| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S F Lisboa, F V Gomes, A L B Terzian, D C Aguiar, F A Moreira, L B M Resstel, F S Guimarãe. The Endocannabinoid System and Anxiety. Vitamins and hormones. vol 103. 2017-11-03. PMID:28061971. |
since the discovery and characterization of the endogenous cannabinoid system, several studies have evaluated how cannabinoid compounds and, particularly, how the modulation of the endocannabinoid (ecb) system influences a wide range of functions, from metabolic to mental disorders. |
2017-11-03 |
2023-08-13 |
Not clear |
| Alessandro Deplano, Carmine Marco Morgillo, Monica Demurtas, Emmelie Björklund, Mariateresa Cipriano, Mona Svensson, Sanaz Hashemian, Giovanni Smaldone, Emilia Pedone, F Javier Luque, Maria G Cabiddu, Ettore Novellino, Christopher J Fowler, Bruno Catalanotti, Valentina Onni. Novel propanamides as fatty acid amide hydrolase inhibitors. European journal of medicinal chemistry. vol 136. 2017-09-26. PMID:28535469. |
faah inhibition represents a promising strategy to activate the cannabinoid system, since it does not result in the psychotropic and peripheral side effects characterizing the agonists of the cannabinoid receptors. |
2017-09-26 |
2023-08-13 |
mouse |
| Orla Haugh, June Penman, Andrew J Irving, Veronica A Campbel. The Emerging Role of the Cannabinoid Receptor Family in Peripheral and Neuro-immune Interactions. Current drug targets. vol 17. issue 16. 2017-08-30. PMID:26758668. |
the classical endogenous cannabinoid (cb) system is composed of the endocannabinoid signalling molecules, 2-arachidonoyl glycerol (2-ag) and anandamide (aea) and their g-protein coupled receptors (gpcr), cb1 and cb2 which together constitutes the endocannabinoid system (ecs). |
2017-08-30 |
2023-08-13 |
Not clear |
| Natalia Schlabritz-Loutsevitch, Nadezhda German, Gary Ventolini, Eneko Larumbe, Jacques Samso. Fetal Syndrome of Endocannabinoid Deficiency (FSECD) In Maternal Obesity. Medical hypotheses. vol 96. 2017-08-03. PMID:27959272. |
cannabinoids have been used for the treatment of chronic pain for millenniums and act through the mechanism of "kick-starting" the components of the endogenous cannabinoid system (ecs). |
2017-08-03 |
2023-08-13 |
Not clear |
| Diana Dow-Edwards, Lindsay Silv. Endocannabinoids in brain plasticity: Cortical maturation, HPA axis function and behavior. Brain research. vol 1654. issue Pt B. 2017-07-31. PMID:27569586. |
these effects derive from the role of the endocannabinoid system, the endogenous cannabinoid system, in the development of cortex, amygdala, hippocampus and hypothalamus during adolescence. |
2017-07-31 |
2023-08-13 |
Not clear |
| Edina Szűcs, Szabolcs Dvorácskó, Csaba Tömböly, Alexandra Büki, Gabriella Kékesi, Gyöngyi Horváth, Sándor Benyh. Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia. Neuroscience letters. vol 633. 2017-07-27. PMID:27639959. |
since the cannabinoid system is significantly influenced in schizophrenic patients, in the present work we investigated cannabinoid (cb) receptor binding and g-protein activation in cortical, subcortical and cerebellar regions of control and 'schizophrenic' rats. |
2017-07-27 |
2023-08-13 |
rat |
| Friedhelm Schroeder, Avery L McIntosh, Gregory G Martin, Huan Huang, Danilo Landrock, Sarah Chung, Kerstin K Landrock, Lawrence J Dangott, Shengrong Li, Martin Kaczocha, Eric J Murphy, Barbara P Atshaves, Ann B Kie. Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias. Lipids. vol 51. issue 6. 2017-07-19. PMID:27117865. |
resolving human fabp1 and the t94a variant's impact on the endocannabinoid and cannabinoid system is an exciting challenge due to the importance of this system in hepatic lipid accumulation as well as behavior, pain, inflammation, and satiety. |
2017-07-19 |
2023-08-13 |
mouse |
| D S M Araújo, V S Miya-Coreixas, P Pandolfo, K C Calaz. Cannabinoid receptors and TRPA1 on neuroprotection in a model of retinal ischemia. Experimental eye research. vol 154. 2017-06-15. PMID:27876485. |
since synthetic and endogenous cannabinoids have been studied as modulators of ischemic events in the central nervous system (cns), the present study aimed to investigate the involvement of cannabinoid system in the cell death induced by ischemia in an avascular (chick) retina. |
2017-06-15 |
2023-08-13 |
chicken |
| Thomas Schwitzer, Raymund Schwan, Karine Angioi-Duprez, Anne Giersch, Vincent Laprevot. The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications. Neural plasticity. vol 2016. 2016-12-13. PMID:26881099. |
mammals are endowed with a functional cannabinoid system including cannabinoid receptors, ligands, and enzymes. |
2016-12-13 |
2023-08-13 |
human |
| Thomas Schwitzer, Raymund Schwan, Karine Angioi-Duprez, Anne Giersch, Vincent Laprevot. The Endocannabinoid System in the Retina: From Physiology to Practical and Therapeutic Applications. Neural plasticity. vol 2016. 2016-12-13. PMID:26881099. |
