Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Melody Cui Sun, Almudena Otálora-Alcaraz, Jack A Prenderville, Eric J Downe. Toll-like receptor signalling as a cannabinoid target. Biochemical pharmacology. 2024-03-04. PMID:38438052. |
cannabinoids should be considered as key regulators of signalling controlled by tlrs, and such regulation should be a major focus in terms of the anti-inflammatory propensity of the cannabinoid system. |
2024-03-04 |
2024-03-07 |
Not clear |
Julie K Johnson, Alexander Colb. History of Cannabis Regulation and Medicinal Therapeutics: It's Complicated. Clinical therapeutics. vol 45. issue 6. 2023-07-06. PMID:37414502. |
from its origins as a therapeutic agent in 2800 bc china, to the current knowledge on cannabinoids and the cannabinoid system, to the complex status of cannabis regulation across continents-knowledge gained from the history of cannabis use can inform research on cannabis-based treatments for patients with medical conditions that remain challenging in 21st century medicine, warranting research and evidence-based policy options. |
2023-07-06 |
2023-08-14 |
Not clear |
Bahareh Abd-Nikfarjam, Amirhossein Dolati-Somarin, Vafa Baradaran Rahimi, Vahid Reza Askar. Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases. BioFactors (Oxford, England). 2023-01-13. PMID:36637897. |
in addition, the identification of psychotropic plant cannabinoids has led to more studies regarding the cannabinoid system and its therapeutic features in the treatment and management of clinical symptoms of neuroinflammatory disorders, such as multiple sclerosis (ms), parkinsons disease (pd), and alzheimers disease (ad). |
2023-01-13 |
2023-08-14 |
Not clear |
Monika Vidlarova, Emil Berta, Petr Prasil, Andrea Prokopova, Sona Gurska, Marta Khoylou, Alona Rehulkova, Pavla Kourilova, Josef Chudacek, Marek Szkorupa, Jiri Klein, Jozef Skarda, Josef Srovnal, Marian Hajduc. Cannabinoid receptor 2 expression in early-stage non-small cell lung cancers identifies patients with good prognosis and longer survival. Translational lung cancer research. vol 11. issue 10. 2022-11-17. PMID:36386452. |
since the endogenous cannabinoid system is involved in both carcinogenesis and anticancer immune defense, we hypothesized that tumor tissue expression of cannabinoid 1 and 2 receptors (cb1 and cb2) may affect survival. |
2022-11-17 |
2023-08-14 |
Not clear |
Ivona Maria Tudorancea, Mitică Ciorpac, Gabriela Dumitrița Stanciu, Cătălin Caratașu, Alina Săcărescu, Bogdan Ignat, Alexandra Burlui, Elena Rezuș, Ioana Creangă, Teodora Alexa-Stratulat, Ionuț Tudorancea, Bogdan Ionel Tamb. The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases. Biomedicines. vol 10. issue 10. 2022-10-27. PMID:36289755. |
furthermore, cannabinoids, as components of the cannabinoid system (cs), have proven beneficial effects such as anti-inflammatory, immunomodulatory, neuromodulatory, antioxidative, and cardioprotective effects. |
2022-10-27 |
2023-08-14 |
Not clear |
Laura López-Gómez, Agata Szymaszkiewicz, Marta Zielińska, Raquel Abal. The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals? Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36235308. |
the endogenous cannabinoid system (ecs) includes endogenous classical cannabinoids (anandamide, 2-arachidonoylglycerol), cannabinoid-like ligands (oleoylethanolamide (oea) and palmitoylethanolamide (pea)), enzymes involved in their metabolism (faah, magl, cox-2) and classical (cb1 and cb2) and non-classical (trpv1, gpr55, ppar) receptors. |
2022-10-14 |
2023-08-14 |
Not clear |
Wujood Khayat, Christian Lehman. The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies. Metabolites. vol 12. issue 6. 2022-06-23. PMID:35736474. |
a growing body of evidence has demonstrated blood coagulation abnormalities in association with cannabinoid use, suggesting the involvement of the endogenous cannabinoid system (ecs) in modulating blood coagulation. |
2022-06-23 |
2023-08-14 |
Not clear |
Priscila A Lima, Bárbara B Berg, Marina Gomes Miranda E Casto. Involvement of the cannabinoid system in chronic inflammatory intestinal diseases: opportunities for new therapies. Intestinal research. 2022-06-01. PMID:35645322. |
thus, this article reviews the involvement of the cannabinoid system in chronic inflammatory diseases that affect the gastrointestinal tract and highlights possible therapeutic approaches related to the use of cannabinoids. |
2022-06-01 |
2023-08-13 |
Not clear |
Courtney A Bouchet, Amy J Eshleman, Aaron Janowsky, Susan L Ingra. Persistent Inflammation Induces Desensitization of the Presynaptic Cannabinoid 1 Receptor in the Ventrolateral Periaqueductal Gray. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552994. |
the cannabinoid system is highly plastic and sensitive to environmental perturbations, often leading to downregulation of the cannabinoid 1 receptor (cb1r). |
2022-05-13 |
2023-08-13 |
rat |
Joshua Lott, Emily M Jutkiewicz, Manojkumar A Puthenveed. The Synthetic Cannabinoid WIN55,212-2 Can Disrupt the Golgi Apparatus Independent of Cannabinoid Receptor-1. Molecular pharmacology. vol 101. issue 5. 2022-04-12. PMID:35236771. |
significance statement: the synthetic cannabinoid win55,212-2 (win), widely used to investigate the cannabinoid system, also shows unique broader effects at cellular and organismal levels compared to endogenous cannabinoids. |
