| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Girstaute Dagyte, Andrea Trentani, Folkert Postema, Paul G Luiten, Johan A Den Boer, Cecilia Gabriel, Elisabeth Mocaër, Peter Meerlo, Eddy A Van der Ze. The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed rats. CNS neuroscience & therapeutics. vol 16. issue 4. 2010-10-21. PMID:20236141. |
agomelatine is a novel antidepressant which acts as a melatonergic (mt1/mt2) receptor agonist and serotonergic (5-ht2c) receptor antagonist. |
2010-10-21 |
2023-08-12 |
rat |
| I Okun, S E Tkachenko, A Khvat, O Mitkin, V Kazey, A V Ivachtchenk. From anti-allergic to anti-Alzheimer's: Molecular pharmacology of Dimebon. Current Alzheimer research. vol 7. issue 2. 2010-06-21. PMID:19939222. |
within serotonergic receptor subtypes, dimebon shows highest affinity for 5-ht7 (ki=8 nm) and 5-ht6 (ki=34 nm) receptors, with the relative affinity rank-order of 5-ht7 > 5-ht6 > or = 5-ht2a = 5-ht2c > 5-ht1a = 5-ht1b > 5-ht2b=5-ht3. |
2010-06-21 |
2023-08-12 |
Not clear |
| Gabor C Petzold, Akari Hagiwara, Venkatesh N Murth. Serotonergic modulation of odor input to the mammalian olfactory bulb. Nature neuroscience. vol 12. issue 6. 2009-10-09. PMID:19430472. |
odor-evoked synaptic input to glomeruli was attenuated by increased serotonin signaling through serotonin 2c (5-ht2c) receptors and amplified by decreased serotonergic activity. |
2009-10-09 |
2023-08-12 |
mouse |
| I Tayfun Uzba. [New pharmacological approaches to the treatment of schizophrenia]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 20. issue 2. 2009-08-20. PMID:19504368. |
blocking the serotonergic 5-ht2a and 5-ht2c receptors is growing growing importance with regard to the action mechanisms of new generation antipsychotic medications. |
2009-08-20 |
2023-08-12 |
Not clear |
| Karen Sugden, Ales Tichopad, Nadeem Khan, Ian W Craig, Ursula M D'Souz. Genes within the serotonergic system are differentially expressed in human brain. BMC neuroscience. vol 10. 2009-08-17. PMID:19445671. |
in this study, we report expression patterns of five serotonergic genes (tph1, tph2, 5-ht2a, 5-ht2c, 5-htt) in seven different human post-mortem brain regions (superior frontal gyrus, superior temporal gyrus, striatum, cerebellum, hippocampus, midbrain and thalamus) using taqman real-time quantitative pcr. |
2009-08-17 |
2023-08-12 |
human |
| Andrew Holme. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18439676. |
serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c, 5-ht3a, 5-ht4, 5-ht5a, 5-ht6, 5-ht7), reuptake (serotonin transporter), and degradation (monoamine oxidase a). |
2009-02-19 |
2023-08-12 |
mouse |
| Asunción Morán, Ana-Vega Ortiz de Urbina, Maria-Luisa Martín, Mónica García, Alicia Rodriguez-Barbero, Fernando Dorado, Luis San Romá. Characterization of contractile 5-hydroxytryptamine receptor subtypes in the in situ autoperfused kidney in the anaesthetized rat. European journal of pharmacology. vol 592. issue 1-3. 2008-10-24. PMID:18644367. |
our data suggest also that the serotonergic vasoconstrictor response induced in the in situ autoperfused rat kidney would be mediated by local 5-ht2c receptor activation. |
2008-10-24 |
2023-08-12 |
rat |
| C M Krall, J B Richards, R A Rabin, J C Winte. Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17935763. |
based upon extensive studies in the rat, it has been suggested that stimulus control by lsd is mediated by 5-ht2a receptors, with serotonergic receptors of the 5-ht1a and 5-ht2c subtypes playing modulatory roles. |
2008-04-09 |
2023-08-12 |
mouse |
| Giorgio Racagni, Marco A Riva, Maurizio Popol. The interaction between the internal clock and antidepressant efficacy. International clinical psychopharmacology. vol 22 Suppl 2. 2008-02-07. PMID:17917564. |
on the basis of the functional relationship between melatonergic and serotonergic signaling in the suprachiasmatic nucleus, and given agomelatine's affinity at melatonergic and 5-ht2c receptors, the therapeutic efficacy of the drug may be due to the potential synergy of its action at these different receptors. |
2008-02-07 |
2023-08-12 |
Not clear |
| Magdalena Zaniewska, Andrew C McCreary, Edmund Przegaliński, Malgorzata Fili. Effects of the serotonin 5-HT2A and 5-HT2C receptor ligands on the discriminative stimulus effects of nicotine in rats. European journal of pharmacology. vol 571. issue 2-3. 2007-10-25. PMID:17617403. |
the present study tested the hypothesis that serotonergic (5-ht) 5-ht2a or 5-ht2c receptors or their pharmacological stimulation modulated the discriminative stimulus effects of nicotine in male wistar rats. |
2007-10-25 |
2023-08-12 |
rat |
| Wolfgang Langhan. Signals generating anorexia during acute illness. The Proceedings of the Nutrition Society. vol 66. issue 3. 2007-10-12. PMID:17637084. |
serotonergic neurons originating in the raphe nuclei and glucagon-like peptide-1-expressing neurons in the hindbrain may be among the targets of these messengers, because serotonin (5-ht), acting through the 5-ht2c receptor, and glucagon-like peptide-1 have recently emerged as neurochemical mediators of lps anorexia. |
