Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Lalita Subedi, Eunhee Ji, Dongyun Shin, Jongsik Jin, Joo Hong Yeo, Sun Yeou Ki. Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro. Nutrients. vol 9. issue 3. 2017-08-17. PMID:28264445. |
equol inhibited the lipopolysaccharide (lps)-induced tlr4 activation, mapk activation, nf-kb-mediated transcription of inflammatory mediators, production of nitric oxide (no), release of prostaglandin e2 (pge-2), secretion of tumor necrosis factor-α (tnf-α) and interleukin 6 (il-6), in lipopolysaccharide (lps)-activated murine microglia cells. |
2017-08-17 |
2023-08-13 |
Not clear |
Liang-En Yu, Chiou-Lian Lai, Ching-Tien Lee, Jiz-Yuh Wan. Highly electronegative low-density lipoprotein L5 evokes microglial activation and creates a neuroinflammatory stress via Toll-like receptor 4 signaling. Journal of neurochemistry. vol 142. issue 2. 2017-08-10. PMID:28444734. |
we found that l5 enables the activation of microglia and elicits an inflammatory response, as evidenced by increased oxygen/nitrogen free radicals (nitric oxide, reactive oxygen species, and peroxides), elevated tumor necrosis factor-α levels, decreased basal interleukin-10 levels, and augmented production of pro-inflammatory proteins (inducible nitric oxide synthase and cyclooxygenase-2). |
2017-08-10 |
2023-08-13 |
human |
Tian-Ya Liu, Xiao-Ying Yang, Long-Tai Zheng, Guang-Hui Wang, Xue-Chu Zhe. Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death. Journal of neurochemistry. vol 140. issue 4. 2017-07-13. PMID:27889907. |
nur77 over-expression or application of nur77 agonist cytosporone b suppressed the expression of proinflammatory genes, such as inducible nitric oxide nos, cyclooxygenase-2, il-1β, and tumor necrosis factor-α in the activated microglia, while silenced nur77 exaggerated the inflammatory responses in microglia. |
2017-07-13 |
2023-08-13 |
mouse |
Changyeol Lee, Soonok Kim, Wei Li, Sunghee Bang, Hanna Lee, Hyun-Jung Lee, Eun-Young Noh, Jung-Eun Park, Woo Young Bang, Sang Hee Shi. Bioactive secondary metabolites produced by an endophytic fungus Gaeumannomyces sp. JS0464 from a maritime halophyte Phragmites communis. The Journal of antibiotics. vol 70. issue 6. 2017-07-11. PMID:28352106. |
chemical investigations of extracts of js0464 led to the isolation of two glycosylated dialkylresorcinol derivatives (1-2), an anthraquinone derivative (3) and eight known compounds (4-11), which were identified by spectroscopic analyses incorporating one-dimensional/2d nmr and ms. nine compounds showed significant nitric oxide reduction activity in lipopolysaccharide-stimulated microglia bv-2 cells, seven of which did not impair cell viability. |
2017-07-11 |
2023-08-13 |
Not clear |
Gyun Jee Song, Youngpyo Nam, Myungjin Jo, Myungsu Jung, Ja Young Koo, Wansang Cho, Minseob Koh, Seung Bum Park, Kyoungho Su. A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype. Neuropharmacology. vol 109. 2017-06-19. PMID:27288982. |
activated microglia and astrocytes play an essential role in neuroinflammation by producing nitric oxide (no), inflammatory cytokines, chemokines, and neurotoxins. |
2017-06-19 |
2023-08-13 |
mouse |
Yang Jiao, Ting Xie, Lu-Hui Zou, Qian Wei, Li Qiu, Li-Xia Che. Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia. Bioorganic & medicinal chemistry letters. vol 26. issue 15. 2017-06-19. PMID:27335254. |
their anti-inflammatory activities were tested by measuring their inhibitory effects on nitric oxide (no) production in bv-2 microglia cells activated by lipopolysaccharide. |
2017-06-19 |
2023-08-13 |
rat |
