| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenji Sudo, Yosuke Takezawa, Shinichi Kohsaka, Kazuyuki Nakajim. Involvement of nitric oxide in the induction of interleukin-1 beta in microglia. Brain research. vol 1625. 2016-08-15. PMID:26335060. |
in response to in vitro stimulation with lipopolysaccharide (lps), microglia induce the production of the inflammatory cytokine interleukin-1 beta (il-1β) together with nitric oxide (no) and superoxide anion (o2(-)). |
2016-08-15 |
2023-08-13 |
Not clear |
| Cheng-Yi Chang, Jian-Ri Li, Yen-Chuan Ou, Wen-Ying Chen, Su-Lan Liao, Shue-Ling Raung, An-Lu Hsiao, Chun-Jung Che. Enterovirus 71 infection caused neuronal cell death and cytokine expression in cultured rat neural cells. IUBMB life. vol 67. issue 10. 2016-08-12. PMID:26399559. |
neurons, astrocytes, and microglia responded to ev71 infection by releasing distinct profiles of cytokines, including nitric oxide (no), tumor necrosis factor-α (tnf-α), interleukin (il)-1β, regulated on activation normal t cell expressed and secreted (rantes), and glutamate. |
2016-08-12 |
2023-08-13 |
human |
| Bao Cheng, Yongsheng Lin, Ming Kuang, Sai Fang, Qiong Gu, Jun Xu, Laiyou Wan. Synthesis and anti-neuroinflammatory activity of lactone benzoyl hydrazine and 2-nitro-1-phenyl-1h-indole derivatives as p38α MAPK inhibitors. Chemical biology & drug design. vol 86. issue 5. 2016-08-01. PMID:25960125. |
fourteen of the seventeen synthesized compounds exhibit significant inhibitory effect on the nitric oxide (no) production induced by lipopolysaccharide (lps)-induced microglia activation with ic50 less than the control 5,6-dehydrokawain. |
2016-08-01 |
2023-08-13 |
Not clear |
| Ki Hyun Kim, Eunjung Moon, Joon Min Cha, Seulah Lee, Jae Sik Yu, Chung Sub Kim, Sun Yeou Kim, Sang Un Choi, Kang Ro Le. Antineuroinflammatory and Antiproliferative Activities of Constituents from Tilia amurensis. Chemical & pharmaceutical bulletin. vol 63. issue 10. 2016-07-25. PMID:26423042. |
showed an inhibitory effect on nitric oxide (no) production in an activated murine microglial cell line. |
2016-07-25 |
2023-08-13 |
Not clear |
| Chung Sub Kim, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Ki Hyun Kim, Kang Ro Le. Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities. Journal of natural products. vol 79. issue 2. 2016-07-22. PMID:26812172. |
all isolated compounds (1-28) were evaluated for their cytotoxicity against four human tumor cell lines (a549, sk-ov-3, sk-mel-2, and hct-116), for their potential neuroprotective effects through induction of nerve growth factor in c6 glioma cells, and for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia bv2 cells. |
2016-07-22 |
2023-08-13 |
human |
| Mina Kim, Sang-Yoon Choi, Pyeongjae Lee, Jinyoung Hu. Neochlorogenic Acid Inhibits Lipopolysaccharide-Induced Activation and Pro-inflammatory Responses in BV2 Microglial Cells. Neurochemical research. vol 40. issue 9. 2016-07-19. PMID:26152332. |
we found that lipopolysaccharide-induced inducible nitric oxide synthase, and cyclooxygenase-2 expression, and nitric oxide formation was suppressed by nca in a dose-dependent manner in bv2 microglia. |
2016-07-19 |
2023-08-13 |
Not clear |
| Fangjiao Song, Kewu Zeng, Lixi Liao, Qian Yu, Pengfei Tu, Xuemei Wan. Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways. PloS one. vol 11. issue 2. 2016-07-19. PMID:26919063. |
our observations showed that sch a could significantly down-regulate the increased production of nitric oxide (no), tumor necrosis factor (tnf)-α and interleukin (il)-6 induced by lipopolysaccharide (lps) both in bv-2 cells and primary microglia cells. |
