| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rudolph M Navar. Olanzapine for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting. European journal of pharmacology. vol 722. 2014-09-28. PMID:24157985. |
it blocks multiple neurotransmitter receptors including dopaminergic at d1, d2, d3, d4 brain receptors, serotonergic at 5-ht2a, 5-ht2c, 5-ht3, 5-ht6 receptors, catecholamines at alpha1 adrenergic receptors, acetylcholine at muscarinic receptors, and histamine at h1 receptors. |
2014-09-28 |
2023-08-12 |
Not clear |
| Stephen M Stah. Mechanism of action of agomelatine: a novel antidepressant exploiting synergy between monoaminergic and melatonergic properties. CNS spectrums. vol 19. issue 3. 2014-09-04. PMID:24901504. |
a striking and unexpected pharmacologic synergy has been shown between antagonist actions at serotonergic 5ht2c receptors, and agonist actions at melatonergic receptors by agomelatine, a drug that has both of these properties. |
2014-09-04 |
2023-08-13 |
Not clear |
| Renato Leonardo de Freitas, Rithiele Cristina de Oliveira, Ricardo de Oliveira, Tatiana Paschoalin-Maurin, Fernando Morgan de Aguiar Corrêa, Norberto Cysne Coimbr. The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT₂A and 5-HT₂C serotonergic receptors in post-ictal antinociception. Synapse (New York, N.Y.). vol 68. issue 1. 2014-06-20. PMID:23913301. |
these findings suggest that serotonergic neurotransmission, which recruits both 5-ht2a and 5-ht2c serotonergic receptors in dmpag and vlpag columns, plays a critical role in the elaboration of post-ictal antinociception. |
2014-06-20 |
2023-08-12 |
Not clear |
| Morteza Zendehdel, Keyvan Hasani, Vahab Babapour, Sepideh Seyedali Mortezaei, Yalda Khoshbakht, Shahin Hassanpou. Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken. Veterinary research communications. vol 38. issue 1. 2014-05-22. PMID:24122738. |
these results suggest that dopamine decrease food intake via d1 receptor and there is an interaction between dopaminergic and serotonergic systems via 5-ht2c receptor in chickens. |
2014-05-22 |
2023-08-12 |
chicken |
| Trevor Humby, Jessica B Eddy, Mark A Good, Amy C Reichelt, Lawrence S Wilkinso. A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 11. 2014-05-05. PMID:23657439. |
additionally, using this model we show novel and highly discrete effects of 5-ht2c receptor antagonism that suggest manipulation of 5-ht2c receptor function may be of use in correcting maladaptive impulsive behaviors and provide further evidence for dissociable contributions of serotonergic transmission to response control. |
2014-05-05 |
2023-08-12 |
mouse |
| Jean-François Perrier, Hanne Borger Rasmussen, Rasmus Kordt Christensen, Anders Victor Peterse. Modulation of the intrinsic properties of motoneurons by serotonin. Current pharmaceutical design. vol 19. issue 24. 2014-01-27. PMID:23360270. |
the somato-dendritic compartments of motoneurons are densely innervated by serotonergic synaptic boutons and several receptors are expressed in the membrane of motoneurons including 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2a, 5-ht2b, 5-ht2c and 5-ht5a. |
2014-01-27 |
2023-08-12 |
Not clear |
| Morteza Zendehdel, Kasra Mokhtarpouriani, Vahab Babapour, Ali Baghbanzadeh, Maryam Pourrahimi, Shahin Hassanpou. The effect of serotonergic system on nociceptin/orphanin FQ induced food intake in chicken. The journal of physiological sciences : JPS. vol 63. issue 4. 2014-01-23. PMID:23615894. |
these results suggest that n/ofq induced hyperphagia is mediated by serotonergic mechanisms, and possibly imply an interaction between n/ofq and the serotonergic system (via 5-ht2c receptors) on food intake in chickens. |
2014-01-23 |
2023-08-12 |
chicken |
| Luis Pennanen, Marieke van der Hart, Lisa Yu, Laurence H Tecot. Impact of serotonin (5-HT)2C receptors on executive control processes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 6. 2014-01-21. PMID:23303047. |
altogether, these findings provide insights into the serotonergic regulation of executive control processes and suggest that impaired 5-ht2c receptor signaling during development may predispose to executive function disorders. |
2014-01-21 |
2023-08-12 |
mouse |
| Marco Milanese, Daniela Tardito, Laura Musazzi, Giulia Treccani, Alessandra Mallei, Tiziana Bonifacino, Cecilia Gabriel, Elisabeth Mocaer, Giorgio Racagni, Maurizio Popoli, Giambattista Bonann. Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes. BMC neuroscience. vol 14. 2013-11-01. PMID:23895555. |
agomelatine, a new antidepressant endowed with mt1/mt2 agonist and 5-ht2c serotonergic antagonist properties, has shown efficacy at both preclinical and clinical levels. |
2013-11-01 |
2023-08-12 |
rat |
| Jan Pecenak, Vladimir Novotn. Agomelatine as monotherapy for major depression: an outpatient, open-label study. Neuropsychiatric disease and treatment. vol 9. 2013-10-31. PMID:24174876. |
agomelatine is a novel antidepressant agonist to mt1 and mt2 subtypes of melatoninergic receptors (mt1 and mt2) and antagonist to 5-ht2c subtype of serotonergic (5-ht2c) receptors, which has shown antidepressant efficacy in short-term and long-term trials as well as in clinical practice. |
