All Relations between microglial cell and nitrogen monoxide

Reference Sentence Publish Date Extraction Date Species
Ammar A Abdelrahman, Katharine L Bunch, Porsche V Sandow, Paul N-M Cheng, Ruth B Caldwell, R William Caldwel. Systemic Administration of Pegylated Arginase-1 Attenuates the Progression of Diabetic Retinopathy. Cells vol 11 issue 18 2022 36139465 under these conditions, inducible nitric oxide synthase (inos) expression is upregulated in the macrophages (m\xce\xa6) and microglia, resulting in increased production of reactive oxygen species (ros) and inflammatory cytokines, which contribute to disease progression. 2022-09-23 2022-09-29 Not clear
Alexander P Young, Eileen M Denovan-Wrigh. The microglial endocannabinoid system is similarly regulated by lipopolysaccharide and interferon gamma. Journal of neuroimmunology vol 372 issue 2022 36150252 furthermore, we demonstrate that the efficacy of different synthetic cannabinoid treatments with respect to inhibition of microglia nitric oxide release is dependent on the concentration and type of pro-inflammatory stimuli presented to the microglia. 2022-09-23 2022-09-29 Not clear
Shuailong Li, Isa Wernersbach, Gregory S Harms, Michael K E Sch\\xc3\\xa4fe. Microglia subtypes show substrate- and time-dependent phagocytosis preferences and phenotype plasticity. Frontiers in immunology vol 13 issue 2022 36105813 to study these issues, primary murine glial cultures were cultivated in the presence of serum, different growth factors and cytokines to obtain m0-like, m1-like, and m2-like microglia as confirmed by morphology, m1/m2 gene marker expression, and nitric oxide assay. 2022-09-16 2022-09-20 Not clear
Elif \\xc3\\x87\\xc4\\xb1nar, Banu Cahide Tel, G\\xc3\\xbcrdal \\xc5\\x9eahi. Neuroinflammation in Parkinson's Disease and its Treatment Opportunities. Balkan medical journal vol issue 2022 36036436 microglia become overactive in response to chronic inflammation, which is observed in pd and causes excessive cytotoxic factor production, such as reactive oxidase, nitric oxide (no), and tumor necrosis factor-alpha. 2022-08-29 2022-08-31 Not clear
Lijun Huang, Leiqiang Gong, Xueyan Huo, Lirong Lei, Qi Zhang, Yunjie Hu, Qixuan Kuang, Yu Gui, Yifei Dai, Yucheng Gu, Yun Deng, Dong Wang, Dale Gu. N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-\\xce\\xbaB and NLRP3/Caspase-1 pathways. Acta biochimica et biophysica Sinica vol issue 2022 36017888 nitric oxide (no) detection, reactive oxygen species (ros) detection and enzyme-linked immunosorbent assay (elisa) results show that nadd attenuates inflammatory signals and proinflammatory cytokines in lps-stimulated bv-2 microglia, including no, ros, tumor necrosis factor (tnf)-\xce\xb1, interleukin (il)-1\xce\xb2 and interleukin-6 (il-6). 2022-08-26 2022-08-29 Not clear
Tingting Guo, Wen Dang, Yaping Zhou, Di Zhou, Qingqi Meng, Libin Xu, Gang Chen, Bin Lin, Degang Qing, Yu Sun, Yue Hou, Ning L. Sesquiterpene coumarins isolated from Ferula bungeana and their anti-neuroinflammatory activities. Bioorganic chemistry vol 128 issue 2022 35998519 the in vitro anti-neuroinflammatory activity assay showed that compounds 2 and 9 showed stronger inhibitory effect on nitric oxide (no) production in lipopolysaccharide (lps)-induced bv-2 microglia, compared with positive control minocycline, and compounds 5 and 10 showed moderate inhibitory effects. 2022-08-23 2022-08-29 Not clear
Sujata Thakur, Rishika Dhapola, Phulen Sarma, Bikash Medhi, Dibbanti HariKrishna Redd. Neuroinflammation in Alzheimer's Disease: Current Progress in Molecular Signaling and Therapeutics. Inflammation vol issue 2022 35986874 numerous pathways like nf\xce\xbab, p38 mapk, akt/mtor, caspase, nitric oxide, and cox are involved in triggering brain immune cells like astrocytes and microglia to secrete inflammatory cytokines such as tumor necrosis factor, interleukins, and chemokines and participate in alzheimer's disease pathology. 2022-08-20 2022-08-22 Not clear
