| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mina Lee, Seung Hyun Kim, Hee Kyoung Lee, Yekyung Cho, Jimmy Kang, Sang Hyun Sun. ent-kaurane and ent-pimarane diterpenes from Siegesbeckia pubescens inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglia. Biological & pharmaceutical bulletin. vol 37. issue 1. 2014-08-26. PMID:24389489. |
among these compounds, compounds 2-9 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in bv2 microglia. |
2014-08-26 |
2023-08-12 |
Not clear |
| Wenjiao Tai, Xuan Ye, Xiuqi Bao, Baozhong Zhao, Xiaoliang Wang, Dan Zhan. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Neuropharmacology. vol 75. 2014-08-19. PMID:23916477. |
in vitro mechanistic study revealed that the inhibitive effect of flz on microglia was mediated by suppressing src kinase related inflammatory signaling pathway activation and subsequent nf-κbp65 nuclear translocation, inhibiting nitric oxide (no) and reactive oxygen species (ros) production, decreasing nicotinamide adenine dinucleotide phosphate (nadph) oxidase activation. |
2014-08-19 |
2023-08-12 |
rat |
| Jian Zhou, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Yan Li, Xiu-Qi Bao, Xiao-Guang Chen, Dan Zhang, Dong-Ming Zhan. Lupane triterpenoids from the stems of Euonymus carnosus. Journal of natural products. vol 77. issue 2. 2014-08-07. PMID:24467317. |
in addition, the compounds were tested for their cytotoxic activity against five human cancer cell lines and their ability to inhibit lps-induced nitric oxide production in the murine microglia bv2 cell line. |
2014-08-07 |
2023-08-12 |
human |
| Amanda N Carey, Derek R Fisher, Agnes M Rimando, Stacey M Gomes, Donna F Bielinski, Barbara Shukitt-Hal. Stilbenes and anthocyanins reduce stress signaling in BV-2 mouse microglia. Journal of agricultural and food chemistry. vol 61. issue 25. 2014-06-27. PMID:23731018. |
microglia that were pretreated with blueberry extract (0.25, 0.5, 1, 2 mg/ml) or its components (1, 10, 20, 30 μm pterostilbene, resveratrol, delphinidin-3-o-glucoside, or malvidin-3-o-glucoside) prior to exposure to lipopolysaccharide (100 ng/ml) demonstrated concentration-dependent reductions in nitric oxide and tumor necrosis factor-alpha release and decreased expression of inducible nitric oxide synthase and cyclooxygenase-2. |
2014-06-27 |
2023-08-12 |
mouse |
| K S Dhami, M A Churchward, G B Baker, K G Tod. Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult. Molecular and cellular neurosciences. vol 56. 2014-06-20. PMID:23876875. |
of the antidepressants tested, most decreased the release of the proinflammatory factors nitric oxide, tumor necrosis factor-alpha, and interleukin 1-beta from activated microglia. |
2014-06-20 |
2023-08-12 |
Not clear |
| Juan A Orellana, Trinidad D Montero, Rommy von Bernhard. Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: involvement of ATP released via pannexin 1 channels. Glia. vol 61. issue 12. 2014-06-20. PMID:24123492. |
under inflammatory conditions, microglia exhibit increased levels of free intracellular ca(2+) and produce high amounts of nitric oxide (no). |
2014-06-20 |
2023-08-12 |
Not clear |
| Dorit Trudler, Orly Weinreb, Silvia A Mandel, Moussa B H Youdim, Dan Frenke. DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24355073. |
furthermore, we discovered that dj-1-deficient microglia had increased monoamine oxidase activity that resulted in elevation of intracellular reactive oxygen species and nitric oxide leading to increased dopaminergic neurotoxicity. |
2014-06-04 |
2023-08-12 |
Not clear |
| Sandra M Rocha, Joel Pires, Marta Esteves, Baltazar Graça, Liliana Bernardin. Histamine: a new immunomodulatory player in the neuron-glia crosstalk. Frontiers in cellular neuroscience. vol 8. 2014-05-12. PMID:24817841. |
we first show that histamine modulates the release of inflammatory mediators, namely nitric oxide, by microglia cells. |
2014-05-12 |
2023-08-13 |
Not clear |
| Takahito Miyake, Hisashi Shirakawa, Ayaka Kusano, Shinya Sakimoto, Masakazu Konno, Takayuki Nakagawa, Yasuo Mori, Shuji Kanek. TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia. Biochemical and biophysical research communications. vol 444. issue 2. 2014-04-30. PMID:24462864. |
trpm2 contributes to lps/ifnγ-induced production of nitric oxide via the p38/jnk pathway in microglia. |
2014-04-30 |
2023-08-12 |
mouse |
| Takahito Miyake, Hisashi Shirakawa, Ayaka Kusano, Shinya Sakimoto, Masakazu Konno, Takayuki Nakagawa, Yasuo Mori, Shuji Kanek. TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia. Biochemical and biophysical research communications. vol 444. issue 2. 2014-04-30. PMID:24462864. |
however, in some pathological conditions, microglia can produce neurotoxic factors such as pro-inflammatory cytokines and nitric oxide (no) that lead to neuronal degeneration. |
2014-04-30 |
2023-08-12 |
mouse |
| Sun Young Park, Se Jin Park, Tae Gyeong Park, Seetharaman Rajasekar, Sang-Joon Lee, Young-Whan Cho. Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia. International immunopharmacology. vol 17. issue 2. 2014-04-22. PMID:23859871. |
