. PMID:29575325. |
during aging-one the most potent risk factors for parkinson's disease (pd)-both astrocytes and microglia undergo functional changes that ultimately hamper homoeostasis, defense, and repair of substantia nigra pars compacta (snpc) midbrain dopaminergic (mda) neurons. |
2019-08-13 |
2023-08-13 |
mouse |
| Bingqing Cao, Tao Wang, Qiumin Qu, Tao Kang, Qian Yan. Long Noncoding RNA SNHG1 Promotes Neuroinflammation in Parkinson's Disease via Regulating miR-7/NLRP3 Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30031125. |
downregulation of snhg1 elevated mir-7 expression, suppressed the activation of microglia and nlrp3 inflammasome as well as dopaminergic neuron loss in the midbrain substantia nigra pars compacta in mptp-treated mice. |
2019-03-29 |
2023-08-13 |
mouse |
| Marco Aurélio Mori, Ana Marcia Delattre, Bruno Carabelli, Claudia Pudell, Mariza Bortolanza, Pedro Vinícius Staziaki, Jesuí Vergilio Visentainer, Paula Fernandes Montanher, Elaine A Del Bel, Anete Curte Ferra. Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson's disease is mediated by a reduction of inducible nitric oxide synthase. Nutritional neuroscience. vol 21. issue 5. 2018-10-29. PMID:28221817. |
the present study investigated the effects of fish oil supplementation that was rich in pufas on dopaminergic neuron loss, the density of inducible nitric oxide synthase (inos)-immunoreactive cells, and microglia and astrocyte reactivity in the substantia nigra pars compacta (snpc) and striatal dopaminergic fibers. |
2018-10-29 |
2023-08-13 |
Not clear |
| Rui-Jun Su, Jun-Li Zhen, Wei Wang, Jian-Liang Zhang, Yan Zheng, Xiao-Min Wan. Time-course behavioral features are correlated with Parkinson's disease‑associated pathology in a 6-hydroxydopamine hemiparkinsonian rat model. Molecular medicine reports. vol 17. issue 2. 2018-08-03. PMID:29257290. |
th‑positive neurons and fibers in the substantia nigra pars compacta (snpc) and striatum, respectively, and glial activation in the snpc, determined by glial fibrillary acidic protein (gfap) expression for astrocytes and cd11b (mac1) expression for microglia, were detected by immunohistological staining. |
2018-08-03 |
2023-08-13 |
rat |
| Giulia Ambrosi, Natasa Kustrimovic, Francesca Siani, Emanuela Rasini, Silvia Cerri, Cristina Ghezzi, Giuseppe Dicorato, Sofia Caputo, Franca Marino, Marco Cosentino, Fabio Blandin. Complex Changes in the Innate and Adaptive Immunity Accompany Progressive Degeneration of the Nigrostriatal Pathway Induced by Intrastriatal Injection of 6-Hydroxydopamine in the Rat. Neurotoxicity research. vol 32. issue 1. 2018-03-27. PMID:28285346. |
a time-course analysis was conducted to assess changes in morphology (activation) and cell density of microglia and astrocytes, microglia polarization (m1 vs. m2 phenotype), lymphocyte infiltration in the lesioned substantia nigra pars compacta (snc), and modifications of cd8+ and subsets of cd4+ t cell in peripheral blood accompanying nigrostriatal degeneration. |
2018-03-27 |
2023-08-13 |
rat |
| Lucia Frau, Nicola Simola, Pier Francesca Porceddu, Micaela Morell. Effect of crowding, temperature and age on glia activation and dopaminergic neurotoxicity induced by MDMA in the mouse brain. Neurotoxicology. vol 56. 2017-11-20. PMID:27451954. |
after the last mdma administration, immunohistochemistry was performed in the caudate-putamen for cd11b and gfap, to mark microglia and astroglia, and in the substantia nigra pars compacta for tyrosine hydroxylase, to mark dopaminergic neurons. |
2017-11-20 |
2023-08-13 |
mouse |
| Nabil El Massri, Cécile Moro, Napoleon Torres, Fannie Darlot, Diane Agay, Claude Chabrol, Daniel M Johnstone, Jonathan Stone, Alim-Louis Benabid, John Mitrofani. Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys. Experimental brain research. vol 234. issue 11. 2017-08-30. PMID:27377070. |
sections of midbrain (containing the substantia nigra pars compacta; snc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; gfap) and ionised calcium-binding adaptor molecule 1 (to label microglia; iba1) immunohistochemistry. |
2017-08-30 |
2023-08-13 |
monkey |
| Tian-Ya Liu, Xiao-Ying Yang, Long-Tai Zheng, Guang-Hui Wang, Xue-Chu Zhe. Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death. Journal of neurochemistry. vol 140. issue 4. 2017-07-13. PMID:27889907. |
lastly, cytosporone b attenuated microglia activation and loss of dopaminergic neuron in the substantia nigra pars compacta (snpc) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-pd mouse model. |
2017-07-13 |
2023-08-13 |
mouse |
| Richard Jay Smeyne, Charles B Breckenridge, Melissa Beck, Yun Jiao, Mark T Butt, Jeffrey C Wolf, Dan Zadory, Daniel J Minnema, Nicholas C Sturgess, Kim Z Travis, Andrew R Cook, Lewis L Smith, Philip A Botha. Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice. PloS one. vol 11. issue 10. 2017-06-12. PMID:27788145. |
