| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Huang, Xu Lu, Jia Wang, Lijuan Tong, Bo Jiang, Wei Zhan. Inhibition of endogenous heat shock protein 70 attenuates inducible nitric oxide synthase induction via disruption of heat shock protein 70/Na(+) /H(+) exchanger 1-Ca(2+) -calcium-calmodulin-dependent protein kinase II/transforming growth factor β-activated kinase 1-nuclear factor-κB signals in BV-2 microglia. Journal of neuroscience research. vol 93. issue 8. 2016-04-01. PMID:25691123. |
this study addresses this issue in bv-2 microglia, showing that hsp70 inhibition or knockdown prevents lps-induced inos protein expression and nitric oxide production. |
2016-04-01 |
2023-08-13 |
Not clear |
| Eun-A Kim, Jiyoung Choi, A Reum Han, Chang Hun Cho, Soo Young Choi, Jee-Yin Ahn, Sung-Woo Ch. 2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride inhibits microglial activation by suppression of nuclear factor-kappa B and mitogen-activated protein kinase signaling. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 4. 2016-03-28. PMID:24752390. |
the results showed that khg26377 reduced the production of prostaglandin e2 (pge2), tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), reactive oxygen species (ros), and nitric oxide (no) in lps-activated microglia. |
2016-03-28 |
2023-08-13 |
rat |
| Ren-Wei Du, Ren-Hong Du, Wen-Guang B. β-Arrestin 2 mediates the anti-inflammatory effects of fluoxetine in lipopolysaccharide-stimulated microglial cells. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 4. 2016-03-28. PMID:25035139. |
in the present study, we found that fluoxetine significantly inhibited lipopolysaccharide (lps)-induced production of tumor necrosis factor-alpha (tnf-α), interleukin- 6 (il-6) and nitric oxide (no) and reduced the phosphorylation of transforming growth factor-beta-activated kinase 1 (tak1) and nuclear factor-kappa b (nf-κb) p65 nuclear translocation in microglia. |
2016-03-28 |
2023-08-13 |
Not clear |
| Daniela Impellizzeri, Akbar Ahmad, Rosanna Di Paola, Michela Campolo, Michele Navarra, Emanuela Esposito, Salvatore Cuzzocre. Role of Toll like receptor 4 signaling pathway in the secondary damage induced by experimental spinal cord injury. Immunobiology. vol 220. issue 9. 2016-03-24. PMID:25990044. |
sci tlr4 ko mice developed severer hind limb motor dysfunction and neuronal death by histological evaluation, myeloid differentiation primary response 88 (myd88) expression as well as an increase in nuclear factor nf-κb activity, tumor necrosis factor (tnf)-α and interleukin (il)-1β levels, glial fibrillary acidic protein (gfap), microglia marker (cd11β), inducible nitric oxide synthases (inos), poly-adp-ribose polymerase (parp) and nitrotyrosine expression compared to wt mice. |
2016-03-24 |
2023-08-13 |
mouse |
| Dennis Y Chuang, Agnes Simonyi, Paul T Kotzbauer, Zezong Gu, Grace Y Su. Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway. Journal of neuroinflammation. vol 12. 2016-03-22. PMID:26520095. |
there is well-established evidence that proinflammatory cytokines and glutamate, as well as reactive oxygen species (ros) and nitric oxide (no), are produced upon microglia activation, and these are important factors contributing to inflammatory responses and cytotoxic damage to surrounding neurons and neighboring cells. |
2016-03-22 |
2023-08-13 |
Not clear |
| Hongfei Qiao, Qiaojun Zhang, Haifeng Yuan, Yali Li, Dong Wang, Rui Wang, Xijing H. Elevated neuronal α-synuclein promotes microglia activation after spinal cord ischemic/reperfused injury. Neuroreport. vol 26. issue 11. 2016-03-10. PMID:26103121. |
furthermore, when cocultured with injured neurons or supernatants from injured neurons, nitric oxide generation, h2o2 production, and tumor necrosis factor-α expression were promoted in microglia. |
2016-03-10 |
2023-08-13 |
Not clear |
