| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Praseeda Mol, Rex Devasahayam Arokia Balaya, Shobha Dagamajalu, Sreeranjini Babu, Pavithra Chandrasekaran, Reshma Raghavan, Sneha Suresh, Namitha Ravishankara, Anu Hemalatha Raju, Bipin Nair, Prashant Kumar Modi, Anita Mahadevan, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raj. A network map of GDNF/RET signaling pathway in physiological and pathological conditions. Journal of cell communication and signaling. 2023-01-30. PMID:36715855. |
glial cell line-derived neurotrophic factor (gdnf) signals through a multi-component receptor system predominantly consisting of glycosyl-phosphatidylinositol-anchored gdnf family receptor alpha-1 (gfrα1) and the rearranged during transfection (ret) receptor tyrosine kinase. |
2023-01-30 |
2023-08-14 |
Not clear |
| Xue-Ming Zhan. GFRα-1 is a reliable marker of bovine gonocytes/undifferentiated spermatogonia: A mini-review. Anatomia, histologia, embryologia. vol 50. issue 1. 2021-10-19. PMID:32761645. |
the glial cell line-derived neurotrophic factor (gdnf) family receptor alpha-1 (gfrα-1) is a conserved marker of the gonocytes/sscs in multiple species including rodents, primates and human; however, its expression in bovine gonocytes/sscs is debated. |
2021-10-19 |
2023-08-13 |
human |
| Guo-Ping Mao, Ming-Hui Niu, Ying-Hong Cui, Rui-Ling Tang, Wei Chen, Bang Liu, Zuping H. Characterization, isolation, and culture of spermatogonial stem cells in Asian journal of andrology. vol 23. issue 3. 2021-06-04. PMID:33533740. |
glial cell line-derived neurotrophic factor family receptor alpha-1 (gfra1)-enriched spermatogonia were isolated from monkeys, namely macaca fascicularis (m. fascicularis), by two-step enzymatic digestion and magnetic-activated cell sorting, and they were cultured on precoated plates in the conditioned medium. |
2021-06-04 |
2023-08-13 |
human |
| Wenxian Li, Di Wei, Jiaxing Lin, Jianye Liang, Xiaomei Xie, Kangping Song, Li'an Huan. Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling Preventing Hippocampal Neuron Apoptosis. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31456664. |
glial cell line-derived neurotrophic factor (gdnf)/gdnf family receptor alpha-1 (gfrα1)/receptor tyrosine kinase (ret) signaling is altered in the hippocampus of cch rats; however, nbp treatment improved cognitive function, protected against hippocampal neuron apoptosis |
2020-09-29 |
2023-08-13 |
rat |
| Huimin Zhao, Tingting Li, Huan Yang, Muhammad Usman Mehmood, Yangqing Lu, Xingwei Liang, Xiaogan Yang, Huiyan Xu, Kehuan Lu, Shengsheng L. The effects of growth factors on proliferation of spermatogonial stem cells from Guangxi Bama mini-pig. Reproduction in domestic animals = Zuchthygiene. vol 54. issue 12. 2020-05-20. PMID:31544277. |
the growth factors glial cell line-derived neurotrophic factor (gdnf), leukaemia inhibitory factor (lif), gdnf family receptor alpha-1 (gfrα1) and basic fibroblast growth factor (bfgf) were investigated. |
2020-05-20 |
2023-08-13 |
mouse |
| Tuulia Saarenpää, Konstantin Kogan, Yulia Sidorova, Arun Kumar Mahato, Igor Tascón, Heidi Kaljunen, Liying Yu, Jukka Kallijärvi, Jaana Jurvansuu, Mart Saarma, Adrian Goldma. Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PloS one. vol 12. issue 5. 2017-09-18. PMID:28467503. |
glial cell line-derived neurotrophic factor (gdnf) is a ligand that activates, through co-receptor gdnf family receptor alpha-1 (gfrα1) and receptor tyrosine kinase "ret", several signaling pathways crucial in the development and sustainment of multiple neuronal populations. |
2017-09-18 |
2023-08-13 |
mouse |
