Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Xuesen Yang, Genlin He, Yutong Hao, Chunhai Chen, Maoquan Li, Yuan Wang, Guangbin Zhang, Zhengping Y. The role of the JAK2-STAT3 pathway in pro-inflammatory responses of EMF-stimulated N9 microglial cells. Journal of neuroinflammation. vol 7. 2010-12-06. PMID:20828402. |
our previous studies have shown that exposure to electromagnetic fields (emf) activates cultured microglia to produce tumor necrosis factor (tnf)-α and nitric oxide (no) through signal transduction involving the activator of transcription stat3. |
2010-12-06 |
2023-08-12 |
Not clear |
Ya-Fang He, Hui-Jin Chen, Long-Hua Qian, Guan-Yi Che. [Effect of 1400W, an inhibitor of inducible nitric oxide synthetase, on blocking the toxicity of lipopolysaccharide-induced activated microglia to preoligodendrocytes]. Zhonghua er ke za zhi = Chinese journal of pediatrics. vol 47. issue 7. 2010-12-02. PMID:19951519. |
[effect of 1400w, an inhibitor of inducible nitric oxide synthetase, on blocking the toxicity of lipopolysaccharide-induced activated microglia to preoligodendrocytes]. |
2010-12-02 |
2023-08-12 |
Not clear |
Ya-Fang He, Hui-Jin Chen, Long-Hua Qian, Guan-Yi Che. [Effect of 1400W, an inhibitor of inducible nitric oxide synthetase, on blocking the toxicity of lipopolysaccharide-induced activated microglia to preoligodendrocytes]. Zhonghua er ke za zhi = Chinese journal of pediatrics. vol 47. issue 7. 2010-12-02. PMID:19951519. |
to explore the toxicity of lps-induced activated microglia to preoligodendrocytes (preols) and the effect of 1400w, a selective inhibitor of inducible nitric oxide synthetase (inos), on the blockage of the toxicity. |
2010-12-02 |
2023-08-12 |
Not clear |
Eun-A Kim, Hanwook Kim, Jee-Yin Ahn, Hoh-Gyu Hahn, Key-Sun Kim, Tae Ue Kim, Sung-Woo Ch. Suppression of lipopolysaccharide-induced microglial activation by a benzothiazole derivative. Molecules and cells. vol 30. issue 1. 2010-11-22. PMID:20652495. |
specifically, khg21834 induces significant reductions in the lipopolysaccharide-induced activation of microglia and production of proinflammatory mediators such as tumor necrosis factor-alpha, interlukin-1beta, nitric oxide, and inducible nitric oxide synthase. |
2010-11-22 |
2023-08-12 |
Not clear |
Heehong Hwang, Shinrye Lee, Won-Ha Lee, Ho-Jae Lee, Kyoungho Su. Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20162721. |
using bv-2 mouse microglia cells and mouse primary microglia cultures, we have demonstrated that 1) both gitr and gitrl are expressed in microglia cells; 2) stimulation of gitrl induces inflammatory activation of microglia on the basis of production of nitric oxide (no) and expression of inducible nitric oxide synthase, cyclooxygenase-2, cd40, and matrix metalloproteinase-9; 3) gitrl-mediated microglial no production partially depends on p38 mapk, jnk, and nuclear factor-kappab pathways; and 4) gitrl stimulation also induces microglia cell death. |
2010-10-26 |
2023-08-12 |
mouse |
Jing Ding, Qin-Ying Li, Xin Wang, Chang-Hai Sun, Chuan-Zhen Lu, Bao-Guo Xia. Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20882700. |
further immunohistochemical analysis and cytokine determination revealed that fasudil inhibited inducible nitric oxide synthase immunoreactivity in microglia and pro-inflammatory factors in brain tissue after h/r, which is consistent with the observation wherein fasudil reduced the pro-inflammatory factors nitric oxide, il-1β, il-6 and tnf-, and increased anti-inflammatory factor il-10 in cultured microglia under normoxic or hypoxic conditions. |
2010-10-19 |