| Philip K-Y Chang, Armen Khatchadourian, Rebecca Anne McKinney, Dusica Maysinge. Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology. Journal of neuroinflammation. vol 12. 2016-03-09. PMID:25889069. |
strong activation of microglia by lps is accompanied by marked release of nitric oxide and formation of lipid bodies (lbs), both dynamic biomarkers of inflammation. |
2016-03-09 |
2023-08-13 |
Not clear |
| Sirish K Lakkaraju, Hannah Mbatia, Marie Hanscom, Zaorui Zhao, Junfang Wu, Bogdan Stoica, Alexander D MacKerell, Alan I Faden, Fengtian Xu. Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5. Bioorganic & medicinal chemistry letters. vol 25. issue 11. 2016-02-17. PMID:25937015. |
the potential protective activity of the new compounds was evaluated using nitric oxide (no) production in bv2 microglial cell cultures treated with lipopolysaccharide (lps), and the toxicity of the new compounds tested using a cell viability assay. |
2016-02-17 |
2023-08-13 |
Not clear |
| Stefan Jean-Pierre Haas, Xiaolai Zhou, Venissa Machado, Andreas Wree, Kerstin Krieglstein, Björn Spitta. Expression of Tgfβ1 and Inflammatory Markers in the 6-hydroxydopamine Mouse Model of Parkinson's Disease. Frontiers in molecular neuroscience. vol 9. 2016-02-12. PMID:26869879. |
taken together, the data presented in this study suggest an important role for tgfβ1 as a lesion-associated factor that might be involved in regulating microglia activation states in the 6-ohda mouse model of pd in order to prevent degeneration of uninjured neurons by microglia-mediated release of neurotoxic factors such as tnfα and nitric oxide (no). |
2016-02-12 |
2023-08-13 |
mouse |
| Ping Gan, Li Zhang, Yanke Chen, Yu Zhang, Fali Zhang, Xiang Zhou, Xiaohu Zhang, Bo Gao, Xuechu Zhen, Jian Zhang, Long Tai Zhen. Anti-inflammatory effects of glaucocalyxin B in microglia cells. Journal of pharmacological sciences. vol 128. issue 1. 2016-02-08. PMID:26003084. |
glaucocalyxin b (glb), one of five ent-kauranoid diterpenoids, significantly decreased the generation of nitric oxide (no), tumor necrosis factor (tnf)-α, interleukin (il)-1β, cyclooxygenase (cox)-2 and inducible nitric oxide synthase (inos) in the lipopolysaccharide (lps)-activated microglia cells. |
2016-02-08 |
2023-08-13 |
Not clear |
| Chung Sub Kim, Lalita Subedi, Kyoung Jin Park, Sun Yeou Kim, Sang Un Choi, Ki Hyun Kim, Kang Ro Le. Salicin derivatives from Salix glandulosa and their biological activities. Fitoterapia. vol 106. 2016-02-01. PMID:26344424. |
isolated compounds were evaluated for their nitric oxide (no) inhibitory efficacy in lipopolysaccharide (lps)-activated microglial cell (bv-2). |
2016-02-01 |
2023-08-13 |
Not clear |
| Cheng Wang, Xiaoke Nie, Yan Zhang, Ting Li, Jiamin Mao, Xinhang Liu, Yiyang Gu, Jiyun Shi, Jing Xiao, Chunhua Wan, Qiyun W. Reactive oxygen species mediate nitric oxide production through ERK/JNK MAPK signaling in HAPI microglia after PFOS exposure. Toxicology and applied pharmacology. vol 288. issue 2. 2016-01-13. PMID:26086160. |
reactive oxygen species mediate nitric oxide production through erk/jnk mapk signaling in hapi microglia after pfos exposure. |
2016-01-13 |
2023-08-13 |
rat |
| Roberta De Simone, Maria Antonietta Ajmone-Cat, Manuela Pandolfi, Antonietta Bernardo, Chiara De Nuccio, Luisa Minghetti, Sergio Visenti. The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses. Journal of neurochemistry. vol 135. issue 1. 2016-01-08. PMID:26173855. |
additionally, ucp2-silenced microglia stimulated with lipopolysaccharide showed an enhanced inflammatory response, characterized by a greater production of nitric oxide and interleukin-6. |
2016-01-08 |
2023-08-13 |
human |
| Beilei Lei, Brian Mace, Hana N Dawson, David S Warner, Daniel T Laskowitz, Michael L Jame. Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. PloS one. vol 9. issue 7. 2015-11-13. PMID:25080336. |
