| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James B Lohr, Hang Chang, Michelle Sexton, Barton W Palme. Allostatic load and the cannabinoid system: implications for the treatment of physiological abnormalities in post-traumatic stress disorder (PTSD). CNS spectrums. vol 25. issue 6. 2021-11-22. PMID:31303187. |
in this paper, we propose that the cannabinoid system may offer just such an approach, and we outline evidence for the potential utility of cannabinoids in reducing many of the chronic physiological abnormalities seen in ptsd which are thought to be related to excess al. |
2021-11-22 |
2023-08-13 |
Not clear |
| Deepthi Rapaka, Veera Raghavulu Bitra, Siva Reddy Challa, Paul C Adiukw. Potentiation of microglial endocannabinoid signaling alleviates neuroinflammation in Alzheimer's disease. Neuropeptides. vol 90. 2021-11-22. PMID:34508923. |
the activation of cannabinoid receptors/ cannabinoid system modulates inflammatory responses. |
2021-11-22 |
2023-08-13 |
Not clear |
| Ondine Lucaciu, Ovidiu Aghiorghiesei, Nausica Bianca Petrescu, Ioana Codruta Mirica, Horea Rareș Ciprian Benea, Dragoș Apost. In quest of a new therapeutic approach in COVID-19: the endocannabinoid system. Drug metabolism reviews. vol 53. issue 4. 2021-11-15. PMID:33683968. |
although the cannabinoid system has many mechanisms to provide certain benefits in the treatment of sars-cov-2 infected patients, research in this field is needed for a better understanding of the cannabinoid impact in this situation. |
2021-11-15 |
2023-08-13 |
human |
| Jenny L Wiley, Julie A Marusich, John W Huffman, Robert L Balster, Brian F Thoma. Hijacking of Basic Research: The Case of Synthetic Cannabinoids. Methods report (RTI Press). vol 2011. 2021-10-21. PMID:23397508. |
originally developed for the legitimate research purpose of furthering understanding of the cannabinoid system, these synthetic cannabinoids are being abused worldwide, creating issues for regulatory and law enforcement agencies that are struggling to keep up with the growing number of compounds of various structural motifs. |
2021-10-21 |
2023-08-12 |
Not clear |
| Mashal Ahmed, Isabelle Boileau, Bernard Le Foll, Andre F Carvalho, Stefan Kloibe. The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 2021-09-01. PMID:34468550. |
emerging evidence suggests that the endogenous cannabinoid system, also referred to as the endocannabinoid system (ecs), could play a potential role in the pathophysiology of sad. |
2021-09-01 |
2023-08-13 |
human |
| Andrew J Kesner, David M Lovinge. Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings. Journal of neurochemistry. vol 157. issue 5. 2021-08-24. PMID:33891706. |
one of the main components being central action on the cannabinoid type-one receptor and downstream intracellular signaling related to the endogenous cannabinoid system. |
2021-08-24 |
2023-08-13 |
Not clear |
| Michelle A Tucci, Yilianys Pride, Suzanne Strickland, Susanna M Salazar Marocho, Ramon J Jackson, Joshua R Jefferson, Alejandro R Chade, Raymond J Grill, Bernadette E Grayso. Delayed Systemic Treatment with Cannabinoid Receptor 2 Agonist Mitigates Spinal Cord Injury-Induced Osteoporosis More Than Acute Treatment Directly after Injury. Neurotrauma reports. vol 2. issue 1. 2021-08-12. PMID:34223557. |
the cannabinoid system modulation of bone metabolism through cannabinoid 1/2 (cb1/2) has been of increasing interest for the preservation of bone mass and density in models of osteoporosis. |
2021-08-12 |
2023-08-13 |
mouse |
| Yann Chye, Rebecca Kirkham, Valentina Lorenzetti, Eugene McTavish, Nadia Solowij, Murat Yüce. Cannabis, Cannabinoids, and Brain Morphology: A Review of the Evidence. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 6. issue 6. 2021-06-24. PMID:32948510. |
exogenous cannabinoids interact with the endogenous cannabinoid system that underpins vital functions in the brain and body, and they are thought to perturb key brain and cognitive function. |
2021-06-24 |
2023-08-13 |
Not clear |
| Patricia Rivera, Antonio Vargas, Antoni Pastor, Anna Boronat, Antonio Jesús López-Gambero, Laura Sánchez-Marín, Dina Medina-Vera, Antonia Serrano, Francisco Javier Pavón, Rafael de la Torre, Ekaitz Agirregoitia, María Isabel Lucena, Fernando Rodríguez de Fonseca, Juan Decara, Juan Suáre. Differential hepatoprotective role of the cannabinoid CB British journal of pharmacology. vol 177. issue 14. 2021-06-21. PMID:32167157. |
differential hepatoprotective role of the cannabinoid cb protective mechanisms of the endogenous cannabinoid system against drug-induced liver injury (dili) are actively being investigated regarding the differential regulatory role of the cannabinoid cb |
2021-06-21 |
2023-08-13 |
Not clear |
| Veronica M Piggott, Scott C Lloyd, James I Matchynski, Shane A Perrine, Alana C Cont. Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-11. PMID:33917316. |
