| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenneth Blum, Amanda Lih Chuan Chen, Thomas J H Chen, Eric R Braverman, Jeffrey Reinking, Seth H Blum, Kimberly Cassel, Bernard W Downs, Roger L Waite, Lonna Williams, Thomas J Prihoda, Mallory M Kerner, Tomas Palomo, David E Comings, Howard Tung, Patrick Rhoades, Marlene Oscar-Berma. Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary. Theoretical biology & medical modelling. vol 5. 2009-03-16. PMID:19014506. |
individuals possessing a paucity of serotonergic and/or dopaminergic receptors, and an increased rate of synaptic da catabolism due to high catabolic genotype of the comt gene, are predisposed to self-medicating any substance or behavior that will activate da release, including alcohol, opiates, psychostimulants, nicotine, gambling, sex, and even excessive internet gaming. |
2009-03-16 |
2023-08-12 |
Not clear |
| Martin Reuter, Sarah Roth, Kati Holve, Jürgen Henni. Identification of first candidate genes for creativity: a pilot study. Brain research. vol 1069. issue 1. 2006-06-13. PMID:16403463. |
therefore, the influence of the catechol-o-methyltransferase (locus: comt val158met) gene and the dopamine d2 receptor gene (locus: drd2 taq ia) on creativity was tested in addition to a serotonergic gene, tph1 (locus: tph-a779c), in a sample of n = 92 healthy caucasian subjects while controlling for intelligence. |
2006-06-13 |
2023-08-12 |
human |
| M C Cavallini, D Di Bella, M Catalano, L Bellod. An association study between 5-HTTLPR polymorphism, COMT polymorphism, and Tourette's syndrome. Psychiatry research. vol 97. issue 2-3. 2001-04-12. PMID:11166081. |
the lack of significance for 5-httlpr and comt polymorphisms in conferring liability to ts does not exclude a role of different functional polymorphisms in genes coding for serotonergic or dopaminergic structures in the etiology of ts. |
2001-04-12 |
2023-08-12 |
human |
| A Frisch, D Postilnick, R Rockah, E Michaelovsky, S Postilnick, E Birman, N Laor, B Rauchverger, A Kreinin, M Poyurovsky, M Schneidman, I Modai, R Weizma. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Molecular psychiatry. vol 4. issue 4. 1999-10-18. PMID:10483058. |
in the present study, 102 unipolar mdd patients and 172 healthy controls were genotyped for polymorphisms in four serotonergic and three dopaminergic candidate genes [tryptophan hydroxylase (tph), serotonin receptor 2a (htr2a), serotonin receptor 2c (htr2c), serotonin transporter promoter region (5-httlpr), dopamine receptor d4 (drd4), dopamine transporter (dat1) and catechol-o-methyl transferase (comt)]. |
1999-10-18 |
2023-08-12 |
Not clear |