assessment of the effects of mptp and paraquat on dopaminergic neurons and microglia in the substantia nigra pars compacta of c57bl/6 mice. |
2017-06-12 |
2023-08-13 |
mouse |
| Richard Jay Smeyne, Charles B Breckenridge, Melissa Beck, Yun Jiao, Mark T Butt, Jeffrey C Wolf, Dan Zadory, Daniel J Minnema, Nicholas C Sturgess, Kim Z Travis, Andrew R Cook, Lewis L Smith, Philip A Botha. Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice. PloS one. vol 11. issue 10. 2017-06-12. PMID:27788145. |
dopamine neurons in the substantia nigra pars compacta (snpc) were identified by antibodies to tyrosine hydroxylase (th+) and microglia were identified using iba-1 immunoreactivity. |
2017-06-12 |
2023-08-13 |
mouse |
| Xiaojin Shi, Yu-Hua Chen, Hao Liu, Hong-Dang Q. Therapeutic effects of paeonol on methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson's disease in mice. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27484986. |
additionally, the levels of tyrosine hydroxylase (th), microglia, interleukin‑1β (il‑1β), and brain‑derived neurotrophic factor (bdnf) in the substantia nigra pars compacta (snpc) were evaluated by immunohistochemical staining. |
2017-04-06 |
2023-08-13 |
mouse |
| Yanwei Li, WeiZhen Liu, Lin Li, Christian Hölsche. Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model. Neuropharmacology. vol 101. 2016-10-05. PMID:26453962. |
d-ala2-gip-glu-pal also reduced the chronic inflammation response as seen in astrocyte and microglia activation in the substantia nigra pars compacta (snpc). |
2016-10-05 |
2023-08-13 |
mouse |
| Hayate Javed, Sheikh Azimullah, M Emdadul Haque, Shreesh K Ojh. Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease. Frontiers in neuroscience. vol 10. 2016-08-17. PMID:27531971. |
rot injections induced a significant loss of dopaminergic (da) neurons in the substantia nigra pars compacta (snpc) and da striatal fibers, following activation of glial cells (astrocytes and microglia). |
2016-08-17 |
2023-08-13 |
rat |
| H J Jyothi, D J Vidyadhara, Anita Mahadevan, Mariamma Philip, Suresh Kumar Parmar, S Gowri Manohari, S K Shankar, Trichur R Raju, Phalguni Anand Allad. Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26433682. |
aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta. |
2016-08-15 |
2023-08-13 |
human |
| Daniela Punzo, Francesco Errico, Luigia Cristino, Silvia Sacchi, Simona Keller, Carmela Belardo, Livio Luongo, Tommaso Nuzzo, Roberta Imperatore, Ermanno Florio, Vito De Novellis, Ornella Affinito, Sara Migliarini, Giacomo Maddaloni, Maria Josè Sisalli, Massimo Pasqualetti, Loredano Pollegioni, Sabatino Maione, Lorenzo Chiariotti, Alessandro Usiell. Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 10. 2016-07-19. PMID:26961959. |
in line with detrimental effects produced by nmdar overstimulation, persistent elevation of d-aspartate levels in ddo(-/-) brains is associated with appearance of dystrophic microglia, precocious caspase-3 activation, and cell death in cortical pyramidal neurons and dopaminergic neurons of the substantia nigra pars compacta. |
2016-07-19 |
2023-08-13 |
mouse |
| Shreesh Ojha, Hayate Javed, Sheikh Azimullah, Salema B Abul Khair, M Emdadul Haqu. Neuroprotective potential of ferulic acid in the rotenone model of Parkinson's disease. Drug design, development and therapy. vol 9. 2016-07-06. PMID:26504373. |
the immunofluorescence analysis revealed a significant increase in the number of activated microglia and astrocytes accompanied by a significant loss of dopamine (da) neurons in the substantia nigra pars compacta area upon rot injection. |
2016-07-06 |
2023-08-13 |
rat |
| Sarah C Hopp, Sarah E Royer, Heather M D'Angelo, Roxanne M Kaercher, David A Fisher, Gary L Wen. Differential neuroprotective and anti-inflammatory effects of L-type voltage dependent calcium channel and ryanodine receptor antagonists in the substantia nigra and locus coeruleus. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 1. 2015-11-12. PMID:25318607. |
corresponding with these behavioral deficits, lps-infused rats also had significant increases in microglia activation and loss of tyrosine hydroxylase (th) immunoreactivity in the substantia nigra pars compacta (snpc) and locus coeruleus (lc). |
2015-11-12 |
2023-08-13 |
rat |
| D M Johnstone, N el Massri, C Moro, S Spana, X S Wang, N Torres, C Chabrol, X De Jaeger, F Reinhart, S Purushothuman, A-L Benabid, J Stone, J Mitrofani. Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience. vol 274. 2015-10-07. PMID:24857852. |
astrocyte and microglia cell numbers in substantia nigra pars compacta were not influenced by either mode of nir treatment. |
2015-10-07 |
2023-08-13 |
mouse |