| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Wierucka-Rybak, M Wolak, E Bojanowsk. The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 65. issue 4. 2015-05-18. PMID:25179081. |
to further investigate whether simultaneous pharmacological intervention in the leptin and cannabinoid system might change food and water intake, preferences for palatable foods, and body weight, we have examined the effects of concomitant intraperitoneal administration of leptin and am 251, a cannabinoid 1 (cb1) receptor antagonist, or cannabidiol (cbd), a plant cannabinoid, in rats maintained on either a high-fat (hf) diet (45% energy from fat) or free-choice (fc) diet consisting of high-sucrose and normal rat chow (83% and 61% energy from carbohydrates, respectively). |
2015-05-18 |
2023-08-13 |
rat |
| Christine A Rabinak, K Luan Pha. Cannabinoid modulation of fear extinction brain circuits: a novel target to advance anxiety treatment. Current pharmaceutical design. vol 20. issue 13. 2015-02-20. PMID:23829364. |
collectively, translational evidence suggest that enhancing cannabinoid transmission may facilitate extinction learning and its recall, and that the cannabinoid system is a potential pharmacological target for improving the active learning that occurs during exposure-based behavioral treatments prompting future research in terms of mechanisms research, novel treatment approaches ('cognitive enhancers'), and pharmacotherapeutic drug discovery. |
2015-02-20 |
2023-08-12 |
Not clear |
| Katia Befor. Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies. Frontiers in pharmacology. vol 6. 2015-02-20. PMID:25698968. |
the endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes for their synthesis and their degradation and two well-characterized receptors, cannabinoid receptors cb1 and cb2. |
2015-02-20 |
2023-08-13 |
mouse |
| S G Fagan, V A Campbel. The influence of cannabinoids on generic traits of neurodegeneration. British journal of pharmacology. vol 171. issue 6. 2014-11-05. PMID:24172185. |
to this end, pharmacological manipulation of the endogenous cannabinoid system, as well as application of phytocannabinoids and synthetic cannabinoids have been investigated. |
2014-11-05 |
2023-08-12 |
Not clear |
| M Peciña, M Martínez-Jauand, C Hodgkinson, C S Stohler, D Goldman, J K Zubiet. FAAH selectively influences placebo effects. Molecular psychiatry. vol 19. issue 3. 2014-10-27. PMID:24042479. |
these results show that a common genetic variation affecting the function of the cannabinoid system is serving as a probe to demonstrate the involvement of cannabinoid and opioid transmitters on the formation of placebo effects. |
2014-10-27 |
2023-08-12 |
human |
| Stéphanie Olière, Antoine Joliette-Riopel, Stéphane Potvin, Didier Jutras-Aswa. Modulation of the endocannabinoid system: vulnerability factor and new treatment target for stimulant addiction. Frontiers in psychiatry. vol 4. 2014-06-24. PMID:24069004. |
thus, cannabinoids modulate brain reward systems closely involved in stimulants addiction, and provide further evidence that the cannabinoid system could be explored as a potential drug discovery target for treating addiction across different classes of stimulants. |
2014-06-24 |
2023-08-12 |
Not clear |
| Hamed Shafaroodi, Leila Moezi, Arsh Bahremand, Ahmad Reza Dehpou. The role of α₂-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice. European journal of pharmacology. vol 714. issue 1-3. 2014-05-06. PMID:23756131. |
cannabinoid system plays a pivotal role in the seizure threshold modulation which is mainly mediated through activation of the cannabinoid cb₁ receptor. |
2014-05-06 |
2023-08-12 |
mouse |
| Eduardo Blanco-Calvo, Patricia Rivera, Sergio Arrabal, Antonio Vargas, Francisco Javier Pavón, Antonia Serrano, Estela Castilla-Ortega, Pablo Galeano, Leticia Rubio, Juan Suárez, Fernando Rodriguez de Fonsec. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Frontiers in integrative neuroscience. vol 7. 2014-01-10. PMID:24409127. |
the endogenous cannabinoid system modulates this proliferative response as demonstrated by the finding that pharmacological activation/blockade of cannabinoid cb1 and cb2 receptors not only modulates neurogenesis but also modulates cell death in the brain. |
2014-01-10 |
2023-08-12 |
rat |
| Claudio D'Addario, Andrea Di Francesco, Mariangela Pucci, Alessandro Finazzi Agrò, Mauro Maccarron. Epigenetic mechanisms and endocannabinoid signalling. The FEBS journal. vol 280. issue 9. 2013-06-18. PMID:23305292. |
here, we review current knowledge of epigenetic regulation of endocannabinoid system components under both physiological and pathological conditions, as well as the epigenetic changes induced by endocannabinoid signalling. |
2013-06-18 |
2023-08-12 |
Not clear |
| F Markus Lewek. Anandamide dysfunction in prodromal and established psychosis. Current pharmaceutical design. vol 18. issue 32. 2013-03-25. PMID:22716147. |
based on these observations, there is growing interest in the role of the endogenous cannabinoid system (ecb system) - the point of action for psychoactive cannabinoids - in psychiatric disorders and schizophrenia in particular. |
2013-03-25 |
2023-08-12 |
Not clear |
