| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W R Anderson, A Martella, Z M Drake, S Hu, P K Peterson, C C Cha. Correlative transmission and scanning electron microscopy study of microglia activated by interferon-gamma and tumor necrosis factor-alpha in vitro. Pathology, research and practice. vol 191. issue 10. 1996-12-03. PMID:8838370. |
microglial cell culture treated with these cytokines generated significant amounts of the free radical nitric oxide (no), a biochemical marker of activation. |
1996-12-03 |
2023-08-12 |
Not clear |
| K Mosley, M L Cuzne. Receptor-mediated phagocytosis of myelin by macrophages and microglia: effect of opsonization and receptor blocking agents. Neurochemical research. vol 21. issue 4. 1996-11-20. PMID:8734442. |
uptake of both myelin preparations by macrophages or microglia is stimulated by interferon-gamma and inhibited by tgf-beta, and the process of ingestion results in increased nitric oxide release and decreased superoxide production, the effect being more pronounced when myelin is opsonized. |
1996-11-20 |
2023-08-12 |
rat |
| A O Caggiano, R P Krai. Eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes. The Journal of comparative neurology. vol 369. issue 1. 1996-11-07. PMID:8723705. |
eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes. |
1996-11-07 |
2023-08-12 |
rat |
| C A Colto. Induction of nitric oxide in cultured microglia: evidence for a cytoprotective role. Advances in neuroimmunology. vol 5. issue 4. 1996-10-25. PMID:8746519. |
induction of nitric oxide in cultured microglia: evidence for a cytoprotective role. |
1996-10-25 |
2023-08-12 |
Not clear |
| Y S Kim, M G Täube. Neurotoxicity of glia activated by gram-positive bacterial products depends on nitric oxide production. Infection and immunity. vol 64. issue 8. 1996-09-26. PMID:8757846. |
cell walls also induced nitric oxide production in cultures of astrocytes or microglia. |
1996-09-26 |
2023-08-12 |
rat |
| Y S Kim, M G Täube. Neurotoxicity of glia activated by gram-positive bacterial products depends on nitric oxide production. Infection and immunity. vol 64. issue 8. 1996-09-26. PMID:8757846. |
we conclude that gram-positive cell walls can cause toxicity in neurons by inducing the production of nitric oxide in astrocytes and microglia. |
1996-09-26 |
2023-08-12 |
rat |
| G B Stefano, Y Liu, M S Goligorsk. Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes. The Journal of biological chemistry. vol 271. issue 32. 1996-09-16. PMID:8702604. |
cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes. |
1996-09-16 |
2023-08-12 |
human |
| H I Magazine, Y Liu, T V Bilfinger, G L Fricchione, G B Stefan. Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 12. 1996-07-25. PMID:8648133. |
morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. |
1996-07-25 |
2023-08-12 |
human |
| H I Magazine, Y Liu, T V Bilfinger, G L Fricchione, G B Stefan. Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 12. 1996-07-25. PMID:8648133. |
we evaluated the contribution of nitric oxide (no) to morphine-induced rounding of spontaneously activated (mobile) ameboid human monocytes, granulocytes, or arterial endothelial cells and invertebrate immunocytes and microglia. |
1996-07-25 |
2023-08-12 |
human |
| J L Goodwin, E Uemura, J E Cunnic. Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548305. |
in the present study nitric oxide release from cultured rat microglia was examined by exposing the cells to synthetic beta-amyloid peptides (beta 25-35 and beta 1-40) alone and in combination with the cytokines ifn-alpha/beta (100 u/ml), il-1 beta (100 u/ml), tnf-alpha (100 u/ml), tnf-beta (100 u/ml), or ifn-gamma (10, 100, 500, or 1000 u/ml). |
1996-02-20 |
2023-08-12 |
rat |
| J L Goodwin, E Uemura, J E Cunnic. Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548305. |
