| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen D Skaper, Laura Facci, Ainsley A Culbert, Nicholas A Evans, Iain Chessell, John B Davis, Jill C Richardso. P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro. Glia. vol 54. issue 3. 2006-09-28. PMID:16817206. |
the deleterious effects of bzatp-treated microglia were prevented by nonselective p2x antagonists (ppads and oxidized atp) and by the more selective p2x(7) antagonist brilliant blue g. similar concentrations of bzatp caused release of superoxide and nitric oxide from isolated microglia, and neuronal cell injury was attenuated by a superoxide dismutase mimetic and by a peroxynitrite decomposition catalyst, suggesting a role for reactive oxide species. |
2006-09-28 |
2023-08-12 |
mouse |
| Poonlarp Cheepsunthorn, Nootchanat Mairaue, Krongkan Nase. Estrogen enhances the inhibitory effect of iron on microglial nitric oxide production. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 89. issue 6. 2006-09-26. PMID:16850686. |
using a rat microglial cell line (hapi), the present study was designed to address the role of iron for immune function of microglia, in particular, the production of nitric oxide (no) in the presence or absence of estrogen, a potential neuroprotective agent. |
2006-09-26 |
2023-08-12 |
rat |
| Yoon-Jung Kim, So-Young Hwang, Inn-Oc Ha. Insoluble matrix components of glioma cells suppress LPS-mediated iNOS/NO induction in microglia. Biochemical and biophysical research communications. vol 347. issue 3. 2006-09-13. PMID:16843440. |
this study examines the influence of insoluble matrix components of glioma (astrocytoma) cells on lps-mediated inducible nitric oxide (no)/no synthase (inos) induction in microglia cells. |
2006-09-13 |
2023-08-12 |
rat |
| Pedro Garção, Catarina R Oliveira, Paula Agostinh. Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration. Journal of neuroscience research. vol 84. issue 1. 2006-09-08. PMID:16634056. |
our results show that abeta1-40 and prp106-126 caused similar morphological changes in microglia and increased the production of nitric oxide and hydroperoxides. |
2006-09-08 |
2023-08-12 |
rat |
| Jiyeon Ock, Heasuk Lee, Sangseop Kim, Won-Ha Lee, Dong-Kug Choi, Eun Jung Park, Sang-Hyun Kim, In Kyeom Kim, Kyoungho Su. Induction of microglial apoptosis by corticotropin-releasing hormone. Journal of neurochemistry. vol 98. issue 3. 2006-09-08. PMID:16893426. |
crh, however, did not influence nitric oxide production or expression of inflammatory genes including those encoding cytokines and chemokines, indicating that crh did not affect the inflammatory activation of microglia. |
2006-09-08 |
2023-08-12 |
mouse |
| Eun Sook Chung, Byung Kwan Ji. Disialogangliosides induce neurodegeneration in rat mesencephalic cultures. Biochemical and biophysical research communications. vol 346. issue 2. 2006-08-30. PMID:16764823. |
moreover, these gangliosides had little effect on nitric oxide (no) production in mesencephalic or microglia cultures. |
2006-08-30 |
2023-08-12 |
rat |
| K S J Rao, M L Hegde, S Anitha, M Musicco, F A Zucca, N J Turro, L Zecc. Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference. Progress in neurobiology. vol 78. issue 6. 2006-08-24. PMID:16682109. |
for example, both molecules can activate microglia, inducing release of toxic factors such as tumor necrosis factor-alpha (tnf-alpha), interleukin-6 (il-6), and nitric oxide (no). |
2006-08-24 |
2023-08-12 |
Not clear |
| Hannah M Gibbons, Mike Draguno. Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide. Brain research. vol 1084. issue 1. 2006-08-10. PMID:16564033. |
microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide. |
2006-08-10 |
2023-08-12 |
human |
| Hannah M Gibbons, Mike Draguno. Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide. Brain research. vol 1084. issue 1. 2006-08-10. PMID:16564033. |
these results suggest that activated microglia release nitric oxide that is, at least partially, responsible for proximity-dependent microglial-mediated neural toxicity. |
2006-08-10 |
2023-08-12 |
human |
| Mami Noda, Helmut Kettenmann, Keiji Wad. Anti-inflammatory effects of kinins via microglia in the central nervous system. Biological chemistry. vol 387. issue 2. 2006-07-07. PMID:16497148. |
in cultured murine microglia, bradykinin (bk) induces mobilization of intracellular ca2+, microglial migration, and increases the release of nitric oxide and prostaglandin e2. |
2006-07-07 |
2023-08-12 |
Not clear |
| Jongseok Lee, Sooan Shin, Ching-Hao Teng, Suk Jin Hong, Kwang Sik Ki. FimH adhesin of Escherichia coli K1 type 1 fimbriae activates BV-2 microglia. Biochemical and biophysical research communications. vol 334. issue 3. 2006-07-05. PMID:16036224. |
in this study, we showed that fimh adhesin, a tip component of type 1 fimbriae of meningitis-causing escherichia coli k1, activated the murine microglial cell line, bv-2, which resulted in the production of nitric oxide and the release of tumor necrosis factor-alpha. |
