| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hisashi Shirakawa, Shuji Kanek. Physiological and Pathophysiological Roles of Transient Receptor Potential Channels in Microglia-Related CNS Inflammatory Diseases. Biological & pharmaceutical bulletin. vol 41. issue 8. 2018-10-16. PMID:30068863. |
however, under certain pathological conditions, microglia can generate neurotoxic factors, such as pro-inflammatory cytokines and molecules like nitric oxide (no), which lead to cns inflammatory diseases. |
2018-10-16 |
2023-08-13 |
Not clear |
| Xiang Cao, Yuexinzi Jin, He Zhang, Linjie Yu, Xinyu Bao, Fei Li, Yun X. The Anti-inflammatory Effects of 4-((5-Bromo-3-chloro-2-hydroxybenzyl) amino)-2-hydroxybenzoic Acid in Lipopolysaccharide-Activated Primary Microglial Cells. Inflammation. vol 41. issue 2. 2018-10-01. PMID:29198015. |
our results indicated that lx007 inhibited lipopolysaccharide (lps)-stimulated nitric oxide (no) and prostaglandin e2 (pge2) expression, as well as their regulatory gene-inducible no syntheses (inos) and cyclooxygenase-2 (cox-2) in lps-treated primary microglia. |
2018-10-01 |
2023-08-13 |
Not clear |
| Do Hee Kim, Hua Li, Yeong Eun Han, Ji Hye Jeong, Hwa Jin Lee, Jae-Ha Ry. Modulation of Inducible Nitric Oxide Synthase Expression in LPS-Stimulated BV-2 Microglia by Prenylated Chalcones from Cullen corylifolium (L.) Medik. through Inhibition of I-κBα Degradation. Molecules (Basel, Switzerland). vol 23. issue 1. 2018-09-03. PMID:29300354. |
the overproduction of nitric oxide (no) and prostaglandin e₂ (pge₂) by microglia may cause neurodegenerative diseases, such as alzheimer's disease and parkinson's disease. |
2018-09-03 |
2023-08-13 |
Not clear |
| A J McFarland, A K Davey, C M McDermott, G D Grant, J Lewohl, S Anoopkumar-Duki. Differences in statin associated neuroprotection corresponds with either decreased production of IL-1β or TNF-α in an in vitro model of neuroinflammation-induced neurodegeneration. Toxicology and applied pharmacology. vol 344. 2018-08-27. PMID:29522792. |
to achieve this, hapi microglia were treated with lps (0.1 μg/ml; 24 h), resulting in increased reactive oxygen species (ros), nitric oxide, and il-1β, tnf-α and pge |
2018-08-27 |
2023-08-13 |
Not clear |
| Peng Xu, Meng-Wei Huang, Chen-Xi Xiao, Fen Long, Ying Wang, Si-Yu Liu, Wan-Wan Jia, Wei-Jun Wu, Di Yang, Jin-Feng Hu, Xin-Hua Liu, Yi-Zhun Zh. Matairesinol Suppresses Neuroinflammation and Migration Associated with Src and ERK1/2-NF-κB Pathway in Activating BV2 Microglia. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28512713. |
the results showed that matairesinol inhibited microglia activation by reducing the production of nitric oxide, the expression of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner (6.25, 12.5, 25 μm). |
2018-08-07 |
2023-08-13 |
Not clear |
| Hang Ma, Shelby L Johnson, Weixi Liu, Nicholas A DaSilva, Susan Meschwitz, Joel A Dain, Navindra P Seera. Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects. International journal of molecular sciences. vol 19. issue 2. 2018-08-07. PMID:29401686. |
in addition, the berry aces (at 20 μg/ml) reduced h₂o₂-induced reactive oxygen species production, and lipopolysaccharide-induced nitric oxide species in bv-2 microglia as well as decreased h₂o₂-induced cytotoxicity and caspase-3/7 activity in bv-2 microglia. |
2018-08-07 |
2023-08-13 |
Not clear |
| Tatsuhiro Akaishi, Kazuho Ab. CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia. European journal of pharmacology. vol 819. 2018-08-06. PMID:29221948. |
cnb-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of nf-κb and p38 mapk pathways in microglia. |
2018-08-06 |
2023-08-13 |
rat |
| Tatsuhiro Akaishi, Kazuho Ab. CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia. European journal of pharmacology. vol 819. 2018-08-06. PMID:29221948. |
in primary cultured rat microglia, cnb-001 (1-10µm) suppressed the lipopolysaccharide (lps)-induced nitric oxide (no) production and expression of inducible no synthase (inos), and the potency of cnb-001 was stronger than curcumin. |
2018-08-06 |
2023-08-13 |
rat |
