| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gonçalo Garcia, Sara Pinto, Sofia Ferreira, Daniela Lopes, Maria João Serrador, Adelaide Fernandes, Ana Rita Vaz, Alexandre de Mendonça, Frank Edenhofer, Tarja Malm, Jari Koistinaho, Dora Brite. Emerging Role of miR-21-5p in Neuron-Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer's Disease. Cells. vol 11. issue 21. 2022-11-11. PMID:36359774. |
here, we show glial cell activation and mir-21 overexpression in mouse organotypic hippocampal slices transplanted with sh-sy5y cells expressing the human |
2022-11-11 |
2023-08-14 |
mouse |
| Wei Liu, Jiaxi Liu, Jie Gao, Xiaoxu Duan, Lifeng Zhan. Effects of Subchronic Aluminum Exposure on Learning, Memory, and Neurotrophic Factors in Rats. Neurotoxicity research. 2022-11-07. PMID:36342585. |
with hematoxylin and eosin staining, western blot, immunofluorescence, and rt-pcr, the morphology of nerve cells in the hippocampus of rat brain were observed, and the levels of activator protein-1 (ap-1) gene and protein, nerve growth factor (ngf), neurotrophin-3 (nt3), glial cell line-derived neurotrophic factor (gdnf), and brain-derived neurotrophic factor (bdnf) gene and protein level, etc. |
2022-11-07 |
2023-08-14 |
human |
| Yijing Su, Yi Zhou, Mariko L Bennett, Shiying Li, Marc Carceles-Cordon, Lu Lu, Sooyoung Huh, Dennisse Jimenez-Cyrus, Benjamin C Kennedy, Sudha K Kessler, Angela N Viaene, Ingo Helbig, Xiaosong Gu, Joel E Kleinman, Thomas M Hyde, Daniel R Weinberger, David W Nauen, Hongjun Song, Guo-Li Min. A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan. Cell stem cell. vol 29. issue 11. 2022-11-04. PMID:36332572. |
the molecular diversity of glia in the human hippocampus and their temporal dynamics over the lifespan remain largely unknown. |
2022-11-04 |
2023-08-14 |
human |
| Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stéphanie Clerget-Froidevaux, Valérie Enderli. A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233235. |
a fine regulation of the hippocampal thyroid signalling protects hypothyroid mice against glial cell activation. |
2022-10-14 |
2023-08-14 |
mouse |
| Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stéphanie Clerget-Froidevaux, Valérie Enderli. A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233235. |
local reduced levels of thyroid hormones (ths) may impair glia morphology and activity, and promote the increase of pro-inflammatory cytokine levels mainly in the hippocampus. |
2022-10-14 |
2023-08-14 |
mouse |
| Mitsuhiro Oishi, Passlick Stefan, Yoshihiko Yamazaki, Miyuki Unekawa, Ruka Adachi, Mayumi Yamada, Itaru Imayoshi, Yoshifumi Abe, Christian Steinhäuser, Kenji F Tanak. Separate optogenetic manipulation of Nerve/glial antigen 2 (NG2) glia and mural cells using the NG2 promoter. Glia. 2022-09-27. PMID:36165697. |
chr2-mediated depolarization was observed in ng2 glia in acute hippocampal slices. |
2022-09-27 |
2023-08-14 |
mouse |
| Alessia Salamone, Gaetano Terrone, Rossella Di Sapia, Silvia Balosso, Teresa Ravizza, Luca Beltrame, Ilaria Craparotta, Laura Mannarino, Sara Raimondi Cominesi, Massimo Rizzi, Alberto Pauletti, Sergio Marchini, Luca Porcu, Till S Zimmer, Eleonora Aronica, Matthew During, Brett Abrahams, Shinichi Kondo, Toshiya Nishi, Annamaria Vezzan. Cholesterol 24-hydroxylase is a novel pharmacological target for anti-ictogenic and disease modification effects in epilepsy. Neurobiology of disease. 2022-08-06. PMID:35932989. |
high throughput rna-sequencing of hippocampal neurons and glia in mice treated with soticlestat during epileptogenesis showed that inhibition of cholesterol 24-hydroxylase did not directly affect the epileptogenic transcriptional network, but rather modulated a non-overlapping set of genes that might oppose the pathogenic mechanisms of the disease. |
2022-08-06 |
2023-08-14 |
mouse |
| Ghazal Naseri Kouzehgarani, Mikhail E Kandel, Masayoshi Sakakura, Joshua S Dupaty, Gabriel Popescu, Martha U Gillett. Circadian Volume Changes in Hippocampal Glia Studied by Label-Free Interferometric Imaging. Cells. vol 11. issue 13. 2022-07-09. PMID:35805157. |
circadian volume changes in hippocampal glia studied by label-free interferometric imaging. |
2022-07-09 |
2023-08-14 |
Not clear |
| Anabel R Simões, Marta Neto, Carolina S Alves, Mariana B Santos, Ismael Fernández-Hernández, Henrique Veiga-Fernandes, David Brea, Irene Durá, Juan M Encinas, Christa Rhine. Damage-responsive neuro-glial clusters coordinate the recruitment of dormant neural stem cells in Drosophila. Developmental cell. 2022-06-18. PMID:35716661. |
mammalian swim (lcn7) is also upregulated in glia of the mouse hippocampus upon brain injury. |
2022-06-18 |
2023-08-14 |
mouse |
| Riaz Ahmad, Amjad Khan, Inayat Ur Rehman, Hyeon Jin Lee, Ibrahim Khan, Myeong Ok Ki. Lupeol Treatment Attenuates Activation of Glial Cells and Oxidative-Stress-Mediated Neuropathology in Mouse Model of Traumatic Brain Injury. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682768. |