Chung Sub Kim, Lalita Subedi, Oh Wook Kwon, Hyun Bong Park, Sun Yeou Kim, Sang Un Choi, Kang Ro Le. Wasabisides A-E, Lignan Glycosides from the Roots of Wasabia japonica. Journal of natural products. vol 79. issue 10. 2017-06-16. PMID:27700070. |
all isolated compounds (1-9) were evaluated for their potential neuroprotective effects through induction of nerve growth factor in c6 glioma cells, for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia bv2 cells, and for their cytotoxicity against four human tumor cell lines (a549, sk-ov-3, sk-mel-2, and bt549). |
2017-06-16 |
2023-08-13 |
human |
Yachao Xing, Ning Li, Di Zhou, Gang Chen, Kun Jiao, Wenli Wang, Yingying Si, Yue Ho. Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors. Planta medica. vol 83. issue 1-02. 2017-05-22. PMID:27420353. |
to identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional chinese medicine "awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. |
2017-05-22 |
2023-08-13 |
Not clear |
Leihua Weng, He Zhang, Xiaoxi Li, Hui Zhan, Fan Chen, Lijuan Han, Yun Xu, Xiang Ca. Ampelopsin attenuates lipopolysaccharide-induced inflammatory response through the inhibition of the NF-κB and JAK2/STAT3 signaling pathways in microglia. International immunopharmacology. vol 44. 2017-05-12. PMID:27998743. |
we found that pre-treatment of microglia cells with amp before lps with a non-cytotoxic concentration range decreased the production of nitric oxide (no) and prostaglandin e2 (pge2). |
2017-05-12 |
2023-08-13 |
Not clear |
Wen-Jun Xu, Rui-Jun Li, Olga Quasie, Ming-Hua Yang, Ling-Yi Kong, Jun Lu. Polyprenylated Tetraoxygenated Xanthones from the Roots of Hypericum monogynum and Their Neuroprotective Activities. Journal of natural products. vol 79. issue 8. 2017-05-02. PMID:27525351. |
compounds 1 and 2 exhibited neuroprotective effects against corticosterone (cort)-induced lesions of pc12 cells at concentrations of 6.25, 12.50, and 25.00 μm, with cell viability greater than 75%, as well as inhibitory effects on nitric oxide production in lipopolysaccharide-induced bv2 microglia cells, with ic50 values of 7.47 ± 0.65 and 9.60 ± 0.12 μm, respectively. |
2017-05-02 |
2023-08-13 |
Not clear |
Chi-Su Yoon, Dong-Cheol Kim, Tran Hong Quang, Jungwon Seo, Dae Gill Kang, Ho Sub Lee, Hyuncheol Oh, Youn-Chul Ki. A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia. Molecules (Basel, Switzerland). vol 21. issue 9. 2017-04-17. PMID:27649130. |
cudratricusxanthone a (1) suppressed the expression of inducible nitric oxide synthase (inos) and cyclooxygenase (cox)-2 enzymes and decreased the production of inos-derived nitric oxide and cox-2-derived prostaglandin e2 in lps-stimulated mouse bv2 microglia. |
2017-04-17 |
2023-08-13 |
mouse |
Yu Jin Kim, Hye-Sun Lim, Jun Lee, Soo-Jin Jeon. Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia. Molecules (Basel, Switzerland). vol 21. issue 8. 2017-04-14. PMID:27548120. |
angelicin, isobavachalcone, and bakuchiol suppressed lipopolysaccharide (lps)-stimulated nitric oxide production in lps-treated bv-2 microglia more significantly than did the other components. |
2017-04-14 |
2023-08-13 |
Not clear |
Jie Ma, Chuang-Jun Li, Jing-Zhi Yang, Yan Li, Xiu-Qi Bao, Nai-Hong Chen, Dong-Ming Zhan. Three new coumarin glycosides from the stems of Hydrangea paniculata. Journal of Asian natural products research. vol 19. issue 4. 2017-04-12. PMID:28367637. |
in addition, compounds 1-3 were screened for their neuroprotective effects against serum deprivation-induced pc12 cell damage, hepatoprotective activities against dl-galactosamine-induced toxicity in hl-7702 cells and their ability to inhibit lps-induced nitric oxide production in the murine microglia bv2 cell line, but they were inactive. |
2017-04-12 |
