| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Liu, Xiaoning Zeng, Yujian Hui, Chenlei Zhu, Jie Wu, Devin H Taylor, Juan Ji, Weimin Fan, Zuhu Huang, Jun H. Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: implications for Parkinson's disease. Neuropharmacology. vol 91. 2015-09-28. PMID:25486621. |
systemic administration of nicotine dramatically alleviated mptp-induced symptoms, protected dopaminergic neurons against degeneration, inhibited astrocytes and microglia activation in the substantia nigra pars compacta (snpc) and blocked the decrease of gdnf in the striatum by activating α7-nachrs. |
2015-09-28 |
2023-08-13 |
Not clear |
| Yuguang Tian, Ying Zhang, Ruoyu Zhang, Song Qiao, Jing Fa. Resolvin D2 recovers neural injury by suppressing inflammatory mediators expression in lipopolysaccharide-induced Parkinson's disease rat model. Biochemical and biophysical research communications. vol 460. issue 3. 2015-08-21. PMID:25824039. |
here we investigated the effects of intrathecal injection of rvd2 for substantia nigra pars compacta (snpc) in vivo and primary microglia in vitro experiment on pro-inflammatory cytokine expression and nf-κb activation in lipopolysaccharide (lps)-induced pd rat model. |
2015-08-21 |
2023-08-13 |
rat |
| Isabelle Bardou, Roxanne M Kaercher, Holly M Brothers, Sarah C Hopp, Sarah Royer, Gary L Wen. Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem. Neurobiology of aging. vol 35. issue 5. 2014-10-06. PMID:24315728. |
age and the duration of a pro-inflammatory environment induced by continuous intraventricular lipopolysaccharide (lps) differentially affect the expression profile of pro- and anti-inflammatory genes and proteins as well as the number of activated microglia (express major histocompatibility complex ii; mhc ii) and the integrity and density of ascending catecholaminergic neural systems originating from the locus coeruleus (lc) and substantia nigra pars compacta (snpc) in rats. |
2014-10-06 |
2023-08-12 |
rat |
| Marcio Lazzarini, Sabine Martin, Mišo Mitkovski, Rita Raisman Vozari, Walter Stühmer, Elaine Del Be. Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model. Glia. vol 61. issue 7. 2014-02-10. PMID:23595698. |
this protective effect was associated with: (1) a reduction of microglia in normal mice as a result of doxycycline administration per se; (2) a decrease in the astrocyte and microglia response to the neurotoxin 6-ohda in the globus pallidus and substantia nigra compacta, and (3) the astrocyte reaction in the striatum. |
2014-02-10 |
2023-08-12 |
mouse |
| Carlos Barcia, Carmen María Ros, Francisco Ros-Bernal, Aurora Gómez, Valentina Annese, María Angeles Carrillo-de Sauvage, José Enrique Yuste, Carmen María Campuzano, Vicente de Pablos, Emiliano Fernández-Villalba, María Trinidad Herrer. Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques. Journal of neuroimmunology. vol 261. issue 1-2. 2013-10-17. PMID:23759319. |
in this study, we report the microanatomical details of microglia and the relationship between microglia and neurons in the substantia nigra pars compacta of parkinsonian monkeys years after insult with mptp. |
2013-10-17 |
2023-08-12 |
monkey |
| Mibel M Pabon, Jennifer N Jernberg, Josh Morganti, Jessika Contreras, Charles E Hudson, Ronald L Klein, Paula C Bickfor. A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease. PloS one. vol 7. issue 9. 2013-02-28. PMID:23028885. |
an increase in microglia activation has been shown in the substantia nigra pars compacta (snpc) of pd models when there has been a decrease in tyrosine hydroxylase (th) positive cells. |
2013-02-28 |
2023-08-12 |
rat |
| C Barcia, C M Ros, V Annese, A Gómez, F Ros-Bernal, D Aguado-Llera, M E Martínez-Pagán, V de Pablos, E Fernandez-Villalba, M T Herrer. IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease. Cell death & disease. vol 3. 2012-11-08. PMID:22914327. |