2016-07-19 |
2023-08-13 |
Not clear |
| Yu-Feng Liu, Ming-Hua Chen, Sheng Lin, Yu-Huan Li, Dan Zhang, Jian-Dong Jiang, Jian-Gong Sh. Indole alkaloid glucosides from the roots of Isatis indigotica. Journal of Asian natural products research. vol 18. issue 1. 2016-07-08. PMID:26651370. |
compound 1 also exhibited inhibitory effect against nitric oxide (no) production in microglial cell bv2 with an inhibition ratio of 93.0% at 10 μm. |
2016-07-08 |
2023-08-13 |
Not clear |
| Chien-Wei Hou, Yu-Tzy Lin, Yi-Ling Chen, Ya-Hui Wang, Jui-Ling Chou, Ling-Yin Ping, Kee-Ching Jen. Neuroprotective effects of carnosic acid on neuronal cells under ischemic and hypoxic stress. Nutritional neuroscience. vol 15. issue 6. 2016-06-23. PMID:22687582. |
in addition, ca also reduced nitric oxide (no) and interleukine (il)-1 and il-6 production from activated bv-2 microglia. |
2016-06-23 |
2023-08-12 |
Not clear |
| Yutaka Nakagawa, Kenji Chib. Diversity and plasticity of microglial cells in psychiatric and neurological disorders. Pharmacology & therapeutics. vol 154. 2016-06-09. PMID:26129625. |
like m1 macrophages, m1 polarized microglia can produce pro-inflammatory cytokines and mediators such as interleukin (il) 1β, il-6, tumor necrosis factor-α, cc-chemokine ligand 2, nitric oxide, and reactive oxygen species, suggesting that these molecules contribute to dysfunction of neural network in the cns. |
2016-06-09 |
2023-08-13 |
Not clear |
| Rui Zhou, Xu-Yang Shi, De-Cheng Bi, Wei-Shan Fang, Gao-Bin Wei, Xu X. Alginate-Derived Oligosaccharide Inhibits Neuroinflammation and Promotes Microglial Phagocytosis of β-Amyloid. Marine drugs. vol 13. issue 9. 2016-06-07. PMID:26389923. |
we found that pretreatment of bv2 microglia with ado prior to lps/aβ stimulation led to a significant inhibition of production of nitric oxide (no) and prostaglandin e₂ (pge₂), expression of inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2) and secretion of proinflammatory cytokines. |
2016-06-07 |
2023-08-13 |
Not clear |
| SeonJu Park, Nguyen Xuan Nhiem, Taek Hwan Lee, Nanyoung Kim, Sun Yeou Kim, Han-Jung Chae, Seung Hyun Ki. Isolation of two new bioactive sesquiterpene lactone glycosides from the roots of Ixeris dentata. Bioorganic & medicinal chemistry letters. vol 25. issue 20. 2016-05-31. PMID:26341134. |
all compounds were tested for their ability to inhibit lipopolysaccharide (lps)-induced nitric oxide (no) production in bv-2 microglial cell. |
2016-05-31 |
2023-08-13 |
Not clear |
| b' Anna Chiarini, Ubaldo Armato, Daisong Liu, Ilaria Dal Pr\\xc3\\xa. Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer\'s Disease. Frontiers in physiology. vol 7. 2016-05-20. PMID:27199760.' |
in parallel, aβ42-os•casr signals also elicit an excess production and secretion of nitric oxide and vascular endothelial growth factor-a from astrocytes, of aβ42-os and myelin basic protein from oligodendrocytes, and of proinflammatory cytokines, nitric oxide and (likely) aβ42-os from microglia. |
2016-05-20 |
2023-08-13 |
human |
| Ismini E Papageorgiou, Andrea Lewen, Lukas V Galow, Tiziana Cesetti, Jörg Scheffel, Tommy Regen, Uwe-Karsten Hanisch, Oliver Kan. TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 1. 2016-05-13. PMID:26699475. |
we show that chronic activation with either bacterial lipopolysaccharide through toll-like receptor 4 (tlr4) or leukocyte cytokine ifn-γ induces reactive phenotypes in microglia associated with morphological changes, population expansion, cd11b and cd68 up-regulation, and proinflammatory cytokine (il-1β, tnf-α, il-6) and nitric oxide (no) release. |
