| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Swati Singh, Gajendra Singh, Swasti Tiwari, Alok Kuma. CCR2 Inhibition Reduces Neurotoxic Microglia Activation Phenotype After Japanese Encephalitis Viral Infection. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32903799. |
using the agonist molecule of ccr2 inhibition; rs102895, significantly reduces microglia reactive phenotype and nitric oxide production. |
2020-09-28 |
2023-08-13 |
mouse |
| M L Chen, J M Gou, X L Meng, C L Chen, X N Li. Cepharanthine, a bisbenzylisoquinoline alkaloid, inhibits lipopolysaccharide-induced microglial activation. Die Pharmazie. vol 74. issue 10. 2020-09-18. PMID:31685086. |
cepharanthine suppressed the release of nitric oxide (no) by lps-activated primary mouse cortical microglia and/or bv2 microglial cell line. |
2020-09-18 |
2023-08-13 |
mouse |
| Teodora Stella Wijasa, Marc Sylvester, Nahal Brocke-Ahmadinejad, Stephanie Schwartz, Francesco Santarelli, Volkmar Gieselmann, Thomas Klockgether, Frederic Brosseron, Michael T Henek. Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease. Journal of neurochemistry. vol 152. issue 6. 2020-08-27. PMID:31520481. |
a downstream event during inflammatory activation of microglia and astrocytes is the induction of nitric oxide synthase type 2, resulting in an increased release of nitric oxide and the post-translational s-nitrosylation of protein cysteine residues. |
2020-08-27 |
2023-08-13 |
mouse |
| Ryo Tsuchihashi, Toshinori Sawano, Fumiya Watanabe, Natsumi Yamaguchi, Wataru Yamaguchi, Kenta Niimi, Satoshi Shibata, Tatsuo Furuyama, Hidekazu Tanaka, Shinobu Inagak. Upregulation of IFN-β induced by Sema4D-dependent partial Erk1/2 inhibition promotes NO production in microglia. Biochemical and biophysical research communications. vol 521. issue 4. 2020-08-03. PMID:31708102. |
our previous study revealed that sema4d is involved in the upregulation of nitric oxide production in microglia after cerebral ischemia. |
2020-08-03 |
2023-08-13 |
Not clear |
| Ryo Tsuchihashi, Toshinori Sawano, Fumiya Watanabe, Natsumi Yamaguchi, Wataru Yamaguchi, Kenta Niimi, Satoshi Shibata, Tatsuo Furuyama, Hidekazu Tanaka, Shinobu Inagak. Upregulation of IFN-β induced by Sema4D-dependent partial Erk1/2 inhibition promotes NO production in microglia. Biochemical and biophysical research communications. vol 521. issue 4. 2020-08-03. PMID:31708102. |
sema4d promoted nitric oxide production and slightly inhibited erk1/2 phosphorylation in microglia. |
2020-08-03 |
2023-08-13 |
Not clear |
| Ryo Tsuchihashi, Toshinori Sawano, Fumiya Watanabe, Natsumi Yamaguchi, Wataru Yamaguchi, Kenta Niimi, Satoshi Shibata, Tatsuo Furuyama, Hidekazu Tanaka, Shinobu Inagak. Upregulation of IFN-β induced by Sema4D-dependent partial Erk1/2 inhibition promotes NO production in microglia. Biochemical and biophysical research communications. vol 521. issue 4. 2020-08-03. PMID:31708102. |
inhibition of erk1/2 phosphorylation induced the expression of ifn-β mrna, and ifn-β promoted nitric oxide production in microglia. |
2020-08-03 |
2023-08-13 |
Not clear |
| Matthew J E Maksoud, Vasiliki Tellios, Dong An, Yun-Yan Xiang, Wei-Yang L. Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane. Glia. vol 67. issue 12. 2020-04-13. PMID:31453646. |
nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane. |
2020-04-13 |
2023-08-13 |
Not clear |
| Matthew J E Maksoud, Vasiliki Tellios, Dong An, Yun-Yan Xiang, Wei-Yang L. Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane. Glia. vol 67. issue 12. 2020-04-13. PMID:31453646. |