as the resident immunomodulatory cells in central nervous system, microglia are activated during acute brain injury and produce inflammatory mediators which contribute to secondary injury including proinflammatory cytokines, and nitric oxide (no) and prostaglandin e2 (pge2), mediated by inducible no synthase (inos) and cyclooxygenase-2 (cox-2), respectively. |
2015-11-13 |
2023-08-13 |
Not clear |
| Azzeme Harun, Sharmili Vidyadaran, Siong Meng Lim, Anthony L J Cole, Kalavathy Ramasam. Malaysian endophytic fungal extracts-induced anti-inflammation in Lipopolysaccharide-activated BV-2 microglia is associated with attenuation of NO production and, IL-6 and TNF-α expression. BMC complementary and alternative medicine. vol 15. 2015-11-05. PMID:26047814. |
excessive production of inflammatory mediators such as nitric oxide (no) and proinflammatory cytokines like tumour necrosis factor-alpha (tnf-α) from activated microglia contributes to uncontrolled inflammation in neurodegenerative diseases. |
2015-11-05 |
2023-08-13 |
Not clear |
| Ana I Rojo, Gethin McBean, Marina Cindric, Javier Egea, Manuela G López, Patricia Rada, Neven Zarkovic, Antonio Cuadrad. Redox control of microglial function: molecular mechanisms and functional significance. Antioxidants & redox signaling. vol 21. issue 12. 2015-10-26. PMID:24597893. |
then, we consider the production of reactive oxygen and nitrogen species by nadph oxidases and nitric oxide synthases and the new findings that also indicate an essential role of glutathione (γ-glutamyl-l-cysteinylglycine) in redox homeostasis of microglia. |
2015-10-26 |
2023-08-12 |
Not clear |
| Songela Chen, Haiyue Zhang, Hongjian Pu, Guohua Wang, Wenjin Li, Rehana K Leak, Jun Chen, Anthony K Liou, Xiaoming H. n-3 PUFA supplementation benefits microglial responses to myelin pathology. Scientific reports. vol 4. 2015-10-09. PMID:25500548. |
docosahexaenoic acid (dha) and eicosapentaenoic acid (epa), the two main forms of n-3 pufas in the brain, inhibited the release of nitric oxide and tumor necrosis factor-α from primary microglia upon ifn-γ and myelin stimulation. |
2015-10-09 |
2023-08-13 |
mouse |
| Dong-Cheol Kim, Hee-Suk Lee, Wonmin Ko, Dong-Sung Lee, Jae Hak Sohn, Joung Han Yim, Youn-Chul Kim, Hyuncheol O. Anti-inflammatory effect of methylpenicinoline from a marine isolate of Penicillium sp. (SF-5995): inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced RAW264.7 macrophages and BV2 microglia. Molecules (Basel, Switzerland). vol 19. issue 11. 2015-10-05. PMID:25379644. |
compound 1 inhibited lipopolysaccharide (lps)-stimulated nitric oxide (no) production by suppressing the expression of inducible no synthase (inos) in raw264.7 macrophages and bv2 microglia. |
2015-10-05 |
2023-08-13 |
Not clear |
| Jeffrey L Dupree, Paul E Polak, Kenneth Hensley, Dale Pelligrino, Douglas L Feinstei. Lanthionine ketimine ester provides benefit in a mouse model of multiple sclerosis. Journal of neurochemistry. vol 134. issue 2. 2015-09-14. PMID:25846048. |
lk ethyl-ester (lke) is a cell-permeable synthetic derivative that promotes neurogenesis, suppresses nitric oxide production from microglia, and reduces neurotoxicity of microglia-conditioned medium. |
2015-09-14 |
2023-08-13 |
mouse |
| Brandon R Selfridge, Xiaohui Wang, Yingning Zhang, Hang Yin, Peter M Grace, Linda R Watkins, Arthur E Jacobson, Kenner C Ric. Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. Journal of medicinal chemistry. vol 58. issue 12. 2015-09-14. PMID:26010811. |
we designed and synthesized compounds based on (+)-naltrexone and (+)-noroxymorphone and evaluated their tlr4 antagonist activities by their effects on inhibiting lipopolysaccharide (lps) induced tlr4 downstream nitric oxide (no) production in microglia bv-2 cells. |
2015-09-14 |
2023-08-13 |
rat |