| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaolai Zhou, Tanja Zöller, Kerstin Krieglstein, Björn Spitta. TGFβ1 inhibits IFNγ-mediated microglia activation and protects mDA neurons from IFNγ-driven neurotoxicity. Journal of neurochemistry. vol 134. issue 1. 2015-09-09. PMID:25827682. |
transforming growth factor β1 (tgfβ1) is able to inhibit the ifnγ-mediated activation of microglia, which is characterized by the release of nitric oxide (no) and tumor necrosis factor α (tnfα). |
2015-09-09 |
2023-08-13 |
Not clear |
| Neeranjini Nallathamby, Lee Guan-Serm, Sharmili Vidyadaran, Sri Nurestri Abd Malek, Jegadeesh Raman, Vikineswary Sabaratna. Ergosterol of Cordyceps militaris Attenuates LPS Induced Inflammation in BV2 Microglia Cells. Natural product communications. vol 10. issue 6. 2015-08-21. PMID:26197508. |
different solvent extracts of cordyceps militaris stroma powder were tested for cell viability and inhibition of nitric oxide (no) production in lipopolysaccharide (lps) triggered bv2 microglia cells. |
2015-08-21 |
2023-08-13 |
Not clear |
| Rommy von Bernhardi, Laura Eugenín-von Bernhardi, Jaime Eugení. Microglial cell dysregulation in brain aging and neurodegeneration. Frontiers in aging neuroscience. vol 7. 2015-08-10. PMID:26257642. |
whereas lps increases nitric oxide (no) secretion in microglia from young mice, induction of reactive oxygen species (ros) predominates in older mice. |
2015-08-10 |
2023-08-13 |
mouse |
| Guijae Yoo, Seon Ju Park, Taek Hwan Lee, Heejung Yang, Yoon-Su Baek, Nanyoung Kim, Yoon Jae Kim, Seung Hyun Ki. Flavonoids isolated from Lespedeza cuneata G. Don and their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV-2 microglia cells. Pharmacognosy magazine. vol 11. issue 43. 2015-08-06. PMID:26246745. |
flavonoids isolated from lespedeza cuneata g. don and their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated bv-2 microglia cells. |
2015-08-06 |
2023-08-13 |
Not clear |
| Wei-Yi Ong, Tahira Farooqui, Hwee-Ling Koh, Akhlaq A Farooqui, Eng-Ang Lin. Protective effects of ginseng on neurological disorders. Frontiers in aging neuroscience. vol 7. 2015-08-03. PMID:26236231. |
this is followed by molecular mechanisms of effects of ginseng on the brain, including glutamatergic transmission, monoamine transmission, estrogen signaling, nitric oxide (no) production, the keap1/nrf2 adaptive cellular stress pathway, neuronal survival, apoptosis, neural stem cells and neuroregeneration, microglia, astrocytes, oligodendrocytes and cerebral microvessels. |
2015-08-03 |
2023-08-13 |
Not clear |
| Wenjing Cheng, Yunhong Li, Xiaolin Hou, Bin Bai, Fan Li, Feijia Ding, Jiao Ma, Nan Zhang, Ying Shen, Yin Wan. Determining the neuroprotective effects of dextromethorphan in lipopolysaccharide‑stimulated BV2 microglia. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25351178. |
results from elisa assay demonstrated that dm reduced the release of hsp60, nitric oxide (no), inducible no synthase, tumor necrosis factor‑α, interleukin (il)‑1β and il‑6 induced by lps in bv2 microglia. |
2015-07-30 |
2023-08-13 |
mouse |
| Soon Min, Sandeep Vasant More, Ju-Young Park, Sae-Bom Jeon, Shin Young Park, Eun-Jung Park, Sung-Hwa Yoon, Dong-Kug Cho. EOP, a newly synthesized ethyl pyruvate derivative, attenuates the production of inflammatory mediators via p38, ERK and NF-κB pathways in lipopolysaccharide-activated BV-2 microglial cells. Molecules (Basel, Switzerland). vol 19. issue 12. 2015-07-27. PMID:25429561. |
in this study, we synthesized a novel ethyl pyruvate derivative, named eop (s-ethyl 2-oxopropanethioate) and studied its effects on lipopolysaccharide (lps)-induced production of nitric oxide (no) in rat primary microglia and mouse bv-2 microglia. |