| M Curcio, I L Salazar, A R Inácio, E P Duarte, L M T Canzoniero, C B Duart. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell death & disease. vol 6. 2016-01-25. PMID:25675305. |
the glial cell line-derived neurotrophic factor (gdnf) has an important role in neuronal survival through binding to the gfrα1 (gdnf family receptor alpha-1) receptor and activation of the receptor tyrosine kinase ret. |
2016-01-25 |
2023-08-13 |
mouse |
| Nikolai Kholodilov, Sang Ryong Kim, Olga Yarygina, Tatyana Kareva, Jin Whan Cho, Amy Baohan, Robert E Burk. Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. Journal of neurochemistry. vol 116. issue 4. 2011-03-22. PMID:21133924. |
many of the cellular effects of glial cell line-derived neurotrophic factor are initiated by binding to gndf family receptor alpha-1 (gfrα1), and mediated by diverse intracellular signaling pathways, most notably through the ret tyrosine kinase. |
2011-03-22 |
2023-08-12 |
mouse |
| Carla Lucini, Lucini Carla, Bruna Facello, Facello Bruna, Lucianna Maruccio, Maruccio Lucianna, Fernanda Langellotto, Langellotto Fernanda, Paolo Sordino, Sordino Paolo, Luciana Castaldo, Castaldo Lucian. Distribution of glial cell line-derived neurotrophic factor receptor alpha-1 in the brain of adult zebrafish. Journal of anatomy. vol 217. issue 2. 2011-01-05. PMID:20572899. |
distribution of glial cell line-derived neurotrophic factor receptor alpha-1 in the brain of adult zebrafish. |
2011-01-05 |
2023-08-12 |
zebrafish |
| Neus Garcia, Manel M Santafé, Marta Tomàs, Maria A Lanuza, Nuria Besalduch, Merche Priego, Josep Tomà. The glial cell line-derived neurotrophic factor (GDNF) does not acutely change acetylcholine release in developing and adult neuromuscular junction. Neuroscience letters. vol 480. issue 2. 2010-10-19. PMID:20542089. |
we use immunocytochemistry to show that the trophic molecule glial cell line-derived neurotrophic factor (gdnf) and its receptor gdnf family receptor alpha-1 (gfralpha-1) are present in both neonatal (p6) and adult (p45) rodent neuromuscular junctions (nmj) colocalized with several synaptic markers. |
2010-10-19 |
2023-08-12 |
Not clear |
| Vandana Zaman, Heather A Boger, Ann-Charlotte Granholm, Baerbel Rohrer, Alfred Moore, Mona Buhusi, Greg A Gerhardt, Barry J Hoffer, Lawrence D Middaug. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. The European journal of neuroscience. vol 28. issue 8. 2009-01-26. PMID:18973577. |
given the established importance of glial cell line-derived neurotrophic factor (gdnf) in maintaining dopaminergic neurotransmitter systems, the nigrostriatal system and associated behaviors of mice with genetic reduction of its high-affinity receptor, gdnf receptor (gfr)alpha-1 (gfralpha-1(+/-)), were compared with wild-type controls. |
2009-01-26 |
2023-08-12 |
mouse |
| Zhanyong Bing, Theresa L Pasha, Priti Lal, John E Tomaszewsk. Expression of glial cell line-derived neurotropic factor receptor alpha-1 in immature teratomas. American journal of clinical pathology. vol 130. issue 6. 2008-12-29. PMID:19019765. |
expression of glial cell line-derived neurotropic factor receptor alpha-1 in immature teratomas. |
2008-12-29 |
2023-08-12 |
Not clear |
| Zhanyong Bing, Theresa L Pasha, Priti Lal, John E Tomaszewsk. Expression of glial cell line-derived neurotropic factor receptor alpha-1 in immature teratomas. American journal of clinical pathology. vol 130. issue 6. 2008-12-29. PMID:19019765. |
in this study, we evaluated the expression of glial cell line-derived neurotropic factor receptor alpha-1 (gfralpha-1) for this purpose. |
2008-12-29 |
2023-08-12 |
Not clear |
| H Qi, D-Q Li, F Bian, E Y Chuang, D B Jones, S C Pflugfelde. Expression of glial cell-derived neurotrophic factor and its receptor in the stem-cell-containing human limbal epithelium. The British journal of ophthalmology. vol 92. issue 9. 2008-10-01. PMID:18723744. |
