| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhan. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins & other lipid mediators. vol 100-101. 2014-01-24. PMID:23219970. |
cannabinoids have been consistently shown to suppress microglia activation and the release of cytotoxic factors including nitric oxide, superoxide and proinflammatory cytokines. |
2014-01-24 |
2023-08-12 |
Not clear |
| Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhan. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins & other lipid mediators. vol 100-101. 2014-01-24. PMID:23219970. |
taken together, these results indicate that both cannabinoid receptor agonists and antagonists might suppress microglia activation by cb1 and cb2 receptor independent mechanisms, and provide a new insight into the mechanisms of microglia inhibition by cannabinoids. |
2014-01-24 |
2023-08-12 |
Not clear |
| Karim Arafah, Dominique Croix, Jacopo Vizioli, Annie Desmons, Isabelle Fournier, Michel Salze. Involvement of nitric oxide through endocannabinoids release in microglia activation during the course of CNS regeneration in the medicinal leech. Glia. vol 61. issue 4. 2013-10-28. PMID:23355252. |
taken together, our results show that in the leech, after injury concurrent with atp production, purinergic receptor activation, no production, microglia recruitment, and accumulation to lesion site, a fine imbalance occurs in the endocannabinoid system. |
2013-10-28 |
2023-08-12 |
Not clear |
| D McHug. GPR18 in microglia: implications for the CNS and endocannabinoid system signalling. British journal of pharmacology. vol 167. issue 8. 2013-05-06. PMID:22563843. |
gpr18 in microglia: implications for the cns and endocannabinoid system signalling. |
2013-05-06 |
2023-08-12 |
Not clear |
| Katarzyna Starowicz, Barbara Przewlock. Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1607. 2013-04-08. PMID:23108547. |
the development of innovative pharmacological strategies has led to the identification of new promising pharmacological targets, including glutamate antagonists, microglia inhibitors and, interestingly, endogenous ligands of cannabinoids and the transient receptor potential vanilloid type 1 (trpv1). |
2013-04-08 |
2023-08-12 |
Not clear |
| Miriam Hernangómez, Leyre Mestre, Fernando G Correa, Frida Loría, Miriam Mecha, Paula M Iñigo, Fabian Docagne, Richard O Williams, José Borrell, Carmen Guaz. CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation. Glia. vol 60. issue 9. 2013-01-14. PMID:22653796. |
the endocannabinoid anandamide (aea) is released by macrophages and microglia on pathological neuroinflammatory conditions such as multiple sclerosis (ms). |
2013-01-14 |
2023-08-12 |
mouse |
| D Fernández-López, J Faustino, N Derugin, M Wendland, I Lizasoain, M A Moro, Z S Vexle. Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. Neuroscience. vol 207. 2012-11-27. PMID:22285309. |
cumulatively, our results show that the cannabinoid agonist win protects against neonatal focal stroke in part due to inhibitory effects on microglia. |
2012-11-27 |
2023-08-12 |
rat |
| Lidia Martín-Couce, Mar Martín-Fontecha, Oscar Palomares, Leyre Mestre, Arnau Cordomí, Miriam Hernangomez, Sara Palma, Leonardo Pardo, Carmen Guaza, María L López-Rodríguez, Silvia Ortega-Gutiérre. Chemical probes for the recognition of cannabinoid receptors in native systems. Angewandte Chemie (International ed. in English). vol 51. issue 28. 2012-10-23. PMID:22689411. |
receptors made visible: the described biotin-tagged small-molecule probes with excellent affinities for the cb(1) and cb(2) cannabinoid receptors (cb(1)r and cb(2)r) enable direct visualization of these receptors in native cellular systems, including neurons, microglia, and immune cells. |
2012-10-23 |
2023-08-12 |
Not clear |
| Mohamed Naguib, Jijun J Xu, Philippe Diaz, David L Brown, David Cogdell, Bihua Bie, Jianhua Hu, Suzanne Craig, Walter N Hittelma. Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system. Anesthesia and analgesia. vol 114. issue 5. 2012-07-17. PMID:22392969. |
cannabinoid type 2 (cb(2)) receptors are expressed in the microglia in neurodegenerative disease models. |
2012-07-17 |
2023-08-12 |
Not clear |
| Alexander Ternianov, José M Pérez-Ortiz, María E Solesio, María S García-Gutiérrez, Antonio Ortega-Álvaro, Francisco Navarrete, Carlos Leiva, María F Galindo, Jorge Manzanare. Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20980074. |
the results revealed that overexpression of cb2 cannabinoid receptors decreased the extent of motor impairment and dopaminergic neuronal loss, reduced the recruitment of astrocytes and microglia to the lesion, and decreased the level of various oxidative parameters. |
2012-04-19 |
2023-08-12 |
mouse |