2023-08-12 |
mouse |
Yasuhiro Yoshioka, Nobuo Takeda, Akiko Yamamuro, Atsushi Kasai, Sadaaki Maed. Nitric oxide inhibits lipopolysaccharide-induced inducible nitric oxide synthase expression and its own production through the cGMP signaling pathway in murine microglia BV-2 cells. Journal of pharmacological sciences. vol 113. issue 2. 2010-09-23. PMID:20484865. |
nitric oxide inhibits lipopolysaccharide-induced inducible nitric oxide synthase expression and its own production through the cgmp signaling pathway in murine microglia bv-2 cells. |
2010-09-23 |
2023-08-12 |
Not clear |
Jiyeon Ock, Su Hyung Hong, Kyoungho Su. Identification of KT-15073 as an inhibitor of lipopolysaccharide-induced microglial activation. Biological & pharmaceutical bulletin. vol 33. issue 3. 2010-09-20. PMID:20190410. |
activated microglia produce various proinflammatory cytokines and nitric oxide (no) that are toxic to neurons. |
2010-09-20 |
2023-08-12 |
Not clear |
Bin Xing, Tao Xin, Lingling Zhao, Randy L Hunter, Yan Chen, Guoying Bin. Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity. Journal of neuroimmunology. vol 225. issue 1-2. 2010-09-16. PMID:20471698. |
aberrant microglia activation causes dopaminergic neuronal loss and nitric oxide produced by microglia plays a critical role in dopaminergic neuronal degeneration. |
2010-09-16 |
2023-08-12 |
Not clear |
Bin Xing, Tao Xin, Lingling Zhao, Randy L Hunter, Yan Chen, Guoying Bin. Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity. Journal of neuroimmunology. vol 225. issue 1-2. 2010-09-16. PMID:20471698. |
we report that gdnf not only reduces lipopolysaccharide-induced degeneration of dopaminergic neurons, suppresses microglia activation and nitric oxide generation, but also reverses the inhibition of phosphoinositide 3-kinase (pi3k) in dopaminergic neurons and microglia. |
2010-09-16 |
2023-08-12 |
Not clear |
Bin Xing, Tao Xin, Lingling Zhao, Randy L Hunter, Yan Chen, Guoying Bin. Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity. Journal of neuroimmunology. vol 225. issue 1-2. 2010-09-16. PMID:20471698. |
it suggests that the neuroprotective effect of gdnf on dopaminergic neurons may be related to its suppression of microglia activation-mediated nitric oxide via releasing the inhibition of pi3k in both neurons and microglia. |
2010-09-16 |
2023-08-12 |
Not clear |
Eliza Hutter, Sebastien Boridy, Simon Labrecque, Melanie Lalancette-Hébert, Jasna Kriz, Françoise M Winnik, Dusica Maysinge. Microglial response to gold nanoparticles. ACS nano. vol 4. issue 5. 2010-09-07. PMID:20329742. |
analysis by dark-field microscopy and by two-photon-induced luminescence (tpl) indicates that the exposure of neural cells to gnps resulted in (i) gnp internalization by both microglial cells and primary hippocampal neurons, as revealed by dark-field microscopy and by two-photon-induced luminescence (tpl), (ii) transient toll-like receptor 2 (tlr-2) up-regulation in the olfactory bulb, after intranasal administration in transgenic mice, in vivo, in real time, and (iii) differential up-regulation in vitro of tlr-2 together with interleukin 1 alpha (il-1alpha), granulocyte macrophage colony-stimulating factor (gm-csf) and nitric oxide (no) in microglia. |
2010-09-07 |
2023-08-12 |
mouse |
Ke-Wu Zeng, Hong Fu, Geng-Xin Liu, Xue-Mei Wan. Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-kappaB and JNK/p38 MAPK pathways. International immunopharmacology. vol 10. issue 6. 2010-09-03. PMID:20347053. |
