| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling-Chu Chang, Lo-Ti Tsao, Chi-Sen Chang, Chun-Jung Chen, Li-Jiau Huang, Sheng-Chu Kuo, Ruey-Hseng Lin, Jih-Pyang Wan. Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in microglia. Biochemical pharmacology. vol 76. issue 4. 2008-09-05. PMID:18586011. |
inhibition of nitric oxide production by the carbazole compound lcy-2-cho via blockade of activator protein-1 and ccaat/enhancer-binding protein activation in microglia. |
2008-09-05 |
2023-08-12 |
rat |
| Ling-Chu Chang, Lo-Ti Tsao, Chi-Sen Chang, Chun-Jung Chen, Li-Jiau Huang, Sheng-Chu Kuo, Ruey-Hseng Lin, Jih-Pyang Wan. Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in microglia. Biochemical pharmacology. vol 76. issue 4. 2008-09-05. PMID:18586011. |
excessive nitric oxide (no) production by activated microglia plays a critical role in neurodegenerative disorders. |
2008-09-05 |
2023-08-12 |
rat |
| Hui-Ming Gao, Paul T Kotzbauer, Kunihiro Uryu, Susan Leight, John Q Trojanowski, Virginia M-Y Le. Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 30. 2008-09-02. PMID:18650345. |
these data suggest that nitric oxide and superoxide released by activated microglia may be mediators that link inflammation and abnormal syn in mechanisms of pd neurodegeneration. |
2008-09-02 |
2023-08-12 |
mouse |
| Hyo Jin Lim, Hyun-Sun Lee, Jae-Ha Ry. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression by tussilagone from Farfarae flos in BV-2 microglial cells. Archives of pharmacal research. vol 31. issue 5. 2008-08-22. PMID:18481023. |
activated microglia produce diverse neurotoxic factors such as nitric oxide (no) and prostaglandin e(2) (pge(2)) that may cause neurodegenerative diseases, including alzheimer's disease and parkinson's disease. |
2008-08-22 |
2023-08-12 |
Not clear |
| Kirubakaran Shanmugam, Lina Holmquist, Megan Steele, Grant Stuchbury, Katrin Berbaum, Oliver Schulz, Obdulio Benavente García, Julián Castillo, Jim Burnell, Vernon Garcia Rivas, Geoff Dobson, Gerald Münc. Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages. Molecular nutrition & food research. vol 52. issue 4. 2008-08-06. PMID:18186104. |
plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages. |
2008-08-06 |
2023-08-12 |
Not clear |
| Xiao-dong Pan, Xiao-chun Chen, Yuan-gui Zhu, Jing Zhang, Tian-wen Huang, Li-min Chen, Qin-yong Ye, Hua-pin Huan. Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia. Biochemical pharmacology. vol 76. issue 3. 2008-08-04. PMID:18602088. |
in the lps-stimulated microglia, the production of tumor necrosis factor-alpha (tnf-alpha), interleukin-1beta (il-1beta), nitric oxide (no), prostaglandin e(2) (pge(2)), and intracellular superoxide anion (soa) was markedly attenuated by tripchlorolide at a dose of 1.25-10 nm in a dose-dependent manner. |
2008-08-04 |
2023-08-12 |
Not clear |
| Akiko Motoyoshi, Hidemitsu Nakajima, Katsura Takano, Mitsuaki Moriyama, Yukiko Kannan, Yoichi Nakamur. Effects of Amphotericin B on the expression of neurotoxic and neurotrophic factors in cultured microglia. Neurochemistry international. vol 52. issue 6. 2008-07-28. PMID:18328601. |
we found that amb, similarly as lipopolysaccharide (lps), could activate microglia to produce nitric oxide via inducible nitric oxide synthase. |
2008-07-28 |
2023-08-12 |
rat |
| Seon-Joo Kwon, Tae-Beom Ahn, Min-Yung Yoon, Beom S Jeo. BV-2 stimulation by lactacystin results in a strong inflammatory reaction and apoptotic neuronal death in SH-SY5Y cells. Brain research. vol 1205. 2008-07-22. PMID:18353281. |
lactacystin treatment increased the amount of nitric oxide and tumor necrosis factor alpha (tnf-alpha) in culture media containing murine microglia (bv-2). |
2008-07-22 |
2023-08-12 |
human |
| Tiina M Kauppinen, Youichirou Higashi, Sang Won Suh, Carole Escartin, Kazuki Nagasawa, Raymond A Swanso. Zinc triggers microglial activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 22. 2008-07-01. PMID:18509044. |
cultured mouse microglia exposed to 15-30 microm zinc increased nitric oxide production, increased f4/80 expression, altered cytokine expression, and assumed the activated morphology. |
2008-07-01 |
2023-08-12 |
mouse |
| Pil-Jae Kong, Hee Jae Lee, Sang-Hyun Lee, Su Young Kim, Su Nam Lee, Wan-Joo Chun, Sung-Soo Ki. c-Jun N-terminal kinase and p38 mitogen-activated protein kinase mediate double-strand RNA-induced inducible nitric oxide synthase expression in microglial cells. Neuroscience letters. vol 433. issue 3. 2008-06-30. PMID:18258363. |
nitric oxide production was increased after exposure of microglia to 50mug/ml dsrna. |
2008-06-30 |
2023-08-12 |
Not clear |