here, we review the distribution of the cannabinoid receptors, ligands, and enzymes in the retina and focus on the role of the cannabinoid system in retinal neurobiology. |
2016-12-13 |
2023-08-13 |
human |
| Elaine M Jennings, Bright N Okine, Weredeselam M Olango, Michelle Roche, David P Fin. Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25988529. |
given the well-documented role of the endocannabinoid system in stress and pain, we investigated associated alterations in endocannabinoid signalling in the dorsal horn of the spinal cord and amygdala. |
2016-05-31 |
2023-08-13 |
rat |
| Jack A Prenderville, Áine M Kelly, Eric J Downe. The role of cannabinoids in adult neurogenesis. British journal of pharmacology. vol 172. issue 16. 2016-05-12. PMID:25951750. |
this timely review summarizes the evidence that the cannabinoid system is intricately associated with neuronal differentiation and maturation of npcs and highlights intrinsic/extrinsic signalling mechanisms that are cannabinoid targets. |
2016-05-12 |
2023-08-13 |
Not clear |
| Abbas Khani, Mojtaba Kermani, Soghra Hesam, Abbas Haghparast, Enrike G Argandoña, Gregor Raine. Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making. Psychopharmacology. vol 232. issue 12. 2015-12-04. PMID:25529106. |
these results provide first direct evidence that the cannabinoid system plays a critical role in regulating cost-benefit decision making in the acc and ofc and implicate cannabinoid modulation of synaptic ends of predominantly interneurons and to a lesser degree other neuronal populations in these two frontal regions. |
2015-12-04 |
2023-08-13 |
rat |
| Luara A Batista, Juliana R Bastos, Fabricio A Moreir. Role of endocannabinoid signalling in the dorsolateral periaqueductal grey in the modulation of distinct panic-like responses. Journal of psychopharmacology (Oxford, England). vol 29. issue 3. 2015-12-01. PMID:25601395. |
since the cannabinoid cb1 receptor modulates various types of aversive responses, this study tested the hypothesis that enhancement of endocannabinoid signalling in the dorsolateral periaqueductal grey inhibits panic-like reactions in rats. |
2015-12-01 |
2023-08-13 |
rat |
| S Del Carlo, C Manera, A Chicca, C Arena, S Bertini, S Burgalassi, S Tampucci, J Gertsch, M Macchia, G Saccomann. Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase. Journal of pharmaceutical and biomedical analysis. vol 108. 2015-12-01. PMID:25743577. |
magl represents the link between the endocannabinoid and the eicosanoid system indeed its inhibition enhances endocannabinoid signalling and lowers eicosanoid production. |
2015-12-01 |
2023-08-13 |
human |
| Marisol S Castaneto, David A Gorelick, Nathalie A Desrosiers, Rebecca L Hartman, Sandrine Pirard, Marilyn A Huesti. Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications. Drug and alcohol dependence. vol 144. 2015-10-30. PMID:25220897. |
synthetic cannabinoids (sc) are a heterogeneous group of compounds developed to probe the endogenous cannabinoid system or as potential therapeutics. |
2015-10-30 |
2023-08-13 |
human |
| M A Huesti. Cannabis (Marijuana) - Effects on Human Performance and Behavior. Forensic science review. vol 14. issue 1-2. 2015-08-11. PMID:26256486. |
recently, tremendous advances have been made in our understanding of the endogenous cannabinoid system with the identification of cannabinoid receptors, cannabinoid receptor antagonists, endogenous neurotransmitters, metabolic enzymes, and reuptake mechanisms. |
2015-08-11 |
2023-08-13 |
human |
| Patrick McDonough, Joseph P McKenna, Christine McCreary, Eric J Downe. Neuropathic orofacial pain: cannabinoids as a therapeutic avenue. The international journal of biochemistry & cell biology. vol 55. 2015-07-24. PMID:25150831. |
analgesia is one the principal therapeutic targets of the cannabinoid system and many studies have demonstrated the efficacy of cannabinoid compounds in the treatment of neuropathic pain. |
2015-07-24 |
2023-08-13 |
Not clear |
| Federico Carbone, François Mach, Nicolas Vuilleumier, Fabrizio Montecucc. Cannabinoid receptor type 2 activation in atherosclerosis and acute cardiovascular diseases. Current medicinal chemistry. vol 21. issue 35. 2015-07-02. PMID:25245379. |
in the last decades, the cannabinoid system (comprising synthetic and endogenous cannabinoid agonists and antagonists, their receptors and degrading enzymes) has been shown to induce potent immunomodulatory activities in atherogenesis and acute ischemic complications. |
2015-07-02 |
2023-08-13 |
human |
| I Heitland, J L Kenemans, K B E Böcker, J M P Baa. Genetic variability in the human cannabinoid receptor 1 is associated with resting state EEG theta power in humans. Behavioural brain research. vol 274. 2015-05-26. PMID:25116250. |
this extends prior findings of exogenous cannabinoid effects on theta power to the endogenous cannabinoid system. |
2015-05-26 |
2023-08-13 |
human |