2022-04-12 |
2023-08-16 |
mouse |
Julia M Salamat, Kodye L Abbott, Patrick C Flannery, Elizabeth L Ledbetter, Satyanarayana R Pondugul. Interplay between the Cannabinoid System and microRNAs in Cancer. ACS omega. vol 7. issue 12. 2022-04-06. PMID:35382335. |
although the understanding of the effects of cannabinoids and mirnas as they relate to cancer continues to improve, the interplay between cannabinoid system and mirnas in cancer pathogenesis and cancer treatment response is poorly understood. |
2022-04-06 |
2023-08-13 |
Not clear |
Julia M Salamat, Kodye L Abbott, Patrick C Flannery, Elizabeth L Ledbetter, Satyanarayana R Pondugul. Interplay between the Cannabinoid System and microRNAs in Cancer. ACS omega. vol 7. issue 12. 2022-04-06. PMID:35382335. |
investigation of such interactions between the cannabinoid system and mirnas could provide novel insights into the underlying mechanisms of the differential effects of cannabinoids in cancer and can help predict and improve the prognosis of cancer patients. |
2022-04-06 |
2023-08-13 |
Not clear |
Jiacheng Du, Menglei Xu, Fanchen Kong, Pengfei Zhu, Yubo Mao, Yijie Liu, Hong Zhou, Zhongchen Dong, Zilin Yu, Tong Du, Ye Gu, Xiexing Wu, Dechun Geng, Haiqing Ma. CB2R Attenuates Intervertebral Disc Degeneration by Delaying Nucleus Pulposus Cell Senescence through AMPK/GSK3β Pathway. Aging and disease. vol 13. issue 2. 2022-04-04. PMID:35371598. |
the cannabinoid type 2 receptor (cb2r) is a member of the cannabinoid system and plays an important role in antioxidative stress, anti-inflammatory and antisenescence activities. |
2022-04-04 |
2023-08-13 |
Not clear |
Megan Malach, Igor Kovalchuk, Olga Kovalchu. Medical Cannabis in Pediatric Oncology: Friend or Foe? Pharmaceuticals (Basel, Switzerland). vol 15. issue 3. 2022-03-26. PMID:35337156. |
since the identification of the components of the endogenous cannabinoid system (ecs) in the 1990s, research into the potential of cannabinoids as medicine has exploded, including in anti-cancer research. |
2022-03-26 |
2023-08-13 |
Not clear |
Mengya Wang, Huayuan Liu, Zegang M. Roles of the Cannabinoid System in the Basal Ganglia in Parkinson's Disease. Frontiers in cellular neuroscience. vol 16. 2022-03-10. PMID:35264932. |
here, we have described the function of the cannabinoid system in the basal ganglia and its association with pd in three parts (ecbs, cannabinoid receptors, and factors regulating the cannabinoid metabolism) and summarized the mechanisms of action related to the cannabinoid analogs currently aimed at treating pd. |
2022-03-10 |
2023-08-13 |
Not clear |
Rachel Kelly, Alexis-Pierre Bemelmans, Charlène Joséphine, Emmanuel Brouillet, Declan P McKernan, Eilís Dow. Time-Course of Alterations in the Endocannabinoid System after Viral-Mediated Overexpression of α-Synuclein in the Rat Brain. Molecules (Basel, Switzerland). vol 27. issue 2. 2022-01-21. PMID:35056822. |
cannabinoids are being investigated as potential therapies for parkinson's disease from numerous aspects, but still little is known about the links between the cannabinoid system and the pathogenic α-synuclein protein; understanding these links will be necessary if cannabinoid therapies are to reach the clinic in the future. |
2022-01-21 |
2023-08-13 |
human |
David De Sa Nogueira, Romain Bourdy, Rafael Alcala-Vida, Dominique Filliol, Virginie Andry, Yannick Goumon, Jean Zwiller, Pascal Romieu, Karine Merienne, Mary C Olmstead, Katia Befor. Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats. Molecular neurobiology. 2022-01-15. PMID:35032317. |
the endogenous cannabinoid system may play a role in this process in that cannabinoid mechanisms modulate drug reward and contribute to cocaine-induced neural adaptations. |
2022-01-15 |
2023-08-13 |
rat |
Luke J Ney, Kevin M Crombie, Leah M Mayo, Kim L Felmingham, Tim Bowser, Allison Matthew. Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next? Neuroscience and biobehavioral reviews. vol 132. 2021-12-11. PMID:34838529. |
here we review how human paradigms can successfully translate animal findings to human subjects, with the view that substantially increased insight into the effect of endocannabinoid signalling on stress responding, emotional and intrusive memories, and fear extinction can be gained using modern paradigms and methods for assessing the state of the endocannabinoid system in ptsd. |
2021-12-11 |
2023-08-13 |
human |
Sebastiaan Dalle, Katrien Kopp. Cannabinoid receptor 1 expression is higher in muscle of old vs. young males, and increases upon resistance exercise in older adults. Scientific reports. vol 11. issue 1. 2021-11-26. PMID:34526596. |
here, we explored the role of the cannabinoid system in muscle plasticity through the expression of muscle cannabinoid receptors (cbs) in young and old humans. |
2021-11-26 |
2023-08-13 |
Not clear |
Fardad Pirri, Ardeshir Akbarabadi, Mitra-Sadat Sadat-Shirazi, Setareh Nouri Zadeh-Tehrani, Sarah Mahboubi, Ali Karimi Goudarzi, Mohammad-Reza Zarrindas. Comparison and interaction of morphine and CB1 agonist conditioned place preference in the rat model of early life stress. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 3. 2021-11-24. PMID:33534920. |
in addition, els disrupts the cannabinoid system and affect the rewarding effect of cannabinoids. |
2021-11-24 |
2023-08-13 |
rat |