it was found that ifn-γ and tnf-α remained higher over the years in the serum and cns of chronic parkinsonian macaques than in untreated animals, accompanied by sustained glial activation (microglia and astroglia) in the substantia nigra pars compacta. |
2012-11-08 |
2023-08-12 |
mouse |
| A R Carta, L Frau, A Pisanu, J Wardas, S Spiga, E Carbon. Rosiglitazone decreases peroxisome proliferator receptor-γ levels in microglia and inhibits TNF-α production: new evidences on neuroprotection in a progressive Parkinson's disease model. Neuroscience. vol 194. 2012-06-25. PMID:21839812. |
changes in ppar-γ levels were measured by immunofluorescence and confocal microscopy in tyrosine hydroxylase (th)-positive neurons and cd11b-positive microglia of the substantia nigra pars compacta (snc). |
2012-06-25 |
2023-08-12 |
mouse |
| Haeman Jang, David Boltz, Jennifer McClaren, Amar K Pani, Michelle Smeyne, Ane Korff, Robert Webster, Richard Jay Smeyn. Inflammatory effects of highly pathogenic H5N1 influenza virus infection in the CNS of mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 5. 2012-03-22. PMID:22302798. |
here, we examined the effects of h5n1 on several pathological aspects affected in parkinsonism, including loss of the phenotype of dopaminergic neurons located in the substantia nigra pars compacta (snpc), expression of monoamines and indolamines in brain, alterations in snpc microglia number and morphology, and expression of cytokines, chemokines, and growth factors. |
2012-03-22 |
2023-08-12 |
mouse |
| Tatyana Verina, Samara F Kiihl, Jay S Schneider, Tomás R Guilart. Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates. Neurotoxicology. vol 32. issue 2. 2012-01-25. PMID:21112353. |
in the present study, we investigated whether chronic mn exposure induces microglia activation in the substantia nigra pars compacta (snc) and snr in cynomolgus macaques. |
2012-01-25 |
2023-08-12 |
Not clear |
| C Barcia, C M Ros, V Annese, A Gómez, F Ros-Bernal, D Aguado-Yera, M E Martínez-Pagán, V de Pablos, E Fernandez-Villalba, M T Herrer. IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease. Cell death & disease. vol 2. 2011-08-05. PMID:21472005. |
it was found that ifn-γ and tnf-α remained higher over the years in the serum and cns of chronic parkinsonian macaques than in untreated animals, accompanied by sustained glial activation (microglia and astroglia) in the substantia nigra pars compacta. |
2011-08-05 |
2023-08-12 |
mouse |
| Emily N Mangano, Shawn Hayle. Inflammatory priming of the substantia nigra influences the impact of later paraquat exposure: Neuroimmune sensitization of neurodegeneration. Neurobiology of aging. vol 30. issue 9. 2009-10-09. PMID:18187236. |
activation of microglia along with the release of inflammatory cytokines and oxidative factors often accompanies toxin-induced degeneration of substantia nigra pars compacta (snc) dopamine (da) neurons. |
2009-10-09 |
2023-08-12 |
Not clear |
| Yi Sui, Davor Stanić, Doris Tomas, Bevyn Jarrott, Malcolm K Horn. Meloxicam reduces lipopolysaccharide-induced degeneration of dopaminergic neurons in the rat substantia nigra pars compacta. Neuroscience letters. vol 460. issue 2. 2009-09-02. PMID:19450656. |
using the intranigral lipopolysaccharide (lps) rat model, we show that meloxicam, a preferential cox-2 inhibitor, diminishes the activation of ox-42-immunoreactive (ir) microglia and reduces the loss of tyrosine hydroxylase (th)-ir dopamine (da) neurons in the substantia nigra pars compacta (snpc) that is normally induced by exposure to lps. |
2009-09-02 |
2023-08-12 |
rat |
| Seonghan Kim, Seo-Hyun Cho, Ka Young Kim, Ki Young Shin, Hye-Sun Kim, Cheol-Hyoung Park, Keun-A Chang, Sang Hyung Lee, Daeho Cho, Yoo-Hun Su. Alpha-synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP. Journal of neurochemistry. vol 109. issue 5. 2009-06-15. PMID:19457162. |