2016-05-13 |
2023-08-13 |
Not clear |
| Dong-Cheol Kim, Tran Hong Quang, Nguyen Thi Thanh Ngan, Chi-Su Yoon, Jae Hak Sohn, Joung Han Yim, Yu Feng, Yongsheng Che, Youn-Chul Kim, Hyuncheol O. Dihydroisocoumarin Derivatives from Marine-Derived Fungal Isolates and Their Anti-inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia. Journal of natural products. vol 78. issue 12. 2016-05-06. PMID:26651366. |
among the isolated metabolites, dihydroisocoumarin derivatives 1-6 (10-80 μm) were shown to inhibit lps-induced nitric oxide (no) and prostaglandin e2 (pge2) production by suppressing the expression of inducible no synthase (inos) and cyclooxygenase-2 (cox-2), respectively, in lps-stimulated bv2 microglia. |
2016-05-06 |
2023-08-13 |
Not clear |
| Krystyna Stepień, Anna Dzierzega-Lecznar, Irena Ta. [The role of neuromelanin in Parkinson's disease--new concepts]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 11-12. 2016-04-23. PMID:18540183. |
extraneuronal melanin may contribute to chronic inflammation by excessive secretion of cytokines and nitric oxide due to prolonged microglia activation. |
2016-04-23 |
2023-08-12 |
Not clear |
| Shaoxia Wang, Hong Wang, Haoran Jing, Shixiang Wang, Liyuan Kang, Xiumei Gao, Limin Hu, Xiaohui Zhen. Anti-inflammatory effects of isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate, a novel metabolite from danshen, on activated microglia. The Chinese journal of physiology. vol 55. issue 6. 2016-04-23. PMID:23286451. |
our data showed that idhp significantly reduced the production of nitric oxide (no), tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β) in lps-induced bv-2 cells and rat primary microglia in a dose-dependent manner. |
2016-04-23 |
2023-08-12 |
rat |
| Sun Young Park, Young Hun Kim, Geuntae Par. Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition. Neuroscience letters. vol 609. 2016-04-15. PMID:26472707. |
neuroinflammatory response is mediated by cellular components such as microglia and molecular components, including nitric oxide, prostaglandins and inflammatory cytokines, activation of complement proteins etc. |
2016-04-15 |
2023-08-13 |
Not clear |
| W Schaafsma, X Zhang, K C van Zomeren, S Jacobs, P B Georgieva, S A Wolf, H Kettenmann, H Janova, N Saiepour, U-K Hanisch, P Meerlo, P J van den Elsen, N Brouwer, H W G M Boddeke, B J L Egge. Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing. Brain, behavior, and immunity. vol 48. 2016-04-13. PMID:25843371. |
in addition to a suppressed pro-inflammatory response, preconditioned primary microglia displayed enhanced phagocytic activity, increased outward potassium currents and nitric oxide production in response to a second lps challenge. |
2016-04-13 |
2023-08-13 |
mouse |
| Bo Kyung Kang, Mi Kyoung Kim, So Young Kim, Seung Jin Lee, Young Whan Choi, Byung Tae Choi, Hwa Kyoung Shi. Anti-Neuroinflammatory Effects of Uncaria sinensis in LPS-Stimulated BV2 Microglia Cells and Focal Cerebral Ischemic Mice. The American journal of Chinese medicine. vol 43. issue 6. 2016-04-08. PMID:26364663. |
hexane extracts of us (heus) significantly suppressed the production of nitric oxide (no) and prostaglandin e2 (pge2) in lps-stimulated bv2 microglia and inhibited lps-induced expression of inos and cox-2 in a dose-dependent manner without causing cytotoxicity in bv2 cells. |
2016-04-08 |
2023-08-13 |
mouse |