| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica E Young, Lawrence S B Goldstei. Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399267. |
human-induced pluripotent stem cell (hipsc)-derived neurons and glia for the elucidation of pathogenic mechanisms in alzheimer's disease. |
2022-11-18 |
2023-08-14 |
human |
| Yijing Su, Yi Zhou, Mariko L Bennett, Shiying Li, Marc Carceles-Cordon, Lu Lu, Sooyoung Huh, Dennisse Jimenez-Cyrus, Benjamin C Kennedy, Sudha K Kessler, Angela N Viaene, Ingo Helbig, Xiaosong Gu, Joel E Kleinman, Thomas M Hyde, Daniel R Weinberger, David W Nauen, Hongjun Song, Guo-Li Min. A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan. Cell stem cell. vol 29. issue 11. 2022-11-04. PMID:36332572. |
leveraging glial subpopulation classifications as a reference map, we revealed the diversity of glia differentiated from human pluripotent stem cells and identified dysregulated genes and pathological processes in specific glial subpopulations in alzheimer's disease (ad). |
2022-11-04 |
2023-08-14 |
human |
| b' J\\xc3\\xbalia Companys-Alemany, Andreea L Turcu, Santiago V\\xc3\\xa1zquez, Merc\\xc3\\xa8 Pall\\xc3\\xa0s, Christian Gri\\xc3\\xb1\\xc3\\xa1n-Ferr\\xc3\\xa. Glial cell reactivity and oxidative stress prevention in Alzheimer\'s disease mice model by an optimized NMDA receptor antagonist. Scientific reports. vol 12. issue 1. 2022-10-26. PMID:36284170.' |
glial cell reactivity and oxidative stress prevention in alzheimer's disease mice model by an optimized nmda receptor antagonist. |
2022-10-26 |
2023-08-14 |
mouse |
| Qing-Shan Yu, Wan-Qing Feng, Lan-Lan Shi, Rui-Ze Niu, Jia Li. Integrated Analysis of Cortex Single-Cell Transcriptome and Serum Proteome Reveals the Novel Biomarkers in Alzheimer's Disease. Brain sciences. vol 12. issue 8. 2022-08-26. PMID:36009085. |
the results obtained from blood alone cannot fully reflect the alterations of nerve cells, including neurons and glia cells, in alzheimer's disease (ad) brains. |
2022-08-26 |
2023-08-14 |
human |
| Chunhui Wang, Hongxia Ye, Yanjie Zheng, Yanqiang Qi, Mengyu Zhang, Yan Long, Yanli H. Phenylethanoid Glycosides of Cistanche Improve Learning and Memory Disorders in APP/PS1 Mice by Regulating Glial Cell Activation and Inhibiting TLR4/NF-κB Signaling Pathway. Neuromolecular medicine. 2022-07-05. PMID:35781783. |
this study explored the mechanisms of phgs, ech, and act in the treatment of alzheimer's disease (ad) from the perspectives of glial cell activation, tlr4/nf-κb signaling pathway, and synaptic protein expression. |
2022-07-05 |
2023-08-14 |
mouse |
| Aditya Sunkaria, Supriya Bhardwa. Sleep Disturbance and Alzheimer's Disease: The Glial Connection. Neurochemical research. 2022-03-18. PMID:35303225. |
role of glia in sleep disturbance and alzheimer's progression. |
2022-03-18 |
2023-08-13 |
Not clear |
| Teresa Trotta, Chiara Porro, Antonia Cianciulli, Maria Antonietta Panar. Beneficial Effects of Spirulina Consumption on Brain Health. Nutrients. vol 14. issue 3. 2022-03-12. PMID:35277035. |
this review focuses on the role of spirulina in the brain, highlighting how it exerts its beneficial anti-inflammatory and antioxidant effects, acting on glial cell activation, and in the prevention and/or progression of neurodegenerative diseases, in particular parkinson's disease, alzheimer's disease and multiple sclerosis; due to these properties, spirulina could be considered a potential natural drug. |
2022-03-12 |
2023-08-13 |
Not clear |
| Juan R Perea, Esther García, Laura Vallés-Saiz, Raquel Cuadros, Félix Hernández, Marta Bolós, Jesús Avil. p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model. Scientific reports. vol 12. issue 1. 2022-02-09. PMID:35136118. |
although this kinase is expressed mainly in glia, its activation in certain neurodegenerative diseases such as alzheimer's disease has been associated with its ability to phosphorylate tau in neurons. |
2022-02-09 |
2023-08-13 |
mouse |
| Bill Yunfeng Ding, Richard Daneman, Sean P Palecek, Eric V Shust. Modelling the role of APOE4 in blood-brain barrier dysfunctions with isogenic IPSC-derived brain microvascular endothelial cells and pericytes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108950. |
apoe4 is the strongest genetic risk factor for late-onset alzheimer's disease, and is known to affect the function of multiple neuronal and glial cell types. |
2022-02-03 |
2023-08-13 |
Not clear |
| Chijioke Akunwafo, Jeiran Choupan, Farshid Sepehrban. Premortem perivascular space morphology is a predictor of postmortem glia tau pathology in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109135. |