based on these data we conclude that the effects of combined traumatic stress and chronic ethanol exposure on the cannabinoid system in reward pathway regions are driven by cie exposure and that traumatic stress affects the cannabinoid components in limbic regions, warranting future investigation of neurotherapeutic treatment to attenuate these effects. |
2021-05-11 |
2023-08-13 |
mouse |
| Hong Zhang, Austin A Lipinski, Erika Liktor-Busa, Angela F Smith, Aubin Moutal, Rajesh Khanna, Paul R Langlais, Tally M Largent-Milnes, Todd W Vandera. The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area. Frontiers in pharmacology. vol 12. 2021-05-09. PMID:33953672. |
taken together, our studies reveal a potential influence of sustained opioids on the endocannabinoid system in the vta, suggesting that the endogenous cannabinoid system may participate in the opioid-induced reward. |
2021-05-09 |
2023-08-13 |
rat |
| Luca Liberale, Fabrizio Montecucco, Federico Carbon. Pharmacological Properties of the Plant-Derived Natural products Cannabinoids and Implications for Cardiovascular Health. Advances in experimental medicine and biology. vol 1308. 2021-04-20. PMID:33861448. |
however, studies on synthetic ligands with selective agonist/antagonist activity on specific cannabinoid receptors, have clarified how complex the cannabinoid system is. |
2021-04-20 |
2023-08-13 |
human |
| Adriana Della Pietra, Rashid Giniatullin, Juha R Savinaine. Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine. International journal of molecular sciences. vol 22. issue 3. 2021-04-13. PMID:33530477. |
to overcome these adverse effects of exogenous cannabinoids, we propose migraine pain relief via activation of the endogenous cannabinoid system (ecs) by inhibiting enzymes degrading endocannabinoids. |
2021-04-13 |
2023-08-13 |
rat |
| Juan Paraíso-Luna, José Aguareles, Ricardo Martín, Ane C Ayo-Martín, Samuel Simón-Sánchez, Daniel García-Rincón, Carlos Costas-Insua, Elena García-Taboada, Adán de Salas-Quiroga, Javier Díaz-Alonso, Isabel Liste, José Sánchez-Prieto, Silvia Cappello, Manuel Guzmán, Ismael Galve-Roper. Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB Development (Cambridge, England). vol 147. issue 24. 2021-01-29. PMID:33168583. |
endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via cb the endocannabinoid (ecb) system, via the cannabinoid cb |
2021-01-29 |
2023-08-13 |
Not clear |
| Caroline Turcotte, Marie-Renée Blanchet, Michel Laviolette, Nicolas Flaman. Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs. Frontiers in pharmacology. vol 7. 2020-10-01. PMID:27695418. |
since the identification of cannabinoid receptors in the 1990s, a research field has been dedicated to exploring the role of the cannabinoid system in immunity and the inflammatory response in human tissues and animal models. |
2020-10-01 |
2023-08-13 |
human |
| Caroline Turcotte, Marie-Renée Blanchet, Michel Laviolette, Nicolas Flaman. Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs. Frontiers in pharmacology. vol 7. 2020-10-01. PMID:27695418. |
although the cannabinoid system is present and crucial in many human tissues, studying the impact of cannabinoids on the lungs is particularly relevant because of their contact with exogenous cannabinoids in the context of marijuana consumption. |
2020-10-01 |
2023-08-13 |
human |
| Mattias Svensson, Puran Chen, Oscar Hammarfjor. Dendritic Cell Regulation by Cannabinoid-Based Drugs. Pharmaceuticals (Basel, Switzerland). vol 3. issue 8. 2020-10-01. PMID:27713374. |
cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. |
2020-10-01 |
2023-08-13 |
human |
| Melanie B Elliott, Sara J Ward, Mary E Abood, Ronald F Tuma, Jack I Jall. Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion. Concussion (London, England). vol 2. issue 4. 2020-09-30. PMID:30202590. |
an objective of this review is to enhance the understanding of how the endogenous cannabinoid system is essential for maintaining the balance of the cns and regulating inflammation after injury, and in turn making the endocannabinoid system a potential modulator of the trigeminal response to concussion. |
2020-09-30 |
2023-08-13 |
Not clear |
| Salar Vaseghi, Vahab Babapour, Mohammad Nasehi, Mohammad-Reza Zarrindas. The role of CA1 CB1 receptors on lithium-induced spatial memory impairment in rats. EXCLI journal. vol 17. 2020-09-29. PMID:30564071. |
lithium, a glycogen synthase kinase-3β (gsk-3β) inhibitor, prevents cannabinoid withdrawal syndrome, but there is limited data exploring the interaction between lithium and cannabinoid system on memory processes. |
2020-09-29 |
2023-08-13 |
rat |
| Riley T Paulsen, Brian D Burrel. Comparative studies of endocannabinoid modulation of pain. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 374. issue 1785. 2020-05-12. PMID:31544609. |
from an evolutionary perspective, the cannabinoid system would appear to be highly conserved given that the most prevalent endogenous cannabinoid (endocannabinoid) transmitters, 2-arachidonyl glycerol and anandamide, have been found throughout the animal kingdom, at least in the species that have been analysed to date. |
2020-05-12 |
2023-08-13 |
Not clear |