| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomohiro Matsui, Hiroyuki Kida, Takuya Iha, Tabito Obara, Sadahiro Nomura, Tatsuya Fujimiya, Michiyasu Suzuk. Effects of hypothermia on ex vivo microglial production of pro- and anti-inflammatory cytokines and nitric oxide in hypoxic-ischemic brain-injured mice. Folia neuropathologica. vol 52. issue 2. 2015-04-06. PMID:25118900. |
activated microglia produce neurotoxic factors, including pro-inflammatory cytokines and nitric oxide (no), in response to neuronal destruction. |
2015-04-06 |
2023-08-13 |
mouse |
| Di Hu, Na Han, Xuechun Yao, Zhihui Liu, Yu Wang, Jingyu Yang, Jun Yi. Structure-activity relationship study of dibenzocyclooctadiene lignans isolated from Schisandra chinensis on lipopolysaccharide-induced microglia activation. Planta medica. vol 80. issue 8-9. 2015-03-30. PMID:24963616. |
to explore the relationship of the dibenzocyclooctadiene lignans from schisandra chinensis to their anti-inflammatory activities, series of dibenzocyclooctadiene lignans were isolated and assessed by testing their inhibitory effects on nitric oxide production in lipopolysaccharide-induced bv2 mouse microglia. |
2015-03-30 |
2023-08-13 |
mouse |
| Li Tao, Fali Zhang, Lili Hao, Jing Wu, Jia Jia, Jiang-yun Liu, Long Tai Zheng, Xuechu Zhe. 1-O-tigloyl-1-O-deacetyl-nimbolinin B inhibits LPS-stimulated inflammatory responses by suppressing NF-κB and JNK activation in microglia cells. Journal of pharmacological sciences. vol 125. issue 4. 2015-03-30. PMID:25018136. |
our study indicated that 1-o-tigloyl-1-o-deacetyl-nimbolinin b (tnb) markedly suppressed the production of nitric oxide (no) and tumor necrosis factor (tnf)-α in lps-stimulated microglia cells. |
2015-03-30 |
2023-08-13 |
Not clear |
| Clara Quintas, Diana Pinho, Clara Pereira, Lucília Saraiva, Jorge Gonçalves, Glória Queiro. Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. Journal of neuroinflammation. vol 11. 2015-03-30. PMID:25178395. |
microglia p2y₆ receptors mediate nitric oxide release and astrocyte apoptosis. |
2015-03-30 |
2023-08-13 |
Not clear |
| Dong-Sung Lee, Gil-Saeng Jeon. Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity. European journal of pharmacology. vol 728. 2015-03-02. PMID:24485892. |
compound (1) inhibited the protein expression of inducible nitric oxide synthase (inos), inos-derived nitric oxide (no), cyclooxygenase (cox)-2, and cox-2-derived prostaglandin e2 (pge2) in lipopolysaccharide (lps)-stimulated mouse bv2 microglia. |
2015-03-02 |
2023-08-12 |
mouse |
| A Y Lai, C D Dibal, G A Armitage, I R Winship, K G Tod. Distinct activation profiles in microglia of different ages: a systematic study in isolated embryonic to aged microglial cultures. Neuroscience. vol 254. 2015-02-23. PMID:24042036. |
upon activation by atp, neo microglia were the most reactive, upregulating nitric oxide, tumor necrosis factor-α, and brain-derived neurotrophic factor release as well as glu uptake. |
2015-02-23 |
2023-08-12 |
rat |
| Hu-Nan Sun, Mei-Hua Jin, Bing Han, Li Feng, Ying-Hao Han, Gui-Nan Shen, Yong-Zhong Yu, Cheng-Hao Jin, Zheng-Xing Lian, Dong-Soek Lee, Sun-Uk Kim, Wen-Zhong Ge, Yu-Dong Cu. 16α,17α-Epoxypregnenolone-20-oxime prevent LPS-induced NO production and iNOS expression in BV-2 microglial cells by inhibiting JNK phosphorylation. Biological & pharmaceutical bulletin. vol 37. issue 7. 2015-02-21. PMID:24989001. |
the free radical nitric oxide (no), a main member of neuroinflammatory cytokine and a gaseous molecule produced by activated microglia, has many physiological functions, including neuroinflammation. |
2015-02-21 |
