| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weihong Yi, Dazhi Yang, Zhen Xu, Zecai Chen, Guozhi Xiao, Lei Qi. Immortalization of mouse primary astrocytes. Gene vol issue 2023 36870428 |
astrocytes, as the most abundant glial cell type in the central nervous system, are promising therapeutical targets for many neuronal disorders, such as alzheimer's disease and parkinson's disease. |
2023-03-04 |
2023-03-06 |
mouse |
| Lihong Sheng, Emily J Shields, Janko Gospocic, Masato Sorida, Linyang Ju, China N Byrns, Faith Carranza, Shelley L Berger, Nancy Bonini, Roberto Bonasi. Ensheathing glia promote increased lifespan and healthy brain aging. Aging cell vol issue 2023 36840361 |
furthermore, an expanded ensheathing glia population prevented amyloid-beta accumulation in a fly model of alzheimer's disease and delayed the premature death of the diseased animals. |
2023-02-25 |
2023-03-06 |
drosophila_melanogaster |
| Dasom Kong, Ki Hoon Park, Da-Hyun Kim, Nam Gyo Kim, Seung-Eun Lee, Nari Shin, Myung Geun Kook, Young Bong Kim, Kyung-Sun Kan. Cortical-blood vessel assembloids exhibit Alzheimer's disease phenotypes by activating glia after SARS-CoV-2 infection. Cell death discovery vol 9 issue 1 2023 36697403 |
cortical-blood vessel assembloids exhibit alzheimer's disease phenotypes by activating glia after sars-cov-2 infection. |
2023-01-25 |
2023-01-31 |
human |
| Georgina Perez-Garcia, Mesude Bicak, Jean-Vianney Haure-Mirande, Gissel M Perez, Alena Otero-Pagan, Miguel A Gama Sosa, Rita De Gasperi, Mary Sano, Carrolee Barlow, Fred H Gage, Benjamin Readhead, Michelle E Ehrlich, Sam Gandy, Gregory A Elde. BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT Neuroscience letters vol issue 2023 36657633 |
bci-838, an orally active mglur2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the ps19 mapt tauopathies are a heterogeneous group of neurodegenerative disorders that are clinically and pathologically distinct from alzheimer's disease (ad) having tau inclusions in neurons and/or glia as their most prominent neuropathological feature. |
2023-01-19 |
2023-01-30 |
Not clear |
| Zhi-Bo Wang, Ya-Hui Ma, Yan Sun, Lan Tan, Hui-Fu Wang, Jin-Tai Y. Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-\\xce\\xb2 and tau pathology in Alzheimer's disease. Journal of neuroinflammation vol 19 issue 1 2022 36578067 |
dysfunction of glial cell communication is involved in alzheimer's disease (ad) pathogenesis, and the recent study reported that astrocytic secreted interleukin-3 (il-3) participated in astrocyte-microglia crosstalk and restricted ad pathology in mice, but the effect of il-3 on the pathological progression of ad in human is still unclear. |
2022-12-28 |
2023-01-30 |
mouse |
| Jessica E Young, Lawrence S B Goldstei. Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.) vol 2561 issue 2022 36399267 |
human-induced pluripotent stem cell (hipsc)-derived neurons and glia for the elucidation of pathogenic mechanisms in alzheimer's disease. |
2022-11-18 |
2023-01-30 |
human |
| Yijing Su, Yi Zhou, Mariko L Bennett, Shiying Li, Marc Carceles-Cordon, Lu Lu, Sooyoung Huh, Dennisse Jimenez-Cyrus, Benjamin C Kennedy, Sudha K Kessler, Angela N Viaene, Ingo Helbig, Xiaosong Gu, Joel E Kleinman, Thomas M Hyde, Daniel R Weinberger, David W Nauen, Hongjun Song, Guo-Li Min. A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan. Cell stem cell vol 29 issue 11 2022 36332572 |
leveraging glial subpopulation classifications as a reference map, we revealed the diversity of glia differentiated from human pluripotent stem cells and identified dysregulated genes and pathological processes in specific glial subpopulations in alzheimer's disease (ad). |
2022-11-04 |
2023-01-30 |
human |
| J\\xc3\\xbalia Companys-Alemany, Andreea L Turcu, Santiago V\\xc3\\xa1zquez, Merc\\xc3\\xa8 Pall\\xc3\\xa0s, Christian Gri\\xc3\\xb1\\xc3\\xa1n-Ferr\\xc3\\xa. Glial cell reactivity and oxidative stress prevention in Alzheimer's disease mice model by an optimized NMDA receptor antagonist. Scientific reports vol 12 issue 1 2022 36284170 |
glial cell reactivity and oxidative stress prevention in alzheimer's disease mice model by an optimized nmda receptor antagonist. |
2022-10-26 |
2023-01-30 |
mouse |
| Qing-Shan Yu, Wan-Qing Feng, Lan-Lan Shi, Rui-Ze Niu, Jia Li. Integrated Analysis of Cortex Single-Cell Transcriptome and Serum Proteome Reveals the Novel Biomarkers in Alzheimer's Disease. Brain sciences vol 12 issue 8 2022 36009085 |
the results obtained from blood alone cannot fully reflect the alterations of nerve cells, including neurons and glia cells, in alzheimer's disease (ad) brains. |
2022-08-26 |
2023-01-30 |
human |
| Oh-Chan Kwon, Jae-Jin Song, Yunseon Yang, Seong-Hoon Kim, Ji Young Kim, Min-Jong Seok, Inhwa Hwang, Je-Wook Yu, Jenisha Karmacharya, Han-Joo Maeng, Jiyoung Kim, Eek-Hoon Jho, Seung Yeon Ko, Hyeon Son, Mi-Yoon Chang, Sang-Hun Le. SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models. EMBO molecular medicine vol 13 issue 4 2021 33646633 |