| Chun-Sung Sung, Zhi-Hong Wen, Chien-Wei Feng, Chun-Hong Chen, Shi-Ying Huang, Nan-Fu Chen, Wu-Fu Chen, Chih-Shung Won. Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1β-induced thermal hyperalgesia in rats. CNS neuroscience & therapeutics. vol 23. issue 7. 2018-07-17. PMID:28544775. |
we previously demonstrated that intrathecal il-1β upregulated phosphorylation of p38 mitogen-activated protein kinase (p-p38 mapk) and inducible nitric oxide synthase (inos) in microglia and astrocytes in spinal cord, increased nitric oxide (no) release into cerebrospinal fluid, and induced thermal hyperalgesia in rats. |
2018-07-17 |
2023-08-13 |
rat |
| Yue Lou, Yaguo L. [Effects of Chlorpyrifos on Dopaminergic Neuronal Viability with Activation of Microglia]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 3. 2018-05-24. PMID:29709151. |
excessive microglial activation and subsequent neuroinflammation lead to neuronal cell death,which are involved in the pathogenesis and progression of several neurodegenerative diseases such as parkinson’s disease.the objective of this study was to determine the involvement of chlorpyrifos(cpf)in the activation of microglia and production of inflammatory factors in response to cpf stimulation and the influence on the viability of dopaminergic(da)neurons.we detected the change of bv-2cells morphology and expression of inducible nitric oxide(inos),cyclooxygenase-2(cox-2)mrna and protein level upon cpf stimulation(0,1,3,6,12,24h)in bv-2(mouse brain microglia)cells by reverse transcription polymerase chain reaction(rt-pcr)or western blot.we randomly assigned bv-2cells into cpf,menstruum dimethysulfoxide(dmso)and normal saline(ns)groups.we stimulated the bv-2cells in the cpf group with cpf,and we stimulated the two control groups with dmso or ns for 12 hours,respectively.we then collected the used culture media from the culture dishes and centrifuged it to remove the detached cells.then,we used the supernatants as microglial conditioned media.we treated sh-sy5 yneurons with various groups of microglial conditioned media for 24 hours.we observed the effect of conditioned media collected from bv-2cell on the viability of dopaminergic cell lines sh-sy5 yusing mtt assay.we found that inflammatory factors inos,cox-2mrna and protein levels were up-regulated upon cpf stimulation.conditioned media from bv-2upon cpf stimulation is toxic to sh-sy5 y.it might be concluded that the exposure to cpf may induce dopaminergic neuronal damage by the activation of inflammatory response,and a mechanism may be involved in parkinson’s disease pathogenesis. |
2018-05-24 |
2023-08-13 |
mouse |
| Dharani Manickavasagam, Kimberly Novak, Moses O Oyewum. Therapeutic Delivery of Simvastatin Loaded in PLA-PEG Polymersomes Resulted in Amplification of Anti-inflammatory Effects in Activated Microglia. The AAPS journal. vol 20. issue 1. 2018-05-16. PMID:29243172. |
studies in bv2 microglia indicated that sim-ps was superior to sim alone in suppressing nitric oxide (no) and proinflammatory cytokines (interleukin-6 (il-6) and tumor necrosis factor alpha (tnf-α) secretion against lps activation. |
2018-05-16 |
2023-08-13 |
mouse |
| Hui Yang, Yijian Chen, Linjie Yu, Yun X. Esculentoside A exerts anti-inflammatory activity in microglial cells. International immunopharmacology. vol 51. 2018-05-10. PMID:28843178. |
our results indicated that esa pretreatment significantly decreased lps-induced production of nitric oxide (no) and prostaglandin e2 (pge2) and impeded lps-mediated upregulation of pro-inflammatory mediators' expression such as nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), interleukin-1β (il-1β), interleukin-6 (il-6), interleukin-12 (il-12) and tumor necrosis factor-a (tnf-α) in both bv2 microglia and primary microglia cells. |
2018-05-10 |
2023-08-13 |
Not clear |
| Jihyeon Yang, Chu-Sook Kim, Thai Hien Tu, Min-Seon Kim, Tsuyoshi Goto, Teruo Kawada, Myung-Sook Choi, Taesun Park, Mi-Kyung Sung, Jong Won Yun, Suck-Young Choe, Jee Hye Lee, Yeonsoo Joe, Hye-Seon Choi, Sung Hoon Back, Hun Taeg Chung, Rina Y. Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction. Nutrients. vol 9. issue 7. 2018-04-26. PMID:28644409. |
