| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zisong Bai, Gang Chen, Wei Li, Yue Hou, Ning L. Natural Inhibitors on Over-Activation of Microglia from Herbals. Chemical & pharmaceutical bulletin. vol 67. issue 7. 2019-07-03. PMID:31257319. |
short-term activation of microglia can be beneficial, but chronically activated microglia can aggravate neuronal dysfunction possibly by secreting potentially cytotoxic substances such as tumor necrosis factor-alpha (tnf-α) and nitric oxide (no), which can result in dysfunction and death of neurons. |
2019-07-03 |
2023-08-13 |
Not clear |
| Namkwon Kim, Cindy Cruz Martínez, Dae Sik Jang, Jong Kil Lee, Myung Sook O. Anti-neuroinflammatory effect of Iresine celosia on lipopolysaccharide-stimulated microglial cells and mouse. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-21. PMID:30841450. |
in bv2 microglia cells, ice markedly inhibited production of nitric oxide and proinflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6 without causing cytotoxicity. |
2019-06-21 |
2023-08-13 |
mouse |
| Shujuan Zhang, Yuying Huang, Yang Li, Yihai Wang, Xiangjiu H. Anti-neuroinflammatory and antioxidant phenylpropanoids from Chinese olive. Food chemistry. vol 286. 2019-05-28. PMID:30827627. |
the phenylpropanoids could significantly inhibit the production of nitric oxide induced by lipopolysaccharide (lps) in microglia cells (bv-2). |
2019-05-28 |
2023-08-13 |
Not clear |
| Emily L Gill, Shreya Raman, Richard A Yost, Timothy J Garrett, Vinata Vedam-Ma. l-Carnitine Inhibits Lipopolysaccharide-Induced Nitric Oxide Production of SIM-A9 Microglia Cells. ACS chemical neuroscience. vol 9. issue 5. 2019-05-21. PMID:29370524. |
l-carnitine inhibits lipopolysaccharide-induced nitric oxide production of sim-a9 microglia cells. |
2019-05-21 |
2023-08-13 |
Not clear |
| Gerwyn Morris, Michael Berk, Michael Maes, Basant K Pur. Could Alzheimer's Disease Originate in the Periphery and If So How So? Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29705945. |
in particular, as a result of increased activity of triggering receptor expressed on myeloid cells 2 (trem-2), the presence of the apolipoprotein e4 (apoe4) isoform, and changes in ank1 expression, with subsequent changes in mir-486 leading to altered levels of protein kinase b (akt), mechanistic (previously mammalian) target of rapamycin (mtor) and signal transducer and activator of transcription 3 (stat3), all of which play major roles in microglial activation, proliferation and survival, there is activation of microglia, leading to the subsequent (further) production of cytokines, chemokines, nitric oxide, prostaglandins, reactive oxygen species, inducible nitric oxide synthase and cyclooxygenase-2, and other mediators of inflammation and neurotoxicity. |
2019-04-01 |
2023-08-13 |
Not clear |
| Yoshinori Haraguchi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshiomi Imamura, Toru Murakawa-Hirachi, Hiromi Nabeta, Hiroshi Tateishi, Takahiro A Kato, Akira Monj. Donepezil suppresses intracellular Ca Journal of neuroinflammation. vol 14. issue 1. 2019-03-21. PMID:29273047. |
donepezil suppresses intracellular ca microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (no) when they are activated in response to immunological stimuli. |
2019-03-21 |
2023-08-13 |
Not clear |
| Xiaolai Zhou, Björn Spitta. Lipopolysaccharide-Induced Microglia Activation Promotes the Survival of Midbrain Dopaminergic Neurons In Vitro. Neurotoxicity research. vol 33. issue 4. 2019-03-20. PMID:29188488. |
lps-induced microglia activation is believed to promote neurodegeneration by release of neurotoxic factors such as interleukin-1β, tumor necrosis factor α, or nitric oxide. |
2019-03-20 |
2023-08-13 |
