| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Liva, J de Velli. IL-5 induces proliferation and activation of microglia via an unknown receptor. Neurochemical research. vol 26. issue 6. 2002-01-29. PMID:11523538. |
to determine whether increased metabolism correlated with activation of microglia, we measured levels of nitrite, a breakdown product of nitric oxide. |
2002-01-29 |
2023-08-12 |
Not clear |
| Anna Bal-Price, Anita Matthias, Guy C Brow. Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production. Journal of neurochemistry. vol 80. issue 1. 2002-01-29. PMID:11796745. |
stimulation of the nadph oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production. |
2002-01-29 |
2023-08-12 |
rat |
| Anna Bal-Price, Anita Matthias, Guy C Brow. Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production. Journal of neurochemistry. vol 80. issue 1. 2002-01-29. PMID:11796745. |
this superoxide production resulted in a rapid rate of superoxide dismutase-sensitive nitric oxide (no) breakdown (155 +/- 30 pmol of no/min/million cells) when no was added to pma stimulated microglia. |
2002-01-29 |
2023-08-12 |
rat |
| M A Ajmone-Cat, A Nicolini, L Minghett. Differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide-releasing derivative, nitroflurbiprofen, on prostaglandin E(2), interleukin-1beta, and nitric oxide synthesis by activated microglia. Journal of neuroscience research. vol 66. issue 4. 2002-01-24. PMID:11746392. |
differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide-releasing derivative, nitroflurbiprofen, on prostaglandin e(2), interleukin-1beta, and nitric oxide synthesis by activated microglia. |
2002-01-24 |
2023-08-12 |
rat |
| C Prosperi, C Scali, G Pepeu, F Casament. NO-flurbiprofen attenuates excitotoxin-induced brain inflammation, and releases nitric oxide in the brain. Japanese journal of pharmacology. vol 86. issue 2. 2001-12-07. PMID:11459126. |
we showed that the excitotoxin-induced microglia reaction, the expression of inducible nitric oxide synthase-positive cells and the production of interleukin-1beta and prostaglandin-e2 in the injected area were attenuated by the no-flurbiprofen (15 mg/kg, p.o.) |
2001-12-07 |
2023-08-12 |
rat |
| M S Yang, I Jou, H Inn-Oc, E Jo. Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia. Neuroscience letters. vol 311. issue 2. 2001-12-04. PMID:11567796. |
the activated microglia produce nitric oxide (no), a major toxic substance from these cells, by inducing expression of inducible no synthase (inos). |
2001-12-04 |
2023-08-12 |
rat |
| Y Li, L Liu, S W Barger, R E Mrak, W S Griffi. Vitamin E suppression of microglial activation is neuroprotective. Journal of neuroscience research. vol 66. issue 2. 2001-12-04. PMID:11592111. |
lipopolysaccharide (lps) treatment of a microglial cell line (n9) induced a time-dependent activation of both p38 mitogen-activated protein kinase (p38 mapk) and nuclear factor-kappab (nfkappab), with consequent increases in interleukin-1alpha (il-1alpha), tumor necrosis factor-alpha (tnf-alpha), and nitric oxide (no) production. |
2001-12-04 |
2023-08-12 |
Not clear |
| F Muehlhauser, U Liebl, S Kuehl, S Walter, T Bertsch, K Fassbende. Aggregation-Dependent interaction of the Alzheimer's beta-amyloid and microglia. Clinical chemistry and laboratory medicine. vol 39. issue 4. 2001-10-18. PMID:11388654. |
we observed that amyloid peptide induced strong cellular activation in primary microglial cell culture as detected by the release of stable metabolites of nitric oxide (no), when the peptide was fibrillar. |
2001-10-18 |
2023-08-12 |
rat |
| A Bal-Price, G C Brow. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517237. |
activated astrocytes or microglia produced nitric oxide (no) (steady-state level approximately 0.5 microm), which immediately inhibited the cellular respiration of cocultured neurons, as did authentic no. |
2001-09-20 |
2023-08-12 |
Not clear |
| K Kawahara, T Gotoh, S Oyadomari, M Kajizono, A Kuniyasu, K Ohsawa, Y Imai, S Kohsaka, H Nakayama, M Mor. Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells. Brain research. Molecular brain research. vol 90. issue 2. 2001-09-13. PMID:11406294. |
nitric oxide (no) produced by activated microglia has been implicated in many pathophysiological events in the brain including neurodegenerative diseases. |