during initial stages of phagocytosis, microglia display increased nitric oxide (no) production via inducible nitric oxide synthase (inos) activity and amplified calcium entry through transient receptor potential vanilloid type 2 (trpv2) channels. |
2020-04-13 |
2023-08-13 |
Not clear |
| Wei Liu, Yongxiang Wang, Fangyi Gong, Yuluo Rong, Yongjun Luo, Pengyu Tang, Zheng Zhou, Zhimin Zhou, Tao Xu, Tao Jiang, Siting Yang, Guoyong Yin, Jian Chen, Jin Fan, Weihua Ca. Exosomes Derived from Bone Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by Suppressing the Activation of A1 Neurotoxic Reactive Astrocytes. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29848167. |
using a series of in vitro functional assays, we also confirmed that treatment with bsmcs-exos significantly enhanced human umbilical vein endothelial cell proliferation, migration, and angiogenic tubule formation, attenuated neuronal cells apoptosis, and suppressed nitric oxide release in microglia. |
2020-04-10 |
2023-08-13 |
human |
| Hsiao-Jou Cortina Chen, Jereme G Spiers, Conrad Sernia, Nickolas A Lavidi. Inhibition of Fatty Acid Amide Hydrolase by PF-3845 Alleviates the Nitrergic and Proinflammatory Response in Rat Hippocampus Following Acute Stress. The international journal of neuropsychopharmacology. vol 21. issue 8. 2020-04-07. PMID:29579222. |
specifically, previous work has shown that enhancement of endocannabinoids via inhibition of fatty acid amide hydrolase with pf-3845 reduced inducible nitric oxide synthase-expressing microglia following traumatic brain injury. |
2020-04-07 |
2023-08-13 |
rat |
| Thuy-Truc Ta, Hasan Onur Dikmen, Simone Schilling, Bruno Chausse, Andrea Lewen, Jan-Oliver Hollnagel, Oliver Kan. Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 10. 2020-03-30. PMID:30782788. |
the rhythm disturbance was caused by moderate microglial nitric oxide (no) release demonstrated by pharmacological microglia depletion and inos inhibition. |
2020-03-30 |
2023-08-13 |
Not clear |
| Xiaoying Yang, Guiqin Wang, Ting Cao, Li Zhang, Yunzhi Ma, Shuhui Jiang, Xinchen Teng, Xiaohui Su. Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia. The Journal of biological chemistry. vol 294. issue 35. 2020-03-30. PMID:31296663. |
furthermore, we noted that bk channels are also expressed intracellularly, and their nuclear expression significantly increases in late stages of lps-mediated microglia activation, possibly contributing to production of nitric oxide, tumor necrosis factor-α, and interleukin-6. |
2020-03-30 |
2023-08-13 |
mouse |
| Guy C Brow. The endotoxin hypothesis of neurodegeneration. Journal of neuroinflammation. vol 16. issue 1. 2020-03-23. PMID:31519175. |
endotoxin directly and indirectly activates microglia that damage neurons via nitric oxide, oxidants and cytokines, and by phagocytosis of synapses and neurons. |
2020-03-23 |
2023-08-13 |
mouse |
| Gang Chen, Weihong Zhao, Yang Li, Di Zhou, Jing Ding, Bin Lin, Wei Li, Yanqiu Yang, Jingyu Liu, Yue Hou, Ning L. Bioactive chemical constituents from the seed testa of Vernicia fordii as potential neuroinflammatory inhibitors. Phytochemistry. vol 171. 2020-03-16. PMID:31911267. |
as a result, isodiverniciasin a, diverniciasin b, diverniciasin c, isoprincepin, princepin, 3, 3'-bisdemethylpinoresinol, (+)-7-epi-sesamin-dicatechol, isoamericanin a, americanin b, 7s, 8r-americanin d, 4-hydroxyl cinnamic aldehyde, 3-hydroxyl-4-methoxyl cinnamic aldehyde and 24r-6β-hydroxy-24- ethylcholest-4-en-3-one exhibited significant inhibitory effects on nitric oxide (no) production and isoprincepin, princepin, americanin b, and 4-hydroxyl cinnamic aldehyde suppressed the overexpression of inflammatory cytokines tnf-α, il-1β, and il-6 in over-activated microglia. |
