All Relations between microglial cell and cannabinoids

Publication Sentence Publish Date Extraction Date Species
L Luongo, E Palazzo, S Tambaro, C Giordano, L Gatta, M A Scafuro, F Sca Rossi, P Lazzari, L Pani, V de Novellis, M Malcangio, S Maion. 1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice. Neurobiology of disease. vol 37. issue 1. 2010-02-22. PMID:19804829. here, we have investigated the effect of chronic treatment with a selective agonist of cannabinoid type 2 receptor (cb2), 1-(2',4'-dichlorophenyl)-6-methyl-n-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3 carboxamide (ness400), on pain thresholds in the spared nerve injury (sni) model in the mouse and on the distribution and activation of spinal microglia. 2010-02-22 2023-08-12 mouse
Ewa Kozela, Maciej Pietr, Ana Juknat, Neta Rimmerman, Rivka Levy, Zvi Voge. Cannabinoids Delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells. The Journal of biological chemistry. vol 285. issue 3. 2010-02-08. PMID:19910459. using the bv-2 mouse microglial cell line and lipopolysaccharide (lps) to induce an inflammatory response, we studied the signaling pathways engaged in the anti-inflammatory effects of cannabinoids as well as their influence on the expression of several genes known to be involved in inflammation. 2010-02-08 2023-08-12 mouse
Nicolas Froger, Juan A Orellana, Martine Cohen-Salmon, Pascal Ezan, Edwige Amigou, Juan C Sáez, Christian Giaum. Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments. Journal of neurochemistry. vol 111. issue 6. 2010-01-08. PMID:20050288. because cannabinoids (cbs) have anti-inflammatory properties and their receptors are expressed by glial cells, we investigated on primary cortical cultures the effects of cb agonists, methanandamide and synthetic cbs on (i) cytokines released from lps-activated microglia and (ii) connexin43 functions in astrocytes subjected to pro-inflammatory treatments. 2010-01-08 2023-08-12 Not clear
Javier Fernández-Rui. The endocannabinoid system as a target for the treatment of motor dysfunction. British journal of pharmacology. vol 156. issue 7. 2009-07-21. PMID:19220290. cb(1) agonists reduce excitotoxicity; cb(2) agonists limit the toxicity of reactive microglia; and antioxidant cannabinoids attenuate oxidative damage). 2009-07-21 2023-08-12 Not clear
Yannick Marchalant, Francesca Cerbai, Holly M Brothers, Gary L Wen. Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17561311. stimulation of endocannabinoid receptors can reduce the number of activated microglia, particularly in the hippocampus, of young rats infused chronically with lipopolysaccharide (lps). 2009-01-23 2023-08-12 rat
Yannick Marchalant, Francesca Cerbai, Holly M Brothers, Gary L Wen. Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17561311. in the current study we demonstrate that endocannabinoid receptor stimulation by administration of win-55212-2 (2mg/kg day) can reduce the number of activated microglia in hippocampus of aged rats and attenuate the spatial memory impairment in the water pool task. 2009-01-23 2023-08-12 rat
Yannick Marchalant, Francesca Cerbai, Holly M Brothers, Gary L Wen. Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17561311. our results suggest that the action of win-55212-2 does not depend upon a direct effect upon microglia or astrocytes but is dependent upon stimulation of neuronal cannabinoid receptors. 2009-01-23 2023-08-12 rat
Marylou V Solbrig, Neal Hermanowic. Cannabinoid rescue of striatal progenitor cells in chronic Borna disease viral encephalitis in rats. Journal of neurovirology. vol 14. issue 3. 2008-09-03. PMID:18569459. cannabinoid treatment protected brdu-positive progenitor cells in striatum that were susceptible to virus-induced injury (p < .01) through suppression of microglia activation (p < .001). 2008-09-03 2023-08-12 rat
Eva de Lago, Javier Fernández-Rui. Cannabinoids and neuroprotection in motor-related disorders. CNS & neurological disorders drug targets. vol 6. issue 6. 2008-05-02. PMID:18220777. in both disorders, the key mechanisms involved in the neuroprotection provided by cannabinoids include cannabinoid receptor-independent effects aimed at reducing the oxidative injury, and also cannabinoid 2 receptors (cb2)-mediated effects exerted by regulating the influence of reactive microglia on neuronal homeostasis. 2008-05-02 2023-08-12 Not clear
