| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuehai Zhang, Yi Wang, Qiuyi Qin, Yihai Wang, Jingwen Xu, Xiangjiu H. Pronounced anti-neuroinflammatory jasmonates and terpenes isolated from lychee seeds. Fitoterapia. vol 152. 2021-09-15. PMID:33984432. |
most of the compounds exhibited pronounced anti-neuroinflammatory activities on nitric oxide (no) induced by lipopolysaccharide (lps) in bv-2 microglia cells. |
2021-09-15 |
2023-08-13 |
Not clear |
| Tomonori Okazaki, Daichi Saito, Masatoshi Inden, Kotoku Kawaguchi, Sayuri Wakimoto, Takashi Nakahari, Shinji Asan. Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton. The journal of physiological sciences : JPS. vol 70. issue 1. 2021-09-08. PMID:33129281. |
however, the msn-ko microglia retained their ability to secrete tumor necrosis factor α and nitric oxide in response to lipopolysaccharide. |
2021-09-08 |
2023-08-13 |
mouse |
| Koay Chien Yi, Ling Anna Pick Kiong, Wong Ying Pei, Koh Rhun Yian, Hussein Sobr. Anti-neuroinflammatory responses in lipopolysaccharide-stimulated BV2 microglial cells upon treatment with methanol extract of Panax ginseng root. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 41. issue 2. 2021-09-08. PMID:33825397. |
to investigate the anti-neuroinflammatory properties of panax ginseng (p. ginseng) root by measuring the levels of nitric oxide (no), tumour necrosis factor-alpha (tnf-α), interleukin-6 (il-6), and interleukin-10 (il-10) in lipopolysaccharide (lps)-stimulated bv2 microglia cells. |
2021-09-08 |
2023-08-13 |
Not clear |
| Lanqiu Zhang, Xiaolin Jiang, Jinlu Zhang, Hejun Gao, Lei Yang, Dihua Li, Qi Zhang, Botao Wang, Lihua Cui, Ximo Wan. (-)-Syringaresinol suppressed LPS-induced microglia activation via downregulation of NF-κB p65 signaling and interaction with ERβ. International immunopharmacology. vol 99. 2021-09-08. PMID:34303280. |
as a result, (-)-syr significantly reduced lipopolysaccharide (lps)-induced production of interleukin - 6 (il-6), tumor necrosis factor α (tnf-α), interleukin -1 beta (il-1β), cycloxygenase-2 (cox-2), and nitric oxide (no) in bv2 microglia cells. |
2021-09-08 |
2023-08-13 |
mouse |
| Zi-Ang Yao, Ling Xu, Li-Ming Jin, Bai-Xiang Wang, Cheng-Zhu Fu, Ying Bai, Hai-Ge W. κ-Carrageenan Oligosaccharides Inhibit the Inflammation of Lipopolysaccharide-Activated Microglia Via TLR4/NF-κB and p38/JNK MAPKs Pathways. Neurochemical research. 2021-09-07. PMID:34491516. |
the production of reactive oxygen species (ros) and nitric oxide (no) in microglia cells was detected by flow cytometry, and the protein expression of immunoinflammation-related signaling pathways were detected by western blot. |
2021-09-07 |
2023-08-13 |
Not clear |
| Tianyu Gao, Ce Gao, Zhidong Liu, Yun Wang, Xiaoxia Jia, Hao Tian, Qian Lu, Lin Gu. Inhibition of Noncanonical Ca Neurochemical research. 2021-09-01. PMID:34468932. |
in the present study, we found that a sigma-1 receptor agonist of 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate (pre-084) suppressed lipopolysaccharide (lps) elevated nitric oxide (no) content in bv-2 microglia culture supernatant and lps-raised mrna levels of tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), inducible nitric oxide synthase (inos) in bv-2 microglia. |
2021-09-01 |
2023-08-13 |
Not clear |
| Yoshika Iwata, Mariko Miyao, Akiko Hirotsu, Kenichiro Tatsumi, Tomonori Matsuyama, Nobuo Uetsuki, Tomoharu Tanak. The inhibitory effects of Orengedokuto on inducible PGE2 production in BV-2 microglial cells. Heliyon. vol 7. issue 8. 2021-08-31. PMID:34458607. |
reactive microglia has been associated with neuroinflammation caused by the production of proinflammatory molecules such as cytokines, nitric oxide, and prostaglandins. |
2021-08-31 |
2023-08-13 |
Not clear |
| Matthew J E Maksoud, Vasiliki Tellios, Yun-Yan Xiang, Wei-Yang L. Nitric oxide displays a biphasic effect on calcium dynamics in microglia. Nitric oxide : biology and chemistry. vol 108. 2021-08-16. PMID:33418057. |
nitric oxide displays a biphasic effect on calcium dynamics in microglia. |
2021-08-16 |
2023-08-13 |
Not clear |
| Matthew J E Maksoud, Vasiliki Tellios, Yun-Yan Xiang, Wei-Yang L. Nitric oxide displays a biphasic effect on calcium dynamics in microglia. Nitric oxide : biology and chemistry. vol 108. 2021-08-16. PMID:33418057. |
in response to inflammation, microglia mobilize intracellular calcium and increase the expression of inducible nitric oxide synthase (inos), which produces nitric oxide (no). |
2021-08-16 |
2023-08-13 |
Not clear |
| Rüdiger Hardelan. Melatonin and Microglia. International journal of molecular sciences. vol 22. issue 15. 2021-08-13. PMID:34361062. |
the immunological interplay in the cns, with microglia playing a central role, is of high complexity and includes signaling toward endothelial cells and other leukocytes by cytokines, chemokines, nitric oxide, and eikosanoids. |
2021-08-13 |
2023-08-13 |