in microglia, schizandrin c significantly inhibited lipoteichoic acid (lta)-stimulated pro-inflammatory cytokines and chemokines, prostaglandin e2 (pge2), nitric oxide (no), and reactive oxygen species (ros) production, and inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and matrix metallopeptidase-9 (mmp-9) protein expressions. |
2014-04-22 |
2023-08-12 |
Not clear |
| Nattinee Jantaratnotai, Pongsak Utaisincharoen, Pimtip Sanvarinda, Anusorn Thampithak, Yupin Sanvarind. Phytoestrogens mediated anti-inflammatory effect through suppression of IRF-1 and pSTAT1 expressions in lipopolysaccharide-activated microglia. International immunopharmacology. vol 17. issue 2. 2014-04-22. PMID:23938252. |
in the current study, we report that the soy phytoestrogens, genistein, daidzein, and coumestrol, decreased nitric oxide (no) production induced by lipopolysaccharide (lps) in the rat microglial cell line (hapi). |
2014-04-22 |
2023-08-12 |
rat |
| Akio Muramoto, Shiro Imagama, Takamitsu Natori, Norimitsu Wakao, Kei Ando, Ryoji Tauchi, Kenichi Hirano, Ryuichi Shinjo, Tomohiro Matsumoto, Naoki Ishiguro, Kenji Kadomats. Midkine overcomes neurite outgrowth inhibition of chondroitin sulfate proteoglycan without glial activation and promotes functional recovery after spinal cord injury. Neuroscience letters. vol 550. 2014-04-11. PMID:23811026. |
moreover, we found that mk activated neither astrocytes nor microglia as evaluated by morphological changes and cell proliferation or nitric oxide production. |
2014-04-11 |
2023-08-12 |
rat |
| Jin-A Shin, Ji-Sun Hwang, Song-Yi Kim, Sei-Kwan Oh, Ghilsoo Nam, Inn-Oc Ha. A novel glucosamine derivative exerts anti-inflammatory actions via inhibition of nuclear factor-kappaB. Neuroscience letters. vol 550. 2014-04-11. PMID:23831355. |
in the present study, we show that the novel glucosamine derivative, 2-deoxy-2-[(o-methylbenzylidene)]-β-glucopyranoside (nk-4), significantly reduced lps-induced production of nitric oxide (no) in bv2 microglia, raw264.7 macrophage, and primary cultured peritoneal macrophages cells. |
2014-04-11 |
2023-08-12 |
mouse |
| Shin Hwa Lee, Jun Hyuk Lee, Eun Young Oh, Gi-Young Kim, Byung Tae Choi, Cheolmin Kim, Yung Hyun Cho. Ethanol extract of Cnidium officinale exhibits anti-inflammatory effects in BV2 microglial cells by suppressing NF-κB nuclear translocation and the activation of the PI3K/Akt signaling pathway. International journal of molecular medicine. vol 32. issue 4. 2014-03-27. PMID:23864034. |
in this study, we investigated the inhibitory effects of an ethanol extract of cnidium officinale rhizomes (eeco), which has been used as a herbal drug in oriental medicine, on the production of lipopolysaccharide (lps)-induced pro-inflammatory mediators, such as nitric oxide (no) and prostaglandin e₂ (pge₂), as well as that of pro-inflammatory cytokines in bv2 microglia cells. |
2014-03-27 |
2023-08-12 |
Not clear |
| E P Azevedo, J H Ledo, G Barbosa, M Sobrinho, L Diniz, A C C Fonseca, F Gomes, L Romão, F R S Lima, F L Palhano, S T Ferreira, D Fogue. Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis. Cell death & disease. vol 4. 2014-03-12. PMID:24008733. |
here, we show that amyloid fibrils formed by a mutant form of ttr, a25t, activate microglia, leading to the secretion of tumor necrosis factor-α (tnf-α), interleukin-6 (il-6) and nitric oxide. |
2014-03-12 |
2023-08-12 |
mouse |
| MinJeong Kim, Yong-Xin Li, Pradeep Dewapriya, BoMi Ryu, Se-Kwon Ki. Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia. BMB reports. vol 46. issue 8. 2014-03-11. PMID:23977987. |
the results show that floridoside has the ability to suppress pro-inflammatory responses in microglia by markedly inhibiting the production of nitric oxide (no) and reactive oxygen species (ros). |
2014-03-11 |
2023-08-12 |
Not clear |
| G Jean Harr. Microglia during development and aging. Pharmacology & therapeutics. vol 139. issue 3. 2014-03-05. PMID:23644076. |
upon activation, microglia cells have the capacity to release a number of substances, e.g., cytokines, chemokines, nitric oxide, and reactive oxygen species, which could be detrimental or beneficial to the surrounding cells. |
2014-03-05 |
2023-08-12 |
Not clear |
| Sandeep Vasant More, Hemant Kumar, In Su Kim, Soo-Yeol Song, Dong-Kug Cho. Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's disease. Mediators of inflammation. vol 2013. 2014-02-26. PMID:23935251. |
although microglia forms the first line of defense for the neural parenchyma, uncontrolled activation of microglia may directly affect neurons by releasing various molecular mediators such as inflammatory cytokines (tumor necrosis factor- α , interleukin [il]-6, and il-1 β ), nitric oxide, prostaglandin e2, and reactive oxygen and nitrogen species. |
2014-02-26 |
2023-08-12 |
Not clear |
| Merian Nassra, Stéphanie Krisa, Yorgos Papastamoulis, Gilbert Deccaux Kapche, Jonathan Bisson, Caroline André, Jan-Pieter Konsman, Jean-Marie Schmitter, Jean-Michel Mérillon, Pierre Waffo-Tégu. Inhibitory activity of plant stilbenoids against nitric oxide production by lipopolysaccharide-activated microglia. Planta medica. vol 79. issue 11. 2014-02-11. PMID:23807809. |
inhibitory activity of plant stilbenoids against nitric oxide production by lipopolysaccharide-activated microglia. |
2014-02-11 |
2023-08-12 |
Not clear |