| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wesley H Godfrey, Soonmyung Hwang, Kaho Cho, Shruthi Shanmukha, Payam Gharibani, Efrat Abramson, Michael Davin Kornber. Therapeutic potential of blocking GAPDH nitrosylation with CGP3466b in experimental autoimmune encephalomyelitis. Frontiers in neurology. vol 13. 2023-02-10. PMID:36761918. |
nitric oxide (no) generated by cns macrophages and microglia contributes to neuroaxonal injury in all phases of ms, but candidate therapies that prevent no-mediated injury have not been identified. |
2023-02-10 |
2023-08-14 |
mouse |
| Philipp Jordan, Amanda Costa, Edgar Specker, Oliver Popp, Andrea Volkamer, Regina Piske, Tessa Obrusnik, Sabrina Kleissle, Kevin Stuke, Andre Rex, Martin Neuenschwander, Jens Peter von Kries, Marc Nazare, Phillip Mertins, Helmut Kettenmann, Susanne A Wol. Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation. PloS one. vol 18. issue 2. 2023-02-06. PMID:36745631. |
microglia are the immune effector cells of the central nervous system (cns) and react to pathologic events with a complex process including the release of nitric oxide (no). |
2023-02-06 |
2023-08-14 |
Not clear |
| Takahito Maki, Masahito Sawahata, Daisuke Uta, Kazuhiro Irie, Toshiaki Kum. Chronic Treatment with Aβ42 with a Toxic Conformer and LPS Induces Inflammatory Responses in BV-2 Microglia with Dysregulation of Hypoxia-Inducible Factor Expression. Biological & pharmaceutical bulletin. vol 46. issue 2. 2023-02-01. PMID:36724966. |
chronic treatment with e22p-aβ42 and lps increased nitric oxide production and the expression of interleukin-6 (il-6), whereas it reduced the expression of hif-1α and hif-3α in bv-2 microglia. |
2023-02-01 |
2023-08-14 |
mouse |
| Sopana Jamornwan, Tanida Chokpanuwat, Kwanchanok Uppakara, Thanet Laorob, Uthai Wichai, Pimonrat Ketsawatsomkron, Witchuda Saengsawan. Nitro Capsaicin Suppressed Microglial Activation and TNF-α-Induced Brain Microvascular Endothelial Cell Damage. Biomedicines. vol 10. issue 11. 2022-11-11. PMID:36359200. |
using the sima9 microglia cell line, we found that nitro capsaicin reduced nitric oxide (no) production in lps-activated microglia better than its parent compound, capsaicin. |
2022-11-11 |
2023-08-14 |
Not clear |
| Nattinee Jantaratnotai, Anusorn Thampithak, Pongsak Utaisincharoen, Darawan Pinthong, Pimtip Sanvarind. Inhibition of LPS-Induced Microglial Activation by the Ethyl Acetate Extract of International journal of environmental research and public health. vol 19. issue 19. 2022-10-14. PMID:36232220. |
proinflammatory substances overproduced by activated microglia, such as cytokines, chemokines, reactive oxygen species, and nitric oxide (no), can result in neuroinflammation that further exacerbates the course of the diseases. |
2022-10-14 |
2023-08-14 |
Not clear |
| Alexander P Young, Eileen M Denovan-Wrigh. The microglial endocannabinoid system is similarly regulated by lipopolysaccharide and interferon gamma. Journal of neuroimmunology. vol 372. 2022-09-23. PMID:36150252. |
furthermore, we demonstrate that the efficacy of different synthetic cannabinoid treatments with respect to inhibition of microglia nitric oxide release is dependent on the concentration and type of pro-inflammatory stimuli presented to the microglia. |
2022-09-23 |
2023-08-14 |
Not clear |
| Shuailong Li, Isa Wernersbach, Gregory S Harms, Michael K E Schäfe. Microglia subtypes show substrate- and time-dependent phagocytosis preferences and phenotype plasticity. Frontiers in immunology. vol 13. 2022-09-15. PMID:36105813. |
to study these issues, primary murine glial cultures were cultivated in the presence of serum, different growth factors and cytokines to obtain m0-like, m1-like, and m2-like microglia as confirmed by morphology, m1/m2 gene marker expression, and nitric oxide assay. |
2022-09-15 |
2023-08-14 |
Not clear |
| Elif Çınar, Banu Cahide Tel, Gürdal Şahi. Neuroinflammation in Parkinson's Disease and its Treatment Opportunities. Balkan medical journal. 2022-08-29. PMID:36036436. |
