| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryan M Walsh, Raffaele Luongo, Elisa Giacomelli, Gabriele Ciceri, Chelsea Rittenhouse, Antonietta Verrillo, Maura Galimberti, Vittoria Dickinson Bocchi, Youjun Wu, Nan Xu, Simone Mosole, James Muller, Elena Vezzoli, Johannes Jungverdorben, Ting Zhou, Roger A Barker, Elena Cattaneo, Lorenz Studer, Arianna Baggiolin. Generation of human cerebral organoids with a structured outer subventricular zone. Cell reports. vol 43. issue 4. 2024-04-07. PMID:38583153. |
outer radial glia (org) emerge as cortical progenitor cells that support the development of an enlarged outer subventricular zone (osvz) and the expansion of the neocortex. |
2024-04-07 |
2024-04-10 |
human |
| Madeline G Andrews, Clara Siebert, Li Wang, Matthew L White, Jayden Ross, Raul Morales, Megan Donnay, Gradi Bamfonga, Tanzila Mukhtar, Arpana Arjun McKinney, Kaila Gemenes, Shaohui Wang, Qiuli Bi, Elizabeth E Crouch, Neelroop Parikshak, Georgia Panagiotakos, Eric Huang, Aparna Bhaduri, Arnold R Kriegstei. LIF signaling regulates outer radial glial to interneuron fate during human cortical development. Cell stem cell. 2023-09-06. PMID:37673072. |
in humans, the outer radial glia (org) subtype is expanded and gives rise to diverse neurons and glia. |
2023-09-06 |
2023-10-07 |
human |
| Ryan Walsh, Elisa Giacomelli, Gabriele Ciceri, Chelsea Rittenhouse, Maura Galimberti, Youjun Wu, James Muller, Elena Vezzoli, Johannes Jungverdorben, Ting Zhou, Roger A Barker, Elena Cattaneo, Lorenz Studer, Arianna Baggiolin. Generation of human cerebral organoids with a structured outer subventricular zone. bioRxiv : the preprint server for biology. 2023-02-24. PMID:36824730. |
mammalian outer radial glia (org) emerge as cortical progenitor cells that directly support the development of an enlarged outer subventricular zone (osvz) and, in turn, the expansion of the neocortex. |
2023-02-24 |
2023-08-14 |
human |
| Jinyue Zhao, Chao Feng, Wenwen Wang, Libo Su, Jianwei Jia. Human SERPINA3 induces neocortical folding and improves cognitive ability in mice. Cell discovery. vol 8. issue 1. 2022-11-22. PMID:36414636. |
further, serpina3 promoted proliferation of the outer radial glia (org, also referred to as the basal radial glia) and increased the number of upper-layer neurons. |
2022-11-22 |
2023-08-14 |
mouse |
| Outer Radial Glia-Like Cells May Promote Glioblastoma Invasiveness. Cancer discovery. vol 10. issue 2. 2021-10-03. PMID:34365410. |
outer radial glia (org)-like glioma stem cells (gsc) were enriched in human glioblastomas. |
2021-10-03 |
2023-08-13 |
human |
| Shirui Hou, Wan-Ling Ho, Lei Wang, Bryan Kuo, Jun Young Park, Young-Goo Ha. Biphasic Roles of Hedgehog Signaling in the Production and Self-Renewal of Outer Radial Glia in the Ferret Cerebral Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 10. 2021-09-15. PMID:34002221. |
hh signaling increases org-producing division modes of ventricular radial glia (vrgs), org self-renewal, and ipc proliferation. |
2021-09-15 |
2023-08-13 |
mouse |
| Aparna Bhaduri, Elizabeth Di Lullo, Diane Jung, Sören Müller, Elizabeth Erin Crouch, Carmen Sandoval Espinosa, Tomoko Ozawa, Beatriz Alvarado, Julien Spatazza, Cathryn René Cadwell, Grace Wilkins, Dmitry Velmeshev, Siyuan John Liu, Martina Malatesta, Madeline Gail Andrews, Mohammed Andres Mostajo-Radji, Eric Jinsheng Huang, Tomasz Jan Nowakowski, Daniel Amos Lim, Aaron Diaz, David Ronan Raleigh, Arnold Richard Kriegstei. Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell stem cell. vol 26. issue 1. 2021-04-27. PMID:31901251. |
within these gscs, we identify an invasive cell population similar to outer radial glia (org), a fetal cell type that expands the stem cell niche in normal human cortex. |
2021-04-27 |
2023-08-13 |
human |
| Madeline G Andrews, Lakshmi Subramanian, Arnold R Kriegstei. mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex. eLife. vol 9. 2021-02-11. PMID:32876565. |
thus, mtor signaling can regulate the architecture of the developing human cortex by maintaining the cytoskeletal organization of org cells and the radial glia scaffold. |
2021-02-11 |
2023-08-13 |
human |
| Nicolas Daviaud, Clément Chevalier, Roland H Friedel, Hongyan Zo. Distinct Vulnerability and Resilience of Human Neuroprogenitor Subtypes in Cerebral Organoid Model of Prenatal Hypoxic Injury. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31417360. |