Kun Liu, Runying Zhu, Hongwei Jiang, Bin Li, Qi Geng, Yanning Li, Jinsheng Q. Taurine inhibits KDM3a production and microglia activation in lipopolysaccharide-treated mice and BV-2 cells. Molecular and cellular neurosciences vol issue 2022 35901929 taurine improved the sociability of lps-treated mice, inhibited microglia activation in the hippocampus, and reduced generation of brain inflammatory factors, such as interleukin-6, tumor necrosis factor-\xce\xb1, inducible nitric oxide synthase, and cyclooxygenase-2. 2022-07-28 2022-08-08 Not clear
Rebekah L Mokry, Benjamin S O'Brien, Jacob W Adelman, Suzette Rosas, Megan L Schumacher, Allison D Ebert, Scott S Terhun. Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization. Journal of virology vol issue 2022 35862705 congenitally infected fetal brains show regions of brain damage, including necrotic foci with infiltrating macrophages and microglia, cell types that produce nitric oxide during infection. 2022-07-21 2022-07-25 Not clear
Chigure Suzuki, Junji Yamaguchi, Takahito Sanada, Juan Alejandro Oliva Trejo, Souichirou Kakuta, Masahiro Shibata, Isei Tanida, Yasuo Uchiyam. Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins. Scientific reports vol 12 issue 1 2022 35804072 microglia and astrocytes were activated in the ctsd-cko thalamus, and inducible nitric oxide synthase (inos), an inflammation marker, was increased in the microglia. 2022-07-08 2022-07-11 Not clear
Jing Li, Peilin Zhu, Yue Li, Kai Xiao, Jing Tang, Xin Liang, Yanmin Luo, Jin Wang, Yuhui Deng, Lin Jiang, Qian Xiao, Yijing Guo, Yong Tang, Chunxia Huan. The liver X receptors agonist GW3965 attenuates depressive-like behaviors and suppresses microglial activation and neuroinflammation in hippocampal subregions in a mouse depression model. The Journal of comparative neurology vol issue 2022 35758275 to investigate the effects of lxrs agonist (gw3965) on neuroinflammation and microglia in the hippocampal formation of mice with chronic unpredictable stress (cus)-induced depression, depressive-like behaviors were evaluated by behavioral tests, hippocampal lxrs gene expression were evaluated by qrt-pcr, the protein expression levels of interleukin-1\xce\xb2, tumor necrosis factor-\xce\xb1, inducible nitric oxide synthase, nuclear factor kappa b, and cluster of differentiation 206 were estimated by western blotting, modern stereological methods were used to precisely quantify the total number of microglia in each hippocampal subregion, and immunofluorescence was used to detect the density of activated microglia and the morphology of microglia. 2022-06-27 2022-07-04 Not clear
Jinqiang Zhang, Dapeng Su, Qin Liu, Qingsong Yuan, Zhen Ouyang, Yuan Wei, Chenghong Xiao, Liangyuan Li, Changgui Yang, Weike Jiang, Lanping Guo, Tao Zho. Gasdermin D-mediated microglial pyroptosis exacerbates neurotoxicity of aflatoxins B1 and M1 in mouse primary microglia and neuronal cultures. Neurotoxicology vol issue 2022 35716928 blockade of gasdermin d activity in afb1- or afm1-treated primary microglia using dimethyl fumarate (dmf) reduced the release of il-1\xce\xb2, il-18 and nitric oxide, as well as the neurotoxicity of microglia-conditioned medium to neurons, astrocytes, oligodendrocytes and neural stem/precursor cells. 2022-06-18 2022-06-20 Not clear
Mengfan Li, Bingtian Xu, Xing Li, Yueqi Li, Shuqin Qiu, Kechun Chen, Zhuhe Liu, Yuewen Ding, Honghao Wang, Jiangping Xu, Haitao Wan. Mitofusin 2 confers the suppression of microglial activation by cannabidiol: insights from in vitro and in vivo models. Brain, behavior, and immunity vol issue 2022 35688339 we found that treatment with cbd decreased the levels of tumor necrosis factor \xce\xb1, interleukin 6, inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and ionized calcium-binding adaptor molecule-1 (iba1) in lipopolysaccharide (lps)-challenged microglia. 2022-06-10 2022-06-13 Not clear
Hye-Rim Choi, Ji Sun Ha, Eun-A Kim, Sung-Woo Cho, Seung-Ju Yan. MiR-30a-5p and miR-153-3p regulate LPS-induced neuroinflammatory response and neuronal apoptosis by targeting NeuroD1. BMB reports vol issue 2022 35651331 in lps-induced microglia, mir-30a-5p and mir-153-3p suppressed pro-inflammatory cytokines, reactive oxygen species, the phosphorylation of c-jun n-terminal kinase, extracellular-signal-regulated kinase (erk), and p38, and the expression of cyclooxygenase and inducible nitric oxide synthase (inos) via the nf-\xce\xbab pathway. 2022-06-02 2022-06-13 Not clear