2020-03-16 |
2023-08-13 |
Not clear |
| Jingwen Yu, Minfang Guo, Yanhua Li, Huiyu Zhang, Zhi Chai, Qing Wang, Yuqing Yan, Jiezhong Yu, Chunyun Liu, Guangxian Zhang, Ma Cunge. Astragaloside IV protects neurons from microglia-mediated cell damage through promoting microglia polarization. Folia neuropathologica. vol 57. issue 2. 2020-02-20. PMID:31556576. |
our results showed that ast-iv partially protected microglia from death evoked by lps and downregulated the release of pro-inflammatory (m1) mediators including interleukin (il)-1β, il-6, tumour necrosis factor α (tnf-α) and nitric oxide, as well as the expression of toll-like receptors 4 (tlr4), myd88, and nuclear factor κb (nf-κb) of these cells. |
2020-02-20 |
2023-08-13 |
Not clear |
| Jack Brelstaff, Aviva M Tolkovsky, Bernardino Ghetti, Michel Goedert, Maria Grazia Spillantin. Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell reports. vol 24. issue 8. 2020-01-27. PMID:30134156. |
to facilitate engulfment, neurons induce contacting microglia to secrete the opsonin milk-fat-globule egf-factor-8 (mfge8) and nitric oxide (no), whereas neurons with tau inclusions are rescued when mfge8 or no production is prevented. |
2020-01-27 |
2023-08-13 |
mouse |
| Chung Sub Kim, Joonseok Oh, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Kang Ro Le. Structural Characterization of Terpenoids from Abies holophylla Using Computational and Statistical Methods and Their Biological Activities. Journal of natural products. vol 81. issue 8. 2019-11-14. PMID:30063340. |
in addition, the compounds were tested for their anti-inflammatory effects in lipopolysaccharide-stimulated murine microglia bv2 cells by measuring nitric oxide levels, and for their neuroprotective activity in c6 cells through induction of nerve growth factor. |
2019-11-14 |
2023-08-13 |
human |
| Katherine Figarella, Nestor L Uzcategui, Stefan Mogk, Katleen Wild, Petra Fallier-Becker, Jonas J Neher, Michael Duszenk. Morphological changes, nitric oxide production, and phagocytosis are triggered in vitro in microglia by bloodstream forms of Trypanosoma brucei. Scientific reports. vol 8. issue 1. 2019-10-30. PMID:30302029. |
morphological changes, nitric oxide production, and phagocytosis are triggered in vitro in microglia by bloodstream forms of trypanosoma brucei. |
2019-10-30 |
2023-08-13 |
human |
| Andrea Mancini, Michela Tantucci, Petra Mazzocchetti, Antonio de Iure, Valentina Durante, Lara Macchioni, Carmela Giampà, Alessandra Alvino, Lorenzo Gaetani, Cinzia Costa, Alessandro Tozzi, Paolo Calabresi, Massimiliano Di Filipp. Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis. Neurobiology of disease. vol 113. 2019-09-06. PMID:29325869. |
this detrimental effect was counteracted by the pharmacological inhibition of microglia, of nitric oxide (no) synthesis and its intracellular pathway (involving soluble guanylyl cyclase, sgc, and protein kinase g, pkg). |
2019-09-06 |
2023-08-13 |
Not clear |
| Takaaki Aratake, Youichirou Higashi, Yusuke Ueba, Tomoya Hamada, Takahiro Shimizu, Shogo Shimizu, Toshio Yawata, Tetsuya Ueba, Motoaki Sait. The inhibitory role of intracellular free zinc in the regulation of Arg-1 expression in interleukin-4-induced activation of M2 microglia. Metallomics : integrated biometal science. vol 10. issue 10. 2019-09-02. PMID:30206632. |
arginase (arg)-1 expressed in interleukin-4 (il-4)-induced m2 microglia reduces nitric oxide (no) production by competing with inducible no synthase for l-arginine, which contributes to the attenuation of brain inflammation. |
2019-09-02 |
2023-08-13 |
Not clear |