| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuyuki Nakajima, Shinichi Kohsak. Microglia: neuroprotective and neurotrophic cells in the central nervous system. Current drug targets. Cardiovascular & haematological disorders. vol 4. issue 1. 2004-05-10. PMID:15032653. |
however, microglia are also thought to contribute to the onset of or to exacerbate neuronal degeneration and/or inflammation in many brain diseases by producing deleterious factors including superoxide anions, nitric oxide and inflammatory cytokines. |
2004-05-10 |
2023-08-12 |
Not clear |
| Chun-Jung Chen, Shue-Ling Raung, Su-Lan Liao, Shih-Yun Che. Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/cytokine-stimulated microglia. Biochemical pharmacology. vol 67. issue 5. 2004-05-07. PMID:15104249. |
excessive production of nitric oxide (no) in the central nervous system (cns) mediated by activation of microglia has been implicated in neurotoxicity after stresses such as ischemia. |
2004-05-07 |
2023-08-12 |
Not clear |
| Tetsuya Mizuno, Tohru Kurotani, Yukio Komatsu, Jun Kawanokuchi, Hideki Kato, Norimasa Mitsuma, Akio Suzumur. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. vol 46. issue 3. 2004-04-21. PMID:14975696. |
in a dose-dependent manner, ibudilast suppressed the production of nitric oxide (no), reactive oxygen species, interleukin (il)-1beta, il-6, and tumor necrosis factor (tnf)-alpha and enhanced the production of the inhibitory cytokine, il-10, and additional neurotrophic factors, including nerve growth factor (ngf), glia-derived neurotrophic factor (gdnf), and neurotrophin (nt)-4 in activated microglia. |
2004-04-21 |
2023-08-12 |
Not clear |
| Paul D Drew, Janet A Chavis, Renu Bhat. Sex steroid regulation of microglial cell activation: relevance to multiple sclerosis. Annals of the New York Academy of Sciences. vol 1007. 2004-03-25. PMID:14993065. |
activated microglia also are believed to contribute to ms pathology; perhaps due in part to production of nitric oxide (no) and tnf-alpha, molecules which can be toxic to cns cells, including oligodendrocytes. |
2004-03-25 |
2023-08-12 |
Not clear |
| Tongguang Wang, Liya Qin, Bin Liu, Yuxin Liu, Belinda Wilson, Thomas E Eling, Robert Langenbach, Seijiro Taniura, Jau-Shyong Hon. Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. Journal of neurochemistry. vol 88. issue 4. 2004-03-15. PMID:14756815. |
as a comparison, scavenging ros had no effect on lps-induced nitric oxide production in microglia. |
2004-03-15 |
2023-08-12 |
mouse |
| Jeong Min Kim, Dongwook Son, Pyeongjae Lee, Kang Jin Lee, Hocheol Kim, Sun Yeou Ki. Ethyl acetate soluble fraction of Cnidium officinale MAKINO inhibits neuronal cell death by reduction of excessive nitric oxide production in lipopolysaccharide-treated rat hippocampal slice cultures and microglia cells. Journal of pharmacological sciences. vol 92. issue 1. 2004-03-11. PMID:12832858. |
ethyl acetate soluble fraction of cnidium officinale makino inhibits neuronal cell death by reduction of excessive nitric oxide production in lipopolysaccharide-treated rat hippocampal slice cultures and microglia cells. |
2004-03-11 |
2023-08-12 |
rat |
| Jeong Min Kim, Dongwook Son, Pyeongjae Lee, Kang Jin Lee, Hocheol Kim, Sun Yeou Ki. Ethyl acetate soluble fraction of Cnidium officinale MAKINO inhibits neuronal cell death by reduction of excessive nitric oxide production in lipopolysaccharide-treated rat hippocampal slice cultures and microglia cells. Journal of pharmacological sciences. vol 92. issue 1. 2004-03-11. PMID:12832858. |
in the present work, we found that the ethyl acetate-soluble fraction of cnidium officinale makino (coea) decreased nitric oxide (no) production in the lipopolysaccharide (lps)-stimulated bv-2 and primary microglia and suppressed expression of inducible nitric oxide synthase (inos) in bv-2 cells with the same pattern of no production. |
2004-03-11 |
2023-08-12 |
rat |
| H Wilms, J Claasen, C Röhl, J Sievers, G Deuschl, R Luciu. Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678758. |
because the functional role of the pbr is unknown, we confirm by immunohistochemistry and pcr (i) that this receptor is expressed on microglia in vitro and (ii) that benzodiazepines modulate proliferation of microglial cells and the release of the inflammatory molecules nitric oxide (no) and tumor necrosis factor-alpha (tnf-alpha) in cell culture supernatants of primary rat microglia. |
2004-03-05 |
2023-08-12 |
human |
| M Sayyah, M Javad-Pour, M Ghazi-Khansar. The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice: involvement of proinflammatory factors: nitric oxide and prostaglandins. Neuroscience. vol 122. issue 4. 2004-03-04. PMID:14643773. |