2001-09-13 |
2023-08-12 |
rat |
| S K Halonen, G A Taylor, L M Weis. Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP. Infection and immunity. vol 69. issue 9. 2001-09-13. PMID:11500431. |
microglia are important ifn-gamma-activated effector cells controlling the growth of t. gondii in the brain via a nitric oxide (no)-mediated mechanism. |
2001-09-13 |
2023-08-12 |
mouse |
| T M Tikka, J E Koistinah. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 12. 2001-08-23. PMID:11390507. |
minocycline also prevented the nmda-induced proliferation of microglial cells and the increased release of il-1beta and nitric oxide in pure microglia cultures. |
2001-08-23 |
2023-08-12 |
Not clear |
| S Johnso. Gradual micronutrient accumulation and depletion in Alzheimer's disease. Medical hypotheses. vol 56. issue 6. 2001-08-23. PMID:11399105. |
therefore, it is possible that cd also hyperactivates the microglia, playing a role in alzheimer's disease (ad).fe also accumulates in the brain as we age and catalyzes super oxide (o2-) formation, which reacts with nitric oxide (no) to form the very harmful peroxynitrite (onoo-). |
2001-08-23 |
2023-08-12 |
Not clear |
| A Takeuchi, O Miyaishi, K Kiuchi, K Isob. Macrophage colony-stimulating factor is expressed in neuron and microglia after focal brain injury. Journal of neuroscience research. vol 65. issue 1. 2001-08-16. PMID:11433427. |
in a previous study, we have demonstrated that damaged neurons within a boundary area around necrosis fall into delayed neuronal death owing to the cytotoxic effect of microglial nitric oxide (no), and these neurons are finally eliminated by activated microglia. |
2001-08-16 |
2023-08-12 |
Not clear |
| M J Wang, H M Huang, H L Chen, J S Kuo, K C Jen. Dehydroepiandrosterone inhibits lipopolysaccharide-induced nitric oxide production in BV-2 microglia. Journal of neurochemistry. vol 77. issue 3. 2001-06-28. PMID:11331412. |
dehydroepiandrosterone inhibits lipopolysaccharide-induced nitric oxide production in bv-2 microglia. |
2001-06-28 |
2023-08-12 |
Not clear |
| K Pahan, F G Sheikh, X Liu, S Hilger, M McKinney, T M Petr. Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11110796. |
because nitric oxide produced from the induction of nitric-oxide synthase (inos) also plays a vital role in the pathophysiology of ms, the present study was undertaken to explore the role of p40 in the induction of no production and the expression of inos in microglia. |
2001-06-21 |
2023-08-12 |
mouse |
| J Kang, M Yang, I Jou, E Jo. Identification of protein kinase C isoforms involved in interferon-gamma-induced expression of inducible nitric oxide synthase in murine BV2 microglia. Neuroscience letters. vol 299. issue 3. 2001-05-21. PMID:11165771. |
it has been known that interferon-gamma (ifn-gamma) induces nitric oxide (no)/inducible nitric oxide synthase (inos) in microglia, and that protein kinase c (pkc) mediates the action of ifn-gamma. |
2001-05-21 |
2023-08-12 |
Not clear |
| P D Drew, J A Chavi. The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells. Journal of neuroimmunology. vol 115. issue 1-2. 2001-04-26. PMID:11282151. |
activated microglia produce nitric oxide (no) and tnf-alpha, molecules which can be toxic to cells including oligodendrocytes, thus potentially contributing to the pathology associated with multiple sclerosis. |
2001-04-26 |
2023-08-12 |
mouse |
| Y R Freund, N T Zaveri, H S Javit. In vitro investigation of host resistance to Toxoplasma gondii infection in microglia of BALB/c and CBA/Ca mice. Infection and immunity. vol 69. issue 2. 2001-03-15. PMID:11159966. |
to better understand the innate mechanisms in the brain that play a role in resistance to te, nitric oxide (no)-dependent and no-independent mechanisms were examined in microglia from balb/c and cba/ca mice and correlated with the ability of these cells to inhibit toxoplasma gondii replication. |
2001-03-15 |
2023-08-12 |
mouse |
| C Knott, G Stern, G P Wilki. Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Molecular and cellular neurosciences. vol 16. issue 6. 2001-02-22. PMID:11124893. |
an up-regulation of nitric oxide synthase- and cyclo-oxygenase-1- and -2-containing amoeboid microglia was found in parkinsonian but not control nigra. |
2001-02-22 |
2023-08-12 |
human |