similarly, our results indicated that lupeol treatment inhibited glial cell activation, p-nf-κb, and downstream signaling molecules, such as tnf-α, cox-2, and il-1β, in the mouse cortex and hippocampus. |
2022-06-10 |
2023-08-14 |
mouse |
| Viktor Aniol, Anna Manolova, Natalia Gulyaev. Early Life Events and Maturation of the Dentate Gyrus: Implications for Neurons and Glial Cells. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457079. |
adverse events in early life provoke proinflammatory changes in hippocampal glia at cellular and molecular levels immediately after stress exposure. |
2022-04-23 |
2023-08-13 |
Not clear |
| Dandan Yan, Lingling Dai, Xing Zhang, Yiqi Wang, Hong Ya. Subchronic Acrylamide Exposure Activates PERK-eIF2α Signaling Pathway and Induces Synaptic Impairment in Rat Hippocampus. ACS chemical neuroscience. 2022-04-20. PMID:35442627. |
acr exposure at 5 and 10 (mg/kg)/day by gavage for 14 weeks results in gait abnormality and cognitive impairment in rats, which were accompanied by neuronal loss, glial cell proliferation, and synaptic ultrastructure damage in the hippocampus. |
2022-04-20 |
2023-08-13 |
rat |
| Yang Xu, Zejie Liu, Shuting Xu, Chengxian Li, Manrui Li, Shuqiang Cao, Yuwen Sun, Hao Dai, Yadong Guo, Xiameng Chen, Weibo Lian. Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature. Nutrients. vol 14. issue 7. 2022-04-12. PMID:35406044. |
this recovery is believed to be achieved by alleviating mitochondrial dysfunction, promoting hippocampal neurogenesis, inhibiting glial cell responses, shaping neural cell plasticity, as well as targeting apoptosis and autophagy. |
2022-04-12 |
2023-08-13 |
Not clear |
| Mengtan Cai, Weihong Li. The Function of NF-Kappa B During Epilepsy, a Potential Therapeutic Target. Frontiers in neuroscience. vol 16. 2022-04-01. PMID:35360161. |
it is upregulated in neurons, glial cells, and endothelial cells, due to neuronal loss, glial cell proliferation, blood-brain barrier dysfunction, and hippocampal sclerosis through the glutamate and γ-aminobutyric acid imbalance, ion concentration changes, and other mechanisms. |
2022-04-01 |
2023-08-13 |
Not clear |
| Junyoung Oh, Woo-Hyun Cho, Ellane Barcelon, Kwang Hwan Kim, Jinpyo Hong, Sung Joong Le. SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death. Scientific reports. vol 12. issue 1. 2022-04-01. PMID:35361832. |
these neurological symptoms were accompanied by neuronal cell death in the dorsal and ventral hippocampus as well as glial cell activation. |
2022-04-01 |
2023-08-13 |
mouse |
| Junyoung Oh, Woo-Hyun Cho, Ellane Barcelon, Kwang Hwan Kim, Jinpyo Hong, Sung Joong Le. SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death. Scientific reports. vol 12. issue 1. 2022-04-01. PMID:35361832. |
in conclusion, our data suggest a novel pathogenic mechanism for the covid-19-associated neurological symptoms that involves glia activation and non-cell autonomous hippocampal neuronal death by the brain-infiltrating s1 protein. |
2022-04-01 |
2023-08-13 |
mouse |
| Noelia Rodríguez-Iglesias, Agnes Nadjar, Amanda Sierra, Jorge Valer. Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328825. |
susceptibility of female mice to the dietary omega-3/omega-6 fatty-acid ratio: effects on adult hippocampal neurogenesis and glia. |
2022-03-25 |
2023-08-13 |
mouse |
| Niya Wang, Yahong Tan, Qixin Zhou, Rongrong Mao, Yuexiong Yan. The impairment of the hippocampal neuro-vascular unit precedes changes in spatial cognition in naturally aged rats. Neuroscience letters. 2022-03-21. PMID:35307332. |
we found that the impairments of microvessels, glia, neurons, and spatial memory were age-dependent in the rat hippocampus. |
2022-03-21 |
2023-08-13 |
rat |
| Christopher Hoyle, Jack P Green, Stuart M Allan, David Brough, Eloise Lemarchan. Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages. Immunology. 2022-02-09. PMID:35137954. |
using murine bone marrow-derived macrophages, mixed glia and organotypic hippocampal slice cultures (ohscs), we demonstrate that dmi, 4oi and dmf pre-treatment inhibit pro-inflammatory cytokine production in response to lipopolysaccharide (lps), as well as inhibiting subsequent nlrp3 inflammasome activation induced by nigericin. |
2022-02-09 |
2023-08-13 |
human |
| Dongze Li, Na Xu, Yanyan Hou, Wenjing Ren, Na Zhang, Xi Wang, Yeying Sun, Wenxue Lu, Guiwu Qu, Yan Yu, Changjun Lv, Fang Ha. Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway. Molecular medicine (Cambridge, Mass.). vol 28. issue 1. 2022-01-15. PMID:35030992. |
here, our study found that about 3 months cih treatment induced lipid droplets (lds) accumulation in hippocampal nerve and glia cells of c57bl/6 mice, and caused severe neuro damage including neuron lesions, neuroblast (nb) apoptosis and abnormal glial activation. |
2022-01-15 |
2023-08-13 |
mouse |