Abdur Rauf, Himani Badoni, Tareq Abu-Izneid, Ahmed Olatunde, Md Mominur Rahman, Sakshi Painuli, Prabhakar Semwal, Polrat Wilairatana, Mohammad S Mubara. Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases. Molecules (Basel, Switzerland) vol 27 issue 10 2022 35630670 entry of any foreign pathogen activates the glial cells (astrocytes and microglia) and overactivation of these cells triggers the release of various neuroinflammatory markers (nms), such as the tumor necrosis factor-\xce\xb1 (tnf-\xce\xb1), interleukin-1\xce\xb2 (il-1\xce\xb2), interleukin-1\xce\xb2 (il-10), nitric oxide (no), and cyclooxygenase-2 (cox-2), among others. 2022-05-28 2022-06-13 Not clear
Amira A Sallam, Mohammed A El-Magd, Mona M Ahmed, Heba I Ghamry, Mohammad Y Alshahrani, Rabab A Hegazy, Ahmed Magdy, Magdy F Abou El-Foto. Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 151 issue 2022 35605300 however, treatment with que ameliorated mwcnts-induced neurotoxicity as revealed by 1) elevated acetylcholinesterase (ache) activity, 2) reduced lipid peroxidation biomarker malondialdehyde (mda), 3) improved antioxidant status as indicated by increased levels of reduced glutathione (gsh) and activities of superoxide dismutase (sod), catalase (cat), as well as upregulated expression of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1) genes, 4) decreased levels and expression of inflammatory biomarkers [nitric oxide (no), interleukin 1 beta (il1\xc3\x9f), tumor necrosis factor-alpha (tnf\xce\xb1), and nuclear factor kappa b (nf-\xce\xbab)], 5) downregulated expression of pyroptosis-related genes [nod-like receptor protein inflammasome 3 (nlrp3) and caspase 1 (casp1)] but with no effect on the apoptotic casp3 gene, 6) minimized axonal degeneration and number of microglia in the cerebral medulla, and 7) diminished the number of degenerated neurons in hippocampus and cerebellum. 2022-05-23 2022-06-13 Not clear
Kimberly Barber, Patricia Mendonca, Karam F Solima. Cardamonin Antioxidant Effects Through the Modulation of Proteins and Genes Expressions in LPS-Activated BV-2 Microglial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 36 Suppl 1 issue 2022 35559544 continuous activation of microglia cells, known as the resident, innate immune cells in the brain, participates in producing numerous neurotoxic factors, including nitric oxide and reactive oxygen species (ros), which induce neurodegeneration. 2022-05-13 2022-06-13 Not clear
Jung-Eun Park, Yea-Hyun Leem, Jin-Sun Park, Do-Yeon Kim, Jihee Lee Kang, Hee-Sun Ki. Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an \\xce\\xb17 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson's Disease Mouse Models. International journal of molecular sciences vol 23 issue 8 2022 35457238 gts-21 inhibited the expression of inducible nitric oxide synthase (inos) and proinflammatory cytokines in lipopolysaccharide (lps)-stimulated bv2 microglial cells and primary microglia. 2022-04-23 2022-04-25 Not clear
Jamal Ahmad Ansari, Shubhendra K Mishra, Rajib K Dey, Opalina Roy, Shaivya Kushwaha, Vikas Singh, Satyakam Patnaik, Debabrata Ghos. Minocycline reverses developmental arsenic exposure-induced microglia activation and functional alteration in BALB/c mice. Environmental toxicology and pharmacology vol issue 2022 35351628 primary microglial were isolated (ex vivo microglia) from experimental animals and used to measure reactive oxygen species (ros), nitric oxide (no), cytokine production and phagocytosis. 2022-03-30 2022-04-14 Not clear
Wenhao Qu, Ying Cheng, Wei Peng, Yan Wu, Tongyu Rui, Chengliang Luo, Jian Zhan. Targeting iNOS Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage via Promoting Ferroptosis of M1 Microglia and Reducing Neuroinflammation. Molecular neurobiology vol issue 2022 35262869 previous studies have found that inducible nitric oxide synthase (inos/no\xe2\x80\xa2) plays an essential role in promoting the survival of m1 microglia by blocking ferroptosis. 2022-03-09 2022-04-14 Not clear
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