2015-07-27 |
2023-08-13 |
mouse |
| M Ohnishi, A Monda, R Takemoto, Y Matsuoka, C Kitamura, K Ohashi, H Shibuya, A Inou. Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage. Neuroscience. vol 232. 2015-07-14. PMID:23228810. |
sesamin (30-100 μm) suppressed thrombin-induced nitric oxide (no) production by primary-cultured rat microglia via inhibition of inducible no synthase (inos) protein expression, independently of the antioxidative effect. |
2015-07-14 |
2023-08-12 |
rat |
| Danijela Savic, Mirjana Stojiljkovic, Irena Lavrnja, Ana Parabucki, Ivana Bjelobaba, Nadezda Nedeljkovic, Thomas Herdegen, Sanja Pekovi. Ribavirin shows immunomodulatory effects on activated microglia. Immunopharmacology and immunotoxicology. vol 36. issue 6. 2015-07-13. PMID:25393884. |
rbv potency to down-regulate microglia inflammatory response was assessed by measuring microglia cell body size, and the production of nitric oxide (no) and pro- and anti-inflammatory cytokines. |
2015-07-13 |
2023-08-13 |
Not clear |
| Junghyung Park, Ju-Sik Min, Bokyung Kim, Un-Bin Chae, Jong Won Yun, Myung-Sook Choi, Il-Keun Kong, Kyu-Tae Chang, Dong-Seok Le. Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways. Neuroscience letters. vol 584. 2015-07-06. PMID:25459294. |
activation of microglia cells in the brain contributes to neurodegenerative processes promoted by many neurotoxic factors such as pro-inflammatory cytokines and nitric oxide (no). |
2015-07-06 |
2023-08-13 |
Not clear |
| Ki Hyun Kim, Eunjung Moon, Sang Keun Ha, Won Se Suh, Ho Kyung Kim, Sun Yeou Kim, Sang Un Choi, Kang Ro Le. Bioactive lignan constituents from the twigs of Lindera glauca. Chemical & pharmaceutical bulletin. vol 62. issue 11. 2015-06-29. PMID:25366316. |
based on the understanding that inflammation is a crucial cause of tumor progression, we also investigated the anti-inflammatory activities of the isolates (1-6) in the lipopolysaccharide-stimulated murine microglia bv-2 cell line by measuring nitric oxide (no) levels. |
2015-06-29 |
2023-08-13 |
human |
| Ana Sierra, Julio Navascués, Miguel A Cuadros, Ruth Calvente, David Martín-Oliva, Rosa M Ferrer-Martín, María Martín-Estebané, María-Carmen Carrasco, José L Marín-Tev. Expression of inducible nitric oxide synthase (iNOS) in microglia of the developing quail retina. PloS one. vol 9. issue 8. 2015-06-26. PMID:25170849. |
inducible nitric oxide synthase (inos), which produce large amounts of nitric oxide (no), is induced in macrophages and microglia in response to inflammatory mediators such as lps and cytokines. |
2015-06-26 |
2023-08-13 |
Not clear |
| Yonghui Lu, Mindi He, Yang Zhang, Shangcheng Xu, Lei Zhang, Yue He, Chunhai Chen, Chuan Liu, Huifeng Pi, Zhengping Yu, Zhou Zho. Differential pro-inflammatory responses of astrocytes and microglia involve STAT3 activation in response to 1800 MHz radiofrequency fields. PloS one. vol 9. issue 9. 2015-06-10. PMID:25275372. |
however, rf exposure induced differential pro-inflammatory responses in astrocytes and microglia, characterized by different expression and release profiles of il-1β, tnf-α, il-6, pge2, nitric oxide (no), inducible nitric oxide synthase (inos) and cyclooxygenase 2 (cox2). |
2015-06-10 |
2023-08-13 |
Not clear |
| Liang-Yu Wu, Xiu-Qi Bao, Hong-Yan Pang, Hua Sun, Dan Zhan. FLZ attenuates learning and memory deficits via suppressing neuroinflammation induced by LPS in mice. Journal of Asian natural products research. vol 17. issue 3. 2015-06-09. PMID:25621771. |