Not clear |
| Byeoung-Kyu Choi, Shin-Young Park, Dong-Kug Choi, Bora Shin, Yern-Hyerk Shin, Dong-Chan Oh, Hwa-Sun Lee, Hyi-Seung Lee, Yeon-Ju Lee, Jong Seok Lee, Ji Hoon Lee, Hee Jae Shi. Streptoglycerides A-D with a Rare 6/5/5 Tricyclic Ring Skeleton from a Marine Actinomycete Streptomyces species. Organic letters. vol 20. issue 19. 2019-03-07. PMID:30259746. |
streptoglyceride c (3) showed a weak inhibitory effect on the production of nitric oxide in bv-2 microglia cells. |
2019-03-07 |
2023-08-13 |
Not clear |
| Hang Yu, Xiaozhi Wang, Fuxin Kang, Zhile Chen, Yunxia Meng, Mingming Da. Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30431058. |
the results of the in vivo experiments revealed that propofol inhibits the abnormal proliferation of microglia, as well as reduces the expression levels of interleukin (il)-6, il-1β, tumor necrosis factor α, and the cytotoxic factor nitric oxide through the a2b receptor. |
2019-03-05 |
2023-08-13 |
rat |
| Juan-Juan Li, Shun-Jin Liu, Xiao-Yu Liu, Eng-Ang Lin. Herbal Compounds with Special Reference to Gastrodin as Potential Therapeutic Agents for Microglia Mediated Neuroinflammation. Current medicinal chemistry. vol 25. issue 42. 2019-03-04. PMID:29446722. |
activated microglia play a pivotal role neurodegenerative diseases by producing a variety of proinflammatory mediators including tumor necrosis factor-alpha (tnf-α), interleukin- 1beta (il-1β) and nitric oxide (no) that are toxic to neurons and oligodendrocytes. |
2019-03-04 |
2023-08-13 |
Not clear |
| Chenli Jiao, Feng Gao, Li Ou, Jinhua Yu, Min Li, Peifeng Wei, Feng Mi. Tetrahydroxystilbene glycoside antagonizes β-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression. Neuroreport. vol 29. issue 10. 2019-02-27. PMID:29668503. |
the results showed that aβ treatment induced the activation of microglia cells and the production of inflammatory molecules, including inducible nitric oxide synthase, nitric oxide, cyclooxygenase 2, and prostaglandin e2, which were significantly inhibited by tsg pretreatment. |
2019-02-27 |
2023-08-13 |
Not clear |
| T Sarajärvi, M Jäntti, K M A Paldanius, T Natunen, J C Wu, P Mäkinen, I Tarvainen, R K Tuominen, V Talman, M Hiltune. Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations. Neuropharmacology. vol 141. 2019-02-13. PMID:30138694. |
hmi-1a3 increased the viability of embryonic primary cortical neurons and decreased the production of the pro-inflammatory mediator tnfα, but not that of nitric oxide, in mouse neuron-bv2 microglia co-cultures upon lps- and ifn-γ-induced neuroinflammation. |
2019-02-13 |
2023-08-13 |
mouse |
| Kyeong Wan Woo, Jong Eel Park, Joon Min Cha, Lalita Subedi, Sun Yeou Kim, Kang Ro Le. Three New Lignan Glycosides from the Firmiana simplex. Chemical & pharmaceutical bulletin. vol 67. issue 1. 2019-02-13. PMID:30606947. |
nitric oxide (no) production was evaluated in the lipopolysaccharide-activated microglial cell line, bv-2 to investigate the anti-neuroinflammatory effects of the isolated compounds (1-9). |
2019-02-13 |
2023-08-13 |
Not clear |
| Arramshetti Venkanna, Kyo Hee Cho, Lama Prema Dhorma, Duddukuri Nandan Kumar, Jung Mi Hah, Hyeung-Geun Park, Sun Yeou Kim, Mi-Hyun Ki. Chemistry-oriented synthesis (ChOS) and target deconvolution on neuroprotective effect of a novel scaffold, oxaza spiroquinone. European journal of medicinal chemistry. vol 163. 2019-02-11. PMID:30530196. |
the logic of the present work consists of (1) the identification of a promising unprecedented scaffold from privileged scaffolds of biological active molecules through our 'chemistry-oriented synthesis' (chos) approach, a compensatory strategy for target-based drug discovery, (2) the positioning of the identified 1,5-oxaza spiroquinone scaffold on neuroinflammation and neurodegenerative disease through nitric oxide (no) inhibitory activity without cytotoxicity in hyper-activated microglia (ic |