the bacterial endotoxin lipopolysaccharide (lps) induces the activation of microglia and the production of proinflammatory factors including nitric oxide (no) and prostaglandins (pgs). |
2004-03-04 |
2023-08-12 |
mouse |
| Sabine Golde, Alasdair Coles, Jonathan A Lindquist, Alastair Compsto. Decreased iNOS synthesis mediates dexamethasone-induced protection of neurons from inflammatory injury in vitro. The European journal of neuroscience. vol 18. issue 9. 2004-01-16. PMID:14622153. |
previously, we have demonstrated that microglia are highly toxic to neurons and that nitric oxide (no) derived from inducible nitric oxide synthase (inos) is necessary and sufficient to mediate this toxicity. |
2004-01-16 |
2023-08-12 |
rat |
| Jeong Min Kim, Pyeongjae Lee, Dongwook Son, Hocheol Kim, Sun Yeou Ki. Falcarindiol inhibits nitric oxide-mediated neuronal death in lipopolysaccharide-treated organotypic hippocampal cultures. Neuroreport. vol 14. issue 15. 2004-01-05. PMID:14561925. |
excessive nitric oxide (no) release from activated microglia has a predominant role in neuronal death. |
2004-01-05 |
2023-08-12 |
Not clear |
| Rolis Chien-Wei Hou, Huan-Lian Chen, Jason T C Tzen, Kee-Ching G Jen. Effect of sesame antioxidants on LPS-induced NO production by BV2 microglial cells. Neuroreport. vol 14. issue 14. 2003-12-29. PMID:14534426. |
in this study, we focused on the effect of sesamin and sesamolin, on nitric oxide (no) induction by lipopolysaccharides (lps) in the murine microglial cell line bv-2 and rat primary microglia. |
2003-12-29 |
2023-08-12 |
rat |
| Yuanli Duan, Sharie J Haugabook, Christie L Sahley, Kenneth J Mulle. Methylene blue blocks cGMP production and disrupts directed migration of microglia to nerve lesions in the leech CNS. Journal of neurobiology. vol 57. issue 2. 2003-12-05. PMID:14556284. |
recent studies on the leech central nervous system (cns), in which synapse regeneration is successful, have shown that nitric oxide (no) generated immediately after injury by endothelial nitric oxide synthase (enos) stops migrating microglia at the lesion. |
2003-12-05 |
2023-08-12 |
Not clear |
| Heasuk Lee, Young Ok Kim, Hocheol Kim, Sun Yeou Kim, Hae Sook Noh, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Kyoungho Su. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 13. 2003-11-12. PMID:12897065. |
wogonin inhibited inflammatory activation of cultured brain microglia by diminishing lipopolysaccharide-induced tumor necrosis factor-alpha (tnf-alpha), interleukin-1beta, and nitric oxide (no) production. |
2003-11-12 |
2023-08-12 |
Not clear |
| K Takano, Y Nakamura, Y Yoned. Microglial cell death induced by a low concentration of polyamines. Neuroscience. vol 120. issue 4. 2003-11-10. PMID:12927202. |
cultured microglia prepared from the whole brains of newborn rats produced nitric oxide (no) by the stimulation with lipopolysaccharide (lps). |
2003-11-10 |
2023-08-12 |
rat |
| Nilufer Esen, Hakan Savl. Stimulated microglia supernatants induced overexpression of neuronal nitric oxide gene in astrocytes. The International journal of neuroscience. vol 113. issue 8. 2003-10-17. PMID:12888421. |
stimulated microglia supernatants induced overexpression of neuronal nitric oxide gene in astrocytes. |
2003-10-17 |
2023-08-12 |
Not clear |
| Hankyoung Pyo, Myung-Soon Yang, Ilo Jou, Eun-hye Jo. Wortmannin enhances lipopolysaccharide-induced inducible nitric oxide synthase expression in microglia in the presence of astrocytes in rats. Neuroscience letters. vol 346. issue 3. 2003-09-30. PMID:12853104. |
activated microglia produce nitric oxide (no), a major toxin to neuronal cells. |
2003-09-30 |
2023-08-12 |
rat |
| Tetsuya Mizuno, Jun Kawanokuchi, Kenji Numata, Akio Suzumur. Production and neuroprotective functions of fractalkine in the central nervous system. Brain research. vol 979. issue 1-2. 2003-09-25. PMID:12850572. |
fractalkine dose-dependently suppressed the production of nitric oxide (no), interleukin (il)-6 and tumor necrosis factor (tnf)-alpha with activated microglia. |
2003-09-25 |
2023-08-12 |
Not clear |
| Allyn Franklin, Sophie Parmentier-Batteur, Lisa Walter, David A Greenberg, Nephi Stell. Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 21. 2003-09-16. PMID:12944505. |
we also found that pea potentiates aea-induced microglial cell migration, without affecting other steps of microglial activation, such as proliferation, particle engulfment, and nitric oxide production. |
2003-09-16 |
2023-08-12 |
mouse |
| Zhong Xie, Todd E Morgan, Irina Rozovsky, Caleb E Finc. Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821383. |
nitric oxide production by microglia from cx of aging brains showed a smaller induction in response to lps, with proportionately less neurotoxicity. |
2003-08-06 |
2023-08-12 |
rat |