premortem perivascular space morphology is a predictor of postmortem glia tau pathology in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Patrick J Paasila, Jason A Aramideh, Greg T Sutherland, Manuel B Graebe. Synapses, Microglia, and Lipids in Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2022-01-31. PMID:35095394. |
alzheimer's disease (ad) is characterised by synaptic dysfunction accompanied by the microscopically visible accumulation of pathological protein deposits and cellular dystrophy involving both neurons and glia. |
2022-01-31 |
2023-08-13 |
Not clear |
| Ashlyn G Johnson, James A Webster, Chadwick M Hale. Glial profiling of human tauopathy brain demonstrates enrichment of astrocytic transcripts in tau-related frontotemporal degeneration. Neurobiology of aging. vol 112. 2022-01-20. PMID:35051675. |
to understand how glia may be altered in frontotemporal degeneration with tau pathology (ftd-tau), we used a nanostring glial profiling panel to measure 770 transcripts related to glial biology in human control (n = 8), alzheimer's disease (ad) (n = 8), and ftd-tau (n = 8) dorsolateral prefrontal cortex. |
2022-01-20 |
2023-08-13 |
human |
| Aviva M Tolkovsky, Maria Grazia Spillantin. Tau aggregation and its relation to selected forms of neuronal cell death. Essays in biochemistry. 2021-12-13. PMID:34897457. |
although alzheimer's disease (ad) is the most prevalent tauopathy, tauopathies comprise an array of over 30 diseases in which the cytoplasmic protein tau aggregates in neurons, and also, in some diseases, in glia. |
2021-12-13 |
2023-08-13 |
Not clear |
| Banglian Hu, Shengshun Duan, Ziwei Wang, Xin Li, Yuhang Zhou, Xian Zhang, Yun-Wu Zhang, Huaxi Xu, Honghua Zhen. Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders. Frontiers in aging neuroscience. vol 13. 2021-12-07. PMID:34867307. |
csf1r loss-of-function mutations are the major cause of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (alsp) and its dysfunction has also been implicated in other neurodegenerative disorders including alzheimer's disease (ad). |
2021-12-07 |
2023-08-13 |
Not clear |
| Lindsey D Goodman, Hugo J Belle. Recent insights into the role of glia and oxidative stress in Alzheimer's disease gained from Drosophila. Current opinion in neurobiology. vol 72. 2021-11-30. PMID:34418791. |
recent insights into the role of glia and oxidative stress in alzheimer's disease gained from drosophila. |
2021-11-30 |
2023-08-13 |
drosophila_melanogaster |
| Hao Tang, Michael Hart. Investigating Markers of the NLRP3 Inflammasome Pathway in Alzheimer's Disease: A Human Post-Mortem Study. Genes. vol 12. issue 11. 2021-11-29. PMID:34828359. |
neuroinflammatory mechanisms with glial cell activation have been implicated in the pathogenic process of alzheimer's disease (ad). |
2021-11-29 |
2023-08-13 |
human |
| Tianbai Li, Xiang Tan, Song Li, Murad Al-Nusaif, Weidong L. Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases. Frontiers in aging neuroscience. vol 13. 2021-11-10. PMID:34744700. |
neurodegenerative diseases (nd), such as alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis, share common mechanisms of the aggregation and propagation of distinct pathologic proteins among cells in the nervous systems and neuroinflammatory reactions mediated by glia during the pathogenic process. |
2021-11-10 |
2023-08-13 |
Not clear |
| Natalija Aleksejenko, Janosch P Helle. Super-resolution imaging to reveal the nanostructure of tripartite synapses. Neuronal signaling. vol 5. issue 4. 2021-11-06. PMID:34737894. |
overall, novel super-resolution microscopy methods are needed to fully illuminate the intimate relationship between glia and neuronal cells that underlies signal transduction in the brain and that might be affected in diseases such as alzheimer's disease and epilepsy. |
2021-11-06 |
2023-08-13 |
Not clear |
| Kendra L Hanslik, Kaitlyn M Marino, Tyler K Ullan. Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease. Frontiers in cellular neuroscience. vol 15. 2021-11-03. PMID:34531726. |
recent evidence suggests that glia can also alter the pathology associated with many neurodegenerative disorders including alzheimer's disease (ad) and parkinson's disease (pd). |
2021-11-03 |
2023-08-13 |
Not clear |
| Junjie Sun, Yixing Song, Zhiheng Chen, Jiaying Qiu, Shunxing Zhu, Liucheng Wu, Lingyan Xin. Heterogeneity and Molecular Markers for CNS Glial Cells Revealed by Single-Cell Transcriptomics. Cellular and molecular neurobiology. 2021-10-27. PMID:34704168. |
this review summarizes the marker genes of major glial cells in the cns and reveals their heterogeneity in different species, cns regions, developmental stages, and pathological states (alzheimer's disease and spinal cord injury), expanding our knowledge of glial cell heterogeneity on both molecular and functional levels. |
2021-10-27 |
2023-08-13 |
Not clear |