furthermore, sgk1 inhibition potentiated glial activity to scavenge glutamate toxicity and prevented glial cell senescence and mitochondrial damage, which have recently been reported as critical pathologic features of and therapeutic targets in parkinson disease (pd) and alzheimer disease (ad). |
2021-10-25 |
2023-01-26 |
Not clear |
| R E Mrak, W St Griffi. Role of Activated Glia and of Glial Cytokines in Alzheimer's Disease: A Review. Eos (Rome, Italy) vol 16 issue 3-4 2021 24478534 |
furthermore, findings in brains of patients dying with conditions known to predispose to alzheimer's disease suggest that activation of glia and overexpression of glial cytokines are early events in alzheimer pathogenesis. |
2021-10-21 |
2023-01-25 |
Not clear |
| Alexandra I Mot, Constanze Depp, Klaus-Armin Nav. An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases. Dialogues in clinical neuroscience vol 20 issue 4 2019 30936768 |
these findings represent a paradigm shift for the physiological function of axon-associated glia, and open the intriguing possibility that oligodendrocytes are important contributors to neurodegenerative diseases in which myelinated axons are lost, such as in alzheimer disease, amyotrophic lateral sclerosis, and multiple system atrophy. |
2019-05-07 |
2023-01-26 |
Not clear |
| David Holtzman, Jason Ulric. Senescent glia spell trouble in Alzheimer's disease. Nature neuroscience vol 22 issue 5 2019 31024116 |
senescent glia spell trouble in alzheimer's disease. |
2019-05-07 |
2023-01-30 |
Not clear |
| Mayu Nishimuta, Kenta Masui, Tomoko Yamamoto, Yuichi Ikarashi, Katsutoshi Tokushige, Etsuko Hashimoto, Yoji Nagashima, Noriyuki Shibat. Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration. Neuropathology : official journal of the Japanese Society of Neuropathology vol 38 issue 3 2018 29468756 |
in the brain, there were both wd-related lesions such as the scattering of opalski cells and changes caused by hepatic encephalopathy including the appearance of alzheimer type ii glia. |
2018-10-15 |
2023-01-26 |
Not clear |
| Aur\\xc3\\xa9lia Poujois, Jacqueline Mikol, France Woiman. Wilson disease: brain pathology. Handbook of clinical neurology vol 142 issue 2018 28433113 |
increased cellularity is noted in the lesions due to the proliferation of modified astrocytes named alzheimer types of glia and specific cells, called opalski cells, that are characteristic of wd. |
2018-03-22 |
2023-01-26 |
Not clear |
| Mortimer Mamela. Energy and the Alzheimer brain. Neuroscience and biobehavioral reviews vol 75 issue 2017 28193453 |
however, pathology engages all of the major elements of the neurovascular unit of the mature alzheimer brain, the neurons, glia and blood vessels. |
2017-10-24 |
2023-01-26 |
Not clear |
| Michael Maes, George Anderso. Overlapping the Tryptophan Catabolite (TRYCAT) and Melatoninergic Pathways in Alzheimer's Disease. Current pharmaceutical design vol 22 issue 8 2016 25547097 |
such trycats have significant impacts on neuronal functioning and survival contributing to the changes seen in alzheimer's disease (ad), including in its association with depression as well as alterations in the reactivity of immune and glia cells. |
2016-12-13 |
2023-01-25 |
Not clear |
| Hesham Montassir, Yoshihiro Maegaki, Kei Murayama, Taro Yamazaki, Masakazu Kohda, Akira Ohtake, Hiroyasu Iwasa, Yukiko Yatsuka, Yasushi Okazaki, Chitose Sugiura, Ikuo Nagata, Mitsuo Toyoshima, Yoshiaki Saito, Masayuki Itoh, Ichizo Nishino, Kousaku Ohn. Myocerebrohepatopathy spectrum disorder due to POLG mutations: A clinicopathological report. Brain & development vol 37 issue 7 2016 25466440 |
neuropathological examination revealed white matter-predominant spongy changes with alzheimer type ii glia and loss of myelin. |
2016-03-10 |
2023-01-25 |
Not clear |
| Donna M Wilcock, W Sue T Griffi. Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis. Journal of neuroinflammation vol 10 issue 2013 23866266 |
the discovery of neuroinflammatory changes, including dramatic proliferation of activated glia overexpressing a chromosome 2 gene product--the pluripotent immune cytokine interleukin-1 (il-1)--and a chromosome 21 gene product--s100b--in the brains of fetuses, neonates, and children with ds opened the possibility that early events in alzheimer pathogenesis were driven by cytokines. |
2013-11-05 |
2023-01-25 |
Not clear |
| Paul Fole. Lipids in Alzheimer's disease: A century-old story. Biochimica et biophysica acta vol 1801 issue 8 2010 20471492 |
three neuropathological features attracted the attention of alzheimer in his examination of the brain of auguste deter: abnormal fibrillary structures, cortical depositions now termed "plaques," and glial proliferation, whereby he noted remarkable lipid granule accumulation in the glia. |
2010-08-10 |
2023-01-25 |
Not clear |