| Shuxian Hu, Wen S Sheng, Robert Bryan Roc. Immunomodulatory properties of kappa opioids and synthetic cannabinoids in HIV-1 neuropathogenesis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 6. issue 4. 2012-02-29. PMID:21850403. |
based upon findings that synthetic cannabinoids inhibit hiv-1 expression in human microglia and suppress production of inflammatory mediators such as nitric oxide (no) in human astrocytes, as well as a substantial literature demonstrating neuroprotective properties of cannabinoids in other systems, synthetic cannabinoids have also emerged as potential therapeutic agents in hiv neuropathogenesis. |
2012-02-29 |
2023-08-12 |
human |
| Young C Chung, Eugene Bok, Sue H Huh, Ju-Young Park, Sung-Hwa Yoon, Sang R Kim, Yoon-Seong Kim, Sungho Maeng, Sung Hyun Park, Byung K Ji. Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 12. 2012-02-07. PMID:22079984. |
this neuroprotection by cannabinoids was accompanied by suppression of nadph oxidase reactive oxygen species production and reduced expression of proinflammatory cytokines from activated microglia. |
2012-02-07 |
2023-08-12 |
mouse |
| Young C Chung, Eugene Bok, Sue H Huh, Ju-Young Park, Sung-Hwa Yoon, Sang R Kim, Yoon-Seong Kim, Sungho Maeng, Sung Hyun Park, Byung K Ji. Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 12. 2012-02-07. PMID:22079984. |
interestingly, cannabinoids protected da neurons against 1-methyl-4-phenyl-pyridinium neurotoxicity in cocultures of mesencephalic neurons and microglia, but not in neuron-enriched mesencephalic cultures devoid of microglia. |
2012-02-07 |
2023-08-12 |
mouse |
| Emanuela Esposito, Irene Paterniti, Emanuela Mazzon, Tiziana Genovese, Rosanna Di Paola, Maria Galuppo, Salvatore Cuzzocre. Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury. Brain, behavior, and immunity. vol 25. issue 6. 2011-12-07. PMID:21354467. |
moreover, pea treatment significantly reduced the activation of microglia and astrocytes expressing cannabinoid cb(2) receptor after sci. |
2011-12-07 |
2023-08-12 |
mouse |
| Ana María Martín-Moreno, David Reigada, Belén G Ramírez, R Mechoulam, Nadia Innamorato, Antonio Cuadrado, María L de Ceballo. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease. Molecular pharmacology. vol 79. issue 6. 2011-08-01. PMID:21350020. |
in the present study, we compared the effects of cbd with those of other cannabinoids on microglial cell functions in vitro and on learning behavior and cytokine expression after aβ intraventricular administration to mice. |
2011-08-01 |
2023-08-12 |
mouse |
| Jan Mulder, Misha Zilberter, Susana J Pasquaré, Alán Alpár, Gunnar Schulte, Samira G Ferreira, Attila Köfalvi, Ana M Martín-Moreno, Erik Keimpema, Heikki Tanila, Masahiko Watanabe, Ken Mackie, Tibor Hortobágyi, Maria L de Ceballos, Tibor Harkan. Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21459826. |
hippocampal protein concentrations for the sn-1-diacylglycerol lipase α and β isoforms, synthesizing 2-arachidonoyl glycerol, significantly increased in definite alzheimer's (braak stage vi), with ectopic sn-1-diacylglycerol lipase β expression found in microglia accumulating near senile plaques and apposing cb(1) cannabinoid receptor-positive presynapses. |
2011-07-01 |
2023-08-12 |
mouse |
| Aurélie Tasiemski, Michel Salze. Leech immunity: from brain to peripheral responses. Advances in experimental medicine and biology. vol 708. 2011-05-19. PMID:21528694. |
in the medicinal leech, the neuroimmune response has been described in the context of septic trauma at the cellular and humoral levels through microglia, toll-like, cannabinoids and chemoattractant factors activation and modulation. |
2011-05-19 |
2023-08-12 |
Not clear |
| Nephi Stell. Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia. vol 58. issue 9. 2010-08-26. PMID:20468046. |
cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. |
2010-08-26 |
2023-08-12 |
Not clear |
| William R Marrs, Jacqueline L Blankman, Eric A Horne, Aurore Thomazeau, Yi Hsing Lin, Jonathan Coy, Agnes L Bodor, Giulio G Muccioli, Sherry Shu-Jung Hu, Grace Woodruff, Susan Fung, Mathieu Lafourcade, Jessica P Alexander, Jonathan Z Long, Weiwei Li, Cong Xu, Thomas Möller, Ken Mackie, Olivier J Manzoni, Benjamin F Cravatt, Nephi Stell. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nature neuroscience. vol 13. issue 8. 2010-08-20. PMID:20657592. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) regulates neurotransmission and neuroinflammation by activating cb1 cannabinoid receptors on neurons and cb2 cannabinoid receptors on microglia. |
2010-08-20 |
2023-08-12 |
mouse |
| John C Ashton, Michelle Glas. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Current neuropharmacology. vol 5. issue 2. 2010-06-10. PMID:18615177. |
we have found that cannabinoid cb2 receptors are up-regulated during the activation of microglia following brain injury. |
2010-06-10 |
2023-08-12 |
human |