2013-10-31 |
2023-08-12 |
Not clear |
| R Hardeland, B Poeggele. Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system. Central nervous system agents in medicinal chemistry. vol 12. issue 3. 2013-06-13. PMID:22640220. |
their differences concerning receptor affinities, preferences for receptor subtypes, and pharmacokinetics are discussed, as well as additional antidepressive actions of agomelatine and tik-301 based on properties as antagonists of the serotonergic 5-ht2c receptor. |
2013-06-13 |
2023-08-12 |
Not clear |
| Charles T Nguyen, Jennifer A Rosen, Robert G Bot. Aripiprazole partial agonism at 5-HT2C: a comparison of weight gain associated with aripiprazole adjunctive to antidepressants with high versus low serotonergic activities. The primary care companion for CNS disorders. vol 14. issue 5. 2013-06-04. PMID:23469329. |
aripiprazole partial agonism at 5-ht2c: a comparison of weight gain associated with aripiprazole adjunctive to antidepressants with high versus low serotonergic activities. |
2013-06-04 |
2023-08-12 |
Not clear |
| Charles T Nguyen, Jennifer A Rosen, Robert G Bot. Aripiprazole partial agonism at 5-HT2C: a comparison of weight gain associated with aripiprazole adjunctive to antidepressants with high versus low serotonergic activities. The primary care companion for CNS disorders. vol 14. issue 5. 2013-06-04. PMID:23469329. |
we theorize that, in the presence of antidepressants with high serotonergic activity, aripiprazole acts as an antagonist at the 5-ht2c receptor, thus increasing the potential for weight gain. |
2013-06-04 |
2023-08-12 |
Not clear |
| Charles T Nguyen, Jennifer A Rosen, Robert G Bot. Aripiprazole partial agonism at 5-HT2C: a comparison of weight gain associated with aripiprazole adjunctive to antidepressants with high versus low serotonergic activities. The primary care companion for CNS disorders. vol 14. issue 5. 2013-06-04. PMID:23469329. |
conversely, in environments with low serotonergic activity, aripiprazole acts as an agonist at the 5-ht2c receptor, therefore having less potential for weight gain. |
2013-06-04 |
2023-08-12 |
Not clear |
| Yasuhito Uezono, Kanako Miyano, Yuka Sudo, Masami Suzuki, Seiji Shiraishi, Kiyoshi Terawak. A review of traditional Japanese medicines and their potential mechanism of action. Current pharmaceutical design. vol 18. issue 31. 2013-05-13. PMID:22632864. |
recent reports have shown that rkt elicits its effects through dual action to the g protein-coupled receptors: inhibition of serotonergic 5-ht2c and 5-ht2b receptors and activation of ghrelin receptors via specific ingredients of rkt. |
2013-05-13 |
2023-08-12 |
Not clear |
| Núria Cruz, Eduard Viet. Asenapine: a new focus on the treatment of mania. Revista de psiquiatria y salud mental. vol 4. issue 2. 2013-04-11. PMID:23446146. |
asenapine, recently marketed in united states and ready to be so in europe, is a multimodal action second-generation antipsychotic, with high affinity for multiple dopaminergic (d2, d3 y d4), serotonergic (5ht2a, 5ht2b, 5ht2c, 5ht6 and 5ht7) and adrenergic (α1a, α2a, α2b and α2c) receptors. |
2013-04-11 |
2023-08-12 |
Not clear |
| Saima Khaliq, Saida Haider, Sadia Saleem, Zahida Memon, Darakhshan J Halee. Influence of serotonergic 5-HT2C receptor antagonist mesulergine in the reversal of memory deficits induced by mCPP. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. vol 22. issue 2. 2012-06-21. PMID:22313641. |
influence of serotonergic 5-ht2c receptor antagonist mesulergine in the reversal of memory deficits induced by mcpp. |
2012-06-21 |
2023-08-12 |
Not clear |
| Giorgio Racagni, Marco Andrea Riva, Raffaella Molteni, Laura Musazzi, Francesca Calabrese, Maurizio Popoli, Daniela Tardit. Mode of action of agomelatine: synergy between melatonergic and 5-HT2C receptors. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 12. issue 8. 2012-04-13. PMID:21999473. |
the new antidepressant agomelatine is an agonist of melatonergic mt₁/mt₂ receptors as well as an antagonist of serotonergic 5-ht2c receptors. |
2012-04-13 |
2023-08-12 |
Not clear |
| Yu Zhang, Aihui Li, Jiajia Xin, Lixing Lao, Ke Ren, Brian M Berman, Ming Tan, Rui-Xin Zhan. Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21556842. |
the present study investigated the effects of intrathecal 5,7-dihydroxytryptamine creatinine sulfate, a selective neurotoxin for serotonergic terminals, the 5-hydroxytryptamine 1a receptor (5-ht1ar) antagonist nan-190 hydrobromide and the 5-ht2c receptor (5-ht2cr) antagonist sb-242,084 on ea anti-hyperalgesia. |
2012-02-08 |
2023-08-12 |
rat |
| Elin Sörman, Dannie Wang, Mihaly Hajos, Bernat Kocsi. Control of hippocampal theta rhythm by serotonin: role of 5-HT2c receptors. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21281651. |
the results of this study demonstrate that 5-ht2c receptors are important element of the serotonergic modulation of hippocampal theta oscillations and thus pharmacological interactions with these receptors can modulate physiological and pathological processes associated with limbic theta activity. |
2011-10-14 |
2023-08-12 |
rat |