quercetin markedly reduced the production of inflammatory mediators (monocyte chemoattractant protein (mcp)-1, interleukin (il-6), il-1β, nitric oxide) by microglia stimulated with saturated fatty acid palmitate and/or lipid-laden microglia-conditioned medium. |
2018-04-26 |
2023-08-13 |
mouse |
| Syntyche Ling-Sing Seow, Murali Naidu, Vikineswary Sabaratnam, Sharmili Vidyadaran, Kah-Hui Won. Tiger's Milk Medicinal Mushroom, Lignosus rhinocerotis (Agaricomycetes) Sclerotium Inhibits Nitric Oxide Production in LPS-Stimulated BV2 Microglia. International journal of medicinal mushrooms. vol 19. issue 5. 2018-04-17. PMID:28845770. |
tiger's milk medicinal mushroom, lignosus rhinocerotis (agaricomycetes) sclerotium inhibits nitric oxide production in lps-stimulated bv2 microglia. |
2018-04-17 |
2023-08-13 |
Not clear |
| Syntyche Ling-Sing Seow, Murali Naidu, Vikineswary Sabaratnam, Sharmili Vidyadaran, Kah-Hui Won. Tiger's Milk Medicinal Mushroom, Lignosus rhinocerotis (Agaricomycetes) Sclerotium Inhibits Nitric Oxide Production in LPS-Stimulated BV2 Microglia. International journal of medicinal mushrooms. vol 19. issue 5. 2018-04-17. PMID:28845770. |
in this study, 10 samples from different preparations of l. rhinocerotis sclerotium, including a hot aqueous extract (hae), an ethanol extract (ee), fractions from the hae and ee, and crude polysaccharides, were tested for their in vitro cytotoxic and nitric oxide (no) inhibitory activities in lipopolysaccharide (lps)--stimulated bv2 microglia. |
2018-04-17 |
2023-08-13 |
Not clear |
| Klaudia Lepka, Katrin Volbracht, Eckhard Bill, Reiner Schneider, Natalia Rios, Thomas Hildebrandt, Jens Ingwersen, Timur Prozorovski, Christopher Horst Lillig, Jack van Horssen, Lawrence Steinman, Hans-Peter Hartung, Rafael Radi, Arne Holmgren, Orhan Aktas, Carsten Bernd. Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia. Glia. vol 65. issue 9. 2018-04-12. PMID:28618115. |
iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia. |
2018-04-12 |
2023-08-13 |
mouse |
| Klaudia Lepka, Katrin Volbracht, Eckhard Bill, Reiner Schneider, Natalia Rios, Thomas Hildebrandt, Jens Ingwersen, Timur Prozorovski, Christopher Horst Lillig, Jack van Horssen, Lawrence Steinman, Hans-Peter Hartung, Rafael Radi, Arne Holmgren, Orhan Aktas, Carsten Bernd. Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia. Glia. vol 65. issue 9. 2018-04-12. PMID:28618115. |
activated microglia are considered a major source of nitric oxide and subsequent peroxynitrite-mediated damage of myelin. |
2018-04-12 |
2023-08-13 |
mouse |
| Klaudia Lepka, Katrin Volbracht, Eckhard Bill, Reiner Schneider, Natalia Rios, Thomas Hildebrandt, Jens Ingwersen, Timur Prozorovski, Christopher Horst Lillig, Jack van Horssen, Lawrence Steinman, Hans-Peter Hartung, Rafael Radi, Arne Holmgren, Orhan Aktas, Carsten Bernd. Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia. Glia. vol 65. issue 9. 2018-04-12. PMID:28618115. |
glutaredoxin 2 levels influence both survival rates of primary oligodendrocyte progenitor cells and preservation of myelin structure in cerebellar organotypic slice cultures challenged with activated microglia or nitric oxide donors. |
2018-04-12 |
2023-08-13 |
mouse |
| Sun Young Park, Mei Ling Jin, Nam Jun Kang, Geuntae Park, Young-Whan Cho. Anti-inflammatory effects of novel polygonum multiflorum compound via inhibiting NF-κB/MAPK and upregulating the Nrf2 pathways in LPS-stimulated microglia. Neuroscience letters. vol 651. 2018-03-26. PMID:28458018. |
in microglia, crpe56igih significantly inhibited lipopolysaccharide (lps)-stimulated nitric oxide and prostaglandin e |
2018-03-26 |
2023-08-13 |
Not clear |
| Li Lu, Xiaorong Li, Pingxiang Xu, Yan Zheng, Xiaomin Wan. Tenuigenin down-regulates the release of nitric oxide, matrix metalloproteinase-9 and cytokines from lipopolysaccharide-stimulated microglia. Neuroscience letters. vol 650. 2018-03-19. PMID:28392358. |
tenuigenin down-regulates the release of nitric oxide, matrix metalloproteinase-9 and cytokines from lipopolysaccharide-stimulated microglia. |
2018-03-19 |
2023-08-13 |
rat |