All Relations between microglial cell and cannabinoids

Reference Sentence Publish Date Extraction Date Species
Linjuan Feng, Hsuan Lo, Hanlin You, Wei Wu, Xiaojuan Cheng, Jiawei Xin, Zucheng Ye, Xiaochun Chen, Xiaodong Pa. Loss of cannabinoid receptor 2 promotes \\xce\\xb1-Synuclein-induced microglial synaptic pruning in nucleus accumbens by modulating the pCREB-c-Fos signaling pathway and complement system. Experimental neurology vol issue 2022 36162511 available literature documents that in microglia, the activation of cannabinoid receptor 2 (cb2r) decreases inflammation, but it remains obscured regarding the roles of cb2r in microglia-mediated synaptic pruning in the nac during the neuropathological progression of \xce\xb1-synucleinopathy. 2022-09-26 2022-09-29 Not clear
Alexander P Young, Eileen M Denovan-Wrigh. The microglial endocannabinoid system is similarly regulated by lipopolysaccharide and interferon gamma. Journal of neuroimmunology vol 372 issue 2022 36150252 microglia are one of few cell types with a self-contained endocannabinoid system and are positioned at the interface between the immune system and the central nervous system. 2022-09-23 2022-09-29 Not clear
Alexander P Young, Eileen M Denovan-Wrigh. The microglial endocannabinoid system is similarly regulated by lipopolysaccharide and interferon gamma. Journal of neuroimmunology vol 372 issue 2022 36150252 thus, we systematically investigated the relationship between the concentration of two distinct pro-inflammatory stimuli, lipopolysaccharide and interferon gamma, on the abundance of components of the endocannabinoid system within microglia. 2022-09-23 2022-09-29 Not clear
Alexander P Young, Eileen M Denovan-Wrigh. The microglial endocannabinoid system is similarly regulated by lipopolysaccharide and interferon gamma. Journal of neuroimmunology vol 372 issue 2022 36150252 furthermore, we demonstrate that the efficacy of different synthetic cannabinoid treatments with respect to inhibition of microglia nitric oxide release is dependent on the concentration and type of pro-inflammatory stimuli presented to the microglia. 2022-09-23 2022-09-29 Not clear
Alberto Llorente-Ovejero, Iker Bengoetxea de Tena, Jonatan Mart\\xc3\\xadnez-Gardeazabal, Marta Moreno-Rodr\\xc3\\xadguez, Laura Lombardero, Iv\\xc3\\xa1n Manuel, Rafael Rodr\\xc3\\xadguez-Puerta. Cannabinoid Receptors and Glial Response Following a Basal Forebrain Cholinergic Lesion. ACS pharmacology & translational science vol 5 issue 9 2022 36110372 using autoradiographic studies, the density and functional coupling to g-proteins of endocannabinoid receptor subtypes were studied in tissue sections from different brain areas where microglia density increased, using cb 2022-09-16 2022-09-20 Not clear
Alexander P Young, Eileen M Denovan-Wrigh. Synthetic cannabinoids reduce the inflammatory activity of microglia and subsequently improve neuronal survival in vitro. Brain, behavior, and immunity vol issue 2022 35764268 microglia produce endocannabinoids and express both cannabinoid receptor subtypes suggesting that this system is a target to suppress neuroinflammation. 2022-06-28 2022-07-04 Not clear
Liu Yang, Zhen Li, Zujin Xu, Bin Zhang, Anpeng Liu, Feng Zheng, Jia Zha. Protective effects of cannabinoid type 2 receptor against microglia overactivation and neuronal pyroptosis in sepsis-associated encephalopathy. Neuroscience vol issue 2022 35460837 protective effects of cannabinoid type 2 receptor against microglia overactivation and neuronal pyroptosis in sepsis-associated encephalopathy. 2022-04-23 2022-04-25 Not clear
Sahar S Abd El-Rahman, Hany M Faye. Improved cognition impairment by activating cannabinoid receptor type 2: Modulating CREB/BDNF expression and impeding TLR-4/NF\\xce\\xbaBp65/M1 microglia signaling pathway in D-galactose-injected ovariectomized rats. PloS one vol 17 issue 3 2022 35349580 improved cognition impairment by activating cannabinoid receptor type 2: modulating creb/bdnf expression and impeding tlr-4/nf\xce\xbabp65/m1 microglia signaling pathway in d-galactose-injected ovariectomized rats. 2022-03-29 2022-04-14 Not clear
Alexander P Young, Eileen M Denovan-Wrigh. The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation. Frontiers in pharmacology vol 12 issue 2022 35185547 the dynamic role of microglia and the endocannabinoid system in neuroinflammation. 2022-02-21 2022-02-23 Not clear
Alexander P Young, Eileen M Denovan-Wrigh. The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation. Frontiers in pharmacology vol 12 issue 2022 35185547 the endocannabinoid system has been identified as a promising therapeutic target for chronic neuroinflammation as there is evidence that synthetic and endogenously produced cannabinoids temper the pro-inflammatory response of microglia and may encourage a switch to an anti-inflammatory phenotype. 2022-02-21 2022-02-23 Not clear
Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, Meghna Yammanur, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast. Experimental eye research vol issue 2022 35143834 raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast. 2022-02-10 2022-02-13 Not clear
Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, Meghna Yammanur, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast. Experimental eye research vol issue 2022 35143834 cannabinoid type-2 receptor (cb2) inverse agonists specifically target activated microglia, biasing them away from the harmful pro-inflammatory m1 state toward the helpful reparative m2 state. 2022-02-10 2022-02-13 Not clear
Valerie L Joers, Hannah Staley, Maclean Bassett, Brenda D Moore, Malu Gamez Tanse. The role of cannabinoid receptor 2 in microglial clearance of human tau. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 17 Suppl 3 issue 2022 35109165 cannabinoid type 2 receptors (cb2) are highly expressed in immune cells and upregulated in activated microglia under conditions of neurologic disease, such as ad. 2022-02-03 2022-02-06 Not clear
Feng Li, Guangjian Zhang, Jing Liang, Yu Ma, Jian Huang, Rui Wang, Hailiang Du, Ge Wang, Qiang Wan. Protection of Intestinal Barrier in Uremic Mice by Electroacupuncture via Regulating the Cannabinoid 1 Receptor of the Intestinal Glial Cells. Journal of biomedical nanotechnology vol 17 issue 11 2021 34906281 the goal of this study is to learn moreabout how electroacupuncture regulates gastrointestinal function, as well as to identify the importance of microglia in electroacupuncture regulation and the cannabinoid receptor signaling pathway in controlling the activity of intestinal glial cells. 2021-12-15 2022-01-13 Not clear
Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, John B Doty, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene Modulates Microglia and Rescues Visual Deficits and Pathology After Impact Traumatic Brain Injury. Frontiers in neuroscience vol 15 issue 2021 34776838 the upregulation of cannabinoid type-2 receptors (cb2) when microglia become activated allows cb2-binding drugs to selectively target microglia. 2021-11-17 2022-01-13 Not clear
Francesca Seghetti, Silvia Gobbi, Federica Belluti, Angela Rampa, Alessandra Bis. Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology. Current medicinal chemistry vol issue 2021 34781863 in this respect, the cannabinoid receptor subtype 2 represents a promising therapeutic target, being overexpressed in microglia cells and thus involved in neuroinflammation. 2021-11-16 2022-01-13 Not clear
Sahar S Alghamdi, Suni M Mustafa, Bob M Moore I. Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. Bioorganic & medicinal chemistry vol 33 issue 2021 33550084 interestingly, microglia locked into a chronic m1 pro-inflammatory phenotype significantly up-regulate the cannabinoid receptor 2 (cb2) expression. 2021-09-08 2022-01-13 Not clear
\\xc3\\x81lvaro Moreno-Garc\\xc3\\xada, Ana Bernal-Chico, Teresa Colomer, Alfredo Rodr\\xc3\\xadguez-Antig\\xc3\\xbcedad, Carlos Matute, Susana Mat. Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination. Biomolecules vol 10 issue 9 2021 32846891 gene expression analysis of astrocyte and microglia endocannabinoid signaling during autoimmune demyelination. 2021-09-07 2022-01-13 Not clear
\\xc3\\x81lvaro Moreno-Garc\\xc3\\xada, Ana Bernal-Chico, Teresa Colomer, Alfredo Rodr\\xc3\\xadguez-Antig\\xc3\\xbcedad, Carlos Matute, Susana Mat. Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination. Biomolecules vol 10 issue 9 2021 32846891 here we used a microfluidic rt-qpcr screen to assess changes in the expression of the main endocannabinoid signaling genes in astrocytes and microglia purified from female mice during the time-course of experimental autoimmune encephalomyelitis (eae). 2021-09-07 2022-01-13 Not clear
\\xc3\\x81lvaro Moreno-Garc\\xc3\\xada, Ana Bernal-Chico, Teresa Colomer, Alfredo Rodr\\xc3\\xadguez-Antig\\xc3\\xbcedad, Carlos Matute, Susana Mat. Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination. Biomolecules vol 10 issue 9 2021 32846891 our results demonstrate that astrocytes and microglia responses to autoimmune demyelination involve alterations in the expression of multiple endocannabinoid signaling-associated genes and suggest that this system may regulate the induction of neurotoxic and pro-inflammatory transcriptional programs in both cell types during ms. 2021-09-07 2022-01-13 Not clear
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