2019-02-11 |
2023-08-13 |
Not clear |
| Dhiraj Kumar Singh, Eng-Ang Ling, Charanjit Kau. Hypoxia and myelination deficits in the developing brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 70. 2019-01-28. PMID:29964158. |
several factors such as augmented release of proinflammatory cytokines by activated microglia and astrocytes, extracellular accumulation of excess glutamate and increased levels of nitric oxide are some of the underlying factors for hypoxia induced damage to the opcs. |
2019-01-28 |
2023-08-13 |
Not clear |
| Dong-Cheol Kim, Tran Hong Quang, Hyuncheol Oh, Youn-Chul Ki. Steppogenin Isolated from Cudrania tricuspidata Shows Antineuroinflammatory Effects via NF-κB and MAPK Pathways in LPS-Stimulated BV2 and Primary Rat Microglial Cells. Molecules (Basel, Switzerland). vol 22. issue 12. 2019-01-11. PMID:29207498. |
when microglia are stimulated, they produce proinflammatory mediators and cytokines, including nitric oxide (no) derived from inducible no synthase (inos), prostaglandin e2 (pge₂) derived from cyclooxygenase-2 (cox-2), tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), interleukin-12 (il-12), and interleukin-6 (il-6). |
2019-01-11 |
2023-08-13 |
rat |
| Yasunori Nishimura, Mitsuaki Moriyama, Kenji Kawabe, Hideyo Satoh, Katsura Takano, Yasu-Taka Azuma, Yoichi Nakamur. Lauric Acid Alleviates Neuroinflammatory Responses by Activated Microglia: Involvement of the GPR40-Dependent Pathway. Neurochemical research. vol 43. issue 9. 2018-11-21. PMID:29947014. |
in several neurodegenerative diseases such as alzheimer's disease (ad), microglia are hyperactivated and release nitric oxide (no) and proinflammatory cytokines, resulting its neuropathology. |
2018-11-21 |
2023-08-13 |
mouse |
| Liuke Sun, Ruifang Shen, Sandeep K Agnihotri, Yun Chen, Zhiwei Huang, Hansruedi Büele. Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death. Scientific reports. vol 8. issue 1. 2018-11-20. PMID:29321620. |
pink1 loss enhances lps/ifn-γ stimulated pro-inflammatory phenotypes of mixed astrocytes/microglia (increased inos, nitric oxide and cox-2, reduced il-10) and pure astrocytes (increased inos, nitric oxide, tnf-α and il-1β), while attenuating expression of both pro-inflammatory (tnf-α, il-1β) and anti-inflammatory (il-10) cytokines in microglia. |
2018-11-20 |
2023-08-13 |
Not clear |
| Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Anna Piotrowska, Bogusława Budziszewska, Marta Kubera, Katarzyna Popiołek-Barczyk, Władysław Lasoń, Joanna Mika, Agnieszka Basta-Kai. Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures. International journal of molecular sciences. vol 19. issue 7. 2018-11-05. PMID:29976873. |
tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (cd40), and major histocompatibility complex class ii (mhc ii) markers, as well as the release of pro-inflammatory factors: interleukin (il)-1β, il-18, il-6, tumor necrosis factor alpha (tnf-α), and chemokine cc motif ligand 2 (ccl2), and the production of nitric oxide and reactive oxygen species. |
2018-11-05 |
2023-08-13 |
Not clear |
| Xiaowen Du, Dong Liu, Jian Huang, Chanjuan Zhang, Peter Proksch, Wenhan Li. Polyketide derivatives from the sponge associated fungus Aspergillus europaeus with antioxidant and NO inhibitory activities. Fitoterapia. vol 130. 2018-11-02. PMID:30193789. |
all polyketides were evaluated for the inhibitory effects toward the lps induced nitric oxide (no) production in mouse microglia bv2 cells and the nf-κb activation in human colon carcinoma cell line sw480. |
2018-11-02 |
2023-08-13 |
mouse |