2023-08-13 |
Not clear |
Van-Tinh Nguyen, Seok-Chun Ko, Gun-Woo Oh, Seong-Yeong Heo, You-Jin Jeon, Won Sun Park, Il-Whan Choi, Sung-Wook Choi, Won-Kyo Jun. Anti-inflammatory effects of sodium alginate/gelatine porous scaffolds merged with fucoidan in murine microglial BV2 cells. International journal of biological macromolecules. vol 93. issue Pt B. 2017-04-07. PMID:27234497. |
following stimulation with 0.5μg/ml lps, microglia cultured in porous sagfu decreased their expression of nitric oxide (no), prostaglandin e2 (pge2), and reactive oxygen species (ros). |
2017-04-07 |
2023-08-13 |
Not clear |
Hu-Nan Sun, Ying-Hao Han, Li Feng, Cheng-Hao Jin, Bing Han, Lei Liu, Dong-Soek Lee, Tea-Ho Kwon, Le-Gong Li, Wen-Zhong Ge, Yu-Dong Cu. 16α, 17α-epoxypregnenolone-20-oxime inhibits NO and IL-6 production in LPS-treated RAW264.7 cells. Molecular medicine reports. vol 13. issue 6. 2017-04-06. PMID:27082161. |
it has previously been reported that 16α, 17α-epoxypregnenolone-20-oxime (eprego) exerts an inhibitory effect on nitric oxide (no) production and inducible no synthase (inos) expression in microglia. |
2017-04-06 |
2023-08-13 |
Not clear |
Nguyen Thi Thanh Ngan, Tran Hong Quang, Kwan-Woo Kim, Hye Jin Kim, Jae Hak Sohn, Dae Gill Kang, Ho Sub Lee, Youn-Chul Kim, Hyuncheol O. Anti-inflammatory effects of secondary metabolites isolated from the marine-derived fungal strain Penicillium sp. SF-5629. Archives of pharmacal research. vol 40. issue 3. 2017-04-04. PMID:28074397. |
evaluation of the anti-inflammatory activity of these metabolites showed that 4 inhibited nitric oxide and prostaglandin e2 production in lipopolysaccharide-stimulated bv2 microglia, with ic |
2017-04-04 |
2023-08-13 |
Not clear |
Fei Li, Jie Ma, Chuang-Jun Li, Jing-Zhi Yang, Dan Zhang, Xiao-Guang Chen, Dong-Ming Zhan. Bioactive isopimarane diterpenoids from the stems of Euonymus oblongifolius. Phytochemistry. vol 135. 2017-03-16. PMID:28003047. |
all of the isolated compounds were evaluated for their ability to inhibit lps-induced nitric oxide production in the murine microglia bv2 cell line, and for their cytotoxic activity against five human cancer cell lines. |
2017-03-16 |
2023-08-13 |
human |
Fei Li, Jie Ma, Chuang-Jun Li, Jing-Zhi Yang, Dan Zhang, Xiao-Guang Chen, Dong-Ming Zhan. Bioactive isopimarane diterpenoids from the stems of Euonymus oblongifolius. Phytochemistry. vol 135. 2017-03-16. PMID:28003047. |
euonymusisopimaric acids a, e and f inhibited lps-induced nitric oxide production in the murine microglia bv2 cell line, with ic |
2017-03-16 |
2023-08-13 |
human |
Li-Long Pan, Peng Xu, Xiao-Ling Luo, Li-Jun Wang, Si-Yu Liu, Yi-Zhun Zhu, Jin-Feng Hu, Xin-Hua Li. Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-14. PMID:28178617. |
our data showed that shizukaol b concentration-dependently suppressed expression of inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2), production of nitric oxide (no), tumor necrosis factor-α (tnf-α), and interleukin-1β (il-1β) in lps-stimulated bv2 microglia. |
2017-03-14 |
2023-08-13 |
Not clear |
Tae-Shin Park, Young-Kyoung Ryu, Hye-Yeon Park, Jae Yun Kim, Jun Go, Jung-Ran Noh, Yong-Hoon Kim, Jung Hwan Hwang, Dong-Hee Choi, Won-Keun Oh, Chul-Ho Lee, Kyoung-Shim Ki. Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. International journal of molecular medicine. vol 39. issue 1. 2017-03-06. PMID:28004107. |
our results revealed that hj significantly decreased the mrna and protein expression levels of tumor necrosis factor-α (tnf‑α), interleukin (il)-1β, il-6 and inducible nitric oxide synthase (inos) induced by lipopolysaccharide in the microglial cell line. |
2017-03-06 |
2023-08-13 |
mouse |