| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jui-Ching Chen, Feng-Ming Ho, Pei-Dawn Lee Chao, Chih-Ping Chen, Kee-Ching G Jeng, Hsiu-Bao Hsu, Sho-Tone Lee, Wen Tung Wu, Wan-Wan Li. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. European journal of pharmacology. vol 521. issue 1-3. 2006-01-25. PMID:16171798. |
in the present study, experiments were performed to explore the action of quercetin, the most widely distributed flavonoids, and its major metabolite, quercetin-3'-sulfate, on lipopolysaccharide (lps)- and interferon-gamma (ifn-gamma)-induced nitric oxide (no) production in bv-2 microglia. |
2006-01-25 |
2023-08-12 |
mouse |
| Josep Saura, Ester Angulo, Aroa Ejarque, Vicent Casadó, Josep M Tusell, Rosario Moratalla, Jiang-Fan Chen, Michael A Schwarzschild, Carme Lluis, Rafael Franco, Joan Serratos. Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. Journal of neurochemistry. vol 95. issue 4. 2006-01-20. PMID:16092928. |
adenosine a2a receptor stimulation potentiates nitric oxide release by activated microglia. |
2006-01-20 |
2023-08-12 |
mouse |
| Jin-Sun Park, Moon-Sook Woo, So-Young Kim, Won-Ki Kim, Hee-Sun Ki. Repression of interferon-gamma-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways. Journal of neuroimmunology. vol 168. issue 1-2. 2006-01-17. PMID:16091294. |
we have reported recently that sodium butyrate suppressed ifn-gamma, but not the lps-mediated induction of nitric oxide and tnf-alpha in microglia via the specific inhibition of nf-kappab. |
2006-01-17 |
2023-08-12 |
Not clear |
| S Duport, J Garthwait. Pathological consequences of inducible nitric oxide synthase expression in hippocampal slice cultures. Neuroscience. vol 135. issue 4. 2006-01-11. PMID:16165295. |
the generation of toxic concentrations of nitric oxide by the inducible nitric oxide synthase expressed in microglia and other brain cell types is frequently invoked as a causative factor in neurodegeneration. |
2006-01-11 |
2023-08-12 |
human |
| S Duport, J Garthwait. Pathological consequences of inducible nitric oxide synthase expression in hippocampal slice cultures. Neuroscience. vol 135. issue 4. 2006-01-11. PMID:16165295. |
it is concluded that inducible nitric oxide synthase is expressed in microglia only in response to specific stimuli involving the innate immune system, and that the resulting level of nitric oxide in intact brain tissue is normally too low to inflict damage directly. |
2006-01-11 |
2023-08-12 |
human |
| S Duport, J Garthwait. Pathological consequences of inducible nitric oxide synthase expression in hippocampal slice cultures. Neuroscience. vol 135. issue 4. 2006-01-11. PMID:16165295. |
quantities of nitric oxide sufficient to contribute directly or indirectly to pathology could be produced should the density of microglia become high enough, although caution must be exercised in extrapolating this finding to the human brain in vivo. |
2006-01-11 |
2023-08-12 |
human |
| Adam B Johnson, Farida Sohrabj. Estrogen's effects on central and circulating immune cells vary with reproductive age. Neurobiology of aging. vol 26. issue 10. 2006-01-04. PMID:16243607. |
in young adult-derived microglia, lps treatment also increased nitric oxide (no), which was attenuated by estrogen, and mmp-9, which was not affected by estrogen. |
2006-01-04 |
2023-08-12 |
rat |
| Jung-Bin Kim, Young-Mi Yu, Seung-Woo Kim, Ja-Kyeong Le. Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain research. vol 1060. issue 1-2. 2005-12-20. PMID:16226231. |
the suppression of microglia activation was evidenced by a reduction in nitric oxide release and by a proinflammatory factor induction in primary microglia culture, which were accompanied by the repression of nuclear factor-kappab activation. |
2005-12-20 |
2023-08-12 |
mouse |
| Guorong Li, Gang Cui, Nian-Ssheng Tzeng, Sung-Jen Wei, Tongguang Wang, Michelle L Block, Jau-Shyong Hon. Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 6. 2005-12-14. PMID:15790998. |
both concentrations of dm decreased lps-induced release of nitric oxide, tumor necrosis factor-alpha, prostaglandin e2 and superoxide from microglia in comparable degrees. |
2005-12-14 |
2023-08-12 |
mouse |
| Claudia Rozenfeld, Rodrigo Martinez, Sérgio Seabra, Celso Sant'anna, J Gabriel R Gonçalves, Marcelo Bozza, Vivaldo Moura-Neto, Wanderley De Souz. Toxoplasma gondii prevents neuron degeneration by interferon-gamma-activated microglia in a mechanism involving inhibition of inducible nitric oxide synthase and transforming growth factor-beta1 production by infected microglia. The American journal of pathology. vol 167. issue 4. 2005-11-21. PMID:16192637. |
however, ifn-gamma-activated microglia may cause tissue injury through production of toxic metabolites such as nitric oxide (no), a potent inducer of central nervous system pathologies related to inflammatory neuronal disturbances. |