2023-08-13 |
Not clear |
| Minho Moon, Jin Gyu Choi, Sun Yeou Kim, Myung Sook O. Bombycis excrementum reduces amyloid-β oligomer-induced memory impairments, neurodegeneration, and neuroinflammation in mice. Journal of Alzheimer's disease : JAD. vol 41. issue 2. 2015-02-09. PMID:24898636. |
furthermore, be significantly attenuated the release of nitric oxide from microglia and reduced aβo-induced s100-β cytokine release from activated astrocytes. |
2015-02-09 |
2023-08-13 |
mouse |
| Seong-Mook Kang, Sandeep Vasant More, Ju-Young Park, Byung-Wook Kim, Park Jeong In, Sung-Hwa Yoon, Dong-Kug Cho. A novel synthetic HTB derivative, BECT inhibits lipopolysaccharide-mediated inflammatory response by suppressing the p38 MAPK/JNK and NF-κB activation pathways. Pharmacological reports : PR. vol 66. issue 3. 2015-02-09. PMID:24905526. |
activated microglia cells are well recognized as mediators of neuroinflammation, as they release nitric oxide and pro-inflammatory cytokines in various neuroinflammatory diseases. |
2015-02-09 |
2023-08-13 |
Not clear |
| Sam Joshva Baskar Jesudasan, Kathryn G Todd, Ian R Winshi. Reduced inflammatory phenotype in microglia derived from neonatal rat spinal cord versus brain. PloS one. vol 9. issue 6. 2015-01-29. PMID:24914808. |
our results demonstrate that spinal microglia assume a less inflammatory phenotype after lps activation, with reduced release of the inflammatory effectors tumor necrosis factor alpha, interleukin-1 beta, and nitric oxide, a less amoeboid morphology, and reduced phagocytosis relative to brain-derived microglia. |
2015-01-29 |
2023-08-13 |
rat |
| Kyong Nyon Nam, Kyoo-Pil Kim, Ki-Ho Cho, Woo-Sang Jung, Jung-Mi Park, Seung-Yeon Cho, Su-Kyung Park, Tae-Hoon Park, Young-Suk Kim, Eunjoo H Le. Prevention of inflammation-mediated neurotoxicity by butylidenephthalide and its role in microglial activation. Cell biochemistry and function. vol 31. issue 8. 2015-01-28. PMID:23400915. |
in rat brain microglia, bp significantly inhibited the lipopolysaccharide (lps)-induced production of nitric oxide (no), tumour necrosis factor-α and interleukin-1β. |
2015-01-28 |
2023-08-12 |
rat |
| Hirokazu Hara, Ryoko Ikeda, Masayuki Ninomiya, Tetsuro Kamiya, Mamoru Koketsu, Tetsuo Adach. Newly synthesized 'hidabeni' chalcone derivatives potently suppress LPS-induced NO production via inhibition of STAT1, but not NF-κB, JNK, and p38, pathways in microglia. Biological & pharmaceutical bulletin. vol 37. issue 6. 2015-01-20. PMID:24882415. |
we previously found that chalcone glycosides from brassica rapa l. 'hidabeni' suppress lipopolysaccharide (lps)-induced nitric oxide (no) production in rat microglia highly aggressively proliferating immortalized (hapi) cells. |
2015-01-20 |
2023-08-13 |
rat |
| Dong-Sung Lee, Wonmin Ko, Chi-Su Yoon, Dong-Cheol Kim, Jinju Yun, Jun-Kyung Lee, Ki-Young Jun, Ilhong Son, Dong-Woung Kim, Bong-Keun Song, Seulah Choi, Jun-Hyeog Jang, Hyuncheol Oh, Sungchul Kim, Youn-Chul Ki. KCHO-1, a Novel Antineuroinflammatory Agent, Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglia Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-12. PMID:25580149. |
kcho-1 inhibited the protein expression of inducible nitric oxide synthase (inos), inos-derived nitric oxide (no), cyclooxygenase- (cox-) 2, and cox-2-derived prostaglandin e2 (pge2) in lps-stimulated bv2 microglia. |
2015-01-12 |
2023-08-13 |
mouse |
| Tomohiro Matsui, Yusuke Yoshida, Masashi Yanagihara, Hiromi Suenag. Hypothermia at 35 °C reduces the time-dependent microglial production of pro-inflammatory and anti-inflammatory factors that mediate neuronal cell death. Neurocritical care. vol 20. issue 2. 2014-12-23. PMID:24072458. |