we demonstrated that transient hypoxia resulted in immediate and prolonged apoptosis in cerebral organoids, with outer radial glia (org), a progenitor population more prominent in primates, and differentiating neuroblasts/immature neurons suffering larger losses. |
2020-10-01 |
2023-08-13 |
human |
| Wei Zhang, Si-Lu Yang, Mei Yang, Stephanie Herrlinger, Qiang Shao, John L Collar, Edgar Fierro, Yanhong Shi, Aimin Liu, Hui Lu, Bruce E Herring, Ming-Lei Guo, Shilpa Buch, Zhen Zhao, Jian Xu, Zhipeng Lu, Jian-Fu Che. Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors. Nature communications. vol 10. issue 1. 2019-07-09. PMID:31197141. |
by creating mutant mice and human cerebral organoids, here we found that wdr62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells (npcs), including outer radial glia (org). |
2019-07-09 |
2023-08-13 |
mouse |
| Xiang-Chun Ju, Qiong-Qiong Hou, Ai-Li Sheng, Kong-Yan Wu, Yang Zhou, Ying Jin, Tieqiao Wen, Zhengang Yang, Xiaoqun Wang, Zhen-Ge Lu. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. eLife. vol 5. 2017-11-01. PMID:27504805. |
here, we found that expression of tbc1d3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vrgs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (org), which are most abundant in primates. |
2017-11-01 |
2023-08-13 |
mouse |
| Tomasz J Nowakowski, Alex A Pollen, Carmen Sandoval-Espinosa, Arnold R Kriegstei. Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development. Neuron. vol 91. issue 6. 2017-10-03. PMID:27657449. |
as a consequence of this transformation, supragranular layer neurons arrive at their terminal positions in the cortical plate along outer radial glia (org) cell fibers. |
2017-10-03 |
2023-08-13 |
human |
| Bridget E L Ostrem, Jan H Lui, Caitlyn C Gertz, Arnold R Kriegstei. Control of outer radial glial stem cell mitosis in the human brain. Cell reports. vol 8. issue 3. 2015-08-24. PMID:25088420. |
evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain called outer radial glia (org). |
2015-08-24 |
2023-08-13 |
human |
| Matthew B Johnson, Peter P Wang, Kutay D Atabay, Elisabeth A Murphy, Ryan N Doan, Jonathan L Hecht, Christopher A Wals. Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex. Nature neuroscience. vol 18. issue 5. 2015-07-09. PMID:25734491. |
specialized progenitors that are common in humans but virtually absent in rodents, called outer radial glia (org), have been suggested to be crucial to the evolutionary expansion of the human cortex. |
2015-07-09 |
2023-08-13 |
mouse |
| b' Kieran Ritchie, L Ashley Watson, Benjamin Davidson, Yan Jiang, Nathalie G B\\xc3\\xa9rub\\xc3\\xa. ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain. Biology open. vol 3. issue 12. 2014-12-16. PMID:25395668.' |
premature differentiation was associated with an increased generation of outer radial glia (org) and tbr2-expressing basal progenitors, as well as increased generation of early-born post-mitotic projection neurons. |
2014-12-16 |
2023-08-13 |
mouse |
| Fernando García-Moreno, Navneet A Vasistha, Nonata Trevia, James A Bourne, Zoltán Molná. Compartmentalization of cerebral cortical germinal zones in a lissencephalic primate and gyrencephalic rodent. Cerebral cortex (New York, N.Y. : 1991). vol 22. issue 2. 2012-05-07. PMID:22114081. |
the proportions of radial glia, intermediate progenitors, and outer radial glial cell (org) populations were similar in midgestation lissencephalic marmoset as in gyrencephalic human or ferret. |
2012-05-07 |
2023-08-12 |
human |
| Hao Huang, Latifa Barakat, Doris Wang, Angélique Borde. Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices. The Journal of physiology. vol 560. issue Pt 3. 2005-04-13. PMID:15331688. |
inhibitors of glycine transport through glyt1 (sarcosine and (n-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (nfps)) reduced glycine currents by approximately 85%, consistent with positive immunostaining for glyt1 in bergmann glia while inhibitors of glycine transport through glyt2 (4-benzyloxy-3,5-dimethoxy-n-[1-(dimethylaminocyclopently)methyl]benzamide (org 25543) and amoxapine) or through systems a and asc did not affect glycine transport currents. |
2005-04-13 |
2023-08-12 |
mouse |
| A J Dekker, J A Tonnae. Binding of the neurotrophic peptide Org 2766 to rat spinal cord sections is affected by a sciatic nerve crush. Brain research. vol 477. issue 1-2. 1989-05-19. PMID:2539231. |
it is suggested that org 2766 binds to axonal sprouts or glia in the dorsal horn of the spinal cord. |
1989-05-19 |
2023-08-11 |
rat |