Not clear |
| Tomoki Minamihata, Katsura Takano, Yoichi Nakamura, Ryoya Seto, Mitsuaki Moriyam. Increase in Cellular Lysophosphatidylserine Content Exacerbates Inflammatory Responses in LPS-Activated Microglia. Neurochemical research. 2021-08-12. PMID:34383250. |
kc01 treatment decreased nitric oxide (no) production, accompanied by a reduction in inducible no synthase expression in bv-2 microglia. |
2021-08-12 |
2023-08-13 |
mouse |
| Awatef Esshili, Marie-Pierre Manitz, Nadja Freund, Georg Jucke. Induction of inducible nitric oxide synthase expression in activated microglia and astrocytes following pre- and postnatal immune challenge in an animal model of schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 35. 2021-08-10. PMID:32439226. |
in the central nervous system, activated microglia and astrocytes produce proinflammatory mediators such as inducible nitric oxide (inos) and cytokines. |
2021-08-10 |
2023-08-13 |
mouse |
| Ling Yan, Min-Qing Gu, Zhi-You Yang, Juan Xia, Peng Li, Eero Vasar, Li Tian, Cai Son. Endogenous n-3 PUFAs attenuated olfactory bulbectomy-induced behavioral and metabolomic abnormalities in Fat-1 mice. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34052364. |
furthermore, cop administration increased the production of pro-inflammatory cytokines and nitric oxide in a microglial cell line bv2. |
2021-08-06 |
2023-08-13 |
mouse |
| Mei-Hua Jin, Dong-Qin Chen, Ying-Hua Jin, Ying-Hao Han, Hu-Nan Sun, Taeho Kwo. Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling. Experimental and therapeutic medicine. vol 22. issue 3. 2021-08-03. PMID:34335912. |
nitric oxide (no) free radicals are produced by activated microglia and prolonged presence of large quantities of no in the cns can lead to neuroinflammation and disease. |
2021-08-03 |
2023-08-13 |
Not clear |
| Yan Zhao, Xialin Sun, Tingwen Zhang, Shuangli Liu, Enbo Cai, Hongyan Zh. Study on the antidepressant effect of panaxynol through the IκB-α/NF-κB signaling pathway to inhibit the excessive activation of BV-2 microglia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-07-22. PMID:33721753. |
meanwhile, pal also inhibited the production of nitric oxide in bv-2 microglia and decreased the level of inflammatory factors. |
2021-07-22 |
2023-08-13 |
mouse |
| Mitsuaki Moriyama, Yasunori Nishimura, Ryosuke Kurebayashi, Tomoki Minamihata, Kenji Kawabe, Katsura Takano, Yoichi Nakamur. Acetate Suppresses Lipopolysaccharide-stimulated Nitric Oxide Production in Primary Rat Microglia but not in BV-2 Microglia Cells. Current molecular pharmacology. vol 14. issue 2. 2021-07-16. PMID:32310055. |
acetate suppresses lipopolysaccharide-stimulated nitric oxide production in primary rat microglia but not in bv-2 microglia cells. |
2021-07-16 |
2023-08-13 |
rat |
| Masaki Kajimoto, Muhammad Nuri, Justin R Sleasman, Kevin A Charette, Branden R Nelson, Michael A Portma. Inhaled nitric oxide reduces injury and microglia activation in porcine hippocampus after deep hypothermic circulatory arrest. The Journal of thoracic and cardiovascular surgery. vol 161. issue 6. 2021-07-12. PMID:32037238. |
inhaled nitric oxide reduces injury and microglia activation in porcine hippocampus after deep hypothermic circulatory arrest. |
2021-07-12 |
2023-08-13 |
Not clear |
| Naufal Kushairi, Chia-Wei Phan, Vikineswary Sabaratnam, Sharmili Vidyadaran, Murali Naidu, Pamela Davi. Comparative Neuroprotective, Anti-Inflammatory and Neurite Outgrowth Activities of Extracts of King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes). International journal of medicinal mushrooms. vol 22. issue 12. 2021-07-12. PMID:33463934. |
nitric oxide (no) released by bv2 microglia was notably (p < 0.0001) increased by 1 μg/ml lipopolysaccharides (lps) from 7.46 ± 0.73 μm to 80.00 ± 3.78 μm indicating an inflammatory reaction. |
2021-07-12 |
2023-08-13 |
Not clear |
| Zhou Feng, Lingxia Min, Hui Chen, Weiwei Deng, Mingliang Tan, Hongliang Liu, Jingming Ho. Iron overload in the motor cortex induces neuronal ferroptosis following spinal cord injury. Redox biology. vol 43. 2021-07-05. PMID:33933882. |
further, we found that activated microglia in the motor cortex following sci secreted abundant nitric oxide (no), which regulated cellular iron homeostasis-related proteins to induce iron overload in motor neurons. |
2021-07-05 |
2023-08-13 |
rat |
| Amanda N Nieman, Guanguan Li, Nicolas M Zahn, Md Yeunus Mian, Brandon N Mikulsky, Dylan A Hoffman, Taylor M Wilcox, Alexander S Kehoe, Ian W Luecke, Michael M Poe, David Alvarez-Carbonell, James M Cook, Douglas C Stafford, Leggy A Arnol. Targeting Nitric Oxide Production in Microglia with Novel Imidazodiazepines for Nonsedative Pain Treatment. ACS chemical neuroscience. vol 11. issue 13. 2021-06-18. PMID:32511908. |
targeting nitric oxide production in microglia with novel imidazodiazepines for nonsedative pain treatment. |
2021-06-18 |
2023-08-13 |
mouse |