mechanistic studies revealed that the neuroprotective effects of flz were due to the suppression of neuroinflammation induced by lps, as indicated by inactivation of astrocytes and microglia, reduced production of tumor necrosis factor-α, interleukin-1β, and nitric oxide, as well as decreased expression of cyclooxygenase-2 and inducible nitric oxide synthase. |
2015-06-09 |
2023-08-13 |
mouse |
| Tiziana Persichini, Roberta Mastrantonio, Silvia Del Matto, Letizia Palomba, Orazio Cantoni, Marco Colasant. The role of arachidonic acid in the regulation of nitric oxide synthase isoforms by HIV gp120 protein in astroglial cells. Free radical biology & medicine. vol 74. 2015-06-01. PMID:24953535. |
excessive amounts of nitric oxide (no), as produced by inducible no synthase (inos) upon exposure of activated microglia and astrocytes to cytokines and/or viral proteins (e.g., hiv tat and gp120), are assumed to contribute to neuronal abnormalities in hand. |
2015-06-01 |
2023-08-13 |
human |
| Wenjing Cheng, Yunhong Li, Xiaolin Hou, Nan Zhang, Jiao Ma, Feijia Ding, Fan Li, Zhenhua Miao, Yanli Zhang, Qi Qi, Guanghua Li, Ying Shen, Juan Liu, Weidong Huang, Yin Wan. HSP60 is involved in the neuroprotective effects of naloxone. Molecular medicine reports. vol 10. issue 4. 2015-05-22. PMID:25051048. |
data from the present study demonstrated that naloxone reduced the expression levels of nf-κb and its upstream protein caspase‑3, and reduced the lps-induced production of nitric oxide, inducible nitric oxide synthase, tumor necrosis factor α, interleukin-1β and interleukin-6 in bv2 microglia. |
2015-05-22 |
2023-08-13 |
Not clear |
| Seok Yong Kang, Hyo Won Jung, Mi-Young Lee, Hye Won Lee, Seong Wook Chae, Yong-Ki Par. Effect of the semen extract of Cuscuta chinensis on inflammatory responses in LPS-stimulated BV-2 microglia. Chinese journal of natural medicines. vol 12. issue 8. 2015-05-12. PMID:25156282. |
(cuscutae semen; cs) on the production of inflammatory mediators, nitric oxide (no), prostaglandin 2 (pge2), and proinflammatory cytokines in lipopolysaccharide (lps)-stimulated bv-2 microglia. |
2015-05-12 |
2023-08-13 |
Not clear |
| Céline Rivière, Stéphanie Krisa, Laurent Péchamat, Merian Nassra, Jean-Claude Delaunay, Axel Marchal, Alain Badoc, Pierre Waffo-Téguo, Jean-Michel Mérillo. Polyphenols from the stems of Morus alba and their inhibitory activity against nitric oxide production by lipopolysaccharide-activated microglia. Fitoterapia. vol 97. 2015-04-21. PMID:24912117. |
polyphenols from the stems of morus alba and their inhibitory activity against nitric oxide production by lipopolysaccharide-activated microglia. |
2015-04-21 |
2023-08-13 |
Not clear |
| Qing-Bo Liu, Xiao-Xiao Huang, Ming Bai, Xiao-Bing Chang, Xin-Jia Yan, Tao Zhu, Wei Zhao, Ying Peng, Shao-Jiang Son. Antioxidant and anti-inflammatory active dihydrobenzofuran neolignans from the seeds of Prunus tomentosa. Journal of agricultural and food chemistry. vol 62. issue 31. 2015-04-13. PMID:25019337. |
moreover, compounds 7 and 11 exhibited much stronger inhibitory activity on nitric oxide (no) production in murine microglia bv-2 compared with positive control minocycline (ic50 = 19.7 ± 1.5 μm). |
2015-04-13 |
2023-08-13 |
Not clear |
| Ki Hyun Kim, Kyeong Wan Woo, Eunjung Moon, Sang Un Choi, Sun Yeou Kim, Sang Zin Choi, Mi Won Son, Kang Ro Le. Identification of antitumor lignans from the seeds of morning glory (Pharbitis nil). Journal of agricultural and food chemistry. vol 62. issue 31. 2015-04-13. PMID:25020073. |
pharbilignan c (3) strongly inhibited nitric oxide (no) production in the lipopolysaccharide (lps)-activated bv-2 microglia cell line with an ic50 value of 12.8 μm. |
2015-04-13 |
2023-08-13 |
human |