2007-10-12 |
2023-08-12 |
mouse |
| Jason C G Halford, Joanne A Harrold, Emma J Boyland, Clare L Lawton, John E Blundel. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs. vol 67. issue 1. 2007-03-21. PMID:17209663. |
numerous serotonin receptor subtypes have been identified; of these, serotonin 5-ht1b and 5-ht2c receptors have been specifically recognised as mediators of serotonin-induced satiety.a number of serotonergic drugs, including selective serotonin reuptake inhibitors (ssris), dexfenfluramine and 5-ht2c receptor agonists, have been shown to significantly attenuate rodent bodyweight gain. |
2007-03-21 |
2023-08-12 |
Not clear |
| Giuseppe Di Giovanni, Vincenzo Di Matteo, Massimo Pierucci, Arcangelo Benigno, Ennio Esposit. Serotonin involvement in the basal ganglia pathophysiology: could the 5-HT2C receptor be a new target for therapeutic strategies? Current medicinal chemistry. vol 13. issue 25. 2006-12-05. PMID:17073648. |
in this paper, evidence demonstrating the serotonergic control of basal ganglia functions will be reviewed, focusing on the role of the 5-ht2c receptor subtype. |
2006-12-05 |
2023-08-12 |
human |
| Timo Heinrich, Henning Böttcher, Helmut Prücher, Rudolf Gottschlich, Karl-August Ackermann, Christoph van Amsterda. 1-(1-phenethylpiperidin-4-yl)-1-phenylethanols as potent and highly selective 5-HT2A antagonists. ChemMedChem. vol 1. issue 2. 2006-11-02. PMID:16892357. |
the enantiomer r-(+)-1-(4-fluorophenyl)-1-{1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl} ethanol (r-(+)-74) was identified to have superior affinity for the serotonergic 5-ht2a receptor [ic50=0.37 nm] and selectivity toward the dopaminergic d2- [ic50=2300 nm], adrenergic alpha1- [ic50=1000 nm] and 5-ht2c receptors [ic50=490 nm]. |
2006-11-02 |
2023-08-12 |
Not clear |
| David L Nelson, Donald R Gehler. Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine. vol 29. issue 1. 2006-06-29. PMID:16622292. |
research continues on serotonergic and histaminergic systems to determine if targets such as the 5-ht2c and h3 receptors may be suitable for developing antiobesity agents. |
2006-06-29 |
2023-08-12 |
Not clear |
| P L Cedraz-Mercez, A C Almeida, R H Costa-e-Sousa, D Badauê-Passos Júnior, L R Castilhos, E L Olivares, A Marinho Júnior, M A Medeiros, L C Rei. Influence of serotonergic transmission anD postsynaptic 5-HT2C action on the feeding behavior of Coturnix japonica (Galliformes: Aves). Brazilian journal of biology = Revista brasleira de biologia. vol 65. issue 4. 2006-04-28. PMID:16532182. |
influence of serotonergic transmission and postsynaptic 5-ht2c action on the feeding behavior of coturnix japonica (galliformes: aves). |
2006-04-28 |
2023-08-12 |
Not clear |
| P L Cedraz-Mercez, A C Almeida, R H Costa-e-Sousa, D Badauê-Passos Júnior, L R Castilhos, E L Olivares, A Marinho Júnior, M A Medeiros, L C Rei. Influence of serotonergic transmission anD postsynaptic 5-HT2C action on the feeding behavior of Coturnix japonica (Galliformes: Aves). Brazilian journal of biology = Revista brasleira de biologia. vol 65. issue 4. 2006-04-28. PMID:16532182. |
we investigated the role of 5-ht2c receptors and serotonergic transmission in the feeding behavior control of quails. |
2006-04-28 |
2023-08-12 |
Not clear |
| Katsuya Morita, Masahiro Hamamoto, Shigeaki Arai, Shigeo Kitayama, Masahiro Irifune, Michio Kawahara, Kenji Kihira, Toshihiro Doh. Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities. Brain research. vol 1057. issue 1-2. 2006-01-04. PMID:16125150. |
these results suggest that the increase of serotonergic neuronal activity through 5-ht2c receptor stimulation was responsible for increased activity of local anesthetics-induced convulsions and support the involvement of this mechanism in cocaine- and meprylcaine- but not in lidocaine-induced convulsions through their direct inhibitory action on central sert. |
2006-01-04 |
2023-08-12 |
mouse |
| Gregory M Holme. 5-Hydroxytryptamine2C receptors on pudendal motoneurons innervating the external anal sphincter. Brain research. vol 1057. issue 1-2. 2006-01-04. PMID:16125683. |
these data suggest that previously identified descending serotonergic immunopositive fibers observed terminating on eas motoneurons might mediate their input through the activation of 5-ht2c receptors. |
2006-01-04 |
2023-08-12 |
rat |
| S Schuhler, A Clark, W Joseph, A Patel, K Lehnen, E Stratford, T L Horan, K C F Fone, F J P Eblin. Involvement of 5-HT receptors in the regulation of food intake in Siberian hamsters. Journal of neuroendocrinology. vol 17. issue 5. 2005-07-26. PMID:15869562. |
we conclude that the anorectic actions of fenfluramine are not an indirect consequence of serotonergic actions on arousal pathways, and that its actions on feeding in the siberian hamster are most likely to be mediated by the 5-ht2c receptor. |
2005-07-26 |
2023-08-12 |
Not clear |