| Eiko K de Jong, Alexander H de Haas, Nieske Brouwer, Hilmar R J van Weering, Marjolein Hensens, Ingo Bechmann, Pierre Pratley, Evelyn Wesseling, Hendrikus W G M Boddeke, Knut Bibe. Expression of CXCL4 in microglia in vitro and in vivo and its possible signaling through CXCR3. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18248618. |
cxcl4 furthermore attenuates lipopolysaccharide-induced microglial phagocytosis and nitric oxide production in microglia and bv-2 cells. |
2008-06-12 |
2023-08-12 |
Not clear |
| Jeong Hoon Yoon, Hyo Jin Lim, Hwa Jin Lee, Hee-Doo Kim, Raok Jeon, Jae-Ha Ry. Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium. Bioorganic & medicinal chemistry letters. vol 18. issue 6. 2008-06-09. PMID:18276135. |
three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (ic(50) values: 0.47, 11.2, 136.5 microm, respectively). |
2008-06-09 |
2023-08-12 |
Not clear |
| Jae Yeon Kim, Hyo Jin Lim, Jae-Ha Ry. In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. Bioorganic & medicinal chemistry letters. vol 18. issue 4. 2008-05-12. PMID:18178435. |
four flavones, 3,4'-o-dimethylquercetin (1), 3,7-o-dimethylquercetin (2), 3-o-methylquercetin (3) and 3,7,4'-o-trimethylquercetin (4) were isolated as the inhibitors of nitric oxide production in activated microglia (ic(50) values: 11.1, 4.2, 3.8, and 25.1 microm, respectively). |
2008-05-12 |
2023-08-12 |
Not clear |
| Hyo Won Jung, Yoo Sun Chung, Yoon Seong Kim, Yong-Ki Par. Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells. Experimental & molecular medicine. vol 39. issue 6. 2008-05-06. PMID:18160842. |
excessive production of nitric oxide (no) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. |
2008-05-06 |
2023-08-12 |
mouse |
| Min-Chul Seo, Sangseop Kim, Sang-Hyun Kim, Long Tai Zheng, Eui Kyun Park, Won-Ha Lee, Kyoungho Su. Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture. Journal of neuroscience research. vol 86. issue 5. 2008-04-23. PMID:17969104. |
using bv-2 mouse microglial cells and mouse primary microglial cultures, we have demonstrated that (1) collagen induces inflammatory activation of microglia as evidenced by production of nitric oxide, expression of inducible nitric oxide synthase, cox-2, cd40, and matrix metalloproteinase-9; (2) ddr1 is expressed in microglia and is phosphorylated by collagen treatment; and (3) collagen-induced microglial activation is abrogated by ddr1 blockade but not by integrin neutralization. |
2008-04-23 |
2023-08-12 |
mouse |
| J Tangpong, P Sompol, M Vore, W St Clair, D A Butterfield, D K St Clai. Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells. Neuroscience. vol 151. issue 2. 2008-04-15. PMID:18160224. |
together, the results suggest that tnf-alpha activates microglia to produce high levels of tnf-alpha and that production of nitric oxide (no) in neurons is an important factor affecting mnsod nitration and subsequent mitochondrial dysfunction. |
2008-04-15 |
2023-08-12 |
mouse |
| Michio Miyoshi, Kanako Miyano, Naoki Moriyama, Makoto Taniguchi, Tatsuo Watanab. Angiotensin type 1 receptor antagonist inhibits lipopolysaccharide-induced stimulation of rat microglial cells by suppressing nuclear factor kappaB and activator protein-1 activation. The European journal of neuroscience. vol 27. issue 2. 2008-04-08. PMID:18190523. |
using primary microglial cell cultures, we examined whether losartan [ang type 1 receptor (at(1)) antagonist] alters the effects of lps on: the production of interleukin-1 (il-1) and nitric oxide, cell morphology, and nf-kappab and ap-1 activities. |
2008-04-08 |
2023-08-12 |
rat |
| Long Tai Zheng, Jiyeon Ock, Byoung-Mog Kwon, Kyoungho Su. Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. International immunopharmacology. vol 8. issue 3. 2008-04-08. PMID:18279803. |
activated microglia can produce various proinflammatory cytokines and nitric oxide (no), which may exert neurotoxic effects. |
2008-04-08 |
2023-08-12 |
Not clear |
| Vikas Kaushal, Lyanne C Schlichte. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 9. 2008-04-08. PMID:18305255. |
the same microglia neurotoxic behavior was evoked without exposure to ogd-stressed neurons, by directly activating microglial group ii mglurs with (2s,2'r,3'r)-2-(2'3'-dicarboxycyclopropyl) glycine or glutamate, which stimulated production of tnf-alpha (not nitric oxide) and mediated tnf-alpha-dependent neurotoxicity through activation of nf-kappab (not p38 mapk). |
2008-04-08 |
2023-08-12 |
Not clear |
| Seija Lehnardt, Eckart Schott, Thorsten Trimbuch, Dinah Laubisch, Christina Krueger, Gregory Wulczyn, Robert Nitsch, Joerg R Webe. A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 10. 2008-04-07. PMID:18322079. |
hsp60-induced synthesis of neurotoxic nitric oxide by microglia is dependent on tlr4. |
2008-04-07 |
2023-08-12 |
mouse |