although there is known to be a marked concentration of reactive microglia in the substantia nigra pars compacta (snpc) of patients with parkinson's disease (pd), a disorder in which alpha-synuclein plays a key pathogenic role, the specific roles of alpha-synuclein and microglia remains poorly understood. |
2009-06-15 |
2023-08-12 |
mouse |
| Shaji Theodore, Shuwen Cao, Pamela J McLean, David G Standaer. Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease. Journal of neuropathology and experimental neurology. vol 67. issue 12. 2009-01-12. PMID:19018246. |
four weeks after injection, there was a marked increase in cd68-positive microglia and greater infiltration of b and t lymphocytes in the substantia nigra pars compacta of the aav2-syn group than in controls. |
2009-01-12 |
2023-08-12 |
mouse |
| Thomas G Beach, Lucia I Sue, Douglas G Walker, Lih Fen Lue, Donald J Connor, John N Caviness, Marwan N Sabbagh, Charles H Adle. Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits. Acta neuropathologica. vol 114. issue 4. 2007-12-26. PMID:17639428. |
sections of substantia nigra from elderly subjects (n = 15; mean 81.3; sd 7.0) and younger subjects (n = 7; mean 30.3; sd = 8.7), all of which had no specific neurologically or neuropathologically defined disorders, were stained immunohistochemically for mhc class ii and the area occupied by microglia was quantified in substantia nigra pars compacta. |
2007-12-26 |
2023-08-12 |
human |
| Kyung-Ae Ji, Myung-Soon Yang, Hey-Kyeong Jeong, Kyoung-Jin Min, Seung-Hee Kang, Ilo Jou, Eun-Hye Jo. Resident microglia die and infiltrated neutrophils and monocytes become major inflammatory cells in lipopolysaccharide-injected brain. Glia. vol 55. issue 15. 2007-11-20. PMID:17823975. |
to understand contribution of microglia and blood inflammatory cells to brain inflammation, the behavior of microglia, neutrophils, and monocytes was investigated in lps (lipopolysaccharide)-injected substantia nigra pars compacta, cortex, and hippocampus of normal and/or leukopenic rats using specific markers of neutrophils (myeloperoxidase, mpo), and microglia and monocytes (ionized calcium binding adaptor molecule-1, iba-1), as well as a general marker for these inflammatory cells (cd11b). |
2007-11-20 |
2023-08-12 |
rat |
| Y Yasuda, R Shinagawa, M Yamada, T Mori, N Tateishi, S Fujit. Long-lasting reactive changes observed in microglia in the striatal and substantia nigral of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain research. vol 1138. 2007-05-21. PMID:17275793. |
after 6 months, the microglia in the striatum and substantia nigra pars compacta of the treated c57bl/6 mice were still more hypertrophic compared with the control, although less hypertrophic than those observed at day two. |
2007-05-21 |
2023-08-12 |
mouse |
| Wanida Tripanichkul, Kittisak Sripanichkulchai, David I Finkelstei. Estrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication. Brain research. vol 1084. issue 1. 2006-08-10. PMID:16564034. |
immunohistochemistry and quantitative study were used to assess the number of tyrosine hydroxylase-immunoreactive (th-ir) neurons in the substantia nigra pars compacta (snpc) and that of activated astrocytes and activated microglia in the snpc and the striatum. |
2006-08-10 |
2023-08-12 |
mouse |
| Yuri Ishida, Atsushi Nagai, Shotai Kobayashi, Seung U Ki. Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase. Journal of neuropathology and experimental neurology. vol 65. issue 1. 2006-03-14. PMID:16410750. |
in the present study, we investigated the expression of protease-activated receptors (pars), receptors for thrombin, in substantia nigra pars compacta (snpc) of parkinson disease (pd) brains and cultures of human neurons, astrocytes, oligodendrocytes, and microglia as determined by immunocytochemistry and reverse transcriptase-polymerase chain reaction (rt-pcr). |
2006-03-14 |
2023-08-12 |
human |