| Jenny L Wiley, Julie A Marusich, Yanan Zhang, Alan Fulp, Rangan Maitra, Brian F Thomas, Anu Mahadeva. Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice. European journal of pharmacology. vol 695. issue 1-3. 2013-03-19. PMID:22975289. |
given the demonstrated role of the endogenous cannabinoid system in appetite regulation, the purpose of the present study was to evaluate structural analogs of two cannabinoids, rimonabant (cannabinoid cb(1) receptor antagonist) and o-2050 (sulfonamide analog of Δ(8)-tetrahydrocannabinol), that showed appetite suppressant effects in previous studies. |
2013-03-19 |
2023-08-12 |
mouse |
| Ricka D Messer, Eric S Levin. Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity. Journal of neuroscience research. vol 90. issue 7. 2013-02-26. PMID:22388975. |
the recently characterized endogenous cannabinoid system thus represents a promising target for novel anticonvulsant agents; however, administration of exogenous cannabinoids has shown mixed results in both human epilepsy and animal models. |
2013-02-26 |
2023-08-12 |
mouse |
| R G Pertwe. Neuropharmacology and therapeutic potential of cannabinoids. Addiction biology. vol 5. issue 1. 2012-10-02. PMID:20575818. |
future research is likely to be directed at characterizing the endogenous cannabinoid system more completely, at obtaining more conclusive clinical data about cannabinoids with regard to both beneficial and adverse effects, at developing improved cannabinoid formulations and modes of administration for use in the clinic and at devising clinical strategies for separating out the sought-after effects of cb₁ receptor agonists from their psychotropic and other unwanted effects. |
2012-10-02 |
2023-08-12 |
Not clear |
| Engin Bojnik, Ezgi Turunç, Güliz Armağan, Lütfiye Kanıt, Sándor Benyhe, Ayfer Yalçın, Anna Borsod. Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures. Epilepsy research. vol 99. issue 1-2. 2012-09-19. PMID:22079489. |
recent studies have advanced our understanding of the endogenous cannabinoid system and renewed the interest in cannabinoids as a potential treatment for epilepsy. |
2012-09-19 |
2023-08-12 |
rat |
| M P Viveros, R Llorente, J Suarez, A Llorente-Berzal, M López-Gallardo, F Rodriguez de Fonsec. The endocannabinoid system in critical neurodevelopmental periods: sex differences and neuropsychiatric implications. Journal of psychopharmacology (Oxford, England). vol 26. issue 1. 2012-08-21. PMID:21669929. |
we will discuss sexual dimorphisms observed within the endogenous cannabinoid system, as well as those observed with exogenously administered cannabinoids. |
2012-08-21 |
2023-08-12 |
Not clear |
| Eleonora Patsenker, Matthias Stoll, Gunda Millonig, Abbas Agaimy, Till Wissniowski, Vreni Schneider, Sebastian Mueller, Rudolf Brenneisen, Helmut K Seitz, Matthias Ocker, Felix Sticke. Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. Molecular medicine (Cambridge, Mass.). vol 17. issue 11-12. 2012-08-03. PMID:21863215. |
the cannabinoid system (cs) is implicated in the regulation of hepatic fibrosis, steatosis and inflammation, with cannabinoid receptors 1 and 2 (cb1 and cb2) being involved in regulation of pro- and antifibrogenic effects. |
2012-08-03 |
2023-08-12 |
mouse |
| Alejandro Higuera-Matas, Miguel Miguéns, Santiago M Coria, María Amparo Assis, Erika Borcel, Nuria del Olmo, Emilio Ambrosi. Sex-specific disturbances of the glutamate/GABA balance in the hippocampus of adult rats subjected to adolescent cannabinoid exposure. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22245681. |
the endogenous cannabinoid system regulates central nervous system development and cannabinoid exposure during adolescence has been linked to several alterations to hippocampal-dependent processes such as cognition and emotion, which rely on intact glutamatergic and gabaergic systems. |
2012-07-23 |
2023-08-12 |
rat |
| Islam Gamaleddin, Carrie Wertheim, Andy Z X Zhu, Kathleen M Coen, Kiran Vemuri, Alex Makryannis, Steven R Goldberg, Bernard Le Fol. Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking. Addiction biology. vol 17. issue 1. 2012-05-14. PMID:21521420. |
the cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (cb) receptor antagonists. |
2012-05-14 |
2023-08-12 |
human |
| Silvia Zoppi, José L M Madrigal, Beatriz G Pérez-Nievas, Ignacio Marín-Jiménez, Javier R Caso, Luis Alou, Borja García-Bueno, Arturo Colón, Jorge Manzanares, M Luisa Gómez-Lus, Luis Menchén, Juan C Lez. Endogenous cannabinoid system regulates intestinal barrier function in vivo through cannabinoid type 1 receptor activation. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 5. 2012-04-16. PMID:22135307. |
endogenous cannabinoid system regulates intestinal barrier function in vivo through cannabinoid type 1 receptor activation. |
2012-04-16 |
2023-08-12 |
mouse |
| Joost Wiskerke, Nicky Stoop, Dustin Schetters, Anton N M Schoffelmeer, Tommy Patti. Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice. PloS one. vol 6. issue 10. 2012-02-13. PMID:22016780. |
we focused on the role of cannabinoid cb1 receptor activation in amphetamine-induced impulsivity as there is evidence that acute challenges with psychostimulants activate the endogenous cannabinoid system, and cb1 receptor activity modulates impulsivity in both rodents and humans. |
2012-02-13 |
2023-08-12 |
rat |