here, we reported the discovery that icariin significantly inhibited the release of nitric oxide (no), prostaglandin e (pge)-2, reactive oxygen species (ros) and mrna expression of proinflammatory cytokines such as tumor necrosis factor (tnf)-alpha, interleukin (il)-1beta and il-6 in lipopolysaccharide (lps)-activated microglia. |
2010-09-03 |
2023-08-12 |
Not clear |
Payam Dibaj, Fabien Nadrigny, Heinz Steffens, Anja Scheller, Johannes Hirrlinger, Eike D Schomburg, Clemens Neusch, Frank Kirchhof. NO mediates microglial response to acute spinal cord injury under ATP control in vivo. Glia. vol 58. issue 9. 2010-08-26. PMID:20468054. |
by investigating acute lesions of spinal cord white matter in anesthetized mice with fluorescently labeled microglia and axons using in vivo two-photon laser-scanning microscopy (2p-lsm), we identified the messenger nitric oxide (no) as a modulator of injury-activated microglia. |
2010-08-26 |
2023-08-12 |
mouse |
Tomohiro Matsui, Camilla I Svensson, Yuka Hirata, Kanae Mizobata, Xiao-Ying Hua, Tony L Yaks. Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. Anesthesia and analgesia. vol 111. issue 2. 2010-08-26. PMID:20610553. |
release of prostaglandin e(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. |
2010-08-26 |
2023-08-12 |
rat |
Shao-Xia Wang, Li-Min Hu, Xiu-Mei Gao, Hong Guo, Guan-Wei Fa. Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuroprotective effect. Neurochemical research. vol 35. issue 7. 2010-08-20. PMID:20238162. |
our results showed that sal b significantly reduced the production of nitric oxide (no), tumor necrosis factor-alpha (tnf-alpha), interleukin-1beta (il-1beta) and reactive oxygen species (ros) induced by lipopolysaccharide (lps) treatment in rat primary microglia in a dose-dependent manner. |
2010-08-20 |
2023-08-12 |
rat |
Birgit Kraus, Horst Wolff, Erich F Elstner, Jörg Heilman. Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages. Naunyn-Schmiedeberg's archives of pharmacology. vol 381. issue 6. 2010-08-16. PMID:20369228. |
upon activation, microglia, the immunocompetent cells in the brain, get highly phagocytic and release pro-inflammatory mediators like nitric oxide (no). |
2010-08-16 |
2023-08-12 |
mouse |
Yan-Qiu Cui, Li-Juan Zhang, Ting Zhang, Ding-Zhen Luo, Yan-Jun Jia, Zi-Xuan Guo, Quan-Bin Zhang, Xuan Wang, Xiao-Min Wan. Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia. Clinical and experimental pharmacology & physiology. vol 37. issue 4. 2010-08-06. PMID:19843098. |
inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia. |
2010-08-06 |
2023-08-12 |
Not clear |
Chung-Kwe Wang, Lih-Geeng Chen, Chi-Luan Wen, Wen-Chi Hou, Ling-Fang Hung, Shish-Jung Yen, Yi-Jyun Shen, Shyr-Yi Lin, Yu-Chih Lian. Neuroprotective activity of Vitis thunbergii var. taiwaniana extracts in vitro and in vivo. Journal of medicinal food. vol 13. issue 1. 2010-08-05. PMID:20136452. |
in this study, we found that the branch and leaf ethanol extracts of vtt significantly inhibited the inducible nitric oxide (no) synthase protein expression and no production in bv2 microglia. |
2010-08-05 |
2023-08-12 |
Not clear |
Jaegyu Hwang, Heehong Hwang, Ho-Won Lee, Kyoungho Su. Microglia signaling as a target of donepezil. Neuropharmacology. vol 58. issue 7. 2010-07-19. PMID:20153342. |
our conclusion is based on the measurement of nitric oxide and proinflammatory mediators using purified microglia cultures and microglia cell lines: donepezil attenuated microglial production of nitric oxide and tumor necrosis factor (tnf)-alpha, and suppressed the gene expression of inducible nitric oxide synthase, interleukin-1 beta, and tnf-alpha. |
2010-07-19 |
2023-08-12 |
Not clear |