to evaluate the expression pattern of glial cell line-derived neurotrophic factor (gdnf) with its receptors gdnf family receptor alpha-1 (gfr alpha-1) and ret in the human corneal and limbal tissues, as well as in the primary human limbal epithelial cultures (phlec). |
2008-10-01 |
2023-08-12 |
human |
| Marina Quartu, Maria Pina Serra, Marianna Boi, Maria Teresa Ferretti, Maria Letizia Lai, Marina Del Fiacc. Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age. Brain research. vol 1173. 2008-01-09. PMID:17825269. |
occurrence and localization of receptor components of the glial cell line-derived neurotrophic factor (gdnf) family ligands, the ret receptor tyrosine kinase and the gdnf family receptor (gfr) alpha-1 to -3, were examined by immunohistochemistry in the normal human brainstem at fetal, neonatal, and adult age. |
2008-01-09 |
2023-08-12 |
human |
| Yuko Suzuki, Itaru Mizoguchi, Nobuhiko Uchid. Detection of neurotrophic factors in taste buds by laser capture microdissection, immunohistochemistry, and in situ hybridization. Archives of histology and cytology. vol 70. issue 2. 2007-12-07. PMID:17827669. |
results showed mrnas of the ciliary neurotrophic factor (cntf), its receptor (cntfr), glial cell line-derived neurotrophic factor (gdnf), gdnf family receptors alpha-1 (gfralpha-1), gfralpha-2, and ret tyrosine kinase receptor (ret), neurotrophin (nt)3, nt4/5, tyrosine kinase (trk) c, nerve growth factor (ngf), and trka were expressed in the isolated taste buds. |
2007-12-07 |
2023-08-12 |
mouse |
| Yu-Qiang Shi, Qing-Zhong Wang, Shang-Ying Liao, Yan Zhang, Yi-Xun Liu, Chun-Sheng Ha. In vitro propagation of spermatogonial stem cells from KM mice. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-27. PMID:16720338. |
sscs from km pups could be cultured on mef feeders in stempro-34 sfm medium supplemented with glial cell line-derived neurotrophic factor (gdnf), soluble gdnf family receptor alpha-1 (gfra1) and basic fibroblast growth factor (bfgf) for 1 month. |
2006-06-27 |
2023-08-12 |
mouse |
| Buom-Yong Ryu, Hiroshi Kubota, Mary R Avarbock, Ralph L Brinste. Conservation of spermatogonial stem cell self-renewal signaling between mouse and rat. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 40. 2006-03-28. PMID:16183739. |
initially, a method to assess in vitro expansion of sscs was developed by using flow cytometric analysis, and, subsequently, we found that a combination of glial cell line-derived neurotrophic factor, soluble glial cell line-derived neurotrophic factor-family receptor alpha-1 and basic fibroblast growth factor supports proliferation of rat sscs. |
2006-03-28 |
2023-08-12 |
mouse |
| Asako Hase, Fumiaki Saito, Hiroki Yamada, Ken Arai, Teruo Shimizu, Kiichiro Matsumur. Characterization of glial cell line-derived neurotrophic factor family receptor alpha-1 in peripheral nerve Schwann cells. Journal of neurochemistry. vol 95. issue 2. 2005-11-02. PMID:16086681. |
characterization of glial cell line-derived neurotrophic factor family receptor alpha-1 in peripheral nerve schwann cells. |
2005-11-02 |
2023-08-12 |
rat |
| Asako Hase, Fumiaki Saito, Hiroki Yamada, Ken Arai, Teruo Shimizu, Kiichiro Matsumur. Characterization of glial cell line-derived neurotrophic factor family receptor alpha-1 in peripheral nerve Schwann cells. Journal of neurochemistry. vol 95. issue 2. 2005-11-02. PMID:16086681. |
glial cell line-derived neurotrophic factor (gdnf) family receptor alpha-1 (gfralpha-1) is a receptor component of gdnf that associates with and activates the tyrosine kinase receptor ret. |
2005-11-02 |
2023-08-12 |
rat |