here we studied whether hypothermic culture at 35 °c had the same effects on the decrease of time-dependent expression of tumor necrosis factor (tnf)-α, interleukin (il)-10, and nitric oxide (no) by stimuli-activated microglia as that at 33 °c, as determined in our previous reports, and whether these factors directly induced neuronal cell death. |
2014-12-23 |
2023-08-12 |
Not clear |
| Hannah Scheiblich, Frank Roloff, Vikramjeet Singh, Martin Stangel, Michael Stern, Gerd Bicke. Nitric oxide/cyclic GMP signaling regulates motility of a microglial cell line and primary microglia in vitro. Brain research. vol 1564. 2014-12-09. PMID:24713349. |
activated microglia generate large amounts of the highly reactive messenger molecule nitric oxide (no). |
2014-12-09 |
2023-08-13 |
Not clear |
| Yutaka Nakagawa, Kenji Chib. Role of microglial m1/m2 polarization in relapse and remission of psychiatric disorders and diseases. Pharmaceuticals (Basel, Switzerland). vol 7. issue 12. 2014-11-28. PMID:25429645. |
m1 polarized microglia can produce pro-inflammatory cytokines, reactive oxygen species, and nitric oxide, suggesting that these molecules contribute to dysfunction of neural network in the cns. |
2014-11-28 |
2023-08-13 |
Not clear |
| Takuji Ito, Kenji Yoshida, Takayuki Negishi, Masayasu Miyajima, Hyota Takamatsu, Hitoshi Kikutani, Atsushi Kumanogoh, Kazunori Yukaw. Plexin-A1 is required for Toll-like receptor-mediated microglial activation in the development of lipopolysaccharide-induced encephalopathy. International journal of molecular medicine. vol 33. issue 5. 2014-11-26. PMID:24604454. |
in wt, but not in the plexin-a1-/- primary microglia treated with lps, sema3a induced significantly more nitric oxide production than in the immunoglobulin g control. |
2014-11-26 |
2023-08-12 |
mouse |
| Ke-Wu Zeng, Shu Wang, Xin Dong, Yong Jiang, Peng-Fei T. Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 3. 2014-11-25. PMID:24055519. |
our findings showed that dsf-52 inhibited the production of nitric oxide (no), prostaglandin e2 (pge2), tumor necrosis factor-α (tnf-α), as well as mrna expression of inducible nitric oxide synthase (inos), cyclooxygenase 2 (cox-2), interleukin-1β (il-1β), granulocyte-macrophage colony-stimulating factor (gm-csf) and macrophage inflammatory protein-1α (mip-1α) in lps-activated bv-2 microglia. |
2014-11-25 |
2023-08-12 |
Not clear |
| Verónica Valero-Esquitino, Kristin Lucht, Pawel Namsolleck, Florianne Monnet-Tschudi, Tobias Stubbe, Franziska Lucht, Meng Liu, Friederike Ebner, Christine Brandt, Leon A Danyel, Daniel C Villela, Ludovit Paulis, Christa Thoene-Reineke, Björn Dahlöf, Anders Hallberg, Thomas Unger, Colin Sumners, U Muscha Steckeling. Direct angiotensin type 2 receptor (AT2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice. Clinical science (London, England : 1979). vol 128. issue 2. 2014-11-25. PMID:25052203. |
cytokine synthesis and nitric oxide production by microglia in vitro were significantly reduced after c21 treatment. |
2014-11-25 |
2023-08-13 |
mouse |
| Xing-Mei Zhang, Harald Lund, Sohel Mia, Roham Parsa, Robert A Harri. Adoptive transfer of cytokine-induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice. Glia. vol 62. issue 5. 2014-11-24. PMID:24677019. |
m2 microglia were characterized by decreased expression or production of cd86, pd-l1, nitric oxide, and il-6, increased expression of pd-l2, and having a potent capacity to retain their phenotype on secondary proinflammatory stimulation. |
2014-11-24 |
2023-08-12 |
mouse |