microglia become overactive in response to chronic inflammation, which is observed in pd and causes excessive cytotoxic factor production, such as reactive oxidase, nitric oxide (no), and tumor necrosis factor-alpha. |
2022-08-29 |
2023-08-14 |
Not clear |
| Lijun Huang, Leiqiang Gong, Xueyan Huo, Lirong Lei, Qi Zhang, Yunjie Hu, Qixuan Kuang, Yu Gui, Yifei Dai, Yucheng Gu, Yun Deng, Dong Wang, Dale Gu. N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways. Acta biochimica et biophysica Sinica. 2022-08-26. PMID:36017888. |
nitric oxide (no) detection, reactive oxygen species (ros) detection and enzyme-linked immunosorbent assay (elisa) results show that nadd attenuates inflammatory signals and proinflammatory cytokines in lps-stimulated bv-2 microglia, including no, ros, tumor necrosis factor (tnf)-α, interleukin (il)-1β and interleukin-6 (il-6). |
2022-08-26 |
2023-08-14 |
Not clear |
| Tingting Guo, Wen Dang, Yaping Zhou, Di Zhou, Qingqi Meng, Libin Xu, Gang Chen, Bin Lin, Degang Qing, Yu Sun, Yue Hou, Ning L. Sesquiterpene coumarins isolated from Ferula bungeana and their anti-neuroinflammatory activities. Bioorganic chemistry. vol 128. 2022-08-23. PMID:35998519. |
the in vitro anti-neuroinflammatory activity assay showed that compounds 2 and 9 showed stronger inhibitory effect on nitric oxide (no) production in lipopolysaccharide (lps)-induced bv-2 microglia, compared with positive control minocycline, and compounds 5 and 10 showed moderate inhibitory effects. |
2022-08-23 |
2023-08-14 |
Not clear |
| Sujata Thakur, Rishika Dhapola, Phulen Sarma, Bikash Medhi, Dibbanti HariKrishna Redd. Neuroinflammation in Alzheimer's Disease: Current Progress in Molecular Signaling and Therapeutics. Inflammation. 2022-08-20. PMID:35986874. |
numerous pathways like nfκb, p38 mapk, akt/mtor, caspase, nitric oxide, and cox are involved in triggering brain immune cells like astrocytes and microglia to secrete inflammatory cytokines such as tumor necrosis factor, interleukins, and chemokines and participate in alzheimer's disease pathology. |
2022-08-20 |
2023-08-14 |
Not clear |
| Rebekah L Mokry, Benjamin S O'Brien, Jacob W Adelman, Suzette Rosas, Megan L Schumacher, Allison D Ebert, Scott S Terhun. Nitric Oxide Attenuates Human Cytomegalovirus Infection yet Disrupts Neural Cell Differentiation and Tissue Organization. Journal of virology. 2022-07-21. PMID:35862705. |
congenitally infected fetal brains show regions of brain damage, including necrotic foci with infiltrating macrophages and microglia, cell types that produce nitric oxide during infection. |
2022-07-21 |
2023-08-14 |
human |
| Jinqiang Zhang, Dapeng Su, Qin Liu, Qingsong Yuan, Zhen Ouyang, Yuan Wei, Chenghong Xiao, Liangyuan Li, Changgui Yang, Weike Jiang, Lanping Guo, Tao Zho. Gasdermin D-mediated microglial pyroptosis exacerbates neurotoxicity of aflatoxins B1 and M1 in mouse primary microglia and neuronal cultures. Neurotoxicology. 2022-06-18. PMID:35716928. |
blockade of gasdermin d activity in afb1- or afm1-treated primary microglia using dimethyl fumarate (dmf) reduced the release of il-1β, il-18 and nitric oxide, as well as the neurotoxicity of microglia-conditioned medium to neurons, astrocytes, oligodendrocytes and neural stem/precursor cells. |
2022-06-18 |
2023-08-14 |
mouse |
| Abdur Rauf, Himani Badoni, Tareq Abu-Izneid, Ahmed Olatunde, Md Mominur Rahman, Sakshi Painuli, Prabhakar Semwal, Polrat Wilairatana, Mohammad S Mubara. Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630670. |
entry of any foreign pathogen activates the glial cells (astrocytes and microglia) and overactivation of these cells triggers the release of various neuroinflammatory markers (nms), such as the tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), interleukin-1β (il-10), nitric oxide (no), and cyclooxygenase-2 (cox-2), among others. |
2022-05-28 |
2023-08-13 |
Not clear |
| Amira A Sallam, Mohammed A El-Magd, Mona M Ahmed, Heba I Ghamry, Mohammad Y Alshahrani, Rabab A Hegazy, Ahmed Magdy, Magdy F Abou El-Foto. Quercetin alleviated multi-walled carbon nanotubes-induced neurotoxicity in mice through inhibition of oxidation, inflammation, and pyroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-23. PMID:35605300. |
