| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Mandel, Gila Maor, Moussa B H Youdi. Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate. Journal of molecular neuroscience : MN. vol 24. issue 3. 2005-05-11. PMID:15655262. |
one of the prominent pathological features of parkinson's disease (pd) is the abnormal accumulation of iron in the substantia nigra pars compacta (snpc), in the reactive microglia, and in association with neuromelanin, within the melanin-containing dopamine (da) neurons. |
2005-05-11 |
2023-08-12 |
mouse |
| Xian-Yu Liu, Hui-Fang Zhou, Yan-Li Pan, Xi-Bin Liang, Dong-Bin Niu, Bing Xue, Feng-Qiao Li, Qi-Hua He, Xin-Hong Wang, Xiao-Min Wan. Electro-acupuncture stimulation protects dopaminergic neurons from inflammation-mediated damage in medial forebrain bundle-transected rats. Experimental neurology. vol 189. issue 1. 2004-10-27. PMID:15296849. |
complement receptor 3 (cr3) immunohistochemical staining revealed that 24 sessions of 100 hz ea stimulation (28 days after mfb transection) significantly inhibited the activation of microglia in the substantia nigra pars compacta (snpc) induced by mfb transection. |
2004-10-27 |
2023-08-12 |
rat |
| Carlos Barcia, Angel Sánchez Bahillo, Emiliano Fernández-Villalba, Víctor Bautista, Máximo Poza Y Poza, Andrés Fernández-Barreiro, Etienne C Hirsch, María-Trinidad Herrer. Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure. Glia. vol 46. issue 4. 2004-07-14. PMID:15095370. |
evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after mptp exposure. |
2004-07-14 |
2023-08-12 |
monkey |
| Thomas Dehmer, Michael T Heneka, Magdalena Sastre, Johannes Dichgans, Jörg B Schul. Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. Journal of neurochemistry. vol 88. issue 2. 2004-02-17. PMID:14690537. |
in mice treated with pioglitazone, there were a reduced activation of microglia, reduced induction of inos-positive cells and less glial fibrillary acidic protein positive cells in both striatum and substantia nigra pars compacta. |
2004-02-17 |
2023-08-12 |
mouse |
| Carlos Barcia, Andrés Fernández Barreiro, Máximo Poza, María-Trinidad Herrer. Parkinson's disease and inflammatory changes. Neurotoxicity research. vol 5. issue 6. 2004-02-02. PMID:14715444. |
in 1988 mcgeer and colleagues (neurology 38, 1285-91) observed an activation of the microglia in substantia nigra pars compacta (snpc) and striatum of brains from patients with parkinson's disease. |
2004-02-02 |
2023-08-12 |
mouse |
| S Sugama, B P Cho, L A Degiorgio, Y Shimizu, S S Kim, Y S Kim, D H Shin, B T Volpe, D J Reis, S Cho, T H Jo. Temporal and sequential analysis of microglia in the substantia nigra following medial forebrain bundle axotomy in rat. Neuroscience. vol 116. issue 4. 2003-04-30. PMID:12617934. |
phagocytic microglia apposed dying dopaminergic neurons in the pars compacta starting at 3 days postlesion; their number increased through 14 days and slowly decreased. |
2003-04-30 |
2023-08-12 |
rat |
| D Berg, M Gerlach, M B Youdim, K L Double, L Zecca, P Riederer, G Becke. Brain iron pathways and their relevance to Parkinson's disease. Journal of neurochemistry. vol 79. issue 2. 2001-12-04. PMID:11677250. |
a central role of iron in the pathogenesis of parkinson's disease (pd), due to its increase in substantia nigra pars compacta dopaminergic neurons and reactive microglia and its capacity to enhance production of toxic reactive oxygen radicals, has been discussed for many years. |
2001-12-04 |
2023-08-12 |
Not clear |
| T Dehmer, J Lindenau, S Haid, J Dichgans, J B Schul. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. Journal of neurochemistry. vol 74. issue 5. 2000-05-25. PMID:10800968. |
in the present study we show that mptp treatment led to activation of microglia in the substantia nigra pars compacta (snpc), which was associated and colocalized with an increase in inducible nitric oxide synthase (inos) expression. |
2000-05-25 |
2023-08-12 |
mouse |