of the cytokines tested, only ifn-gamma (1000 u/ml) induced nitric oxide release from microglia. |
1996-02-20 |
2023-08-12 |
rat |
| J L Goodwin, E Uemura, J E Cunnic. Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548305. |
these findings warrant a further investigation into the role of microglia in the neurodegeneration of alzheimer's disease via nitric oxide toxicity induced by the synergistic action of beta-amyloid and a costimulatory factor. |
1996-02-20 |
2023-08-12 |
rat |
| J Gehrmann, R B Banati, C Wiessner, K A Hossmann, G W Kreutzber. Reactive microglia in cerebral ischaemia: an early mediator of tissue damage? Neuropathology and applied neurobiology. vol 21. issue 4. 1996-01-11. PMID:7494596. |
activated microglia may exert a cytotoxic effector function by releasing reactive oxygen species, nitric oxide, proteinases or inflammatory cytokines. |
1996-01-11 |
2023-08-12 |
Not clear |
| N Sakai, S Kaufman, S Milstie. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cells. Journal of neurochemistry. vol 65. issue 2. 1995-08-24. PMID:7616251. |
in this study, we compared the induction by lipopolysaccharide, interferon-gamma, and tumor necrosis factor-alpha of nitric oxide production and synthesis of tetrahydrobiopterin, the required cofactor for nitric oxide synthase, in microglia and peritoneal macrophages. |
1995-08-24 |
2023-08-12 |
rat |
| N Sakai, S Kaufman, S Milstie. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cells. Journal of neurochemistry. vol 65. issue 2. 1995-08-24. PMID:7616251. |
activation of microglia induced parallel increases in nitric oxide and intracellular tetrahydrobiopterin levels, although induction of the latter appears to be somewhat more sensitive to diverse stimulators. |
1995-08-24 |
2023-08-12 |
rat |
| N Sakai, S Kaufman, S Milstie. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cells. Journal of neurochemistry. vol 65. issue 2. 1995-08-24. PMID:7616251. |
as with macrophages, inducible nitric oxide production in microglia was blocked by inhibitors of tetrahydrobiopterin biosynthesis. |
1995-08-24 |
2023-08-12 |
rat |
| N Sakai, S Kaufman, S Milstie. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cells. Journal of neurochemistry. vol 65. issue 2. 1995-08-24. PMID:7616251. |
interleukin-2, an important component of the neuroimmunomodulatory system, was only a weak activator of microglia by itself but potently synergized with interferon-gamma to stimulate production of both nitric oxide and tetrahydrobiopterin. |
1995-08-24 |
2023-08-12 |
rat |
| N Sakai, S Kaufman, S Milstie. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cells. Journal of neurochemistry. vol 65. issue 2. 1995-08-24. PMID:7616251. |
biopterin synthesis was increased to higher levels in astrocytes than in microglia, but maximal induction of nitric oxide production required higher concentrations of cytokines than microglia and the response was much lower. |
1995-08-24 |
2023-08-12 |
rat |
| H P Hartung, J J Archelos, J Zielasek, R Gold, M Koltzenburg, K H Reiners, K V Toyk. Circulating adhesion molecules and inflammatory mediators in demyelination: a review. Neurology. vol 45. issue 6 Suppl 6. 1995-07-20. PMID:7783908. |
cytokines released by th1 cells render resident and immigrant macrophages, as well as microglia, activated to synthesize and release increased amounts of inflammatory mediators, such as oxygen radicals, nitric oxide metabolites, and components of the complement system. |
1995-07-20 |
2023-08-12 |
Not clear |
| B Mitrovic, L J Ignarro, H V Vinters, M A Akers, I Schmid, C Uittenbogaart, J E Merril. Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes. Neuroscience. vol 65. issue 2. 1995-07-10. PMID:7777166. |
genomic dna isolated from astrocytes and microglia, treated for 18 h with varying concentrations of a nitric oxide donor, was analysed by electrophoresis. |
1995-07-10 |
2023-08-12 |
Not clear |