however, treatment with que ameliorated mwcnts-induced neurotoxicity as revealed by 1) elevated acetylcholinesterase (ache) activity, 2) reduced lipid peroxidation biomarker malondialdehyde (mda), 3) improved antioxidant status as indicated by increased levels of reduced glutathione (gsh) and activities of superoxide dismutase (sod), catalase (cat), as well as upregulated expression of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1) genes, 4) decreased levels and expression of inflammatory biomarkers [nitric oxide (no), interleukin 1 beta (il1ß), tumor necrosis factor-alpha (tnfα), and nuclear factor kappa b (nf-κb)], 5) downregulated expression of pyroptosis-related genes [nod-like receptor protein inflammasome 3 (nlrp3) and caspase 1 (casp1)] but with no effect on the apoptotic casp3 gene, 6) minimized axonal degeneration and number of microglia in the cerebral medulla, and 7) diminished the number of degenerated neurons in hippocampus and cerebellum. |
2022-05-23 |
2023-08-13 |
mouse |
| Kimberly Barber, Patricia Mendonca, Karam F Solima. Cardamonin Antioxidant Effects Through the Modulation of Proteins and Genes Expressions in LPS-Activated BV-2 Microglial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35559544. |
continuous activation of microglia cells, known as the resident, innate immune cells in the brain, participates in producing numerous neurotoxic factors, including nitric oxide and reactive oxygen species (ros), which induce neurodegeneration. |
2022-05-13 |
2023-08-13 |
cat |
| Jamal Ahmad Ansari, Shubhendra K Mishra, Rajib K Dey, Opalina Roy, Shaivya Kushwaha, Vikas Singh, Satyakam Patnaik, Debabrata Ghos. Minocycline reverses developmental arsenic exposure-induced microglia activation and functional alteration in BALB/c mice. Environmental toxicology and pharmacology. 2022-03-30. PMID:35351628. |
primary microglial were isolated (ex vivo microglia) from experimental animals and used to measure reactive oxygen species (ros), nitric oxide (no), cytokine production and phagocytosis. |
2022-03-30 |
2023-08-13 |
mouse |
| Anne-Marie Howe, Sinéad Burke, Marcella E O'Reilly, Fiona C McGillicuddy, Derek A Costell. Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages. Molecular neurobiology. 2022-01-26. PMID:35079937. |
using the tlr2 agonist lipoteichoic acid (lta), we report that pre-exposure to either palmitic acid (pa) or oleic acid (oa) attenuated cytokine secretion from microglia, but heightened sensitivity to nitric oxide (no) production. |
2022-01-26 |
2023-08-13 |
Not clear |
| Anna Starinets, Anna Tyrtyshnaia, Yulia Kipryushina, Igor Manzhul. Analgesic Activity of Synaptamide in a Rat Sciatic Nerve Chronic Constriction Injury Model. Cells, tissues, organs. 2021-12-14. PMID:34510045. |
further, synaptamide suppressed the cci-induced increase in the activity of microglia (13.1 ± 0.5% in cci+syn, compared to 15.3 ± 0.7% in the cci group) and the number of nitric oxide synthase-positive neurons (58,307 ± 5,206 cells/mm3 in cci+syn, compared to 80,288 ± 4,287 cells/mm3 in the cci group) in the dorsal horns of the spinal cord, and also reduced the concentration of interleukin 1 beta in the spinal cord (169.3 ± 4 pg/mg of protein in cci+syn, compared to 236.9 ± 9.3 pg/mg of protein in cci group) 35 days after surgery. |
2021-12-14 |
2023-08-15 |
rat |
| Yingjie Wang, Gang Chen, Qingqi Meng, Xiaohu Yao, Yang Li, Honglin Cao, Bin Lin, Yue Hou, Di Zhou, Ning L. Potential inhibitors of microglial activation from the roots of Vernicia montana Lour. Phytochemistry. vol 194. 2021-12-09. PMID:34826794. |
during our continuous investigation of natural, herbal inhibitors of microglial over-activation in the euphorbiaceae family, two plants of the vernicia genus showed remarkable inhibitory effects on nitric oxide (no) production in over-activated microglia. |
2021-12-09 |
2023-08-13 |
Not clear |