2005-11-21 |
2023-08-12 |
Not clear |
| Dong-Chan Kim, Sun-Hee Kim, Min-Woo Jeong, Nam-In Baek, Kyong-Tai Ki. Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. Biochemical and biophysical research communications. vol 337. issue 1. 2005-11-14. PMID:16182255. |
pretreatment of microglia cells with rottlerin decreased lps- and taxol-induced nitric oxide production in a concentration-dependent manner (ic50 = 99.1+/-1.5 nm). |
2005-11-14 |
2023-08-12 |
Not clear |
| R L Haynes, O Baud, J Li, H C Kinney, J J Volpe, D R Folkert. Oxidative and nitrative injury in periventricular leukomalacia: a review. Brain pathology (Zurich, Switzerland). vol 15. issue 3. 2005-10-27. PMID:16196389. |
rodent in vitro data further suggest 2 mechanisms of nitric oxide damage: one involving the direct effect of nitric oxide on ol mitochondrial integrity and function, and the other involving an activation of microglia and subsequent release of reactive nitrogen species. |
2005-10-27 |
2023-08-12 |
human |
| Yinghui Zhong, Ravi V Bellamkond. Controlled release of anti-inflammatory agent alpha-MSH from neural implants. Journal of controlled release : official journal of the Controlled Release Society. vol 106. issue 3. 2005-10-21. PMID:15978692. |
the alpha-msh released on day 21 was still bioactive, and successfully inhibited nitric oxide (no) production by lps-stimulated microglia. |
2005-10-21 |
2023-08-12 |
Not clear |
| Takayuki Nagano, Masakazu Osakada, Yukio Ago, Yutaka Koyama, Akemichi Baba, Sadaaki Maeda, Motohiko Takemura, Toshio Matsud. SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia. British journal of pharmacology. vol 144. issue 5. 2005-09-22. PMID:15678087. |
using sea0400, a potent and selective inhibitor of the na+-ca2+ exchanger (ncx), we examined whether ncx is involved in nitric oxide (no)-induced disturbance of endoplasmic reticulum (er) ca2+ homeostasis followed by apoptosis in cultured rat microglia. |
2005-09-22 |
2023-08-12 |
rat |
| Siming Shen, Sue Yu, Joshua Binek, Malgorzata Chalimoniuk, Xiaolin Zhang, Shih-Ching Lo, Mark Hannink, Jinmei Wu, Kevin Fritsche, Rosario Donato, Grace Y Su. Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells. Neurochemistry international. vol 47. issue 4. 2005-09-08. PMID:15955597. |
nitric oxide (no) release upon microglial cell activation has been implicated in the tissue injury and cell death in many neurodegenerative diseases. |
2005-09-08 |
2023-08-12 |
Not clear |
| Sadayuki Hashioka, Akira Monji, Tadashi Ueda, Shigenobu Kanba, Hiroshi Nakanish. Amyloid-beta fibril formation is not necessarily required for microglial activation by the peptides. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:16005113. |
according to in vitro studies, microglia activated by amyloid-beta (abeta) peptides have been reported to damage or kill neurons by the release of neurotoxic molecules such as tumor necrosis factor-alpha (tnf-alpha), interleukin-1beta, nitric oxide or reactive oxygen species. |
2005-09-08 |
2023-08-12 |
Not clear |
| Yuanli Duan, Joseph Panoff, Brian D Burrell, Christie L Sahley, Kenneth J Mulle. Repair and regeneration of functional synaptic connections: cellular and molecular interactions in the leech. Cellular and molecular neurobiology. vol 25. issue 2. 2005-09-01. PMID:16047551. |
in particular, microglia up to 900 microm from the lesion respond within minutes by moving rapidly toward the injury, controlled in part by nitric oxide (no), which is generated immediately at the lesion and acts via a soluble guanylate cyclase (sgc). |
2005-09-01 |
2023-08-12 |
Not clear |
| Andrew Cordle, Gary Landret. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 2. 2005-08-17. PMID:15647473. |
we report that statins robustly inhibited the abeta-stimulated expression of interleukin-1beta and inducible nitric oxide synthase and the production of nitric oxide by microglia and monocytes. |
2005-08-17 |
2023-08-12 |
Not clear |
| Xiu Li Bi, Jing Yu Yang, Ying Xu Dong, Ji Ming Wang, Yong Hong Cui, Takashi Ikeshima, Yu Qing Zhao, Chun Fu W. Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia. International immunopharmacology. vol 5. issue 1. 2005-08-08. PMID:15589480. |
resveratrol inhibits nitric oxide and tnf-alpha production by lipopolysaccharide-activated microglia. |
2005-08-08 |
2023-08-12 |
mouse |
| Xiu Li Bi, Jing Yu Yang, Ying Xu Dong, Ji Ming Wang, Yong Hong Cui, Takashi Ikeshima, Yu Qing Zhao, Chun Fu W. Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia. International immunopharmacology. vol 5. issue 1. 2005-08-08. PMID:15589480. |
as resveratrol, an antioxidant component of grape, has been reported to exert anti-inflammatory activities on macrophages, we investigated its effects on the production of tnf-alpha (tnf-alpha) and nitric oxide (no) by lipopolysaccharide (lps)-activated microglia. |
2005-08-08 |
2023-08-12 |
mouse |