G A Cabral, E S Raborn, L Griffin, J Dennis, F Marciano-Cabra. CB2 receptors in the brain: role in central immune function. British journal of pharmacology. vol 153. issue 2. 2008-04-02. PMID:18037916. in contrast, we have shown in vivo and in vitro that the exogenous cannabinoids delta-9-tetrahydrocannabinol and cp55940 inhibit the chemotactic response of microglia to acanthamoeba culbertsoni, an opportunistic pathogen that is the causative agent of granulomatous amoebic encephalitis, through activation of the cb2r. 2008-04-02 2023-08-12 Not clear
Fernando Correa, Fabian Docagne, Leyre Mestre, Frida Loría, Miriam Hernangómez, José Borrell, Carmen Guaz. Cannabinoid system and neuroinflammation: implications for multiple sclerosis. Neuroimmunomodulation. vol 14. issue 3-4. 2008-03-31. PMID:18073512. we also show our results on the modulation of cytokines of the il-12 family by cannabinoids in macrophages and brain microglia. 2008-03-31 2023-08-12 Not clear
Fernando Correa, Fabian Docagne, Leyre Mestre, Frida Loría, Miriam Hernangómez, José Borrell, Carmen Guaz. Cannabinoid system and neuroinflammation: implications for multiple sclerosis. Neuroimmunomodulation. vol 14. issue 3-4. 2008-03-31. PMID:18073512. we used murine primary cultures of macrophage and microglia activated by lipopolysaccharide/ifn-gamma and theiler's virus to study the effects of cannabinoids on the regulation of il-12 and il-23 mrna and protein il-12p40, evaluated by rt-pcr and elisa, respectively. 2008-03-31 2023-08-12 Not clear
V A Campbell, A Gowra. Alzheimer's disease; taking the edge off with cannabinoids? British journal of pharmacology. vol 152. issue 5. 2008-02-25. PMID:17828287. targeting cannabinoid receptors on microglia may reduce the neuroinflammation that is a feature of alzheimer's disease, without causing psychoactive effects. 2008-02-25 2023-08-12 Not clear
Onintza Sagredo, Moisés García-Arencibia, Eva de Lago, Simone Finetti, Alessandra Decio, Javier Fernández-Rui. Cannabinoids and neuroprotection in basal ganglia disorders. Molecular neurobiology. vol 36. issue 1. 2007-12-18. PMID:17952653. there are two key mechanisms involved in the neuroprotection by cannabinoids in experimental models of these two disorders: first, a cannabinoid receptor-independent mechanism aimed at producing a decrease in the oxidative injury and second, an induction/upregulation of cannabinoid cb2 receptors, mainly in reactive microglia, that is capable to regulate the influence of these glial cells on neuronal homeostasis. 2007-12-18 2023-08-12 Not clear
Y Marchalant, S Rosi, G L Wen. Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17178196. cannabinoid receptors 1 were not expressed by microglia and astrocytes, suggesting an indirect effect of win-55212-2 on microglia activation and memory impairment. 2007-05-21 2023-08-12 rat
R G Pertwe. Pharmacological actions of cannabinoids. Handbook of experimental pharmacology. issue 168. 2006-04-19. PMID:16596770. certain cannabinoids also appear to have non-cb1, non-cb2, non-trpv1 targets, for example cb2-like receptors that can mediate antinociception and "abnormal-cannabidiol" receptors that mediate vasorelaxation and promote microglial cell migration. 2006-04-19 2023-08-12 Not clear
Serge Rives. Cannabinoids in microglia: a new trick for immune surveillance and neuroprotection. Neuron. vol 49. issue 1. 2006-02-14. PMID:16387633. cannabinoids in microglia: a new trick for immune surveillance and neuroprotection. 2006-02-14 2023-08-12 Not clear
G A Cabral, F Marciano-Cabra. Cannabinoid receptors in microglia of the central nervous system: immune functional relevance. Journal of leukocyte biology. vol 78. issue 6. 2006-02-09. PMID:16204639. cannabinoid receptors in microglia of the central nervous system: immune functional relevance. 2006-02-09 2023-08-12 Not clear
G A Cabral, F Marciano-Cabra. Cannabinoid receptors in microglia of the central nervous system: immune functional relevance. Journal of leukocyte biology. vol 78. issue 6. 2006-02-09. PMID:16204639. microglia, in addition to exhibiting phenotypic markers for macrophages, express cb1 and cb2 cannabinoid receptors. 2006-02-09 2023-08-12 Not clear
G A Cabral, F Marciano-Cabra. Cannabinoid receptors in microglia of the central nervous system: immune functional relevance. Journal of leukocyte biology. vol 78. issue 6. 2006-02-09. PMID:16204639. the recognition that microglia express cannabinoid receptors and that their activation results in modulation of select cellular activities suggests that they may be amenable to therapeutic manipulation for ablating untoward inflammatory responses in the central nervous system. 2006-02-09 2023-08-12 Not clear