2006-07-05 |
2023-08-12 |
Not clear |
| Giuseppe Esposito, Daniele De Filippis, Carla Cirillo, Giovanni Sarnelli, Rosario Cuomo, Teresa Iuvon. The astroglial-derived S100beta protein stimulates the expression of nitric oxide synthase in rodent macrophages through p38 MAP kinase activation. Life sciences. vol 78. issue 23. 2006-05-25. PMID:16376947. |
s100beta is responsible to start up a gliotic reaction by the release of pro-inflammatory mediators, including nitric oxide (no) and cytokines from microglia and astrocytes, which are, in turn, deleterious for neurons. |
2006-05-25 |
2023-08-12 |
rat |
| Yu-Ping Chang, Kuan-Ming Fang, Tsung-I Lee, Shun-Fen Tzen. Regulation of microglial activities by glial cell line derived neurotrophic factor. Journal of cellular biochemistry. vol 97. issue 3. 2006-04-13. PMID:16187294. |
we found that treatment of primary rat microglia with gdnf had no effect on the secretion of the proinflammatory cytokines, tumor necrosis factor-alpha (tnf-alpha) and interleukin-1beta (il-1beta), but it increased the nitric oxide (no) production to some extent. |
2006-04-13 |
2023-08-12 |
mouse |
| M G Vannucchi, L Corsani, M Gianfriddo, F Pedata, M S Faussone-Pellegrin. Expression of neuronal and inducible nitric oxide synthase in neuronal and glial cells after transient occlusion of the middle cerebral artery. Neuroscience. vol 136. issue 4. 2006-04-12. PMID:16216429. |
in conclusion, we demonstrated that a neurotoxic insult such as ischemia can induce neuronal nitric oxide synthase expression in the neurones and that when neuronal nitric oxide synthase-immunoreactive neurones increase in number, microglia activation is less extended, inducible nitric oxide synthase-immunoreactive cells are absent, tissue damage reduced and the rats survive longer. |
2006-04-12 |
2023-08-12 |
rat |
| M G Vannucchi, L Corsani, M Gianfriddo, F Pedata, M S Faussone-Pellegrin. Expression of neuronal and inducible nitric oxide synthase in neuronal and glial cells after transient occlusion of the middle cerebral artery. Neuroscience. vol 136. issue 4. 2006-04-12. PMID:16216429. |
conversely, when there is a significant decrease of neuronal nitric oxide synthase-immunoreactive neurones, microglia cells are intensely activated, inducible nitric oxide synthase-immunoreactive cells appear and the animal survival is shortened. |
2006-04-12 |
2023-08-12 |
rat |
| Jihong Xu, Paul D Dre. 9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes. Journal of neuroimmunology. vol 171. issue 1-2. 2006-03-30. PMID:16303184. |
the studies demonstrated that 9-cis-ra inhibited the production of nitric oxide (no) as well as the pro-inflammatory cytokines tnf-alpha, il-1beta and il-12 p40 by lps-stimulated microglia. |
2006-03-30 |
2023-08-12 |
mouse |
| Pyeongjae Lee, Jinyoung Hur, Jongseok Lee, Jeongmin Kim, Jueun Jeong, Insook Kang, Sun Yeou Kim, Hocheol Ki. 15,16-dihydrotanshinone I suppresses the activation of BV-2 cell, a murine microglia cell line, by lipopolysaccharide. Neurochemistry international. vol 48. issue 1. 2006-03-02. PMID:16298020. |
in this study, we isolated cryptotanshinone and 15,16-dihydrotanshinone i from salvia miltiorrhiza, a traditional korean herb medicine, by bioactivity-guided fractionation based on inhibitory effect on nitric oxide in a lipopolysaccharide-stimulated bv-2 cells, a murine microglial cell line. |
2006-03-02 |
2023-08-12 |
Not clear |
| Jie Zhao, Diane M Brooks, Diana I Luri. Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta. Glia. vol 53. issue 3. 2006-02-22. PMID:16265671. |
lipopolysaccharide-activated shp-1-deficient motheaten microglia release increased nitric oxide, tnf-alpha, and il-1beta. |
2006-02-22 |
2023-08-12 |
mouse |
| Jie Zhao, Diane M Brooks, Diana I Luri. Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta. Glia. vol 53. issue 3. 2006-02-22. PMID:16265671. |
to determine whether abnormally activated microglia contribute to neuronal death in me/me mice, primary microglial cultures from me/me and wild-type mouse cortices were stimulated by the bacterial endotoxin lipopolysaccharide (lps) to evaluate the secretion of the neurotoxic mediators nitric oxide (no), tumor necrosis factor-alpha (tnf-alpha), and interleukin-1beta (il-1beta). |
2006-02-22 |
2023-08-12 |
mouse |
| Christopher B Fordyce, Ravi Jagasia, Xiaoping Zhu, Lyanne C Schlichte. Microglia Kv1.3 channels contribute to their ability to kill neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 31. 2006-02-07. PMID:16079396. |
a major neurotoxic molecule in this model was peroxynitrite, which is formed from superoxide and nitric oxide; thus, it is significant that kv1.3 channel blockers reduced the respiratory burst, but not nitric oxide production, by the activated microglia. |
2006-02-07 |
2023-08-12 |
rat |